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PBE - ETF AI Analysis

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PBE

Invesco Dynamic Biotechnology & Genome ETF (PBE)

Rating:72Outperform
Price Target:
PBE, the Invesco Dynamic Biotechnology & Genome ETF, earns a solid rating largely because many of its biggest holdings—like Gilead Sciences, Amgen, Regeneron, Incyte, and United Therapeutics—show strong financial performance, positive earnings commentary, and healthy growth prospects. A few names such as Alnylam and Dynavax face profitability or valuation concerns, which slightly weigh on the fund’s appeal. The main risk is its heavy concentration in the biotechnology and genomics sector, which can lead to higher volatility and sensitivity to industry-specific news and regulation.
Positive Factors
Leading Biotech and Genomics Holdings
The ETF’s largest positions are well-known biotechnology and genomics companies, several of which have shown strong or steady performance this year, helping support the fund.
Focused Health Care Exposure
Almost all assets are invested in the health care sector, giving investors targeted exposure to biotechnology and genome-related companies rather than a broad market mix.
Recent Short-Term Momentum
Despite slightly negative results so far this year, the ETF has shown strong performance over the last three months, suggesting improving short-term momentum.
Negative Factors
High Sector Concentration
With nearly all assets in health care and biotechnology, the fund is heavily exposed to swings in a single, often volatile sector.
Mixed Performance Among Top Holdings
Several of the largest positions have been weak or lagging this year, which has weighed on the ETF’s overall year-to-date results.
Relatively High Expense Ratio
The fund’s expense ratio is on the higher side for an ETF, meaning more of the returns are used to cover fees instead of staying with investors.

PBE vs. SPDR S&P 500 ETF (SPY)

PBE Summary

The Invesco Dynamic Biotechnology & Genome ETF (PBE) tracks the Dynamic Biotech & Genome Intellidex Index, focusing on U.S. biotech and genomics companies working on new drugs, genetic testing, and advanced medical treatments. It holds well-known names like Amgen and Gilead Sciences, along with smaller innovators, giving investors a way to bet on the long-term growth of cutting-edge health care in a single fund. This can offer strong growth potential but also comes with higher risk, as biotech stocks can be very volatile and the ETF can go up and down sharply with news about drug trials and regulations.
How much will it cost me?The expense ratio for the Invesco Dynamic Biotechnology & Genome ETF (PBE) is 0.58%, which means you’ll pay $5.80 per year for every $1,000 invested. This is higher than average because the fund is actively managed, focusing on specialized biotechnology and genomic research companies that require more in-depth analysis and management.
What would affect this ETF?The Invesco Dynamic Biotechnology & Genome ETF (PBE) could benefit from advancements in biotechnology and genomic research, as well as increased demand for innovative healthcare solutions. However, it may face challenges from regulatory changes, high research and development costs, or economic downturns that could impact funding for biotech companies. The ETF’s focus on U.S.-based firms and top holdings like Vertex Pharmaceuticals and Gilead Sciences highlights its reliance on the performance of leading biotech innovators.

PBE Top 10 Holdings

PBE is a pure-play U.S. biotech fund, and its story right now is all about a tug-of-war between high-flyers and laggards in a very concentrated health care niche. Illumina, Incyte, and smaller names like Dynavax and Amicus are doing the heavy lifting, with shares generally rising on upbeat earnings and solid pipelines. On the other side, Alnylam has been losing steam, while big players like Biogen and Regeneron have seen more mixed, choppy trading. With everything tied to biotech, the fund’s fortunes hinge squarely on drug data and FDA headlines.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Gilead Sciences5.92%$15.69M$188.19B57.77%
78
Outperform
Amgen5.49%$14.57M$202.37B26.68%
77
Outperform
Biogen5.36%$14.20M$28.44B39.04%
74
Outperform
Incyte5.02%$13.30M$21.41B64.38%
81
Outperform
Regeneron5.01%$13.28M$82.48B17.25%
78
Outperform
United Therapeutics4.85%$12.85M$20.37B33.91%
79
Outperform
Illumina4.55%$12.06M$17.92B16.46%
71
Outperform
Amicus3.85%$10.22M$4.49B49.42%
73
Outperform
Dynavax3.61%$9.58M$1.82B22.05%
70
Outperform
Alnylam Pharma3.60%$9.55M$42.28B18.96%
60
Neutral

PBE Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
82.21
Positive
100DMA
77.75
Positive
200DMA
71.17
Positive
Market Momentum
MACD
0.22
Positive
RSI
51.17
Neutral
STOCH
61.77
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For PBE, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 82.59, equal to the 50-day MA of 82.21, and equal to the 200-day MA of 71.17, indicating a bullish trend. The MACD of 0.22 indicates Positive momentum. The RSI at 51.17 is Neutral, neither overbought nor oversold. The STOCH value of 61.77 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PBE.

PBE Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$267.28M0.58%
$918.26M0.62%
$762.29M0.40%
$721.38M0.38%
$406.85M0.57%
$129.80M0.50%
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PBE
Invesco Dynamic Biotechnology & Genome ETF
82.73
15.27
22.64%
FXH
First Trust Health Care AlphaDEX Fund
RSPH
Invesco S&P 500 Equal Weight Health Care ETF
IHF
iShares U.S. Healthcare Providers ETF
PJP
Invesco Dynamic Pharmaceuticals ETF
SBIO
ALPS Medical Breakthroughs ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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