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GlaxoSmithKline (GSK)
NYSE:GSK

GlaxoSmithKline (GSK) AI Stock Analysis

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GSK

GlaxoSmithKline

(NYSE:GSK)

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Outperform 77 (OpenAI - 4o)
Rating:77Outperform
Price Target:
$52.00
▲(6.45% Upside)
GSK's overall stock score of 77 reflects its strong financial performance and positive earnings call, which highlight robust growth in specialty medicines and upgraded guidance. The technical analysis supports a positive momentum, although nearing overbought levels. Valuation is reasonable, with a solid dividend yield adding to the stock's attractiveness. Despite some challenges, GSK's strategic focus on R&D and specialty medicines positions it well for future growth.
Positive Factors
Revenue Growth
GSK's consistent revenue growth, driven by strong sales in specialty medicines and vaccines, indicates robust market demand and effective product strategies.
R&D Investment
Significant investment in R&D underscores GSK's commitment to innovation, potentially leading to new product developments and long-term competitive advantages.
Cash Flow Generation
Strong cash flow generation supports GSK's ability to invest in growth initiatives, manage debt, and provide shareholder returns, enhancing financial stability.
Negative Factors
Challenges in U.S. Vaccine Market
Slowing vaccine penetration and competitive pressures in the U.S. could limit growth in this key market, affecting GSK's revenue from vaccines.
Delay in HIV Treatment Study
Delays in clinical trials can postpone product launches, impacting GSK's ability to capitalize on new treatments and affecting future revenue streams.
Zantac Settlement Payments
Significant settlement payments can strain financial resources, potentially limiting GSK's ability to invest in growth opportunities and impacting profitability.

GlaxoSmithKline (GSK) vs. SPDR S&P 500 ETF (SPY)

GlaxoSmithKline Business Overview & Revenue Model

Company DescriptionGSK plc, together with its subsidiaries, engages in the research, development, and manufacture of vaccines, and specialty and general medicines to prevent and treat disease in the United Kingdom, the United States, and internationally. It operates through two segments, Commercial Operations and Total R&D. The company offers shingles, meningitis, respiratory syncytial virus, flu, polio, influenza, and pandemic vaccines. It also provides medicines for HIV, oncology, respiratory/immunology, and other specialty medicine products, as well as inhaled medicines for asthma and chronic obstructive pulmonary disease, and antibiotics for infections. It has a collaboration agreement with CureVac to develop mRNA-based influenza vaccines, and with Wave Life Sciences and Elsie Biotechnologies, Inc for oligonucleotide platform development; two strategic collaborations with Relation to advance therapeutics for fibrotic diseases and osteoarthritis; and multi-target strategic alliance with GSK to develop breakthrough treatments for people afflicted with Parkinson's disease; as well as collaboration with Flagship Pioneering to discover novel medicines and vaccines. The company was formerly known as GlaxoSmithKline plc and changed its name to GSK plc in May 2022. GSK plc was founded in 1715 and is headquartered in Brentford, the United Kingdom.dom.
How the Company Makes MoneyGSK generates revenue primarily through the sale of prescription medicines, vaccines, and consumer healthcare products. Its key revenue streams include sales from its pharmaceutical division, which focuses on innovative medicines and specialty pharmaceuticals, and its vaccines division, which provides immunizations against various diseases. The consumer healthcare segment contributes additional revenue through over-the-counter products, including oral health, pain relief, and wellness items. GSK also engages in collaborations and partnerships with other pharmaceutical and biotechnology companies, allowing for shared development costs and enhanced market access. Significant partnerships with organizations for vaccine distribution, especially during global health crises, further bolster its earnings.

