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Astrazeneca Plc (AZN)
NASDAQ:AZN
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AstraZeneca (AZN) AI Stock Analysis

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AZN

AstraZeneca

(NASDAQ:AZN)

Rating:79Outperform
Price Target:
$84.00
▲(4.93% Upside)
AstraZeneca's strong financial performance and positive earnings call are the most significant factors driving the score. Technical analysis shows bullish momentum, though caution is advised due to overbought signals. The valuation suggests the stock may be overvalued, which slightly tempers the overall score.
Positive Factors
Earnings
The company reported Total Product Sales of $13.795bn, above consensus estimates, driven by the oncology segment.
Regulatory Developments
Regulatory filings accepted for multiple products in the US, EU, and Japan.
Negative Factors
Clinical Trials
The clinical program evaluating anselamimab did not achieve statistical significance in the overall population for the primary endpoint.
Product Performance
Performance across non-oncology products were mixed, with some products below consensus.

AstraZeneca (AZN) vs. SPDR S&P 500 ETF (SPY)

AstraZeneca Business Overview & Revenue Model

Company DescriptionAstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization of prescription medicines. The company's marketed products include Tagrisso, Imfinzi, Lynparza, Calquence, Enhertu, Orpathys, Truqap, Zoladex, Faslodex, Farxiga, Brilinta, Lokelma, Roxadustat, Andexxa, Crestor, Seloken, Onglyza, Bydureon, Fasenra, Breztri, Symbicort, Saphnelo, Tezspire, Pulmicort, Bevespi, and Daliresp for cardiovascular, renal, metabolism, and oncology. Its marketed products also comprise Vaxzevria, Beyfortus, Synagis, FluMist, Soliris, Ultomiris, Strensiq, Koselugo, and Kanuma for covid-19 and rare disease. The company serves primary care and specialty care physicians through distributors and local representative offices in the United Kingdom, rest of Europe, the Americas, Asia, Africa, and Australasia. It has a collaboration agreement with Neurimmune AG to develop and commercialize NI006; BenevolentAI for drug discovery for systemic lupus erythematosus; Lunit for developing AI-Powered Digital Pathology Risk Assessment Tools for NSCLC; and Absci Corporation for AI-driven drug discovery against an oncology target. The company was formerly known as Zeneca Group PLC and changed its name to AstraZeneca PLC in April 1999. AstraZeneca PLC was incorporated in 1992 and is headquartered in Cambridge, the United Kingdom.
How the Company Makes MoneyAstraZeneca generates revenue primarily through the sale of its pharmaceutical products across various therapeutic areas. The company's revenue model is built on a combination of direct sales of its branded medications and partnerships with other pharmaceutical companies for co-development and co-marketing. Key revenue streams include sales from its oncology segment, which has seen significant growth due to the increasing demand for cancer treatments. The company also benefits from strategic collaborations and licensing agreements with other firms, which provide additional income through upfront payments, milestone payments, and royalties on future sales. Additionally, AstraZeneca invests heavily in research and development to innovate and expand its product portfolio, which contributes to its long-term revenue potential.

AstraZeneca Key Performance Indicators (KPIs)

Any
Any
Revenue by Therapy Areas
Revenue by Therapy Areas
Examines revenue from various therapy areas, indicating AstraZeneca's strengths in specific medical fields and potential for innovation and market expansion.
Chart InsightsAstraZeneca's Oncology segment is experiencing robust growth, reflecting strategic focus and successful product launches. CVRM and Rare Diseases are also showing steady revenue increases, indicating solid market demand. However, Vaccination and Immunology revenues have significantly declined from their peak, suggesting waning demand or market saturation. Respiratory & Immunology is recovering, but at a slower pace. The decline in Other Medicines suggests a strategic deprioritization or competitive pressures. Overall, AstraZeneca's diversified portfolio is driving growth, but the Vaccination segment's volatility could pose risks to sustained revenue momentum.
Data provided by:Main Street Data

AstraZeneca Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: 12.21%|
Next Earnings Date:Nov 06, 2025
Earnings Call Sentiment Positive
AstraZeneca demonstrated strong financial performance and significant pipeline advancements, particularly in oncology and biopharmaceuticals. However, challenges remain with Medicare Part D redesign, biosimilar competition, and specific pipeline setbacks.
Q2-2025 Updates
Positive Updates
Solid Financial Growth
Total revenue increased by 11%, and core EPS grew 17% in the first half of 2025, reflecting strong demand for AstraZeneca's innovative medicines.
Pipeline Success
AstraZeneca announced 12 positive Phase III trial results this year, including the first pivotal data for 5 new molecular entities, with a potential to generate over $10 billion in peak year revenue.
Oncology Revenue Surge
Oncology total revenues grew 16% to $12 billion in the first half, driven by strong double-digit growth across the U.S., Europe, and emerging markets.
Enhertu Growth
Enhertu total revenues grew 42% in the second quarter, reflecting sustained market leadership in HER2-positive and HER2 low metastatic breast cancer.
Biopharmaceuticals Revenue Growth
Biopharmaceuticals delivered strong performance with 10% growth, reaching total revenue of $11.2 billion, with R&I and CVRM segments showing robust increases.
Baxdrostat Phase III Success
Baxdrostat showed significant promise in the BaxHTN Phase III trial for uncontrolled resistant hypertension, meeting primary and secondary endpoints with a favorable safety profile.
Negative Updates
Impact of Medicare Part D Redesign
The total revenue core gross margin is anticipated to decline by around 60 to 70 basis points in 2025 due to factors including Medicare Part D redesign.
Challenges with Anselamimab
The Phase III CARES program for anselamimab in severe light chain amyloidosis did not achieve statistical significance for the primary endpoint in the overall patient population.
Farxiga VBP Implementation
Farxiga's revenues in China are expected to be impacted by the VBP implementation in the second half of 2025, affecting its growth trajectory.
Soliris Biosimilar Competition
The gross margin is expected to decline due to Soliris biosimilar competition, posing challenges for the rare disease segment.
Company Guidance
During the AstraZeneca H1 and Q2 2025 conference call, the company provided an optimistic financial outlook, highlighting an 11% revenue growth in the first half of the year, driven by strong demand for innovative medicines. Core EPS rose by 17%, showcasing the company's commitment to pipeline investment and operational efficiency. AstraZeneca reported 19 regulatory approvals in key regions and 12 positive Phase III trial results, including five new molecular entities. The oncology segment saw a 16% revenue increase, while biopharmaceuticals grew by 10%. The company also reiterated its 2030 revenue target of $80 billion, emphasizing its diverse pipeline and transformative technologies poised to sustain long-term growth. Despite the challenges, AstraZeneca remains confident, supported by a strong cash flow, significant investments in R&D, and strategic global expansions.

