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United Therapeutics (UTHR)
NASDAQ:UTHR
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United Therapeutics (UTHR) AI Stock Analysis

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UTHR

United Therapeutics

(NASDAQ:UTHR)

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Outperform 79 (OpenAI - 4o)
Rating:79Outperform
Price Target:
$520.00
▲(15.84% Upside)
United Therapeutics' strong financial performance and positive earnings call are the most significant factors contributing to the score. The company's robust revenue growth, profitability, and strategic initiatives provide a solid foundation for future growth. Technical analysis supports a bullish trend, although valuation metrics suggest the stock is fairly valued. The absence of a dividend yield indicates a focus on reinvestment for growth. Potential risks include market competition and regulatory uncertainties.
Positive Factors
Revenue Growth
Consistent revenue growth indicates strong market demand for United Therapeutics' products, supporting long-term financial stability and expansion.
Pipeline Advancements
Successful clinical trials enhance the company's product portfolio, potentially leading to new revenue streams and strengthening its competitive position.
Strategic Collaborations
Strategic partnerships can expand market reach and leverage combined expertise, driving growth and innovation in product offerings.
Negative Factors
Regulatory Uncertainties
Regulatory uncertainties can delay product launches and affect market entry timing, impacting revenue projections and strategic planning.
Market Competition
Increased competition could pressure pricing and market share, challenging United Therapeutics' ability to maintain its growth trajectory.
Revenue Miss
Missing revenue expectations may indicate challenges in meeting market demand or operational inefficiencies, potentially affecting investor confidence.

United Therapeutics (UTHR) vs. SPDR S&P 500 ETF (SPY)

United Therapeutics Business Overview & Revenue Model

Company DescriptionUnited Therapeutics Corporation is a biotechnology company focused on the development and commercialization of unique products to address the unmet needs of patients with chronic and life-threatening conditions. The company operates primarily in the pulmonary and vascular disease sectors, offering therapies for conditions such as pulmonary arterial hypertension (PAH) and organ transplantation. Its core products include Remodulin, Tyvaso, and Orenitram, which are designed to improve the quality of life for patients suffering from these serious health issues.
How the Company Makes MoneyUnited Therapeutics generates revenue primarily through the sale of its pharmaceutical products, which treat chronic and life-threatening diseases. The company’s key revenue streams come from the commercial sales of its approved therapies, including Remodulin, Tyvaso, and Orenitram, which are prescribed to patients with pulmonary arterial hypertension. In addition to direct product sales, United Therapeutics may also earn revenue from partnerships with other biotechnology and pharmaceutical companies, including co-development agreements and licensing deals. The company invests heavily in research and development to innovate new therapies and expand its product offerings, which can enhance its market position and revenue potential. Moreover, the increasing prevalence of PAH and other related conditions contributes to a growing demand for its treatments, further supporting its earnings.

United Therapeutics Key Performance Indicators (KPIs)

Any
Any
Revenue by Geography
Revenue by Geography
Breaks down revenue across different regions, revealing where the company is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Chart InsightsUnited Therapeutics' U.S. revenue continues its robust growth trajectory, with a notable surge in recent quarters, driven by the success of Tyvaso DPI. The international segment, however, remains relatively stagnant, highlighting potential growth opportunities abroad. The latest earnings call underscores strong overall financial health, with record revenue and a strategic share buyback, yet it also flags competitive pressures from Liquidia's new product. Investors should watch for upcoming TETON 2 study results, which could significantly impact future revenue streams.
Data provided by:Main Street Data

