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Bristol-Myers Squibb Company (BMY)
NYSE:BMY

Bristol-Myers Squibb (BMY) AI Stock Analysis

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BMY

Bristol-Myers Squibb

(NYSE:BMY)

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Outperform 71 (OpenAI - 5.2)
Rating:71Outperform
Price Target:
$67.00
▲(9.66% Upside)
Action:ReiteratedDate:02/17/26
The score is driven primarily by strong cash generation and improving profitability, supported by constructive technical momentum. Valuation is reasonable with a solid dividend yield, while high leverage and earnings volatility, plus upcoming legacy/LOE headwinds (notably Eliquis timing) temper the overall rating.
Positive Factors
Consistent strong cash generation
Bristol-Myers Squibb produces large, recurring operating and free cash flows that support debt service, dividends, and R&D reinvestment. Sustained FCF in the low‑double‑digit billions provides durable financial flexibility to fund pipelines and strategic buybacks despite episodic earnings noise.
High-growth, diversified growth portfolio
A sizable growth portfolio now drives the business and offsets legacy declines. Multiple franchises (Breyanzi, Camzyos, Reblozyl, Opdualag) are scaling to multi‑billion revenues, diversifying risk and creating a more sustainable revenue base than reliance on a single legacy molecule.
Deep late‑stage pipeline with near‑term catalysts
A broad, data‑rich pipeline with multiple pivotal readouts and planned launches through 2030 increases the probability of durable, organic growth. Successful readouts would broaden indications, sustain product lifecycles, and support long‑term commercial expansion across oncology, immunology and cardiovascular areas.
Negative Factors
Elevated leverage and constrained equity base
High absolute debt relative to a reduced equity base limits balance sheet optionality and raises refinancing and covenant risk. Even with modest de‑levering, interest and principal obligations constrain capital allocation choices and increase sensitivity to cash‑flow variability or adverse trial/regulatory outcomes.
Material LOE risk for legacy franchise (Eliquis)
Predicted multi‑billion Eliquis erosion is a structural headwind: loss of exclusivity will materially reduce a major cash and profit contributor, forcing greater reliance on new launches and pipeline success to replace this recurring revenue over several years.
Earnings volatility and one‑time charge exposure
Historic swings, including large non‑recurring charges, undermine predictability of reported earnings and margins. Persistent volatility increases forecasting risk, complicates capital allocation and could pressure credit metrics if additional write‑downs or regulatory costs arise.

Bristol-Myers Squibb (BMY) vs. SPDR S&P 500 ETF (SPY)

Bristol-Myers Squibb Business Overview & Revenue Model

Company DescriptionBristol-Myers Squibb Company discovers, develops, licenses, manufactures, and markets biopharmaceutical products worldwide. It offers products for hematology, oncology, cardiovascular, immunology, fibrotic, neuroscience, and covid-19 diseases. The company's products include Revlimid, an oral immunomodulatory drug for the treatment of multiple myeloma; Eliquis, an oral inhibitor for reduction in risk of stroke/systemic embolism in NVAF, and for the treatment of DVT/PE; Opdivo for anti-cancer indications; Pomalyst/Imnovid indicated for patients with multiple myeloma; and Orencia for adult patients with active RA and psoriatic arthritis. It also provides Sprycel for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia; Yervoy for the treatment of patients with unresectable or metastatic melanoma; Abraxane, a protein-bound chemotherapy product; Reblozyl for the treatment of anemia in adult patients with beta thalassemia; and Empliciti for the treatment of multiple myeloma. In addition, the company offers Zeposia to treat relapsing forms of multiple sclerosis; Breyanzi, a CD19-directed genetically modified autologous T cell immunotherapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma; Inrebic, an oral kinase inhibitor indicated for the treatment of adult patients with myelofibrosis; and Onureg for the treatment of adult patients with AML. It sells products to wholesalers, distributors, pharmacies, retailers, hospitals, clinics, and government agencies. The company was formerly known as Bristol-Myers Company. The company was founded in 1887 and is headquartered in New York, New York.
How the Company Makes MoneyBristol-Myers Squibb generates revenue primarily through the sale of its pharmaceutical products, which include prescription medications and biologics. The company benefits from a diverse portfolio of blockbuster drugs, which contribute significantly to its earnings. Key revenue streams consist of sales from oncology products like Opdivo and Yervoy, as well as from its cardiovascular drug Eliquis. Additionally, BMY engages in strategic partnerships and collaborations, including licensing agreements and co-development deals with other pharmaceutical companies, which can provide additional revenue sources through milestone payments and royalties. The company's strong focus on research and development, along with a robust pipeline of new therapies, further positions it to capitalize on future market opportunities and sustain its revenue growth.

