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Beam Therapeutics (BEAM)
NASDAQ:BEAM
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Beam Therapeutics (BEAM) AI Stock Analysis

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BEAM

Beam Therapeutics

(NASDAQ:BEAM)

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Neutral 46 (OpenAI - 4o)
Rating:46Neutral
Price Target:
$24.50
▲(5.83% Upside)
Beam Therapeutics' overall stock score is primarily impacted by its financial performance challenges, including declining revenues and negative cash flows. While technical indicators show some positive momentum, the lack of profitability and valuation concerns weigh heavily on the score.
Positive Factors
Technological Advancements
Beam's proprietary base editing technology positions it as a leader in genetic medicine, offering a durable competitive advantage in treating genetic disorders.
Low Leverage
A low debt-to-equity ratio indicates financial stability and flexibility, allowing Beam to invest in R&D and strategic initiatives without significant financial strain.
Strategic Partnerships
Partnerships provide steady revenue streams and validate Beam's technology, enhancing its market position and supporting long-term growth.
Negative Factors
Revenue Decline
Declining revenues suggest challenges in commercializing products and achieving market penetration, impacting long-term financial performance.
Negative Cash Flows
Negative cash flows limit Beam's ability to fund operations and R&D internally, potentially requiring external financing and impacting financial sustainability.
Profitability Challenges
Persistent negative profit margins highlight ongoing challenges in achieving profitability, which may affect Beam's long-term viability and investor confidence.

Beam Therapeutics (BEAM) vs. SPDR S&P 500 ETF (SPY)

Beam Therapeutics Business Overview & Revenue Model

Company DescriptionBeam Therapeutics is a biotechnology company focused on developing precision genetic medicines using its proprietary base editing technology. The company operates in the biotechnology sector, targeting genetic diseases through innovative therapies that aim to correct genetic mutations at the single-base level. Beam's core products include various pipeline candidates designed to treat conditions such as sickle cell disease, beta-thalassemia, and other genetic disorders, leveraging its advanced editing capabilities to provide potentially curative options.
How the Company Makes MoneyBeam Therapeutics generates revenue primarily through collaborations and partnerships with pharmaceutical companies and other biotech firms. These partnerships often involve licensing agreements where Beam provides access to its base editing technology in exchange for upfront payments, research funding, and milestone payments tied to the achievement of specific developmental and regulatory objectives. Additionally, the company may earn royalties on future sales of products developed using its technology. As the company advances its clinical programs and moves towards regulatory approvals, potential revenue from product commercialization could also contribute significantly to its earnings.

Beam Therapeutics Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2024)
|
% Change Since: |
Next Earnings Date:Mar 03, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mix of significant advancements in Beam's clinical programs, particularly in sickle cell disease and liver genetic diseases, alongside notable challenges related to patient safety in ongoing trials. While the progress in clinical data and technology development is promising, the safety concerns related to conditioning agents are a critical issue.
Q3-2024 Updates
Positive Updates
Advancements in Sickle Cell Disease Treatment
Beam Therapeutics reported initial clinical data from the BEACON trial for BEAM-101, showing a significant increase in fetal hemoglobin (HbF) and a reduction in sickle hemoglobin (HbS) in patients with sickle cell disease. Patients achieved greater than 60% HbF, reducing HbS to less than 40%, which is consistent with sickle cell trait profiles.
Progress in Liver Genetic Disease Program
Beam-302, aimed at treating alpha-1 antitrypsin deficiency (AATD), has dosed its first patient, with plans to report initial data in 2025. This program intends to address both lung and liver manifestations of the disease.
ESCAPE Technology Development
Beam has nominated development candidates for ESCAPE technology, aiming to eliminate chemotherapy in transplants. Early nonhuman primate studies show promising engraftment and HbF induction without chemotherapy.
Strong Financial Position
Beam Therapeutics reported a strong financial position, supporting ongoing and future clinical development programs.
Negative Updates
Patient Death in BEACON Trial
A patient in the BEACON trial died due to respiratory failure, likely related to busulfan conditioning. This highlights the risks associated with myeloablative conditioning in gene therapy.
Potential Safety Concerns with Conditioning
The use of busulfan in the BEACON trial has raised safety concerns, with known risks including lung injury and respiratory failure. This underscores the need for safer conditioning methods.
Company Guidance
In the Q3 2024 earnings call, Beam Therapeutics provided comprehensive updates on its clinical programs, highlighting significant progress and future expectations. The company reported that 35 patients have been enrolled in the BEACON trial for BEAM-101, with 8 patients already treated. The trial evaluates BEAM-101 for sickle cell disease, aiming for a best-in-class profile through efficient editing and induction of fetal hemoglobin (HbF) to over 60%, significantly reducing sickle hemoglobin (HbS) levels. Beam also shared promising preclinical data for its ESCAPE technology, which aims to eliminate the use of chemotherapy in stem cell transplants, potentially expanding the patient population up to fourfold. Additionally, Beam announced the completion of dosing in the first cohort of its BEAM-302 program for alpha-1 antitrypsin deficiency (AATD) and expects to report initial data in 2025. Financially, the company remains strong, supporting the continued development and potential commercialization of its pipeline.

