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Beam Therapeutics (BEAM)
NASDAQ:BEAM
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Beam Therapeutics (BEAM) AI Stock Analysis

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BEAM

Beam Therapeutics

(NASDAQ:BEAM)

Rating:50Neutral
Price Target:
$19.00
▲(1.28% Upside)
Beam Therapeutics' overall stock score is primarily influenced by its financial challenges, including declining revenues and negative cash flows. The technical analysis suggests a neutral trend, while the valuation is constrained by unprofitability. The recent acquisition provides a positive strategic outlook, but financial stability remains a concern.
Positive Factors
Clinical Trials
The update is incrementally positive on safety across 17 patients, with clean results reported and dose-dependent increases in functional AAT suggesting room for improved efficacy.
Financial Health
The company has approximately $1.15 billion in cash, cash equivalents, and marketable securities, with an expected cash runway into 2028.
Product Development
BEAM-302 has a competitive edge in the AATD space due to its potential for a one-time treatment, offering an advantage over multidose options.
Negative Factors
Market Competition
Wave Life Science's WVE-006 falls behind BEAM-302 in several key metrics relevant to AATD treatment.
Regulatory Delays
Pushing data to 2026 delays a near-term catalyst, which could be seen as a setback for investors looking for immediate developments.

Beam Therapeutics (BEAM) vs. SPDR S&P 500 ETF (SPY)

Beam Therapeutics Business Overview & Revenue Model

Company DescriptionBeam Therapeutics Inc., a biotechnology company, develops precision genetic medicines for patients suffering from serious diseases in the United States. The company is developing BEAM-101 for the treatment of sickle cell disease and beta thalassemia; BEAM-102 for the treatment of sickle cell disease; and BEAM-201, an allogeneic chimeric antigen receptor T cell for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia; and BEAM-301, a liver-targeted development candidate for the treatment of patients with Glycogen Storage Disease Type Ia. It also develops therapies for alpha-1 antitrypsin deficiency; ocular diseases; and other liver, muscle, and central nervous system disorders. The company has an alliance with Boston Children's Hospital; a research and clinical trial collaboration agreement with Magenta Therapeutics, Inc.; license agreement with Sana Biotechnology, Inc.; and a research collaboration with the Institute of Molecular and Clinical Ophthalmology Basel. It also has a research collaboration agreement with Pfizer Inc. and Apellis Pharmaceuticals, Inc.; and collaboration and license agreement with Verve Therapeutics, Inc. The company was incorporated in 2017 and is based in Cambridge, Massachusetts.
How the Company Makes MoneyBeam Therapeutics generates revenue primarily through collaborations and partnerships with pharmaceutical companies and other biotech firms. These partnerships often involve licensing agreements where Beam provides access to its base editing technology in exchange for upfront payments, research funding, and milestone payments tied to the achievement of specific developmental and regulatory objectives. Additionally, the company may earn royalties on future sales of products developed using its technology. As the company advances its clinical programs and moves towards regulatory approvals, potential revenue from product commercialization could also contribute significantly to its earnings.

Beam Therapeutics Earnings Call Summary

Earnings Call Date:Aug 05, 2025
(Q3-2024)
|
% Change Since: |
Next Earnings Date:Nov 10, 2025
Earnings Call Sentiment Neutral
The earnings call presented a mix of significant advancements in Beam's clinical programs, particularly in sickle cell disease and liver genetic diseases, alongside notable challenges related to patient safety in ongoing trials. While the progress in clinical data and technology development is promising, the safety concerns related to conditioning agents are a critical issue.
Q3-2024 Updates
Positive Updates
Advancements in Sickle Cell Disease Treatment
Beam Therapeutics reported initial clinical data from the BEACON trial for BEAM-101, showing a significant increase in fetal hemoglobin (HbF) and a reduction in sickle hemoglobin (HbS) in patients with sickle cell disease. Patients achieved greater than 60% HbF, reducing HbS to less than 40%, which is consistent with sickle cell trait profiles.
Progress in Liver Genetic Disease Program
Beam-302, aimed at treating alpha-1 antitrypsin deficiency (AATD), has dosed its first patient, with plans to report initial data in 2025. This program intends to address both lung and liver manifestations of the disease.
ESCAPE Technology Development
Beam has nominated development candidates for ESCAPE technology, aiming to eliminate chemotherapy in transplants. Early nonhuman primate studies show promising engraftment and HbF induction without chemotherapy.
Strong Financial Position
Beam Therapeutics reported a strong financial position, supporting ongoing and future clinical development programs.
Negative Updates
Patient Death in BEACON Trial
A patient in the BEACON trial died due to respiratory failure, likely related to busulfan conditioning. This highlights the risks associated with myeloablative conditioning in gene therapy.
Potential Safety Concerns with Conditioning
The use of busulfan in the BEACON trial has raised safety concerns, with known risks including lung injury and respiratory failure. This underscores the need for safer conditioning methods.
Company Guidance
In the Q3 2024 earnings call, Beam Therapeutics provided comprehensive updates on its clinical programs, highlighting significant progress and future expectations. The company reported that 35 patients have been enrolled in the BEACON trial for BEAM-101, with 8 patients already treated. The trial evaluates BEAM-101 for sickle cell disease, aiming for a best-in-class profile through efficient editing and induction of fetal hemoglobin (HbF) to over 60%, significantly reducing sickle hemoglobin (HbS) levels. Beam also shared promising preclinical data for its ESCAPE technology, which aims to eliminate the use of chemotherapy in stem cell transplants, potentially expanding the patient population up to fourfold. Additionally, Beam announced the completion of dosing in the first cohort of its BEAM-302 program for alpha-1 antitrypsin deficiency (AATD) and expects to report initial data in 2025. Financially, the company remains strong, supporting the continued development and potential commercialization of its pipeline.