United Therapeutics Earnings Call Summary

Earnings Call Date:Oct 29, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 25, 2026
Earnings Call Sentiment Positive
The earnings call reflected strong financial performance, successful clinical trials, and strategic growth initiatives, indicating a positive outlook. However, there are some uncertainties related to market competition and regulatory processes.
Q3-2025 Updates
Positive Updates
Record-Breaking Revenue
The company reported record total revenues of $800 million, representing 7% growth from the third quarter of 2024.
Successful Clinical Trials
United Therapeutics fully enrolled three Phase III trials and reported the best-ever results for pulmonary fibrosis, indicating potential to help tens of thousands of IPF patients.
Tyvaso DPI Growth
Continued double-digit revenue growth for Tyvaso DPI, with no material impact from the launch of competitor YUTREPIA. Launching new 80-microgram cartridges to provide added convenience for patients.
Strategic Collaborations and Future Growth
Potential partnerships with companies like Merck, J&J, and Novartis due to strong IPF data. Guidance for a $4 billion revenue run rate by 2027.
Innovation and Expansion
Launch of RemunityPRO pump and significant progress in ralinepag trials, with a 2040 patent life and potential for combination treatments.
Negative Updates
Uncertain Market Dynamics
Potential competition impacts are still being monitored, with some trialing of competitor products. Future market dynamics remain uncertain.
Regulatory and Timing Uncertainties
Pending results from TETON 1 in 2026 and ongoing discussions with the FDA may affect the timing of regulatory reviews and approvals.
Company Guidance
During the United Therapeutics Corporation's third-quarter 2025 corporate update, significant guidance was provided, highlighting a projected $4 billion revenue run rate by 2027, driven by substantial advancements in their pipeline and product portfolio. The company reported record total revenues of $800 million for the quarter, representing a 7% growth compared to the same period in 2024, fueled by strong sales of Tyvaso and Orenitram. They achieved full enrollment in three Phase III trials and revealed unprecedented results for pulmonary fibrosis. The company also announced plans to launch new Tyvaso DPI cartridges with higher doses, enhancing convenience for patients. The potential for partnerships with major pharmaceutical companies for international expansion was discussed, alongside the strategic positioning of ralinepag, set to leverage its long patent life and synergistic potential.

United Therapeutics Financial Statement Overview

Summary
United Therapeutics exhibits a strong financial position with impressive growth and profitability metrics. The income statement reflects robust revenue and profit margins, while the balance sheet is characterized by low leverage and high equity ratios, indicating financial stability. Cash flow generation is strong, supporting operational and strategic initiatives. The overall financial health is solid, with potential for sustained growth.
Income Statement
85
Very Positive
United Therapeutics has demonstrated strong financial performance with a consistent increase in total revenue over multiple years. The TTM revenue growth rate is approximately 4.06%, and the gross profit margin stands at a robust 89.00%. Net profit margin is currently 40.43%, indicating efficient cost management and profitability. EBIT and EBITDA margins are also strong, at 46.87% and 52.21% respectively, reflecting solid operational efficiency.
Balance Sheet
80
Positive
The balance sheet is marked by a strong equity position with an equity ratio of 87.89%, indicating a low reliance on debt. The debt-to-equity ratio is low at 0.03, showcasing financial stability. Return on equity is a healthy 17.79%, reflecting effective use of equity capital in generating profits. However, the relatively low total liabilities suggest limited financial leverage.
Cash Flow
78
Positive
The company has demonstrated positive cash flow metrics with a free cash flow growth rate of 4.45%. The operating cash flow to net income ratio is 1.17, indicating strong cash generation relative to net income. The free cash flow to net income ratio is 0.93, showing efficient translation of earnings into free cash flow. The cash flow is stable and supports the company's operational needs.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue3.13B2.88B2.33B1.94B1.69B1.48B
Gross Profit2.77B2.57B2.07B1.79B1.56B1.38B
EBITDA1.71B1.65B1.39B1.04B736.80M646.30M
Net Income1.27B1.20B984.80M727.30M475.80M514.80M
Balance Sheet
Total Assets7.35B7.36B7.17B6.04B5.17B4.62B
Cash, Cash Equivalents and Short-Term Investments2.77B3.27B2.99B2.84B1.93B1.83B
Total Debt0.00300.00M700.00M800.00M800.00M800.00M
Total Liabilities760.90M920.00M1.18B1.25B1.21B1.22B
Stockholders Equity6.59B6.44B5.98B4.80B3.96B3.40B
Cash Flow
Free Cash Flow1.12B1.08B747.60M663.70M477.40M696.40M
Operating Cash Flow1.56B1.33B978.00M802.50M598.20M755.70M
Investing Cash Flow-446.90M417.20M-719.60M-811.50M-486.90M-738.50M
Financing Cash Flow-1.32B-1.25B-11.90M75.40M44.80M-16.90M

United Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price448.91
Price Trends
50DMA
423.96
Positive
100DMA
361.14
Positive
200DMA
339.07
Positive
Market Momentum
MACD
7.72
Negative
RSI
58.56
Neutral
STOCH
58.28
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For UTHR, the sentiment is Positive. The current price of 448.91 is above the 20-day moving average (MA) of 435.53, above the 50-day MA of 423.96, and above the 200-day MA of 339.07, indicating a bullish trend. The MACD of 7.72 indicates Negative momentum. The RSI at 58.56 is Neutral, neither overbought nor oversold. The STOCH value of 58.28 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for UTHR.

United Therapeutics Risk Analysis

United Therapeutics disclosed 32 risk factors in its most recent earnings report. United Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

United Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
81
Outperform
$20.65B17.7830.39%18.09%3563.21%
79
Outperform
$19.27B17.2120.04%13.50%17.16%
76
Outperform
$10.94B17.1830.56%9.93%54.33%
74
Outperform
$17.80B14.1926.08%23.25%64.46%
73
Outperform
$9.96B19.289.07%12.31%60.21%
61
Neutral
$12.07B55.77%46.81%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
UTHR
United Therapeutics
448.91
48.47
12.10%
BMRN
BioMarin Pharmaceutical
51.46
-14.91
-22.46%
EXEL
Exelixis
40.81
4.62
12.77%
INCY
Incyte
105.98
24.45
29.99%
ASND
Ascendis Pharma
197.74
69.34
54.00%
GMAB
Genmab
28.66
5.46
23.53%

United Therapeutics Corporate Events

United Therapeutics Reports Record Q3 2025 Results
Oct 30, 2025

United Therapeutics Corporation is a biotechnology company that focuses on the development of pharmaceutical therapies and technologies to address unmet medical needs, particularly in the area of pulmonary diseases and organ transplantation. As a public benefit corporation, it aims to provide innovative solutions while fulfilling its public benefit purpose.

United Therapeutics Corp’s Earnings Call Highlights Growth and Innovation
Oct 30, 2025

United Therapeutics Corp’s recent earnings call painted a picture of robust financial health and strategic growth, with positive sentiments echoing throughout the discussion. The company showcased strong financial performance, successful clinical trials, and strategic growth initiatives, although some uncertainties linger regarding market competition and regulatory processes.

United Therapeutics’ Promising Study on Inhaled Treprostinil for Lung Disease
Oct 27, 2025

Study Overview: United Therapeutics Corp. is conducting a study titled ‘An Open-label Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease (TETON-OLE)’. The study aims to evaluate the long-term safety and tolerability of inhaled treprostinil in patients with idiopathic pulmonary fibrosis or progressive pulmonary fibrosis. This research is significant as it addresses the need for effective long-term treatments for these serious lung conditions.

United Therapeutics’ Promising Phase 3 Study on Inhaled Treprostinil for Pulmonary Fibrosis
Oct 27, 2025

Study Overview: United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF).’ The study aims to evaluate the safety and efficacy of inhaled treprostinil in patients with progressive pulmonary fibrosis over a 52-week period. This research is significant as it targets a serious lung condition with limited treatment options.

United Therapeutics’ AI-Driven Study: A Potential Game-Changer for Pulmonary Hypertension Diagnosis
Oct 27, 2025

The MOMENTOUS Study, officially titled ‘Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension,’ aims to evaluate the effectiveness of an ECG-based AI device in predicting the risk of undiagnosed pulmonary hypertension in patients with interstitial lung disease (ILD). This study is significant as it could enhance early diagnosis and treatment strategies for pulmonary hypertension, potentially improving patient outcomes.

