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Pfizer Inc (PFE)
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Pfizer (PFE) AI Stock Analysis

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PFE

Pfizer

(NYSE:PFE)

Rating:78Outperform
Price Target:
$28.00
▲(14.10% Upside)
Pfizer's strong financial performance and positive earnings call are the most significant factors driving the stock score. The company's robust cash flow and strategic R&D advancements support long-term growth. Technical analysis and valuation provide additional support, though mixed signals in technical indicators and competitive pressures in oncology present challenges.
Positive Factors
Earnings Guidance
Pfizer raised its EPS guidance midpoint for 2025, reflecting confidence in future financial performance.
Financial Performance
Pfizer reported EPS that was 36% above consensus expectations, driven by higher revenues and lower-than-anticipated R&D spending.
Stock Valuation
Pfizer shares are viewed as undervalued with potential for better fundamentals, top-line growth, and margin expansion compared to U.S. BioPharma peers.
Negative Factors
Acquisition Challenges
Pfizer's acquisition of Global Blood Therapeutics has proven disappointing with inclacumab's failure and Oxbryta's withdrawal from the market.
Competition and Market Dynamics
The long-term outlook for many of Pfizer's larger franchises remains uncertain due to upcoming patent expiries and competitive threats.
Revenue Uncertainty
A sustained re-rate will require better visibility on structural questions around aging franchises amidst ongoing uncertainty on the revenue contribution.

Pfizer (PFE) vs. SPDR S&P 500 ETF (SPY)

Pfizer Business Overview & Revenue Model

Company DescriptionPfizer Inc. is a multinational pharmaceutical corporation headquartered in New York City, primarily engaged in the research, development, manufacturing, and marketing of healthcare products. The company operates in several sectors, including pharmaceuticals, vaccines, and consumer healthcare. Pfizer's core products encompass a wide range of therapeutic areas, including oncology, cardiology, immunology, and infectious diseases, with notable offerings such as the COVID-19 vaccine, Prevnar for pneumonia, and a variety of prescription medications.
How the Company Makes MoneyPfizer generates revenue primarily through the sale of prescription medicines and vaccines. The company's revenue model is largely driven by its extensive portfolio of patented drugs, which allows it to charge premium prices. Key revenue streams include sales from its innovative therapies, as well as established brands that continue to perform well in the market. Pfizer also earns revenue from collaborations and partnerships, such as its alliance with BioNTech for the development of the COVID-19 vaccine, which significantly boosted its earnings. Additionally, Pfizer benefits from licensing agreements and royalties associated with its research and development efforts. The company's ability to navigate patent expirations and introduce new products is critical for sustaining its revenue growth.

Pfizer Key Performance Indicators (KPIs)

Any
Any
Global Biopharmaceuticals Revenue by Type
Global Biopharmaceuticals Revenue by Type
Chart Insights
Data provided by:Main Street Data

Pfizer Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 04, 2025
Earnings Call Sentiment Positive
The earnings call reflects a positive sentiment overall, with Pfizer showing strong financial performance, significant advancements in its R&D pipeline, and effective cost management. However, there are some challenges, particularly related to pricing pressures from the IRA Medicare Part D redesign and competitive pressures in the oncology sector.
Q2-2025 Updates
Positive Updates
Strong Year-to-Date Performance and Raised EPS Guidance
Pfizer raised its adjusted diluted EPS guidance for the full year 2025 due to strong year-to-date performance, indicating confidence in its financial outlook.
Significant R&D Advancements
Pfizer highlighted several promising developments in its R&D pipeline, including Elrexfio's notable performance in multiple myeloma and Sigvotatug Vedotin's potential in non-small cell lung cancer.
Strong Growth in Key Products
The Vyndaqel family saw a 21% year-over-year operational growth, and Padcev experienced a 38% operational growth, demonstrating robust demand for key products.
Cost Management and Operating Margins
Pfizer's cost optimization strategies led to an 8% decline in total adjusted operating expenses, contributing to improved operating margins.
Strategic Business Development Initiatives
Pfizer closed an in-licensing agreement with 3SBio, granting exclusive rights to develop and commercialize a promising bispecific antibody.
Negative Updates
Impact of IRA and 340B on Revenue
The IRA Medicare Part D redesign and the 340B program exerted pressure on net revenues, particularly affecting products like Nurtec.
Challenges in Oncology Sector
Seagen products, including ADCETRIS and TUKYSA, faced increased competitive pressures leading to muted growth in certain segments.
Company Guidance
During Pfizer's Second Quarter 2025 Earnings Conference Call, the company provided several key metrics and updates on its performance and future guidance. CEO Albert Bourla highlighted Pfizer's strong performance, noting a 10% operational revenue increase to $14.7 billion and raising the adjusted diluted EPS guidance for the full year 2025. The company is actively engaging with policymakers to navigate geopolitical challenges while focusing on R&D productivity, commercial portfolio maximization, and expanding margins. Notable achievements include the progress of Elrexfio in multiple myeloma, with a median overall survival of over two years, and the potential of Sigvotatug Vedotin in non-small cell lung cancer, expected to impact a market projected to reach over $60 billion by 2030. CFO David Denton emphasized strategic financial management, reporting an adjusted EPS of $0.78 and highlighting cost management initiatives contributing to robust operating margins. Pfizer is also preparing for a Phase III start for its C. difficile vaccine candidate and advancing a Phase III program for a Lyme disease vaccine. The company continues to invest in its business, focusing on R&D and strategic partnerships, with a current business development capacity of approximately $13 billion. Overall, Pfizer remains committed to creating long-term shareholder value through disciplined execution and strategic investments.

