Revenue and EPS Beat in Q1 2026
Total revenues of $14.5 billion in Q1 2026, exceeding expectations and representing a 2% operational increase year-over-year. Reported diluted EPS was $0.47 and adjusted diluted EPS was $0.75, both above expectations.
Underlying Business Momentum Ex-COVID
Excluding COVID products, the underlying business delivered approximately 7% operational revenue growth in the quarter, signaling broad demand across key brands.
Strong Performance from Launched and Acquired Products
Launches and acquisitions generated $3.1 billion in Q1 revenue and grew ~22% operationally. Notable contributors: Nurtec grew 41% operationally and Seagen products grew 20% year-over-year operationally.
Clinical and R&D Progress — Multiple Positive Readouts
R&D delivered 3 positive Phase III readouts in early 2026 and encouraging mid-stage results. Key clinical wins: Padcev (EV-304) plus pembrolizumab reduced risk of recurrence or death by nearly 50% in cisplatin-eligible muscle-invasive bladder cancer; MagnetisMM-5 for Elrexfio showed significant improvement in progression-free survival in relapsed/refractory multiple myeloma; positive Phase II data for atirmociclib and tilrekimig. Management targets ~20 pivotal study starts, ~8 key data readouts and ~4 regulatory decisions in 2026.
Vyndamax Settlement and Belgian Court Ruling Improve Long-Term Profile
Settlement agreements related to Vyndamax patent matters and a favorable Belgian court ruling on Comirnaty contracts increase visibility into post-2028 cash flows and EPS. Management now expects to enter a 5-year period of high single-digit revenue CAGR starting in 2029 and reduced LOE impact (company noted LOE exposure is now closer to $14–15B vs prior ~$17B).
Vaccines and Pipeline Advancement
Initiated Phase III for a 25-valent pediatric pneumococcal conjugate candidate and advanced directly to a fifth-generation adult vaccine candidate covering 35 serotypes, with clinical development expected to begin this year — moves intended to sustain long-term leadership in vaccines.
Cost Savings, Margins and Capital Allocation Discipline
Adjusted gross margin ~76% in Q1 (mid-70s range guidance maintained). Manufacturing optimization Phase I expected to deliver ~$700 million in savings in 2026 with ~$175 million realized in Q1. Company reaffirmed plan to deliver ~$7.2 billion in total net cost savings by end of 2026. Capital actions: invested $2.5 billion in internal R&D in Q1, returned $2.4 billion to shareholders via dividend, sold ViiV stake for approx. $1.65 billion net proceeds (Q2) and reported BD capacity of about $7 billion; leverage ~2.8x and operating cash flow $2.6 billion in Q1.
Guidance Reaffirmed
Management reaffirmed full-year 2026 guidance: total revenues $59.5B–$62.5B and adjusted diluted EPS $2.80–$3.00 per share, reflecting confidence in execution while accounting for COVID seasonality.