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Biocryst Pharmaceuticals (BCRX)
NASDAQ:BCRX
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BioCryst (BCRX) AI Stock Analysis

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BCRX

BioCryst

(NASDAQ:BCRX)

Rating:56Neutral
Price Target:
$8.50
▲(2.53% Upside)
BioCryst's strong earnings call and strategic corporate events are major positives, but financial instability and bearish technical indicators weigh down the overall score. Continued focus on profitability and debt management is crucial for future stability.
Positive Factors
Debt Management
The sale of the European Orladeyo business provides a clear line of sight for settling outstanding debt, which had been a concern for some investors.
Market Demand
Increasing demand from patients with normal C1-inhibitor status supports continued revenue growth into the future.
Product Advantage
Orladeyo’s status as the only oral prophylactic therapy for HAE on the market provides a competitive advantage.
Negative Factors
Geographic Revenue Impact
The company announced the sale of their EU franchise, which no longer includes EU sales in peak sales models.
Regulatory Challenges
The FDA extended the PDUFA for the Orladeyo granule formulation in pediatric HAE patients by 3 months, indicating potential regulatory delays.

BioCryst (BCRX) vs. SPDR S&P 500 ETF (SPY)

BioCryst Business Overview & Revenue Model

Company DescriptionBioCryst Pharmaceuticals, Inc., a biotechnology company, discovers novel, oral, and small-molecule medicines. The company markets peramivir injection, an intravenous neuraminidase inhibitor for the treatment of acute uncomplicated influenza under the RAPIVAB, RAPIACTA, and PERAMIFLU names; and ORLADEYO, an oral serine protease inhibitor to treat hereditary angioedema. It is also developing BCX9930, an oral factor D inhibitor, which is in Phase II clinical trial for complement-mediated diseases; BCX9250, an oral activin receptor-like kinase-2 inhibitor that is in Phase I clinical trial to treat fibrodysplasia ossificans progressiva; and Galidesivir, a RNA dependent-RNA polymerase inhibitor, which is in Phase I clinical trial to treat various RNA viruses, including Marburg, Yellow Fever, Ebola, and Zika. The company has collaborations and in-license relationships with the Torii Pharmaceutical Co., Ltd.; Seqirus UK Limited; Shionogi & Co., Ltd.; Green Cross Corporation; Mundipharma International Holdings Limited; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; the U.S. Department of Health and Human Services; and The University of Alabama at Birmingham, as well as Albert Einstein College of Medicine of Yeshiva University and Industrial Research, Ltd. BioCryst Pharmaceuticals, Inc. was founded in 1986 and is headquartered in Durham, North Carolina.
How the Company Makes MoneyBioCryst generates revenue primarily through the sale of its approved products, such as Orladeyo, which contributes to its direct sales revenue. In addition, the company may earn revenue from licensing agreements and collaborations with other pharmaceutical companies, which can include upfront payments, milestone payments upon achieving certain development or sales targets, and royalties on sales of partnered products. The company's ongoing research and development efforts may also lead to additional revenue opportunities through future product launches and potential government grants or partnerships aimed at bringing innovative therapies to market.

BioCryst Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Analyzes revenue from different business segments, offering insight into which parts of BioCryst's operations are most profitable and where there may be opportunities or challenges.
Chart InsightsBioCryst's Orladeyo segment shows robust growth, with revenue significantly increasing year-over-year, reflecting strong market demand and strategic execution. The latest earnings call underscores this momentum, highlighting Orladeyo's best quarter since approval and a 45% year-over-year increase. Despite challenges like the European business sale, BioCryst remains optimistic, expecting to hit the upper half of its revenue guidance. The company's strong cash position and leadership transition are poised to drive future growth, focusing on pipeline advancements and rare disease opportunities.
Data provided by:Main Street Data