Beam Therapeutics Financial Statement Overview

Summary
Beam Therapeutics faces significant financial challenges, with declining revenues, persistent losses, and negative cash flows. Despite a low debt-to-equity ratio, the negative profitability metrics and cash flow issues highlight the need for strategic improvements.
Income Statement
30
Negative
Beam Therapeutics has experienced declining revenue growth, with a negative growth rate of -5.2% in the TTM period. The company has consistently reported negative net profit margins, with the TTM net profit margin at -6.61%. Gross profit margin has also decreased significantly from previous periods. These factors indicate challenges in achieving profitability and revenue stability.
Balance Sheet
45
Neutral
The company's debt-to-equity ratio has improved to 0.15 in the TTM period, indicating a relatively low level of leverage. However, the return on equity remains negative at -43.15%, reflecting ongoing losses. The equity ratio is stable, suggesting a solid equity base relative to total assets, but profitability issues persist.
Cash Flow
35
Negative
Beam Therapeutics has negative operating and free cash flows, with a declining free cash flow growth rate of -149.2% in the TTM period. The operating cash flow to net income ratio is negative, indicating cash flow challenges. Despite a positive free cash flow to net income ratio, the overall cash flow position remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue46.00M63.52M377.71M60.92M51.84M24.00K
Gross Profit-6.57M41.59M-59.67M38.34M35.40M-103.16M
EBITDA-422.25M-383.98M-156.47M-324.33M-392.46M-128.03M
Net Income-414.64M-376.74M-132.53M-263.59M-341.36M-256.42M
Balance Sheet
Total Assets1.31B1.10B1.46B1.34B1.47B451.68M
Cash, Cash Equivalents and Short-Term Investments1.07B850.74M1.19B1.08B965.65M299.67M
Total Debt151.42M161.43M172.69M179.00M142.35M100.23M
Total Liabilities345.08M370.28M478.38M608.24M647.72M206.12M
Stockholders Equity966.00M733.54M981.33M733.47M826.74M245.56M
Cash Flow
Free Cash Flow-352.36M-356.19M-182.93M-26.42M-113.08M-112.10M
Operating Cash Flow-338.18M-347.25M-149.19M22.53M-66.27M-95.74M
Investing Cash Flow-103.56M185.01M71.84M-461.34M-294.14M-100.12M
Financing Cash Flow479.61M7.74M276.45M111.59M756.14M322.32M

Beam Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price23.15
Price Trends
50DMA
23.88
Negative
100DMA
21.27
Positive
200DMA
21.50
Positive
Market Momentum
MACD
-0.29
Positive
RSI
42.57
Neutral
STOCH
10.85
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BEAM, the sentiment is Neutral. The current price of 23.15 is below the 20-day moving average (MA) of 26.02, below the 50-day MA of 23.88, and above the 200-day MA of 21.50, indicating a neutral trend. The MACD of -0.29 indicates Positive momentum. The RSI at 42.57 is Neutral, neither overbought nor oversold. The STOCH value of 10.85 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for BEAM.

