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Amgen (AMGN)
NASDAQ:AMGN

Amgen (AMGN) AI Stock Analysis

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AMGN

Amgen

(NASDAQ:AMGN)

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Outperform 77 (OpenAI - 4o)
Rating:77Outperform
Price Target:
$392.00
▲(19.64% Upside)
Amgen's overall stock score is driven by strong financial performance and positive earnings call insights. The stock shows bullish technical indicators, although the high P/E ratio suggests potential overvaluation. The company's strategic initiatives and robust revenue growth are significant positives, but the high debt level and competitive pressures pose risks.
Positive Factors
Revenue Growth
Strong revenue growth indicates effective market strategies and product demand, supporting long-term financial health and expansion potential.
FDA Approval
Full FDA approval for IMDELLTRA enhances Amgen's product portfolio and market position in oncology, potentially driving future revenue growth.
Cash Flow Generation
Strong cash flow growth supports operational flexibility and investment in R&D, ensuring sustained innovation and competitive advantage.
Negative Factors
High Debt Levels
High debt levels can limit financial flexibility, increasing risk and potentially impacting the company's ability to invest in growth opportunities.
Increased Competition
Rising competition for key products like Prolia may pressure margins and market share, challenging Amgen's revenue growth and profitability.
Study Delays
Delays in clinical studies can postpone product launches, affecting revenue timelines and potentially hindering competitive positioning.

Amgen (AMGN) vs. SPDR S&P 500 ETF (SPY)

Amgen Business Overview & Revenue Model

Company DescriptionAmgen Inc. discovers, develops, manufactures, and delivers human therapeutics worldwide. It focuses on inflammation, oncology/hematology, bone health, cardiovascular disease, nephrology, and neuroscience areas. The company's products include Enbrel to treat plaque psoriasis, rheumatoid arthritis, and psoriatic arthritis; Neulasta that reduces the chance of infection due a low white blood cell count in patients cancer; Prolia to treat postmenopausal women with osteoporosis; Xgeva for skeletal-related events prevention; Otezla for the treatment of adult patients with plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's disease; Aranesp to treat a lower-than-normal number of red blood cells and anemia; KYPROLIS to treat patients with relapsed or refractory multiple myeloma; and Repatha, which reduces the risks of myocardial infarction, stroke, and coronary revascularization. It also markets Nplate, Vectibix, MVASI, Parsabiv, EPOGEN, KANJINTI, BLINCYTO, Aimovig, EVENITY, AMGEVITATM, Sensipar/Mimpara, NEUPOGEN, IMLYGIC, Corlanor, and AVSOLA. Amgen Inc. serves healthcare providers, including physicians or their clinics, dialysis centers, hospitals, and pharmacies. It distributes its products through pharmaceutical wholesale distributors, as well as direct-to-consumer channels. It has collaboration agreements with Novartis Pharma AG; UCB; Bayer HealthCare LLC; BeiGene, Ltd.; Eli Lilly and Company; Datos Health; and Verastem, Inc. to evaluate VS-6766 in combination with lumakrastm (Sotorasib) in patients with KRAS G12C-mutant non-small cell lung cancer. It has an agreement with Kyowa Kirin Co., Ltd. to jointly develop and commercialize KHK4083, a Phase 3-ready anti-OX40 fully human monoclonal antibody for the treatment of atopic dermatitis and other autoimmune diseases; and research and development collaboration with Neumora Therapeutics, Inc. and Plexium, Inc. Amgen Inc. was incorporated in 1980 and is headquartered in Thousand Oaks, California.
How the Company Makes MoneyAmgen generates revenue primarily through the sale of its biologic drugs, which are often administered for chronic and life-threatening conditions. The company's revenue model is largely driven by product sales, which encompass both domestic and international markets. Key revenue streams include direct sales of its leading therapies, royalties from partnerships, and licensing agreements for its drug development programs. Significant partnerships with other pharmaceutical companies and collaborations with academic institutions also play a crucial role in its revenue generation, allowing Amgen to expand its product pipeline and enter new therapeutic areas. Overall, the company's strong focus on research and development, combined with an established portfolio of blockbuster drugs, underpins its financial performance.