AstraZeneca Financial Statement Overview

Summary
AstraZeneca demonstrates robust financial health with strong revenue growth and improved profitability. The balance sheet is stable with manageable leverage, and cash flow metrics indicate strong cash generation and reinvestment capacity.
Income Statement
85
Very Positive
AstraZeneca has shown strong revenue growth with a 6% increase in the TTM compared to the previous year, driven by consistent sales performance. The company maintains solid profitability, with a gross profit margin of 79.4% and a net profit margin of 14.7% in TTM. The EBIT margin improved to 19.9%, indicating enhanced operational efficiency.
Balance Sheet
78
Positive
The balance sheet reflects a stable financial position with a debt-to-equity ratio of 0.73, demonstrating manageable leverage. The equity ratio stands at 39.8%, showing a robust capital structure. Return on equity has improved to 18.6%, indicating effective use of shareholder funds.
Cash Flow
82
Very Positive
AstraZeneca exhibits a strong cash flow position, with a 31.4% growth in free cash flow in the TTM period. The operating cash flow to net income ratio is 1.62, evidencing strong cash generation capability. However, the free cash flow to net income ratio of 1.15 suggests effective reinvestment in operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue42.91B54.07B45.81B44.35B37.42B26.62B
Gross Profit34.63B43.87B37.77B31.96B24.98B21.32B
EBITDA13.49B15.44B13.91B9.09B5.11B8.08B
Net Income5.38B7.04B5.96B3.29B112.00M3.20B
Balance Sheet
Total Assets112.42B104.03B101.12B96.48B105.36B66.73B
Cash, Cash Equivalents and Short-Term Investments7.11B5.53B5.86B6.41B6.40B7.99B
Total Debt32.84B30.11B28.62B29.23B30.78B20.38B
Total Liabilities67.61B63.16B61.95B59.42B66.08B51.09B
Stockholders Equity44.72B40.79B39.14B37.04B39.27B15.62B
Cash Flow
Free Cash Flow5.44B7.28B6.57B7.24B3.76B2.19B
Operating Cash Flow9.68B11.86B10.35B9.81B5.96B4.80B
Investing Cash Flow-4.80B-7.98B-4.06B-2.96B-11.06B-285.00M
Financing Cash Flow-4.28B-4.00B-6.57B-6.82B3.65B-2.20B

AstraZeneca Technical Analysis

Technical Analysis Sentiment
Positive
Last Price80.05
Price Trends
50DMA
72.95
Positive
100DMA
71.18
Positive
200DMA
69.97
Positive
Market Momentum
MACD
2.29
Negative
RSI
66.94
Neutral
STOCH
71.00
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AZN, the sentiment is Positive. The current price of 80.05 is above the 20-day moving average (MA) of 76.81, above the 50-day MA of 72.95, and above the 200-day MA of 69.97, indicating a bullish trend. The MACD of 2.29 indicates Negative momentum. The RSI at 66.94 is Neutral, neither overbought nor oversold. The STOCH value of 71.00 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AZN.

AstraZeneca Risk Analysis

AstraZeneca disclosed 19 risk factors in its most recent earnings report. AstraZeneca reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

AstraZeneca Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
82
Outperform
$142.93B13.7612.16%6.86%14.72%
81
Outperform
$213.09B13.4735.44%3.77%2.00%20.01%
79
Outperform
$249.96B30.1619.76%1.96%15.08%29.15%
78
Outperform
$241.52B18.2732.82%3.15%12.38%-12.67%
78
Outperform
$80.32B18.5023.04%4.13%3.46%-13.29%
76
Outperform
$122.44B12.778.39%4.40%-9.32%120.62%
51
Neutral
$7.81B-0.15-40.08%2.29%21.29%-1.80%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AZN
AstraZeneca
80.05
-5.37
-6.29%
GSK
GlaxoSmithKline
39.83
-2.42
-5.73%
MRK
Merck & Company
84.99
-27.71
-24.59%
NVS
Novartis
126.64
10.33
8.88%
PFE
Pfizer
24.92
-2.01
-7.46%
SNY
Sanofi
50.30
-4.28
-7.84%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 19, 2025