Strong Contribution from Growth Drivers
Six key growth drivers generated ~70% of product sales in Q1 and grew 24% year-over-year in aggregate, providing momentum to offset losses of exclusivity.
Overall Product Sales Growth and Broad Product Strength
Total product sales grew 4% year-over-year; 16 products achieved double-digit growth and 17 products are annualizing at $1 billion or more in sales.
Repatha: Large Sales Increase and Outcomes Evidence
Repatha Q1 sales of $876 million, up 34% YoY; VESALIUS-CV subgroup data showed a 31% reduction in major cardiovascular events in high-risk diabetes patients and nominal reductions in cardiovascular and all-cause mortality (32% and 24% respectively).
Evenity and Bone Franchise Momentum
Evenity sales rose 27% YoY to $562 million (U.S. +35% YoY), holding a 65% U.S. bone-builder market share; ~320,000 U.S. patients treated to date and strong positioning in Japan (>900,000 patients, >55% share).
Rare Disease and Specialty Growth
Rare disease portfolio grew 25% YoY to $1.2 billion; Eplisna sales increased 188% YoY to $262 million; TEPEZZA U.S. sales grew 29% YoY to $490 million with >25,000 patients treated since launch and positive Phase III data for on-body injector supporting subcutaneous dosing.
Oncology and Biosimilars Performance
Innovative oncology portfolio grew 25% YoY to $1.8 billion (Imdeltra $258 million; Blincyto $415 million, +12% YoY); biosimilars grew 14% YoY to $835 million (PABLUE $280 million in Q1).
Financial Strength and Improved Guidance
Non-GAAP operating margin was 45%; generated $1.5 billion in free cash flow in Q1; increased 2026 guidance to $37.1B–$38.5B revenue and non-GAAP EPS $21.70–$23.10.
Investing in R&D and Manufacturing
Non-GAAP R&D spending increased 16% YoY in Q1 to support late-stage assets (Meritide, Imdeltra, olpasiran); Q1 capex of $700 million with expected full-year capex of ~$2.6 billion to scale manufacturing, including for Meritide launch.
Pipeline Progress: Meritide and Olpasiran
Meritide advancing with multiple Phase III studies including switch and long-term maintenance (evaluating every 8- and 12-week dosing) and three-step dose escalation improving GI tolerability; olpasiran progressing in Phase III with >95% Lp(a) reductions and initiation of OCEANA CCTA study.
AI and R&D Productivity Gains
AI initiatives reportedly accelerated antibody lead optimization by ~50%, improved clinical site enrollment rates (up to 3x in some cases), reduced production line clearance time from ~30 minutes to ~2 minutes per batch, and produced early regulatory-documentation efficiencies.