United Therapeutics’ DeciPHer-ILD Study: A Closer Look at PH-ILD Patient Registry
Oct 27, 2025

United Therapeutics Corp. is currently recruiting for the DeciPHer-ILD study, a real-world patient registry focusing on Group 3 Pulmonary Hypertension associated with Interstitial Lung Disease (PH-ILD). The study aims to gather comprehensive data on patients with PH-ILD to better understand the condition and improve treatment strategies. This registry is significant as it could lead to enhanced patient outcomes and inform future therapeutic developments.

United Therapeutics’ Xenokidney Study: A New Hope for ESRD Patients
Oct 27, 2025

Study Overview: United Therapeutics Corp. is conducting a study titled EXPAND: A Prospective Study to Evaluate the Safety and Efficacy of the 10 GE Xenokidney in Patients With End-stage Renal Disease (ESRD). This study aims to assess the safety and efficacy of the 10 GE Xenokidney in patients with ESRD who are either ineligible for conventional kidney transplantation or are on a transplant waitlist with a high risk of not receiving a transplant within five years. The study’s significance lies in its potential to offer a new treatment option for patients with limited alternatives.

United Therapeutics’ PHINDER Study: A Step Forward in Early Detection of Pulmonary Hypertension
Oct 27, 2025

United Therapeutics Corp. is conducting a study titled ‘Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection (PHINDER).’ The study aims to evaluate screening strategies for pulmonary hypertension in patients with interstitial lung disease, which could lead to earlier detection and treatment of this serious condition.

United Therapeutics Advances Ralinepag Study for PAH Treatment
Oct 27, 2025

United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Phase 3 Open-label Extension (OLE) Study to Evaluate the Long-term Safety and Efficacy of Ralinepag in Subjects With World Health Organization (WHO) Group 1 Pulmonary Arterial Hypertension (PAH)’. The study aims to assess the long-term safety and efficacy of Ralinepag, a drug designed to treat PAH, a serious cardiovascular condition.

Business Operations and StrategyProduct-Related Announcements
United Therapeutics Announces Positive TETON-2 Study Results
Positive
Sep 2, 2025

On September 2, 2025, United Therapeutics announced positive results from the TETON-2 clinical study of Tyvaso® for idiopathic pulmonary fibrosis (IPF). The study met its primary endpoint, showing significant improvement in forced vital capacity compared to placebo, and demonstrated benefits across various subgroups. These results could potentially reshape IPF treatment and offer new hope for patients, as the company plans to use this data to support a supplemental New Drug Application to the FDA.

The most recent analyst rating on (UTHR) stock is a Buy with a $347.00 price target. To see the full list of analyst forecasts on United Therapeutics stock, see the UTHR Stock Forecast page.

United Therapeutics’ Phase 3 Study on Inhaled Treprostinil: A Potential Game-Changer for Pulmonary Fibrosis
Aug 14, 2025

United Therapeutics Corp. is conducting a Phase 3 study titled A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF). The study aims to evaluate the safety and efficacy of inhaled treprostinil in treating progressive pulmonary fibrosis (PPF) over a 52-week period, which is significant for advancing treatment options for this condition.

United Therapeutics’ Promising Phase 3 Study on Inhaled Treprostinil for Pulmonary Fibrosis
Aug 12, 2025

United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF).’ The study aims to evaluate the safety and efficacy of inhaled treprostinil in patients with progressive pulmonary fibrosis over a 52-week period, highlighting its potential significance in treating this condition.

United Therapeutics’ Phase 3 Study on Inhaled Treprostinil for Pulmonary Fibrosis: A Potential Game-Changer
Aug 8, 2025

United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)’. The study aims to evaluate the safety and efficacy of inhaled treprostinil in patients with progressive pulmonary fibrosis over a 52-week period, which is significant for advancing treatment options for this condition.