BioCryst Earnings Call Summary

Earnings Call Date:Aug 04, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Oct 29, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant achievements, including record-breaking ORLADEYO performance, strong financial management, and strategic advancements in the pipeline. The successful sale of the European business and leadership transition further strengthened the company's position. While there are potential challenges with new market entrants and a delay in the pediatric ORLADEYO approval, the positive aspects of the call significantly outweigh the lowlights.
Q2-2025 Updates
Positive Updates
Record ORLADEYO Performance
The second quarter of 2025 was the best ever for ORLADEYO, with new patient prescriptions up over 10% above the first quarter of the launch in 2021 and over 15% above Q1 this year. ORLADEYO revenue exceeded expectations by more than $22 million above Q1 and showed a 45% growth year-over-year.
Strong Financial Position
Total revenue for the quarter was $163.4 million, with ORLADEYO accounting for $156.8 million. The company generated $45 million of cash in the second quarter before any debt prepayment and paid down $75 million in principal from its term loan in April and an additional $50 million in July.
European Business Sale
BioCryst signed a definitive agreement to sell its European business to Neopharmed Gentili, expected to close in early October. This deal will enable the company to pay off its term debt and improve its operating profit margin.
Pipeline Progress
The Netherton syndrome and DME pipeline programs remain on track to have data by the end of the year. The company anticipates FDA approval of ORLADEYO granules in December.
Successful Leadership Transition
Charlie Gayer was chosen as the next CEO, following a successful succession planning process. Jon Stonehouse will work with Charlie for a smooth transition into the new year.
Negative Updates
Potential Challenges with New HAE Approvals
Questions were raised about the impact of new HAE treatments, such as garadacimab and Ekterly, approved in June and July, on ORLADEYO demand.
PDUFA Date Delay for Pediatric ORLADEYO
The PDUFA date for the pediatric indication of ORLADEYO has been delayed to December 12 due to the FDA requiring more time for final report reviews.
Company Guidance
In the recent BioCryst Second Quarter 2025 Earnings Conference Call, the company reported impressive metrics, particularly for ORLADEYO, which achieved its best quarter since approval. ORLADEYO's revenue for Q2 was $156.8 million, representing a 45% increase year-over-year, with $140.3 million generated in the U.S. The company anticipates reaching the upper half of its revenue guidance of $580 million to $600 million for the full year, despite removing European revenue in Q4 due to the sale of its European business. The commercial performance was bolstered by a 10% increase in new patient prescriptions from Q1 2021 and a 15% rise from Q1 this year. BioCryst's non-GAAP operating expenses were $106.4 million, up from $87.4 million in Q2 2024, while non-GAAP operating profit was $57 million. The company generated $45 million in cash before debt prepayment and paid down $125 million in principal from its term loan, reducing the balance to $199 million. BioCryst is on track to generate $700 million in cash by 2027 and plans to use this financial strength to explore opportunities for growth through acquisitions and pipeline expansion.

BioCryst Financial Statement Overview

Summary
BioCryst has strong revenue growth and gross profit margins, but faces challenges with persistent net losses and negative equity, indicating high financial risk. Improvements in cash flow generation are noted but reliance on external financing remains.
Income Statement
45
Neutral
BioCryst shows a positive trend in revenue growth with a significant increase to $503.5M in TTM, up from $450.7M in 2024. Gross profit margin remains strong at approximately 97%, indicating efficient cost management. However, the company continues to report net losses, with a net profit margin of -10.6% in TTM. The EBIT and EBITDA margins have improved but remain low due to ongoing operational challenges.
Balance Sheet
30
Negative
The balance sheet reflects financial instability with negative stockholders' equity, which stands at -$451.9M in TTM, indicating liabilities exceed assets. The debt-to-equity ratio is not meaningful due to negative equity. Return on equity is negative due to consistent net losses. The equity ratio is non-existent, highlighting significant financial leverage and risk.
Cash Flow
40
Negative
Free cash flow improved slightly but remains negative at -$27.3M in TTM. Operating cash flow is also negative, impacting the company’s ability to fund operations internally. The free cash flow to net income ratio indicates challenges in converting earnings to cash, although there is a positive trend in reducing cash flow deficits over time.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue503.49M450.71M331.41M270.83M157.17M17.81M
Gross Profit487.82M438.44M325.10M262.80M149.13M16.14M
EBITDA43.80M12.81M-116.33M-143.85M-121.74M-167.56M
Net Income-53.47M-88.88M-226.54M-247.12M-184.06M-182.81M
Balance Sheet
Total Assets480.05M490.42M516.96M550.00M588.15M334.71M
Cash, Cash Equivalents and Short-Term Investments295.09M320.85M388.99M424.31M507.60M300.37M
Total Debt794.99M841.42M848.71M741.45M593.24M279.50M
Total Liabilities931.97M966.35M972.49M844.60M695.14M353.98M
Stockholders Equity-451.93M-475.93M-455.53M-294.60M-106.99M-19.26M
Cash Flow
Free Cash Flow-27.29M-53.14M-97.31M-163.20M-144.54M-137.73M
Operating Cash Flow-26.25M-52.02M-95.14M-161.85M-142.16M-137.22M
Investing Cash Flow50.93M52.59M-131.50M-128.24M15.80M-6.86M
Financing Cash Flow-4.18M-5.76M32.48M88.03M359.67M300.59M

