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PBE - ETF AI Analysis

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PBE

Invesco Dynamic Biotechnology & Genome ETF (PBE)

Rating:72Outperform
Price Target:
PBE, the Invesco Dynamic Biotechnology & Genome ETF, earns a solid overall rating thanks to several strong biotech leaders like United Therapeutics, Regeneron, Amgen, Gilead, and Incyte, which all show robust financial performance, positive earnings commentary, and generally supportive technical trends that point to healthy long-term growth potential. This strength is partly offset by weaker names such as BioCryst, where financial challenges and valuation concerns create more uncertainty, and by holdings like Alnylam and Protagonist Therapeutics that face potential overvaluation risks. The main risk factor for PBE is its concentrated exposure to the biotechnology and genomics sector, which can be volatile and sensitive to regulation, competition, and drug development outcomes.
Positive Factors
Leading Biotech and Genomics Holdings
The ETF’s largest positions are well-known biotechnology and genomics companies, several of which have shown strong or steady performance this year, helping support the fund.
Focused Health Care Exposure
Almost all assets are invested in the health care sector, giving investors targeted exposure to biotechnology and genome-related companies rather than a broad market mix.
Recent Short-Term Momentum
Despite slightly negative results so far this year, the ETF has shown strong performance over the last three months, suggesting improving short-term momentum.
Negative Factors
High Sector Concentration
With nearly all assets in health care and biotechnology, the fund is heavily exposed to swings in a single, often volatile sector.
Mixed Performance Among Top Holdings
Several of the largest positions have been weak or lagging this year, which has weighed on the ETF’s overall year-to-date results.
Relatively High Expense Ratio
The fund’s expense ratio is on the higher side for an ETF, meaning more of the returns are used to cover fees instead of staying with investors.

PBE vs. SPDR S&P 500 ETF (SPY)

PBE Summary

The Invesco Dynamic Biotechnology & Genome ETF (PBE) tracks the Dynamic Biotech & Genome Intellidex Index, focusing on U.S. biotech and genomics companies working on new drugs, genetic testing, and advanced medical treatments. It holds well-known names like Amgen and Gilead Sciences, along with smaller innovators, giving investors a way to bet on the long-term growth of cutting-edge health care in a single fund. This can offer strong growth potential but also comes with higher risk, as biotech stocks can be very volatile and the ETF can go up and down sharply with news about drug trials and regulations.
How much will it cost me?The expense ratio for the Invesco Dynamic Biotechnology & Genome ETF (PBE) is 0.58%, which means you’ll pay $5.80 per year for every $1,000 invested. This is higher than average because the fund is actively managed, focusing on specialized biotechnology and genomic research companies that require more in-depth analysis and management.
What would affect this ETF?The Invesco Dynamic Biotechnology & Genome ETF (PBE) could benefit from advancements in biotechnology and genomic research, as well as increased demand for innovative healthcare solutions. However, it may face challenges from regulatory changes, high research and development costs, or economic downturns that could impact funding for biotech companies. The ETF’s focus on U.S.-based firms and top holdings like Vertex Pharmaceuticals and Gilead Sciences highlights its reliance on the performance of leading biotech innovators.

PBE Top 10 Holdings

PBE is a pure-play U.S. biotech fund, and its story right now is one of sharp contrasts. United Therapeutics is helping lead the charge, with BioCryst and Protagonist Therapeutics sprinting ahead and giving the ETF some real upside spark. On the other side, Alnylam and Incyte have been lagging, acting like a bit of a weight in the portfolio, while Regeneron looks softer in the near term despite solid fundamentals. Gilead, Amgen, and Biogen are steadier anchors, keeping this health care–heavy, innovation-focused fund on a mostly biotech-driven track.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
United Therapeutics6.04%$14.23M$25.99B93.23%
79
Outperform
Illumina5.24%$12.34M$18.85B57.24%
71
Outperform
Regeneron5.23%$12.31M$81.67B25.22%
78
Outperform
Alnylam Pharma5.22%$12.28M$43.88B29.37%
60
Neutral
Biogen5.16%$12.14M$26.91B38.85%
74
Outperform
Amgen4.99%$11.74M$189.67B14.64%
77
Outperform
Gilead Sciences4.98%$11.72M$173.02B25.24%
78
Outperform
Incyte4.89%$11.51M$18.73B54.52%
81
Outperform
BioCryst3.66%$8.62M$2.39B31.31%
55
Neutral
Protagonist Therapeutics3.38%$7.96M$6.73B124.83%
68
Neutral

PBE Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
80.31
Negative
100DMA
80.47
Negative
200DMA
74.16
Positive
Market Momentum
MACD
-0.84
Negative
RSI
53.12
Neutral
STOCH
48.75
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For PBE, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 77.53, equal to the 50-day MA of 80.31, and equal to the 200-day MA of 74.16, indicating a neutral trend. The MACD of -0.84 indicates Negative momentum. The RSI at 53.12 is Neutral, neither overbought nor oversold. The STOCH value of 48.75 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PBE.

PBE Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$242.16M0.58%
72
Outperform
$980.36M0.38%
70
Outperform
$831.83M0.61%
71
Outperform
$704.17M0.40%
71
Outperform
$663.28M0.38%
69
Neutral
$126.28M0.50%
52
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PBE
Invesco Dynamic Biotechnology & Genome ETF
79.18
16.61
26.55%
IHE
iShares U.S. Pharmaceuticals ETF
FXH
First Trust Health Care AlphaDEX Fund
RSPH
Invesco S&P 500 Equal Weight Health Care ETF
IHF
iShares U.S. Healthcare Providers ETF
SBIO
ALPS Medical Breakthroughs ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
DisclaimerThis AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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