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Beam Therapeutics, Inc. (BEAM)
NASDAQ:BEAM
US Market

Beam Therapeutics (BEAM) AI Stock Analysis

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BEAM

Beam Therapeutics

(NASDAQ:BEAM)

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Neutral 58 (OpenAI - 4o)
Rating:58Neutral
Price Target:
$28.00
▲(4.63% Upside)
Beam Therapeutics' overall stock score is primarily influenced by its weak financial performance, characterized by significant losses and negative cash flows. However, the stock shows positive technical indicators, suggesting potential short-term price appreciation. The recent corporate event, resulting in a substantial cash gain, provides a positive outlook and liquidity boost. Despite these positives, the negative valuation metrics reflect ongoing profitability challenges, keeping the overall score moderate.
Positive Factors
Innovative Gene Editing Technology
Beam's proprietary base editing technology positions it as a leader in precision genetic medicine, offering a competitive advantage in treating genetic disorders.
Recent Clinical Trial Success
Positive clinical trial results for BEAM-101 demonstrate potential efficacy in treating sickle cell disease, enhancing Beam's product pipeline and market position.
Cash Infusion from Orbital Acquisition
The cash gain from Orbital acquisition strengthens Beam's balance sheet, providing liquidity to support ongoing R&D and operational activities.
Negative Factors
Declining Revenue and Profitability
Ongoing revenue decline and negative profitability highlight operational challenges, potentially impacting long-term financial health and sustainability.
Negative Cash Flow
Negative cash flow growth indicates financial strain, limiting Beam's ability to invest in growth opportunities and maintain operational flexibility.
High Net Profit Margin Loss
A deeply negative net profit margin reflects severe financial losses, challenging Beam's path to profitability and long-term viability.

Beam Therapeutics (BEAM) vs. SPDR S&P 500 ETF (SPY)

Beam Therapeutics Business Overview & Revenue Model

Company DescriptionBeam Therapeutics Inc., a biotechnology company, develops precision genetic medicines for patients suffering from serious diseases in the United States. The company is developing BEAM-101 for the treatment of sickle cell disease and beta thalassemia; BEAM-102 for the treatment of sickle cell disease; and BEAM-201, an allogeneic chimeric antigen receptor T cell for the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia; and BEAM-301, a liver-targeted development candidate for the treatment of patients with Glycogen Storage Disease Type Ia. It also develops therapies for alpha-1 antitrypsin deficiency; ocular diseases; and other liver, muscle, and central nervous system disorders. The company has an alliance with Boston Children's Hospital; a research and clinical trial collaboration agreement with Magenta Therapeutics, Inc.; license agreement with Sana Biotechnology, Inc.; and a research collaboration with the Institute of Molecular and Clinical Ophthalmology Basel. It also has a research collaboration agreement with Pfizer Inc. and Apellis Pharmaceuticals, Inc.; and collaboration and license agreement with Verve Therapeutics, Inc. The company was incorporated in 2017 and is based in Cambridge, Massachusetts.
How the Company Makes MoneyBeam Therapeutics generates revenue through a combination of research and development collaborations, licensing agreements, and potential future product sales. The company partners with pharmaceutical companies and research institutions to co-develop its therapies, often receiving upfront payments, milestone payments as projects advance, and royalties on future sales. Additionally, Beam may monetize its proprietary technologies through licensing deals, allowing other companies to use their base editing technology in exchange for fees. As their product candidates advance through clinical trials and toward commercialization, potential sales of successful therapies will also contribute to revenue.

Beam Therapeutics Earnings Call Summary

Earnings Call Date:Nov 05, 2024
(Q3-2024)
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% Change Since: |
Next Earnings Date:Mar 03, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mix of significant advancements in Beam's clinical programs, particularly in sickle cell disease and liver genetic diseases, alongside notable challenges related to patient safety in ongoing trials. While the progress in clinical data and technology development is promising, the safety concerns related to conditioning agents are a critical issue.
Q3-2024 Updates
Positive Updates
Advancements in Sickle Cell Disease Treatment
Beam Therapeutics reported initial clinical data from the BEACON trial for BEAM-101, showing a significant increase in fetal hemoglobin (HbF) and a reduction in sickle hemoglobin (HbS) in patients with sickle cell disease. Patients achieved greater than 60% HbF, reducing HbS to less than 40%, which is consistent with sickle cell trait profiles.
Progress in Liver Genetic Disease Program
Beam-302, aimed at treating alpha-1 antitrypsin deficiency (AATD), has dosed its first patient, with plans to report initial data in 2025. This program intends to address both lung and liver manifestations of the disease.
ESCAPE Technology Development
Beam has nominated development candidates for ESCAPE technology, aiming to eliminate chemotherapy in transplants. Early nonhuman primate studies show promising engraftment and HbF induction without chemotherapy.
Strong Financial Position
Beam Therapeutics reported a strong financial position, supporting ongoing and future clinical development programs.
Negative Updates
Patient Death in BEACON Trial
A patient in the BEACON trial died due to respiratory failure, likely related to busulfan conditioning. This highlights the risks associated with myeloablative conditioning in gene therapy.
Potential Safety Concerns with Conditioning
The use of busulfan in the BEACON trial has raised safety concerns, with known risks including lung injury and respiratory failure. This underscores the need for safer conditioning methods.
Company Guidance
In the Q3 2024 earnings call, Beam Therapeutics provided comprehensive updates on its clinical programs, highlighting significant progress and future expectations. The company reported that 35 patients have been enrolled in the BEACON trial for BEAM-101, with 8 patients already treated. The trial evaluates BEAM-101 for sickle cell disease, aiming for a best-in-class profile through efficient editing and induction of fetal hemoglobin (HbF) to over 60%, significantly reducing sickle hemoglobin (HbS) levels. Beam also shared promising preclinical data for its ESCAPE technology, which aims to eliminate the use of chemotherapy in stem cell transplants, potentially expanding the patient population up to fourfold. Additionally, Beam announced the completion of dosing in the first cohort of its BEAM-302 program for alpha-1 antitrypsin deficiency (AATD) and expects to report initial data in 2025. Financially, the company remains strong, supporting the continued development and potential commercialization of its pipeline.

