Strong Revenue Growth
BioCryst reported quarterly revenue of $134 million, leading to an increased annual revenue guidance for ORLADEYO to between $580 million and $600 million, reflecting 33% to 37% growth over the previous year.
Accelerated Profitability
The company now expects to be profitable on a full-year basis in 2025, a year earlier than previously planned, due to increased financial strength and improved cash flow.
Successful Debt Reduction
BioCryst paid down $75 million of its debt in April, reducing outstanding debt to $249 million and saving approximately $23 million in interest payments over the life of the debt.
Pediatric NDA Submission for ORLADEYO
The company submitted a pediatric NDA for ORLADEYO, introducing an oral granule formulation for younger patients, aiming to be the first targeted oral prophylactic therapy for children aged two to eleven.
High Patient Satisfaction and Preference
A recent patient survey indicated that 70% of U.S. HAE patients strongly prefer oral prophylaxis, up from 51% in 2023, suggesting increased satisfaction with ORLADEYO.
Pipeline Progress
BioCryst received authorization to initiate patient enrollment for BCX17725 in Netherton syndrome and avoralstat in diabetic macular edema, with clinical data expected by the end of the year.