Bristol-Myers Squibb Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Analyzes revenue from different business segments, highlighting which areas drive growth and profitability, and indicating how well the company diversifies its income streams.
Chart InsightsBristol-Myers Squibb's 'Other' segment revenue surged in late 2024, possibly reflecting strategic shifts or new product launches, aligning with the earnings call's emphasis on growth portfolio performance. The 'Product' segment shows resilience with a recent uptick, while 'Alliance' revenue is declining, consistent with challenges in legacy portfolios. The earnings call highlights robust demand for key brands and raised revenue guidance, suggesting confidence in sustained growth despite some unmet expectations in trials.
Data provided by:The Fly

Bristol-Myers Squibb Earnings Call Summary

Earnings Call Date:Feb 05, 2026
(Q4-2025)
|
% Change Since: |
Next Earnings Date:Apr 30, 2026
Earnings Call Sentiment Positive
The call emphasized substantial positive momentum: a high-growth portfolio delivering double-digit growth, multiple products achieving billion-dollar status, a robust near-term pipeline with numerous data catalysts, disciplined cost savings, and a strengthened balance sheet. Offsetting risks include LOE/generic pressures on the legacy portfolio (notably Eliquis over time), mix-driven margin pressure, one-time R&D charges, and the execution risk inherent in upcoming clinical readouts. Overall, the positives (strong commercial growth, pipeline depth, cost execution, and financial flexibility) outweigh the challenges.
Q4-2025 Updates
Positive Updates
Growth Portfolio Outperformance
Growth portfolio revenue increased 15% year-over-year in Q4 (to $7.4B) and 17% for the full year, representing ~60% of total Q4 revenue and nearly offsetting ~ $4B decline in the legacy portfolio for the year.
Multiple High-Performing Products
Opdualag, Breyanzi, and Camzyos each exceeded $1B in full-year sales; Reblozyl exceeded $2B. Notable Q4 product growth: Breyanzi +47% (Q4), Reblozyl +21% (Q4), Camzyos +57% (Q4), Opdivo +7% (Q4), Eliquis +6% (Q4).
Strong Commercial Momentum for New Launches
Early launches showed traction: Qvantik $133M in Q4 with positive practice feedback; CoBinfy $51M in Q4 with uptake surpassing schizophrenia comparators and >100k TRx since launch.
Robust Pipeline and Near-Term Catalysts
Data-rich 2026: top-line registrational data expected for ~6 potential new products this year and over 30 meaningful launch opportunities by 2030. Key milestones include Breyanzi expansion (FDA approval in marginal zone lymphoma), multiple pemigatinib registrational studies, Break Free SSC for Zolacel, and upcoming Nablometastat oral data.
2026 Financial Guidance and EPS Outlook
2026 revenue guidance of $46.0B–$47.5B and adjusted diluted EPS guidance of $6.05–$6.35, reflecting continued growth portfolio performance and planned legacy declines.
Progress on Cost Savings and Expense Management
Delivered approximately $1B of a $2B strategic productivity initiative in 2025 with the remaining ~$1B targeted across 2026–2027. Full-year operating expenses (ex-IPR&D) decreased to $16.6B, down $1.2B vs 2024; 2026 operating expense guidance ~ $16.3B.
Balance Sheet and Cash Flow Strength
Approximately $11B in cash and marketable securities as of 12/31/2025, completed targeted $10B debt paydown ahead of schedule, and generated ~$2B operating cash flow in Q4.
Commercial Positioning and Market Access Wins
Eliquis remains a growth driver with US market share ~75% in AFib and company guidance expecting Eliquis revenue growth of 10%–15% in 2026; Opdualag and Opdivo share gains in metastatic melanoma and first-line NSCLC respectively; Opdivo subQ (Qvantik/Opdivo SC) adoption tracking to conversion target of 30%–40% of IV business by 2028.
Negative Updates
Legacy Portfolio Declines and LOE Headwinds
Full-year legacy portfolio revenue declined roughly $4B; company projects legacy portfolio revenue decline of 12%–16% in 2026 driven by ongoing loss-of-exclusivity (LOE) impacts and expected generic entries.
Gross Margin Pressure
Q4 gross margin declined 210 basis points to 71.9% (driven by product mix, notably Eliquis and Revlimid). 2026 gross margin guidance of 69%–70% reflects continued mix pressure.
One-Time Charges and EPS Impact
Net in-process R&D and licensing charges reduced EPS by $0.60 in Q4 and $1.40 for the full year, and contributed to an elevated effective tax rate in Q4 (22.1% vs 19.9% prior year).
Eliquis Future Sales Step-Down Risk
Management expects a 2027 Eliquis sales step-down of $1.5B–$2B vs 2026 due to patent expirations and generics outside the U.S.; country-by-country litigation and timing introduce uncertainty to future revenue.
Concentration and Early-Stage Sales for Some New Products
While new launches have positive indicators, several key products remain early in adoption (e.g., CoBinfy $51M Q4, Qvantik $133M Q4) and will need sustained uptake and label/indication expansion to drive inflection.
Regulatory/Clinical and Competitive Risks
Despite confidence in a data-rich 2026, clinical readouts (e.g., Milvexian in AFib, multiple CELMoD programs, pemigatinib registrational studies) carry inherent execution risk; competitive dynamics (bispecifics, biosimilars) could affect future positioning and uptake.
Company Guidance
The company guided 2026 non‑GAAP revenue of $46.0–47.5B, gross margin of 69–70%, adjusted diluted EPS of $6.05–6.35, total operating expenses of ≈$16.3B, OI&E of ≈$700M and an ~18% tax rate; it expects the growth portfolio (Q4: +15% to $7.4B, ~60% of Q4 revenue; FY: +17%; Reblozyl >$2B; Opdualag, Breyanzi, Camzyos >$1B each; Qvantik $133M Q4; CoBinfy $51M Q4) to drive performance while the legacy portfolio is projected to decline 12–16% (Eliquis is forecast to grow 10–15% in 2026 with H2 > H1), Q1 to show typical seasonal destocking, and a 2027 Eliquis step‑down of $1.5–2.0B is expected; financial flexibility is supported by ~$11B cash and marketable securities, a completed $10B debt paydown, ~$2B Q4 operating cash flow, and execution of a $2B productivity program (≈$1B realized in 2025, remaining ~$1B in 2026–27).