Beam Therapeutics Financial Statement Overview

Summary
Beam Therapeutics faces significant financial challenges, with declining revenues, substantial losses, and negative cash flows. The company has a manageable debt level, but profitability and cash flow issues persist. While there are some signs of potential revenue growth, the overall financial health is weak, requiring strategic improvements to achieve stability and profitability.
Income Statement
30
Negative
Beam Therapeutics has experienced declining revenue and negative profit margins over the TTM period. The company shows a negative revenue growth rate of -7.58% and a significant net profit margin of -901.34%, indicating substantial losses. The EBIT and EBITDA margins are also deeply negative, reflecting operational challenges. Despite these issues, the company has shown some historical revenue growth, suggesting potential for future improvement.
Balance Sheet
45
Neutral
The balance sheet shows a moderate debt-to-equity ratio of 0.16, indicating a relatively low level of leverage. However, the return on equity is negative at -42.86%, reflecting ongoing losses. The equity ratio is not explicitly calculated, but the company maintains a reasonable level of stockholders' equity relative to its total assets, suggesting some financial stability despite profitability challenges.
Cash Flow
35
Negative
Beam Therapeutics has negative operating and free cash flows, with a free cash flow growth rate of -90.3% over the TTM period. The operating cash flow to net income ratio is -1.85, indicating cash flow challenges. However, the free cash flow to net income ratio is slightly positive at 1.04, suggesting some ability to cover net losses with free cash flow, albeit limited.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue55.70M63.52M377.71M60.92M51.84M24.00K
Gross Profit-356.09M-304.04M377.71M-250.67M-180.29M-103.16M
EBITDA-430.13M-393.64M-146.95M-324.33M-230.06M-128.03M
Net Income-414.64M-376.74M-132.53M-289.09M-370.64M-194.59M
Balance Sheet
Total Assets1.31B1.10B1.46B1.34B1.47B451.68M
Cash, Cash Equivalents and Short-Term Investments1.07B850.74M1.19B1.08B965.65M299.67M
Total Debt151.42M161.43M172.69M179.00M147.64M107.64M
Total Liabilities345.08M370.28M478.38M608.24M647.72M206.12M
Stockholders Equity966.00M733.54M981.33M733.47M826.74M245.56M
Cash Flow
Free Cash Flow-352.36M-356.19M-182.93M-26.42M-113.08M-112.10M
Operating Cash Flow-338.18M-347.25M-149.19M22.53M-66.27M-95.74M
Investing Cash Flow-103.56M185.01M71.84M-461.34M-294.14M-100.12M
Financing Cash Flow479.61M7.74M276.45M111.59M756.14M322.32M

Beam Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price26.76
Price Trends
50DMA
25.17
Positive
100DMA
22.66
Positive
200DMA
20.99
Positive
Market Momentum
MACD
0.80
Negative
RSI
50.61
Neutral
STOCH
29.88
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BEAM, the sentiment is Positive. The current price of 26.76 is above the 20-day moving average (MA) of 25.38, above the 50-day MA of 25.17, and above the 200-day MA of 20.99, indicating a bullish trend. The MACD of 0.80 indicates Negative momentum. The RSI at 50.61 is Neutral, neither overbought nor oversold. The STOCH value of 29.88 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BEAM.

Beam Therapeutics Risk Analysis

Beam Therapeutics disclosed 90 risk factors in its most recent earnings report. Beam Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Beam Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$3.49B-79.94-28.17%129.21%80.35%
58
Neutral
$2.72B-47.19%-84.07%-157.71%
53
Neutral
$1.83B-61.31-7.52%27.51%38.72%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
45
Neutral
$2.66B-5.77-44.44%-5.30%
45
Neutral
$5.36B-9.54-95.93%-27.70%
43
Neutral
$3.45B-16.33-34.78%-34.96%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BEAM
Beam Therapeutics
25.60
-0.85
-3.21%
DNLI
Denali Therapeutics
16.81
-4.62
-21.56%
IMVT
Immunovant
26.61
0.36
1.37%
ARQT
Arcutis Biotherapeutics
28.34
14.94
111.49%
IRON
Disc Medicine
91.47
27.97
44.05%
IMCR
Immunocore Holdings
35.82
7.56
26.75%

Beam Therapeutics Corporate Events

M&A TransactionsFinancial Disclosures
Beam Therapeutics Gains $255M from Orbital Acquisition
Positive
Dec 11, 2025

On December 8, 2025, Bristol-Myers Squibb completed its acquisition of Orbital Therapeutics, in which Beam Therapeutics held a 17% stake. Beam’s shares were converted into $255.1 million in cash, with potential for additional consideration, impacting its financial outlook ahead of the 2026 J.P. Morgan Healthcare Conference.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 12, 2025