Beam Therapeutics Financial Statement Overview

Summary
Beam Therapeutics is experiencing significant financial challenges typical of early-stage biotech firms. The company has ongoing losses due to high R&D and operational costs. Despite a healthy gross profit margin, the net profit margin is deeply negative, reflecting difficulties in scaling operations profitably. The balance sheet shows manageable debt levels but negative return on equity due to consistent net losses. Cash flow is negative, indicating increasing cash consumption without corresponding revenue growth.
Income Statement
30
Negative
Beam Therapeutics shows significant challenges in profitability, with consistent negative net income and EBIT over recent periods. The gross profit margin is relatively healthy, indicating some cost control, but the net profit margin remains deeply negative due to high operating expenses. Revenue growth is stagnant, especially compared to the larger increases in operating losses, indicating a struggle to scale operations profitably.
Balance Sheet
45
Neutral
The company's balance sheet reflects moderate leverage with a debt-to-equity ratio that suggests manageable debt levels relative to equity. However, the return on equity is negative due to consistent net losses, indicating that shareholders' equity is not generating positive returns. The equity ratio indicates a stable capital structure, with a significant portion of assets funded by equity, which is a positive aspect amidst financial struggles.
Cash Flow
35
Negative
Beam Therapeutics has negative free cash flow, reflecting ongoing operational cash burn. The operating cash flow to net income ratio indicates that cash flow is less negative than net income, suggesting non-cash expenses. However, the negative free cash flow growth rate is concerning, indicating increasing cash consumption without corresponding revenue growth.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue60.27M63.52M377.71M60.92M51.84M24.00K
Gross Profit2.22M63.52M-59.67M38.34M35.40M-103.16M
EBITDA-396.47M-383.98M-156.47M-324.33M-392.46M-128.03M
Net Income-398.58M-376.74M-132.53M-263.59M-341.36M-256.42M
Balance Sheet
Total Assets1.39B1.10B1.46B1.34B1.47B451.68M
Cash, Cash Equivalents and Short-Term Investments1.15B850.74M1.19B1.08B965.65M299.67M
Total Debt154.80M161.43M172.69M179.00M142.35M100.23M
Total Liabilities344.34M370.28M478.38M608.24M647.72M206.12M
Stockholders Equity1.05B733.54M981.33M733.47M826.74M245.56M
Cash Flow
Free Cash Flow-355.57M-356.19M-182.93M-26.42M-113.08M-112.10M
Operating Cash Flow-344.82M-347.25M-149.19M22.53M-66.27M-95.74M
Investing Cash Flow-144.52M185.01M71.84M-461.34M-294.14M-100.12M
Financing Cash Flow479.19M7.74M276.45M111.59M756.14M322.32M

Beam Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price18.76
Price Trends
50DMA
18.68
Positive
100DMA
18.15
Positive
200DMA
21.93
Negative
Market Momentum
MACD
-0.49
Negative
RSI
58.45
Neutral
STOCH
46.88
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BEAM, the sentiment is Positive. The current price of 18.76 is above the 20-day moving average (MA) of 17.06, above the 50-day MA of 18.68, and below the 200-day MA of 21.93, indicating a neutral trend. The MACD of -0.49 indicates Negative momentum. The RSI at 58.45 is Neutral, neither overbought nor oversold. The STOCH value of 46.88 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BEAM.

Beam Therapeutics Risk Analysis

Beam Therapeutics disclosed 90 risk factors in its most recent earnings report. Beam Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Beam Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$864.09M181.41%1049.81%7.85%
55
Neutral
$1.22B-56.95%14.99%14.42%
51
Neutral
$7.89B-0.33-41.61%2.23%23.26%-2.03%
50
Neutral
$1.66B-41.94%-82.90%-155.64%
45
Neutral
$2.56B-77.58%-48.38%
42
Neutral
$1.34B-86.86%-82.75%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BEAM
Beam Therapeutics
18.76
-5.32
-22.09%
NTLA
Intellia Therapeutics
11.71
-9.56
-44.95%
PHAT
Phathom Pharmaceuticals
11.88
-5.12
-30.12%
ETNB
89bio
9.24
0.44
5.00%
IMVT
Immunovant
16.70
-13.99
-45.58%

Beam Therapeutics Corporate Events

M&A TransactionsBusiness Operations and Strategy
Beam Therapeutics Acquires Early-Stage Life Sciences Firm
Positive
Jul 3, 2025

On July 1, 2025, Beam Therapeutics Inc. acquired an early-stage life sciences company, agreeing to issue 403,128 shares of its common stock as an upfront payment and up to $89 million in additional milestone payments. This strategic acquisition is expected to enhance Beam’s capabilities and market position, potentially impacting its operations and stakeholders positively.

Executive/Board ChangesShareholder Meetings
Beam Therapeutics Confirms Key Decisions at Annual Meeting
Neutral
Jun 6, 2025

On June 4, 2025, Beam Therapeutics held its annual meeting of stockholders, where key decisions were made regarding the company’s leadership and operations. The election of Class II directors, the ratification of Deloitte & Touche LLP as the independent auditor, and the approval of executive compensation were all confirmed, reflecting strong shareholder support and potentially impacting the company’s governance and financial oversight.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 04, 2025