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Mannkind Corp. (MNKD)
NASDAQ:MNKD
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MannKind (MNKD) AI Stock Analysis

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MNKD

MannKind

(NASDAQ:MNKD)

Rating:61Neutral
Price Target:
$3.50
▼(-5.41% Downside)
MannKind's overall stock score reflects strong financial performance and positive earnings call sentiment, offset by a weak balance sheet and bearish technical indicators. The company's strategic growth plans and product pipeline advancements are promising, but financial risks and valuation concerns weigh on the score.
Positive Factors
Market Share Expansion
The time to approval for TPIP is expected to allow Tyvaso DPI to continue gaining market share and moving into new indications.
Pipeline Development
The Ph3 study of MNKD-101 is nearing target patient enrollment for the interim analysis ahead of schedule, which suggests strong progress in their clinical trials.
Revenue Growth
Afrezza's strong growth in net revenue reflects the initial positive effect from increased promotional efforts, with management expecting the trend to continue.
Negative Factors
Financial Concerns
Stock weakness may be due to investor concerns related to a financing agreement for up to $500M, which could be perceived as potential dilution or financial strain.
Royalty Revenue
Tyvaso DPI royalties reflect Q/Q deceleration in Tyvaso growth as reported, with a decrease from +11% to 4%.
Study Skepticism
There is skepticism about the likelihood of success for TETON given the primarily vasodilative mechanism and different patient population compared to previous studies.

MannKind (MNKD) vs. SPDR S&P 500 ETF (SPY)

MannKind Business Overview & Revenue Model

Company DescriptionMannKind Corporation (MNKD) is a biopharmaceutical company focused on the development and commercialization of innovative therapies for diabetes and other endocrine-related conditions. The company is primarily known for its flagship product, Afrezza, an inhaled insulin that offers a rapid-acting alternative to traditional subcutaneous insulin injections. MannKind also explores other therapeutic areas, leveraging its proprietary Technosphere technology platform to deliver medications via inhalation.
How the Company Makes MoneyMannKind generates revenue primarily through the sales of Afrezza, which is marketed to patients with diabetes requiring insulin therapy. The company earns money from the direct sale of Afrezza to pharmacies and healthcare providers, as well as from partnerships with pharmaceutical distributors. Additionally, MannKind may receive royalties and milestone payments from collaborations with other companies that utilize its Technosphere technology for their own drug formulations. The company’s revenue model is heavily impacted by the demand for Afrezza, market competition, and ongoing marketing efforts to educate both healthcare professionals and patients about the benefits of inhaled insulin.

MannKind Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: -7.27%|
Next Earnings Date:Nov 11, 2025
Earnings Call Sentiment Positive
The earnings call presented strong financial metrics and promising advancements in MannKind's product pipeline, particularly with significant growth in Tyvaso DPI and Afrezza revenues. However, there were challenges noted in V-Go revenue and manufacturing timing, as well as trial enrollment difficulties in the U.S. for Nintedanib DPI. Despite these challenges, the overall outlook remains positive with strategic plans and financial resources in place to support future growth.
Q2-2025 Updates
Positive Updates
Record Revenue in Tyvaso DPI Sales
Achieved record revenue from Tyvaso DPI sales, with Q2 royalties contributing $31 million, an increase of 22% over the same quarter last year.
Strong Financial Position
MannKind has a strong balance sheet with $201 million in cash and access to $500 million from Blackstone for nondilutive capital to accelerate growth and innovation.
Afrezza Growth and Expansion
Afrezza net revenues for Q2 were $18 million, a 13% increase over the prior year, with year-over-year growth of 22% on new prescriptions.
Advancement in Nintedanib DPI
Nintedanib DPI for IPF is moving forward into Phase II with a trial named INFLO, expected to launch by year-end 2025.
Inhaled Clofazimine Developments
Enrollment in the ICoN-1 trial for inhaled Clofazimine is progressing well with 90 patients enrolled, aiming for 100 evaluable patients by 2026.
Negative Updates
Decline in V-Go Net Revenue
V-Go net revenue was approximately $4 million for Q2, an 8% decrease from the prior year, driven by lower product demand.
Manufacturing Revenue Fluctuations
Collaboration and services revenue decreased by 12% from the prior year as a result of the timing of manufacturing.
Challenges with U.S. Trial Enrollment
Difficulties in executing a placebo-controlled trial in the U.S. for the Nintedanib DPI program due to IRB and patient enrollment challenges.
Company Guidance
During the MannKind Corporation Second Quarter 2025 Financial Results Conference Call, CEO Michael Castagna provided guidance focusing on shareholder value and strategic growth. The company highlighted its financial strength with Q2 revenues at $77 million, a 6% increase over 2024, and a robust balance sheet featuring $201 million in cash. MannKind announced a significant financial partnership with Blackstone, ensuring access to $500 million in nondilutive capital to fuel growth. Key operational highlights included record Tyvaso DPI sales, impressive Afrezza revenue of $18.3 million reflecting a 13% year-over-year growth, and promising advancements in their pipeline, notably the inhaled clofazimine and Nintedanib DPI programs. The company plans to expand its sales force, particularly in anticipation of a pediatric Afrezza launch, and aims to increase market coverage to approximately 50% by 2026.

