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Beam Therapeutics (BEAM)
NASDAQ:BEAM
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Beam Therapeutics (BEAM) AI Stock Analysis

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BEAM

Beam Therapeutics

(NASDAQ:BEAM)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
$24.00
▼(-0.21% Downside)
Beam Therapeutics' overall stock score is primarily impacted by its weak financial performance, characterized by significant losses and negative cash flows. The technical analysis provides some short-term bullish signals, but the valuation remains unattractive due to a negative P/E ratio and lack of dividends. The absence of earnings call and corporate events data limits additional insights into the company's future prospects.
Positive Factors
Innovative Pipeline
Beam's growing pipeline in genetic disease base editing, including BEAM-302 and BEACON trials, indicates strong future potential and innovation in addressing genetic disorders.
Strategic Partnerships
Strategic partnerships provide Beam with financial support and access to broader markets, enhancing its ability to develop and commercialize its genetic editing technologies.
Low Leverage
A low debt-to-equity ratio suggests financial stability, allowing Beam to focus on R&D and strategic growth without the burden of high financial obligations.
Negative Factors
Declining Revenue
Declining revenue impacts Beam's ability to fund its R&D and operational activities, potentially hindering long-term growth and innovation capacity.
Negative Cash Flow
Negative cash flow indicates potential liquidity issues, which could limit Beam's capacity to invest in new projects and sustain operations over the long term.
Profitability Challenges
Substantial losses and negative profit margins reflect operational inefficiencies, which may require strategic changes to achieve sustainable profitability.

Beam Therapeutics (BEAM) vs. SPDR S&P 500 ETF (SPY)

Beam Therapeutics Business Overview & Revenue Model

Company DescriptionBeam Therapeutics Inc., a biotechnology company, develops precision genetic medicines for patients suffering from serious diseases in the United States. The company is developing BEAM-101 for the treatment of sickle cell disease and beta thalassemia; BEAM-102 for the treatment of sickle cell disease; and BEAM-201, an allogeneic chimeric antigen receptor T cell for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia; and BEAM-301, a liver-targeted development candidate for the treatment of patients with Glycogen Storage Disease Type Ia. It also develops therapies for alpha-1 antitrypsin deficiency; ocular diseases; and other liver, muscle, and central nervous system disorders. The company has an alliance with Boston Children's Hospital; a research and clinical trial collaboration agreement with Magenta Therapeutics, Inc.; license agreement with Sana Biotechnology, Inc.; and a research collaboration with the Institute of Molecular and Clinical Ophthalmology Basel. It also has a research collaboration agreement with Pfizer Inc. and Apellis Pharmaceuticals, Inc.; and collaboration and license agreement with Verve Therapeutics, Inc. The company was incorporated in 2017 and is based in Cambridge, Massachusetts.
How the Company Makes MoneyBeam Therapeutics generates revenue primarily through collaborations and partnerships with pharmaceutical companies and other biotech firms. These partnerships often involve licensing agreements where Beam provides access to its base editing technology in exchange for upfront payments, research funding, and milestone payments tied to the achievement of specific developmental and regulatory objectives. Additionally, the company may earn royalties on future sales of products developed using its technology. As the company advances its clinical programs and moves towards regulatory approvals, potential revenue from product commercialization could also contribute significantly to its earnings.