GlaxoSmithKline Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Breaks down revenue by different business segments, highlighting which areas drive the most sales and profitability, and indicating where the company might focus its strategic efforts.
Chart InsightsGSK's Specialty Medicines segment has emerged as a key growth driver, with recent earnings highlighting a 15% sales increase, aligning with its projected dominance by 2031. While the Vaccines segment also shows positive momentum with a 9% rise, challenges persist in China and supply chain costs. The company's strategic focus on R&D and successful FDA approvals bolster its long-term growth outlook, despite delayed product launches. GSK's robust cash generation supports continued investments and shareholder returns, positioning it well to reach the upper end of its 2025 financial guidance.
Data provided by:The Fly

GlaxoSmithKline Earnings Call Summary

Earnings Call Date:Oct 29, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 04, 2026
Earnings Call Sentiment Positive
The earnings call highlighted GSK's strong financial performance, significant growth in specialty medicines, and progress in R&D with FDA approvals. However, challenges remain in the U.S. vaccine market, delays in the HIV treatment study, and impacts from Medicare redesign and Zantac settlements.
Q3-2025 Updates
Positive Updates
Strong Financial Performance
Total sales were up 8% for the quarter, with core operating profit up 11% and core earnings per share up 14% to 55p. Cash generation continues to be very positive at GBP 6.3 billion for the year so far.
Specialty Medicines Growth
Specialty Medicines saw a 16% increase with strong growth in RI&I, oncology, and HIV. Benlysta and Nucala grew by 17% and 14%, respectively. Jemperli sales increased for the 10th consecutive quarter.
R&D Progress and FDA Approvals
GSK secured four FDA approvals this year, including BLENREP, with a fifth, depemokimab, expected before year-end. GSK continues to strengthen its late-stage portfolio and plans significant investment in R&D.
Upgraded Guidance
GSK upgraded its guidance for the year with meaningful improvement for 2025 sales and profits. Sales expectations increased from 3%-5% to 6%-7%, operating profit to 9%-11%, and EPS to 10%-12%.
Vaccine Sales Growth
Shingrix sales grew 13% overall, with a strong performance in Europe (up 48%). Arexvy and Bexsero also showed strong demand.
Negative Updates
Challenges in U.S. Vaccine Market
In the U.S., Shingrix penetration is slowing with immunization rates at 43% of the eligible population, and there is competitive pressure in the flu vaccine market.
Delay in HIV Q4M Study
The QUATRO Phase III study for the Q4M HIV treatment is delayed to H1 2026 due to a clinical trial supply delay by Janssen.
Impact of IRA and Medicare Redesign
GSK navigated the impact of the Medicare redesign from the IRA, with an expected impact closer to the lower end of the GBP 400 million to GBP 500 million range.
Zantac Settlement Payments
Zantac payments year-to-date totaled nearly GBP 0.7 billion, with the remaining GBP 0.5 billion expected to be paid by the end of the year.
Company Guidance
During the GSK Q3 2025 Results Call, the company provided an upgraded guidance for the year, driven by strong sales and operational performance. GSK reported an 8% increase in total sales for the quarter, with core operating profit rising by 11% and core earnings per share by 14% to 55p. Cash generation reached GBP 6.3 billion year-to-date, supporting both investments in growth priorities and a dividend of 16p per share for the quarter. Specialty medicines, including RI&I, oncology, and HIV, continued to drive growth, with a 16% increase in Specialty Medicines sales. GSK also highlighted the successful launch of BLENREP in eight markets and anticipated approval of depemokimab by year-end. The company reiterated its commitment to investing in R&D, with GBP 30 billion earmarked for R&D and advanced manufacturing in the U.S. over the next five years. Looking forward, GSK upgraded its full-year sales growth expectations from 3-5% to 6-7%, operating profit growth from 9-11%, and EPS growth from 10-12%, underscoring confidence in achieving long-term revenue targets of over GBP 40 billion by 2031.