MannKind Financial Statement Overview

Summary
MannKind has exhibited strong revenue growth and improved profitability with a significant increase in revenue and net profit margin. However, the balance sheet shows high leverage and negative equity, which are concerning financial risks. Cash flow management is positive, but overall, the company needs to address its balance sheet weaknesses.
Income Statement
75
Positive
MannKind has shown a remarkable revenue growth trajectory, increasing from $65.1M in 2020 to $297.6M in TTM (Trailing-Twelve-Months). The gross profit margin is strong at 74.6% for the TTM, indicating effective cost management. The net profit margin improved significantly to 10.1% in TTM, highlighting the company's transition to profitability. However, EBIT and EBITDA margins have room for improvement at 26.1% and 25.7% respectively.
Balance Sheet
45
Neutral
The company shows a high debt-to-equity ratio due to negative stockholders' equity. This presents a financial risk, although net debt has improved to a negative $62K in TTM, suggesting cash reserves exceed debt. The return on equity is difficult to interpret with negative equity, but the equity ratio is concerning at -14.3% in TTM, indicating financial instability.
Cash Flow
68
Positive
Positive free cash flow of $21.7M in TTM is an encouraging sign of operational efficiency. The operating cash flow to net income ratio is 0.97, showing close alignment between cash flow and reported profits. Although free cash flow growth has fluctuated, the recent trend is positive, suggesting improved cash management.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue285.50M198.96M99.77M75.44M65.14M
Gross Profit208.90M136.19M42.27M36.59M40.50M
EBITDA77.47M15.13M-56.34M-61.09M-45.01M
Net Income27.59M-11.94M-112.17M-91.79M-57.24M
Balance Sheet
Total Assets393.84M475.20M295.28M321.16M108.61M
Cash, Cash Equivalents and Short-Term Investments197.26M295.10M170.85M204.12M67.00M
Total Debt47.70M382.38M382.91M382.74M123.44M
Total Liabilities472.66M721.37M545.82M530.51M289.03M
Stockholders Equity-78.82M-246.17M-250.54M-209.35M-180.42M
Cash Flow
Free Cash Flow32.82M-8.35M-88.27M-73.17M-32.91M
Operating Cash Flow42.51M34.09M-80.68M-61.71M-28.13M
Investing Cash Flow-96.65M-1.99M4.87M-151.54M15.22M
Financing Cash Flow-137.27M136.61M21.41M270.27M49.85M

MannKind Technical Analysis

Technical Analysis Sentiment
Negative
Last Price3.70
Price Trends
50DMA
3.83
Negative
100DMA
4.25
Negative
200DMA
5.21
Negative
Market Momentum
MACD
-0.08
Positive
RSI
47.65
Neutral
STOCH
45.82
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MNKD, the sentiment is Negative. The current price of 3.7 is below the 20-day moving average (MA) of 3.79, below the 50-day MA of 3.83, and below the 200-day MA of 5.21, indicating a bearish trend. The MACD of -0.08 indicates Positive momentum. The RSI at 47.65 is Neutral, neither overbought nor oversold. The STOCH value of 45.82 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for MNKD.

MannKind Risk Analysis

MannKind disclosed 51 risk factors in its most recent earnings report. MannKind reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

MannKind Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
61
Neutral
$1.14B33.85-35.00%21.48%162.30%
58
Neutral
$2.13B3.3264.05%30.57%
53
Neutral
$2.85B-33.26%-49.51%-44.09%
51
Neutral
$7.44B-0.20-46.00%2.27%22.80%-2.27%
50
Neutral
$1.75B18.68%45.85%76.36%
47
Neutral
$2.46B-34.80%2816.21%73.33%
41
Neutral
$1.71B-41.94%-82.90%-155.64%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
MNKD
MannKind
3.70
-1.44
-28.02%
ARWR
Arrowhead Pharmaceuticals
18.78
-3.92
-17.27%
BCRX
BioCryst
8.45
0.81
10.60%
AGIO
Agios Pharma
36.68
-8.35
-18.54%
BEAM
Beam Therapeutics
17.63
-6.80
-27.83%
KYMR
Kymera Therapeutics
41.55
-2.25
-5.14%

MannKind Corporate Events

Executive/Board ChangesShareholder Meetings
MannKind Stockholders Approve Board and Compensation
Neutral
May 19, 2025

At the 2025 Annual Meeting of Stockholders held on May 14, 2025, MannKind‘s stockholders elected nine board members to serve until the next annual meeting. Additionally, stockholders approved the executive compensation package and ratified Deloitte & Touche LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

The most recent analyst rating on (MNKD) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on MannKind stock, see the MNKD Stock Forecast page.

Executive/Board Changes
MannKind Announces CMO Transition and Separation Agreement
Neutral
May 15, 2025

On May 9, 2025, MannKind Corporation and its Chief Medical Officer, Burkhard Blank, agreed on his transition from the role of executive officer, with a formal separation agreement established on May 14, 2025. Mr. Blank will continue as a non-executive employee until August 1, 2025, and will receive salary continuation, a special bonus, and COBRA premium reimbursements post-separation, while his equity awards remain eligible for vesting during his employment.

The most recent analyst rating on (MNKD) stock is a Buy with a $10.00 price target. To see the full list of analyst forecasts on MannKind stock, see the MNKD Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 07, 2025