Amgen Key Performance Indicators (KPIs)

Any
Any
Revenue by Type
Revenue by Type
Distinguishes between different revenue streams, such as product sales and royalties, providing insights into Amgen's business model and diversification.
Chart InsightsAmgen's product sales have shown a robust upward trajectory, reflecting a strategic focus on high-growth areas like biosimilars and rare diseases. The recent earnings call underscores this with a 9% revenue growth, driven by a 13% volume increase and significant contributions from Repatha and EVENITY. However, challenges such as declining Prolia sales and increased R&D expenses could pressure margins. The company's commitment to innovation and AI integration suggests a proactive approach to sustaining growth and addressing pricing pressures.
Data provided by:The Fly

Amgen Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 03, 2026
Earnings Call Sentiment Positive
The earnings call showcased strong financial performance with a 12% revenue increase and significant volume growth driven by key products. There were notable advances in cardiovascular studies and the biosimilar portfolio, alongside new initiatives like AmgenNow to improve patient access. However, the call also highlighted challenges such as increased competition in certain segments, generic impacts on rare disease products, and some delays in study readouts. Overall, the positives in growth and strategic initiatives outweighed the negatives.
Q3-2025 Updates
Positive Updates
Strong Revenue Growth
Revenues increased 12% year-over-year to $9.6 billion, driven by strong performance from key growth drivers like Repatha, EVENITY, TEZSPIRE, innovative oncology, rare disease, and biosimilar portfolios.
Record Volume Growth
Volume growth was up 14% year-over-year with 16 products achieving double-digit growth rates; 14 products are now annualizing at over $1 billion in sales.
Significant Advances in Cardiovascular Studies
The Repatha Phase III VESALIUS-CV study met its primary endpoints demonstrating significant reductions in major adverse cardiovascular events in high-risk individuals without prior heart attacks or strokes.
Biosimilar Growth
The biosimilar portfolio delivered a 52% increase in sales year-over-year, now annualizing at $3 billion.
Introduction of AmgenNow
AmgenNow initiative launched to provide direct-to-patient access for Repatha at reduced prices, significantly increasing accessibility for patients.
Debt Reduction and Financial Discipline
Successfully retired $6.0 billion of debt in 2025 and achieved pre-Horizon capital structure ahead of plan.
Negative Updates
RAVICTI Sales Impact
RAVICTI sales in rare disease were impacted by the introduction of a generic competitor, with $105 million reported in Q3.
Increased Competition for Prolia
Prolia sales grew by 9% year-over-year, but future quarters are expected to see negative impacts due to increased competition from three biosimilars.
Olpasiran Study Delays
The event-driven OCEAN(a) Phase III study for Olpasiran is progressing slower than initial predictions, potentially delaying the base case readout.
Bemarituzumab Efficacy Concerns
Phase Ib/III study in gastric cancer was stopped due to inadequate efficacy at an ad hoc analysis, highlighting development challenges.
Company Guidance
During the Amgen Q3 2025 earnings call, the company reported a strong performance with a 12% year-over-year revenue increase, reaching $9.6 billion, driven by 14% volume growth. Sixteen products grew at double-digit rates, with 14 annualizing at over $1 billion in sales. Key growth drivers included Repatha, EVENITY, TEZSPIRE, and the innovative oncology, rare disease, and biosimilar portfolios. Amgen launched AmgenNow to improve access to Repatha, offering it at a significantly reduced price. The company highlighted its $3 billion investment in U.S. manufacturing and announced ongoing advancements in its pipeline, including MariTide for obesity and cardiovascular disease. They raised their 2025 guidance, expecting total revenues between $35.8 billion and $36.6 billion, and non-GAAP earnings per share between $20.60 and $21.40. The call emphasized long-term growth prospects, driven by innovative therapies and sustained financial discipline.