Beam Therapeutics Earnings Call Summary

Earnings Call Date:Nov 05, 2024
(Q3-2024)
|
% Change Since: |
Next Earnings Date:Mar 03, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mix of significant advancements in Beam's clinical programs, particularly in sickle cell disease and liver genetic diseases, alongside notable challenges related to patient safety in ongoing trials. While the progress in clinical data and technology development is promising, the safety concerns related to conditioning agents are a critical issue.
Q3-2024 Updates
Positive Updates
Advancements in Sickle Cell Disease Treatment
Beam Therapeutics reported initial clinical data from the BEACON trial for BEAM-101, showing a significant increase in fetal hemoglobin (HbF) and a reduction in sickle hemoglobin (HbS) in patients with sickle cell disease. Patients achieved greater than 60% HbF, reducing HbS to less than 40%, which is consistent with sickle cell trait profiles.
Progress in Liver Genetic Disease Program
Beam-302, aimed at treating alpha-1 antitrypsin deficiency (AATD), has dosed its first patient, with plans to report initial data in 2025. This program intends to address both lung and liver manifestations of the disease.
ESCAPE Technology Development
Beam has nominated development candidates for ESCAPE technology, aiming to eliminate chemotherapy in transplants. Early nonhuman primate studies show promising engraftment and HbF induction without chemotherapy.
Strong Financial Position
Beam Therapeutics reported a strong financial position, supporting ongoing and future clinical development programs.
Negative Updates
Patient Death in BEACON Trial
A patient in the BEACON trial died due to respiratory failure, likely related to busulfan conditioning. This highlights the risks associated with myeloablative conditioning in gene therapy.
Potential Safety Concerns with Conditioning
The use of busulfan in the BEACON trial has raised safety concerns, with known risks including lung injury and respiratory failure. This underscores the need for safer conditioning methods.
Company Guidance
In the Q3 2024 earnings call, Beam Therapeutics provided comprehensive updates on its clinical programs, highlighting significant progress and future expectations. The company reported that 35 patients have been enrolled in the BEACON trial for BEAM-101, with 8 patients already treated. The trial evaluates BEAM-101 for sickle cell disease, aiming for a best-in-class profile through efficient editing and induction of fetal hemoglobin (HbF) to over 60%, significantly reducing sickle hemoglobin (HbS) levels. Beam also shared promising preclinical data for its ESCAPE technology, which aims to eliminate the use of chemotherapy in stem cell transplants, potentially expanding the patient population up to fourfold. Additionally, Beam announced the completion of dosing in the first cohort of its BEAM-302 program for alpha-1 antitrypsin deficiency (AATD) and expects to report initial data in 2025. Financially, the company remains strong, supporting the continued development and potential commercialization of its pipeline.

Beam Therapeutics Financial Statement Overview

Summary
Beam Therapeutics faces significant financial challenges, with declining revenues, substantial losses, and negative cash flows. The company has a manageable debt level, but profitability and cash flow issues persist. While there are some signs of potential revenue growth, the overall financial health is weak, requiring strategic improvements to achieve stability and profitability.
Income Statement
30
Negative
Beam Therapeutics has experienced declining revenue and negative profit margins over the TTM period. The company shows a negative revenue growth rate of -7.58% and a significant net profit margin of -901.34%, indicating substantial losses. The EBIT and EBITDA margins are also deeply negative, reflecting operational challenges. Despite these issues, the company has shown some historical revenue growth, suggesting potential for future improvement.
Balance Sheet
45
Neutral
The balance sheet shows a moderate debt-to-equity ratio of 0.16, indicating a relatively low level of leverage. However, the return on equity is negative at -42.86%, reflecting ongoing losses. The equity ratio is not explicitly calculated, but the company maintains a reasonable level of stockholders' equity relative to its total assets, suggesting some financial stability despite profitability challenges.
Cash Flow
35
Negative
Beam Therapeutics has negative operating and free cash flows, with a free cash flow growth rate of -90.3% over the TTM period. The operating cash flow to net income ratio is -1.85, indicating cash flow challenges. However, the free cash flow to net income ratio is slightly positive at 1.04, suggesting some ability to cover net losses with free cash flow, albeit limited.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue55.70M63.52M377.71M60.92M51.84M24.00K
Gross Profit-356.09M-304.04M377.71M-250.67M-180.29M-103.16M
EBITDA-430.13M-393.64M-146.95M-324.33M-230.06M-128.03M
Net Income-414.64M-376.74M-132.53M-289.09M-370.64M-194.59M
Balance Sheet
Total Assets1.31B1.10B1.46B1.34B1.47B451.68M
Cash, Cash Equivalents and Short-Term Investments1.07B850.74M1.19B1.08B965.65M299.67M
Total Debt151.42M161.43M172.69M179.00M147.64M107.64M
Total Liabilities345.08M370.28M478.38M608.24M647.72M206.12M
Stockholders Equity966.00M733.54M981.33M733.47M826.74M245.56M
Cash Flow
Free Cash Flow-352.36M-356.19M-182.93M-26.42M-113.08M-112.10M
Operating Cash Flow-338.18M-347.25M-149.19M22.53M-66.27M-95.74M
Investing Cash Flow-103.56M185.01M71.84M-461.34M-294.14M-100.12M
Financing Cash Flow479.61M7.74M276.45M111.59M756.14M322.32M