BioCryst Technical Analysis

Technical Analysis Sentiment
Negative
Last Price8.29
Price Trends
50DMA
8.59
Negative
100DMA
9.14
Negative
200DMA
8.47
Negative
Market Momentum
MACD
-0.08
Negative
RSI
43.55
Neutral
STOCH
31.28
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BCRX, the sentiment is Negative. The current price of 8.29 is below the 20-day moving average (MA) of 8.38, below the 50-day MA of 8.59, and below the 200-day MA of 8.47, indicating a bearish trend. The MACD of -0.08 indicates Negative momentum. The RSI at 43.55 is Neutral, neither overbought nor oversold. The STOCH value of 31.28 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for BCRX.

BioCryst Risk Analysis

BioCryst disclosed 56 risk factors in its most recent earnings report. BioCryst reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

BioCryst Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
$1.76B50.41-35.00%21.48%162.30%
60
Neutral
$2.28B3.6864.05%30.57%
57
Neutral
$3.55B-34.80%2816.21%73.33%
57
Neutral
$2.91B-33.26%-49.51%-44.09%
56
Neutral
$1.74B18.68%45.85%76.36%
51
Neutral
$7.90B-0.33-41.70%2.23%23.45%-1.99%
43
Neutral
$2.13B-26.36%-22.19%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BCRX
BioCryst
8.29
0.16
1.97%
ARWR
Arrowhead Pharmaceuticals
27.80
4.55
19.57%
MNKD
MannKind
5.51
-0.52
-8.62%
AGIO
Agios Pharma
40.61
-3.43
-7.79%
IRON
Disc Medicine
61.59
11.39
22.69%
KYMR
Kymera Therapeutics
43.30
-3.30
-7.08%

BioCryst Corporate Events

Executive/Board Changes
BioCryst’s Chief R&D Officer Resigns Amid CEO Decision
Neutral
Aug 11, 2025

On August 6, 2025, Dr. Helen Thackray announced her resignation as Chief Research and Development Officer of BioCryst Pharmaceuticals, effective September 1, 2025, after not being selected as the next CEO. The company has entered into a Separation Agreement with Dr. Thackray, offering various benefits, and a Consulting Agreement for transition services until the end of 2025, ensuring a smooth transition and continuity in operations.

M&A TransactionsBusiness Operations and StrategyFinancial Disclosures
BioCryst Reports Strong Q2 2025 Financial Performance
Positive
Aug 4, 2025

In the second quarter of 2025, BioCryst Pharmaceuticals reported a significant financial performance with ORLADEYO net revenue reaching $156.8 million, a 45% increase year-over-year, and an operating profit of $29.8 million, marking a 239% rise. The company also announced plans to retire its remaining term debt through the sale of its European ORLADEYO business, which is expected to further strengthen its financial position. The growth in ORLADEYO’s demand, particularly in the U.S., and the promising pipeline developments, including new drug applications and ongoing trials, highlight BioCryst’s strategic focus on expanding its market presence and delivering value to stakeholders.