GlaxoSmithKline Financial Statement Overview

Summary
GlaxoSmithKline demonstrates a strong financial position with consistent revenue and profit growth, effective cost management, and solid cash generation. The income statement shows robust profitability, while the balance sheet indicates a balanced leverage approach. The cash flow metrics reflect effective cash management, supporting strategic initiatives.
Income Statement
85
Very Positive
GlaxoSmithKline's income statement shows strong profitability with a TTM gross profit margin of 72.37% and a net profit margin of 17.08%. The company has demonstrated consistent revenue growth, with a TTM revenue growth rate of 1.69%. The EBIT and EBITDA margins are also robust at 23.94% and 35.03%, respectively, indicating efficient operations and cost management. Overall, the income statement reflects a healthy financial performance with solid growth and profitability metrics.
Balance Sheet
78
Positive
The balance sheet of GlaxoSmithKline reveals a moderate debt-to-equity ratio of 1.10 in the TTM period, indicating a balanced approach to leveraging. The return on equity is strong at 37.40%, showcasing effective utilization of shareholder funds. The equity ratio stands at 26.33%, suggesting a stable capital structure. While the company maintains a healthy balance between debt and equity, there is room for improvement in reducing leverage to enhance financial stability further.
Cash Flow
80
Positive
GlaxoSmithKline's cash flow statement highlights a positive trajectory with a TTM free cash flow growth rate of 27.59%. The operating cash flow to net income ratio is 0.37, and the free cash flow to net income ratio is 0.60, indicating strong cash generation relative to earnings. The company has shown resilience in improving its cash flow position, which supports its operational and strategic initiatives. Overall, the cash flow metrics reflect a solid financial footing with effective cash management.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue32.17B31.38B30.33B29.32B24.70B24.35B
Gross Profit23.25B22.33B21.76B19.77B16.53B16.43B
EBITDA10.80B6.67B9.08B8.60B6.49B8.07B
Net Income5.49B2.58B4.93B14.96B4.38B5.75B
Balance Sheet
Total Assets82.58B59.46B75.22B60.15B107.14B109.95B
Cash, Cash Equivalents and Short-Term Investments4.45B3.71B6.61B7.88B5.87B8.71B
Total Debt23.90B16.99B22.97B20.99B32.74B37.11B
Total Liabilities61.37B46.38B58.91B50.05B78.23B81.50B
Stockholders Equity21.74B13.67B17.01B10.60B20.39B19.94B
Cash Flow
Free Cash Flow5.95B3.57B6.26B6.75B5.30B6.50B
Operating Cash Flow8.60B6.55B7.89B8.16B7.95B8.44B
Investing Cash Flow-5.04B-1.23B-2.40B-10.88B-1.78B2.16B
Financing Cash Flow-4.06B-4.73B-6.07B2.05B-7.59B-10.13B

GlaxoSmithKline Technical Analysis

Technical Analysis Sentiment
Positive
Last Price48.85
Price Trends
50DMA
46.74
Positive
100DMA
43.37
Positive
200DMA
40.36
Positive
Market Momentum
MACD
0.58
Positive
RSI
58.33
Neutral
STOCH
54.94
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GSK, the sentiment is Positive. The current price of 48.85 is above the 20-day moving average (MA) of 48.39, above the 50-day MA of 46.74, and above the 200-day MA of 40.36, indicating a bullish trend. The MACD of 0.58 indicates Positive momentum. The RSI at 58.33 is Neutral, neither overbought nor oversold. The STOCH value of 54.94 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GSK.

GlaxoSmithKline Risk Analysis

GlaxoSmithKline disclosed 1 risk factors in its most recent earnings report. GlaxoSmithKline reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

GlaxoSmithKline Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$285.96B30.3621.73%1.70%12.95%44.28%
78
Outperform
$111.27B18.3333.84%4.84%1.26%
77
Outperform
$98.80B13.7435.62%3.43%5.97%128.66%
77
Outperform
$178.45B25.6381.71%3.00%11.03%65.22%
75
Outperform
$117.50B11.988.39%4.58%-9.32%120.62%
74
Outperform
$143.34B14.5010.59%6.65%4.44%128.96%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GSK
GlaxoSmithKline
48.85
16.12
49.25%
AMGN
Amgen
331.49
76.61
30.06%
AZN
AstraZeneca
92.14
26.98
41.41%
BMY
Bristol-Myers Squibb
54.28
-0.97
-1.76%
PFE
Pfizer
24.88
0.11
0.44%
SNY
Sanofi
48.32
1.38
2.94%

GlaxoSmithKline Corporate Events

GSK Executes Share Buyback as Part of Capital Management Strategy
Aug 29, 2025

On August 28, 2025, GSK plc announced the purchase of 236,167 of its own ordinary shares at prices ranging from 1,460.50p to 1,479.00p per share, as part of its ongoing buyback program initiated on June 4, 2025. This transaction, executed through Merrill Lynch International, increases the total number of shares held in treasury to 244,155,883, representing 6.00% of the voting rights, and reflects GSK’s strategy to manage its capital structure effectively.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 18, 2025