Total Revenue and Profit Growth
Total revenue grew 8% in Q1 2026; core operating profit increased 12%, and core EPS rose 5% to $2.58 (growth tempered by a low prior-period tax rate).
Strong Oncology Performance
Oncology revenues grew 16% to $6.8 billion with notable brand performances: Tagrisso +5% to $1.8 billion, Imfinzi +30% (Imfinzi & Imjudo combined +28%), Calquence +17% to >$900 million, and Enhertu +34% (annualizing as a ~$5 billion brand on an alliance view).
Biopharmaceutical Growth Areas
Respiratory & Immunology up 7% to $2.3 billion. Key brands: Fasenra +11% to $483 million (emerging markets +63% in China uptake), Breztri +13% to $353 million (first asthma label expansion), Tezspire +34% to $303 million, and Saphnelo +24% to $171 million.
Rare Disease Momentum and New Assets
Rare Disease revenue rose 15% to $2.4 billion. Ultomiris grew 18% and Strensiq grew 43%. Efzimfotase alfa reported positive Phase III data and is positioned for broad adoption with an estimated peak-year sales opportunity of $3–$5 billion.
Pipeline and R&D Delivery
Four positive high-value Phase III program readouts announced in early 2026 (including tozorakimab and efzimfotase alfa). Number of active clinical trials +10% and patient enrollment +30% year-on-year; ongoing investment in transformative technologies (cell therapies, T-cell engagers).
High Core Gross Margin and Operating Leverage
Core gross margin of 83% in Q1 with expectation of stable to slightly higher margin for the full year; operating leverage contributed to stronger operating profit growth.
Solid Cash Generation and Capital Allocation
Operating cash flow was $3.4 billion in the quarter (slight decline versus prior year due to one-time milestone in Q1 2025), CapEx $600 million supporting multiyear manufacturing investments, and the company reiterated mid- to high-single-digit revenue growth and low-double-digit core EPS growth guidance at CER for the full year.
Tozorakimab: Potential First-in-Class COPD Biologic
Tozorakimab achieved statistically significant, clinically meaningful reductions in annualized moderate-to-severe exacerbations across pivotal trials (OBERON, TITANIA, MIRANDA) with favorable tolerability; potential addressable COPD biologic population highlighted and regulatory submissions planned.