Executive/Board ChangesBusiness Operations and Strategy
BioCryst Announces New President Amid Leadership Change
Positive
Jul 31, 2025

On July 31, 2025, BioCryst Pharmaceuticals announced the retirement of Jon Stonehouse as President and CEO, effective December 31, 2025, with Charlie Gayer appointed as the new President effective August 1, 2025, and CEO starting January 1, 2026. Gayer, who has been instrumental in the commercial success of ORLADEYO and shaping the company’s business strategy, is expected to continue driving growth and value creation for stakeholders.

Executive/Board ChangesBusiness Operations and Strategy
BioCryst Appoints New CFO to Drive Growth
Positive
Jul 7, 2025

On July 7, 2025, BioCryst Pharmaceuticals announced the appointment of Babar Ghias as Chief Financial Officer and Head of Corporate Development. Mr. Ghias brings extensive experience from his previous roles at AvenCell Therapeutics and Paragon Biosciences, where he was instrumental in launching biotechnology companies and raising significant capital. His appointment is expected to bolster BioCryst’s leadership team as the company aims to accelerate growth and enhance value creation. This strategic move is seen as pivotal for BioCryst’s operational excellence and financial discipline, supporting its ambitious growth plans.

M&A TransactionsBusiness Operations and Strategy
BioCryst Sells BioCryst Ireland to Neopharmed Gentili
Neutral
Jun 30, 2025

On June 27, 2025, BioCryst Pharmaceuticals entered into a Stock Purchase Agreement to sell its equity interests in BioCryst Ireland to Neopharmed Gentili S.p.A. for $250 million, with potential additional payments based on revenue milestones. This transaction, expected to close in October 2025, will involve amendments to existing intellectual property agreements and establish BioCryst as the exclusive supplier of ORLADEYO® to the company, impacting BioCryst’s operations and market positioning in Europe.

M&A TransactionsBusiness Operations and Strategy
BioCryst Sells European ORLADEYO Business for $264M
Positive
Jun 27, 2025

On June 27, 2025, BioCryst Pharmaceuticals announced the sale of its European ORLADEYO business to Neopharmed Gentili for up to $264 million. The transaction will allow BioCryst to eliminate its remaining term debt, saving approximately $70 million in future interest payments, and is expected to leave the company with $700 million in cash by the end of 2027. This strategic move aligns with BioCryst’s goal of enhancing profitability and sustaining growth, while Neopharmed Gentili aims to strengthen its position in the European specialty pharmaceutical market.

Product-Related AnnouncementsRegulatory Filings and Compliance
FDA Extends BioCryst’s ORLADEYO Review Deadline
Neutral
Jun 25, 2025

On June 23, 2025, the FDA extended the PDUFA goal date for BioCryst‘s new drug application for ORLADEYO® oral granules for pediatric HAE patients aged 2 to 11. This extension, moving the target action date to December 12, 2025, was due to the submission of additional reports and data, which the FDA considered a major amendment requiring a full review.

Executive/Board ChangesShareholder Meetings
BioCryst Stockholders Approve Stock Incentive Plan Amendment
Neutral
Jun 16, 2025

On June 11, 2025, George B. Abercrombie announced his retirement from BioCryst‘s Board of Directors, effective at the 2025 Annual Meeting. The company expressed gratitude for his 13 years of service. On June 12, 2025, BioCryst’s stockholders approved an amendment to the Stock Incentive Plan, increasing available shares by 11 million. The meeting also included the election of directors, ratification of Ernst & Young LLP as accountants, and approval of executive compensation.

Executive/Board Changes
BioCryst Extends Consulting Agreement with Former CFO
Neutral
Jun 4, 2025

BioCryst Pharmaceuticals extended a Consulting Agreement with its former CFO, Anthony Doyle, to ensure a smooth transition in leadership. The agreement, effective April 9, 2025, and extended on May 31, 2025, will continue on a month-to-month basis after December 31, 2025, providing stability during the CFO transition.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 30, 2025