Beam Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price24.05
Price Trends
50DMA
24.60
Negative
100DMA
21.97
Positive
200DMA
21.17
Positive
Market Momentum
MACD
-0.06
Negative
RSI
52.22
Neutral
STOCH
87.65
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BEAM, the sentiment is Positive. The current price of 24.05 is above the 20-day moving average (MA) of 22.76, below the 50-day MA of 24.60, and above the 200-day MA of 21.17, indicating a neutral trend. The MACD of -0.06 indicates Negative momentum. The RSI at 52.22 is Neutral, neither overbought nor oversold. The STOCH value of 87.65 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BEAM.

Beam Therapeutics Risk Analysis

Beam Therapeutics disclosed 90 risk factors in its most recent earnings report. Beam Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Beam Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$3.72B-28.17%129.21%80.35%
59
Neutral
$1.99B-7.52%27.51%38.72%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
$2.64B-44.44%-5.30%
45
Neutral
$4.23B-95.93%-27.70%
44
Neutral
$2.44B-5.42-47.19%-84.07%-157.71%
43
Neutral
$3.52B-34.78%-34.96%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BEAM
Beam Therapeutics
24.05
-1.93
-7.43%
DNLI
Denali Therapeutics
18.16
-5.73
-23.98%
IMVT
Immunovant
22.75
-5.47
-19.38%
ARQT
Arcutis Biotherapeutics
30.37
18.10
147.51%
IRON
Disc Medicine
91.69
26.99
41.72%
IMCR
Immunocore Holdings
37.59
5.37
16.67%

Beam Therapeutics Corporate Events

Beam Therapeutics Reports Q3 2025 Financial Results
Nov 5, 2025

Beam Therapeutics, Inc., a biotechnology company based in Cambridge, Massachusetts, focuses on developing precision genetic medicines through its base editing technology to provide life-long cures for genetic diseases. The company operates in the biotechnology sector and is committed to advancing its portfolio of programs and maintaining a strong intellectual property position.

Beam Therapeutics Advances BEAM-302 Study for AATD: Key Insights for Investors
Oct 27, 2025

Study Overview: Beam Therapeutics, Inc. is conducting a Phase 1/2 study titled ‘A Phase 1/2 Dose-exploration and Dose-expansion Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)-Associated Lung Disease and/or Liver Disease.’ The study aims to assess the safety, tolerability, pharmacokinetics/pharmacodynamics (PK/PD), and efficacy of BEAM-302, as well as to determine the optimal biological dose (OBD) for treating AATD-associated conditions.

Beam Therapeutics’ BEAM-301 Study: A Promising Step in Rare Disease Treatment
Oct 27, 2025

Beam Therapeutics, Inc. is conducting a Phase 1/2 study titled A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa). This study aims to assess the safety, tolerability, and efficacy of BEAM-301, a novel treatment for patients with GSDIa who have specific genetic variants. The study’s significance lies in its potential to offer a new therapeutic option for this rare metabolic disorder.

Beam Therapeutics’ BEACON Trial: A New Hope for Sickle Cell Disease
Oct 27, 2025

Beam Therapeutics, Inc. is conducting the BEACON trial, officially titled ‘A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of Autologous CD34+ Base Edited Hematopoietic Stem Cells (BEAM-101) in Patients With Sickle Cell Disease and Severe Vaso-Occlusive Crises.’ The study aims to assess the safety and efficacy of BEAM-101 in treating severe sickle cell disease, a condition with significant health impacts. This trial holds potential significance for advancing treatment options for this debilitating disease.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 26, 2025