Bristol-Myers Squibb Financial Statement Overview

Summary
Strong, consistent operating cash flow and free cash flow support debt service and shareholder returns, and 2025 showed a sharp profitability rebound. Offsetting this is elevated leverage (high debt relative to equity) and notable earnings volatility, including a major loss in 2024.
Income Statement
68
Positive
Revenue has been relatively stable over the last several years with a notable step-up in 2025 (annual revenue growth of ~33%). Profitability improved sharply in 2025 (mid-teens net margin and low-20s operating margin), rebounding from a significant loss in 2024. Gross margin also strengthened meaningfully in 2025 versus 2024. Key weakness is earnings volatility—large net losses in 2024 and 2020 highlight non-recurring charges and/or margin instability, which reduces confidence in the durability of reported profits.
Balance Sheet
52
Neutral
Leverage is elevated: 2024 debt-to-equity is ~3.1x and equity has trended down from 2021–2024, limiting balance-sheet flexibility. While total debt declined modestly in 2025 versus 2024, debt remains large relative to equity (roughly $49B debt vs ~$18B equity in 2025), and the 2024 loss translated into negative return on equity. Strengths include a large asset base and some recent de-levering, but overall financial risk remains meaningful due to the capital structure.
Cash Flow
74
Positive
Cash generation is consistently strong: operating cash flow has generally been ~$13B–$16B annually and free cash flow has remained robust (~$12B–$15B) across the period, including years with accounting losses. Free cash flow did decline in 2025 (down ~16% year over year), but the level remains healthy and supports debt service and shareholder returns. The main drawback is the recent free-cash-flow pullback and some variability in year-to-year cash flow growth.
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue48.19B48.30B45.01B46.16B46.38B
Gross Profit32.60B27.43B25.36B26.49B26.76B
EBITDA14.54B3.17B19.37B19.22B20.12B
Net Income7.05B-8.95B8.03B6.33B6.99B
Balance Sheet
Total Assets90.04B92.60B95.16B96.82B109.31B
Cash, Cash Equivalents and Short-Term Investments10.67B10.86B12.28B9.25B17.22B
Total Debt47.14B51.20B41.46B40.72B45.60B
Total Liabilities71.53B76.22B65.67B65.70B73.31B
Stockholders Equity18.47B16.34B29.43B31.06B35.95B
Cash Flow
Free Cash Flow12.85B13.94B12.65B11.95B15.23B
Operating Cash Flow14.16B15.19B13.86B13.07B16.21B
Investing Cash Flow-4.13B-21.35B-2.29B-1.06B-538.00M
Financing Cash Flow-10.35B5.13B-9.42B-16.96B-16.22B

Bristol-Myers Squibb Technical Analysis

Technical Analysis Sentiment
Positive
Last Price61.10
Price Trends
50DMA
56.66
Positive
100DMA
51.50
Positive
200DMA
48.54
Positive
Market Momentum
MACD
1.60
Positive
RSI
69.22
Neutral
STOCH
75.83
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BMY, the sentiment is Positive. The current price of 61.1 is above the 20-day moving average (MA) of 59.84, above the 50-day MA of 56.66, and above the 200-day MA of 48.54, indicating a bullish trend. The MACD of 1.60 indicates Positive momentum. The RSI at 69.22 is Neutral, neither overbought nor oversold. The STOCH value of 75.83 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BMY.