Pfizer Financial Statement Overview

Summary
Pfizer demonstrates strong financial health across its income statement, balance sheet, and cash flow statement. The company shows solid profitability and cash generation, with manageable leverage levels. While there are some concerns about increasing debt and slight operational efficiency pressures, the overall financial position remains strong, supporting continued growth and stability.
Income Statement
85
Very Positive
Pfizer's income statement shows strong profitability with a gross profit margin of 74.09% and a net profit margin of 16.83% for the TTM period. Revenue growth is positive at 2.19%, indicating a recovery from previous declines. The EBIT and EBITDA margins are healthy at 15.14% and 27.78%, respectively, reflecting efficient operations. However, the decline in EBIT margin from the previous year suggests some pressure on operational efficiency.
Balance Sheet
78
Positive
The balance sheet is solid with a debt-to-equity ratio of 0.70, indicating a manageable level of leverage. Return on equity is 11.95%, showing decent profitability relative to shareholder equity. The equity ratio stands at 43.03%, suggesting a strong equity base. However, the increase in total debt over the years could pose a risk if not managed carefully.
Cash Flow
82
Very Positive
Pfizer's cash flow statement is robust, with a free cash flow growth rate of 10.86% in the TTM period. The operating cash flow to net income ratio is 0.40, and the free cash flow to net income ratio is 0.82, indicating strong cash generation relative to earnings. The company has improved its free cash flow position significantly, enhancing financial flexibility.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue63.83B63.63B59.55B100.33B81.29B41.65B
Gross Profit42.99B41.85B30.34B62.09B46.88B29.88B
EBITDA22.77B18.13B9.56B41.03B30.79B13.17B
Net Income10.73B8.02B2.13B31.36B22.15B9.16B
Balance Sheet
Total Assets206.09B213.40B226.50B197.21B181.48B154.23B
Cash, Cash Equivalents and Short-Term Investments13.25B20.48B12.69B22.73B31.07B12.22B
Total Debt61.80B63.65B70.84B34.86B37.00B38.27B
Total Liabilities117.08B124.90B137.21B101.29B104.01B90.76B
Stockholders Equity88.69B88.20B89.01B95.66B77.20B63.24B
Cash Flow
Free Cash Flow12.44B9.84B4.79B26.03B29.87B11.61B
Operating Cash Flow15.19B12.74B8.70B29.27B32.58B14.40B
Investing Cash Flow3.54B2.65B-32.28B-15.78B-22.55B-4.27B
Financing Cash Flow-18.17B-17.14B26.07B-14.83B-9.82B-9.65B

Pfizer Technical Analysis

Technical Analysis Sentiment
Negative
Last Price24.54
Price Trends
50DMA
24.62
Negative
100DMA
23.67
Positive
200DMA
24.19
Positive
Market Momentum
MACD
0.09
Positive
RSI
46.35
Neutral
STOCH
19.22
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PFE, the sentiment is Negative. The current price of 24.54 is below the 20-day moving average (MA) of 24.98, below the 50-day MA of 24.62, and above the 200-day MA of 24.19, indicating a neutral trend. The MACD of 0.09 indicates Positive momentum. The RSI at 46.35 is Neutral, neither overbought nor oversold. The STOCH value of 19.22 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PFE.

Pfizer Risk Analysis

Pfizer disclosed 26 risk factors in its most recent earnings report. Pfizer reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Pfizer Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$209.94B12.9835.44%3.81%2.00%20.01%
78
Outperform
$139.52B13.1812.16%6.97%14.72%
78
Outperform
$239.55B18.2232.82%3.11%12.38%-12.67%
78
Outperform
$428.83B19.0430.21%2.84%4.69%34.88%
75
Outperform
$374.37B100.85112.90%3.04%6.05%-29.75%
67
Neutral
$150.80B23.2299.14%3.35%13.10%110.67%
51
Neutral
$7.91B-0.36-41.71%2.23%23.45%-1.86%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PFE
Pfizer
24.54
-2.10
-7.88%
AMGN
Amgen
280.10
-33.76
-10.76%
JNJ
Johnson & Johnson
178.76
18.94
11.85%
MRK
Merck & Company
84.05
-30.67
-26.73%
NVS
Novartis
128.42
15.36
13.59%
ABBV
AbbVie
213.00
26.80
14.39%

Pfizer Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
Pfizer Completes €3.3 Billion Notes Offering
Neutral
May 19, 2025

On May 19, 2025, Pfizer Netherlands International Finance B.V., a subsidiary of Pfizer Inc., completed a public offering of €3.3 billion in aggregate principal amount of notes with varying maturity dates and interest rates. This strategic financial move, backed by a senior unsecured guarantee from Pfizer Inc., is part of the company’s broader financial strategy to strengthen its market position and ensure operational liquidity.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 05, 2025