Revenue and Product Revenue Growth
Total revenue increased 8% in 2025, with product revenue (product sales + alliance revenue) up 10%, driven by global demand for innovative medicines.
Earnings and Profitability Gains
Core EPS grew 11% in 2025; operating profit increased 9%. Core gross margin was 82% for the year, broadly in line with expectation.
Strong Cash Flow and Capital Allocation
Operating cash flow rose 23% to $14.6 billion in 2025. CapEx increased to $3.3 billion (up $1.1 billion year-on-year) with planned ~33% further CapEx increase in 2026 to expand capacity; net debt-to-EBITDA at 1.2x and management comfortable with leverage.
Dividend Increase
Declared full-year 2025 dividend of $3.20 per share and intention to increase the annual declared dividend to $3.30 per share in 2026, reflecting confidence in cash generation and capital allocation.
Oncology Commercial Momentum
Oncology revenues of $25.6 billion in 2025, up 14% (17% excluding a 2024 Lynparza sales milestone). Key brands: Tagrisso >$7 billion, Imfinzi >$6 billion, Calquence >$3.5 billion, Enhertu >$2.5 billion (Enhertu Q4 growth +46%); Q4 oncology sales exceeded $7 billion (up ~20% y/y excl milestone).
Pipeline Productivity and Late-stage Readiness
16 positive Phase III trial readouts in 2025 with a combined peak-year sales potential of ~$10 billion. Over 100 Phase III trials ongoing and >300 active trials overall; management expects ~20 Phase III readouts in 2026 and risk-adjusted peak-year revenue opportunities in excess of $10 billion for 2026 (and similar for 2027).
Regulatory and Launch Success
43 approvals in the last 12 months across major regions; strong launches and rapid NRDL/Hospital listing traction in China for products such as Enhertu, Fasenra, Truqap and Calquence tablets.
BioPharma and Rare Disease Growth
BioPharmaceuticals grew 5% to $23.0 billion in 2025 with R&I up 10% in Q4 and growth medicines up 27%; Rare Disease delivered $9.1 billion (+4%) with Ultomiris up 15% in the quarter and Strensiq +15%.