Bristol-Myers Squibb Risk Analysis

Bristol-Myers Squibb disclosed 23 risk factors in its most recent earnings report. Bristol-Myers Squibb reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Bristol-Myers Squibb Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
$306.13B17.0136.91%3.12%1.59%58.02%
74
Outperform
$184.91B21.9740.49%2.52%2.76%6407.19%
71
Outperform
$127.01B18.0340.53%4.84%1.26%
71
Outperform
$209.24B27.28106.10%3.00%11.03%65.22%
67
Neutral
$119.31B15.9038.48%3.41%5.97%128.66%
64
Neutral
$157.23B20.398.87%6.65%4.44%128.96%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BMY
Bristol-Myers Squibb
62.37
5.38
9.44%
AMGN
Amgen
388.16
86.83
28.82%
GILD
Gilead Sciences
148.95
36.11
32.00%
GSK
GlaxoSmithKline
59.13
22.63
62.01%
MRK
Merck & Company
123.82
34.05
37.93%
PFE
Pfizer
27.65
3.18
12.98%

Bristol-Myers Squibb Corporate Events

Business Operations and StrategyDividendsFinancial Disclosures
Bristol Myers Squibb Posts 2025 Results, Raises Dividend
Positive
Feb 5, 2026

On February 5, 2026, Bristol Myers Squibb reported its fourth-quarter and full-year 2025 financial results, showing modest top-line performance but strong contributions from its newer medicines. Fourth-quarter revenues in 2025 rose 1% year-on-year to $12.5 billion as Growth Portfolio sales grew 16% to $7.4 billion, offsetting a 15% decline in the Legacy Portfolio, while GAAP EPS came in at $0.53 and non-GAAP EPS at $1.26, both reflecting a negative earnings impact from acquired in-process R&D charges and licensing income. For full-year 2025, revenues were essentially flat at $48.2 billion, but profitability improved sharply, with GAAP EPS of $3.46 and non-GAAP EPS of $6.15, and management highlighting disciplined execution, a strengthened balance sheet and strong momentum in core franchises such as immuno-oncology, Camzyos, Breyanzi and Reblozyl. Looking ahead, the company issued 2026 guidance calling for revenues of about $46.0 billion to $47.5 billion and non-GAAP EPS of $6.05 to $6.35, and underscored its confidence in a “data-rich” year with multiple pivotal pipeline readouts, while continuing its shareholder return strategy by raising the quarterly dividend to $0.63 per share, marking the 17th consecutive annual increase.

The most recent analyst rating on (BMY) stock is a Hold with a $57.00 price target. To see the full list of analyst forecasts on Bristol-Myers Squibb stock, see the BMY Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Bristol Myers Squibb Showcases Growth Strategy at JPM Conference
Positive
Jan 12, 2026

On January 12, 2026, Bristol Myers Squibb used its appearance at the 44th Annual J.P. Morgan Healthcare Conference to highlight that it has been “built for growth,” emphasizing a 17% year-on-year increase in Growth Portfolio sales for the first nine months of 2025, four assets already annualizing above $1 billion in revenue, stronger operating cash flow, and productivity initiatives including scaled use of AI to generate cost savings for reinvestment. The company detailed a broad late-stage pipeline with multiple potential multi-billion-dollar assets across cardiovascular, immunology, oncology and neuroscience, outlined significant registrational and pivotal trial readouts expected from 2026 through 2028, and projected more than 10 potential new product launches by 2030, underscoring a strategic focus on sustaining industry-leading long-term growth and reinforcing its competitive position in key therapeutic areas.

The most recent analyst rating on (BMY) stock is a Hold with a $47.00 price target. To see the full list of analyst forecasts on Bristol-Myers Squibb stock, see the BMY Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Bristol-Myers Squibb Adjusts Tender Offer Terms
Neutral
Nov 18, 2025

On November 17, 2025, Bristol-Myers Squibb announced the early participation results and amendments to its cash tender offers to purchase outstanding notes. The company adjusted the maximum purchase amounts for its Pool 1 and Pool 2 Notes and confirmed that all validly tendered notes before the deadline will be accepted without proration, except for the 2033 Notes, which will be prorated. The early settlement is set for November 20, 2025, and no further tenders will be accepted after the early deadline, as the maximum thresholds have been met.

The most recent analyst rating on (BMY) stock is a Hold with a $45.00 price target. To see the full list of analyst forecasts on Bristol-Myers Squibb stock, see the BMY Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Feb 17, 2026