Beam Therapeutics Risk Analysis

Beam Therapeutics disclosed 90 risk factors in its most recent earnings report. Beam Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Beam Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
63
Neutral
$1.61B-5.38%26.90%62.72%
59
Neutral
$2.94B-28.17%129.21%80.35%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$2.31B-47.19%-84.07%-157.71%
45
Neutral
$2.18B-5.31-39.69%-100.00%1.62%
45
Neutral
$4.22B-77.58%-48.38%
43
Neutral
$3.22B-26.36%-22.19%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BEAM
Beam Therapeutics
23.15
-2.95
-11.30%
DNLI
Denali Therapeutics
14.41
-15.19
-51.32%
IMVT
Immunovant
23.67
-6.26
-20.92%
ARQT
Arcutis Biotherapeutics
25.10
14.70
141.35%
IRON
Disc Medicine
87.00
23.67
37.38%
IMCR
Immunocore Holdings
31.60
-2.71
-7.90%

Beam Therapeutics Corporate Events

Beam Therapeutics Advances BEAM-302 Study for AATD: Key Insights for Investors
Oct 27, 2025

Study Overview: Beam Therapeutics, Inc. is conducting a Phase 1/2 study titled ‘A Phase 1/2 Dose-exploration and Dose-expansion Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)-Associated Lung Disease and/or Liver Disease.’ The study aims to assess the safety, tolerability, pharmacokinetics/pharmacodynamics (PK/PD), and efficacy of BEAM-302, as well as to determine the optimal biological dose (OBD) for treating AATD-associated conditions.

Beam Therapeutics’ BEAM-301 Study: A Promising Step in Rare Disease Treatment
Oct 27, 2025

Beam Therapeutics, Inc. is conducting a Phase 1/2 study titled A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa). This study aims to assess the safety, tolerability, and efficacy of BEAM-301, a novel treatment for patients with GSDIa who have specific genetic variants. The study’s significance lies in its potential to offer a new therapeutic option for this rare metabolic disorder.

Beam Therapeutics’ BEACON Trial: A New Hope for Sickle Cell Disease
Oct 27, 2025

Beam Therapeutics, Inc. is conducting the BEACON trial, officially titled ‘A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of Autologous CD34+ Base Edited Hematopoietic Stem Cells (BEAM-101) in Patients With Sickle Cell Disease and Severe Vaso-Occlusive Crises.’ The study aims to assess the safety and efficacy of BEAM-101 in treating severe sickle cell disease, a condition with significant health impacts. This trial holds potential significance for advancing treatment options for this debilitating disease.

Beam Therapeutics Reports Q2 2025 Financial Results
Aug 6, 2025

Beam Therapeutics, Inc., a biotechnology company based in Cambridge, Massachusetts, is focused on developing precision genetic medicines through its base editing platform, aiming to provide life-long cures for genetic diseases. In its latest earnings report for the quarter ending June 30, 2025, Beam Therapeutics highlighted significant financial activities, including a substantial increase in marketable securities and a successful public offering that raised $470.5 million. The company reported a net loss of $102.3 million for the quarter, with operating expenses primarily driven by research and development efforts. Despite the losses, Beam’s financial position remains strong with $1.2 billion in cash, cash equivalents, and marketable securities, providing a solid foundation for future operations. Looking ahead, Beam Therapeutics is poised to continue its strategic focus on advancing its clinical trials and expanding its portfolio of genetic medicine candidates, with management expressing confidence in the company’s ability to sustain its operations and pursue growth opportunities in the biotechnology sector.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 30, 2025