United Therapeutics’ Inhaled Treprostinil Study: A Potential Game-Changer for IPF Treatment
Aug 7, 2025

Study Overview: United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis (TETON-2).’ The study aims to evaluate the efficacy and safety of inhaled treprostinil in improving lung function, specifically measuring the change in forced vital capacity (FVC) over 52 weeks, compared to a placebo. This research is significant as it targets idiopathic pulmonary fibrosis (IPF), a progressive lung disease with limited treatment options.

Business Operations and StrategyStock Buyback
United Therapeutics Launches $1 Billion Share Buyback
Positive
Aug 1, 2025

On August 1, 2025, United Therapeutics Corporation announced the initiation of a $1 billion accelerated share repurchase program, reflecting confidence in its stock value and future growth prospects. The company entered into agreements with Citibank to repurchase shares, with settlements expected in late 2025 and early 2026, highlighting a strategic move to balance investment in growth with returning capital to shareholders.

The most recent analyst rating on (UTHR) stock is a Hold with a $319.00 price target. To see the full list of analyst forecasts on United Therapeutics stock, see the UTHR Stock Forecast page.

United Therapeutics’ Inhaled Treprostinil Study: A Potential Game-Changer for IPF Treatment
Aug 1, 2025

United Therapeutics Corp. is conducting a Phase 3 clinical study titled A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis. The study aims to evaluate the effectiveness of inhaled treprostinil compared to a placebo in improving lung function, as measured by forced vital capacity (FVC), over a 52-week period in patients with idiopathic pulmonary fibrosis (IPF).

United Therapeutics Advances in Pulmonary Fibrosis Treatment with Phase 3 Study
Aug 1, 2025

United Therapeutics Corp. is conducting a Phase 3 clinical study titled A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF). The study aims to evaluate the safety and efficacy of inhaled treprostinil in patients with progressive pulmonary fibrosis over a 52-week period. This research is significant as it seeks to provide a new treatment option for a challenging condition.

United Therapeutics’ PAH Study Update: Implications for Investors
Aug 1, 2025

The DelIVery for Pulmonary Arterial Hypertension (PAH) Clinical Study aims to evaluate the safety of the Medtronic Model 10642 Implantable Intravascular Catheter, used with the SynchroMed® II Implantable Infusion System to deliver Remodulin® (treprostinil) Injection. This study is significant as it seeks to improve patient convenience and reduce complications associated with external delivery systems for PAH, a severe chronic condition.

United Therapeutics Reports Record Revenue and Growth
Aug 1, 2025

United Therapeutics Corp.’s recent earnings call painted a picture of strong performance and growth, tempered by some concerns. The company reported record revenue growth and significant advancements in its pipeline, reflecting a generally positive sentiment. However, there were some apprehensions regarding the TPIP Phase IIb PAH data and the potential market competition. The authorization of a substantial share buyback demonstrates confidence in the company’s future prospects.

United Therapeutics Reports Record Q2 2025 Financial Results
Jul 31, 2025

United Therapeutics Corporation, a public benefit biotech company, specializes in developing pharmaceutical therapies and technologies to expand transplantable organ availability, with a focus on treating pulmonary diseases.

United Therapeutics’ Promising Phase 3 Study on Inhaled Treprostinil for Pulmonary Fibrosis
Jul 30, 2025

Study Overview: United Therapeutics Corp. is conducting a Phase 3 study titled A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF). The study aims to evaluate the safety and efficacy of inhaled treprostinil in treating progressive pulmonary fibrosis (PPF) over a 52-week period, which is significant for advancing treatment options for this condition.

United Therapeutics’ Phase 3 Study on Inhaled Treprostinil: A Potential Game-Changer for IPF Treatment
Jul 30, 2025

United Therapeutics Corp. is conducting a Phase 3 study titled ‘A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis.’ The study aims to assess the efficacy and safety of inhaled treprostinil compared to a placebo in improving lung function, specifically the forced vital capacity (FVC), in patients with idiopathic pulmonary fibrosis (IPF) over a 52-week period. This research is significant as it explores a potential treatment for a condition with limited therapeutic options.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 30, 2025