Amgen Financial Statement Overview

Summary
Amgen demonstrates strong profitability with consistent revenue growth and healthy margins. However, high debt levels and declining free cash flow growth present potential risks. The company should focus on managing its leverage and improving cash flow generation to maintain financial stability.
Income Statement
Amgen's income statement shows a solid performance with a steady revenue growth rate of 2.32% in the TTM period. The gross profit margin of 63% and net profit margin of 17.39% indicate strong profitability, although both have decreased compared to previous years. The EBIT and EBITDA margins remain healthy at 24.20% and 36.27% respectively, reflecting efficient operations. However, the slight decline in margins suggests rising costs or competitive pressures.
Balance Sheet
The balance sheet reveals a high debt-to-equity ratio of 9.24, indicating significant leverage, which could pose financial risks if not managed carefully. The return on equity is robust at 92.94%, showcasing effective use of equity to generate profits. However, the equity ratio is relatively low, suggesting a heavy reliance on debt financing.
Cash Flow
Cash flow analysis shows a slight decline in free cash flow growth by -2.84% in the TTM period, which could be a concern if it continues. The operating cash flow to net income ratio of 0.53 and free cash flow to net income ratio of 0.90 indicate strong cash generation relative to net income, supporting the company's liquidity position.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue35.96B33.42B28.19B26.32B25.98B25.42B
Gross Profit23.79B20.57B19.77B19.92B19.52B19.27B
EBITDA16.54B13.36B14.80B12.17B11.30B13.00B
Net Income7.00B4.09B6.72B6.55B5.89B7.26B
Balance Sheet
Total Assets90.14B91.84B97.15B65.12B61.16B62.95B
Cash, Cash Equivalents and Short-Term Investments9.45B11.97B10.94B9.30B8.04B10.65B
Total Debt54.59B60.10B64.61B38.95B33.31B32.99B
Total Liabilities80.52B85.96B90.92B61.46B54.47B53.54B
Stockholders Equity9.62B5.88B6.23B3.66B6.70B9.41B
Cash Flow
Free Cash Flow11.54B10.39B7.36B8.79B8.38B9.89B
Operating Cash Flow13.13B11.49B8.47B9.72B9.26B10.50B
Investing Cash Flow-1.65B-1.05B-26.20B-6.04B733.00M-5.40B
Financing Cash Flow-11.04B-9.41B21.05B-4.04B-8.27B-4.87B

Amgen Technical Analysis

Technical Analysis Sentiment
Positive
Last Price327.64
Price Trends
50DMA
322.67
Positive
100DMA
304.02
Positive
200DMA
294.22
Positive
Market Momentum
MACD
1.25
Positive
RSI
50.55
Neutral
STOCH
42.61
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AMGN, the sentiment is Positive. The current price of 327.64 is above the 20-day moving average (MA) of 326.43, above the 50-day MA of 322.67, and above the 200-day MA of 294.22, indicating a bullish trend. The MACD of 1.25 indicates Positive momentum. The RSI at 50.55 is Neutral, neither overbought nor oversold. The STOCH value of 42.61 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AMGN.

Amgen Risk Analysis

Amgen disclosed 29 risk factors in its most recent earnings report. Amgen reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Amgen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$264.21B14.0839.51%3.12%1.59%58.02%
78
Outperform
$108.83B18.0533.84%4.84%1.26%
78
Outperform
$150.87B18.8340.53%2.52%2.76%6407.19%
77
Outperform
$176.43B25.3381.71%3.00%11.03%65.22%
75
Outperform
$116.66B11.998.39%4.58%-9.32%120.62%
74
Outperform
$143.17B14.6810.59%6.65%4.44%128.96%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AMGN
Amgen
327.64
77.20
30.83%
BMY
Bristol-Myers Squibb
53.46
-0.49
-0.91%
GILD
Gilead Sciences
121.60
32.85
37.01%
MRK
Merck & Company
106.45
10.34
10.76%
PFE
Pfizer
25.18
0.10
0.40%
SNY
Sanofi
48.23
0.56
1.17%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 30, 2025