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United Therapeutics (UTHR)
NASDAQ:UTHR

United Therapeutics (UTHR) AI Stock Analysis

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UTHR

United Therapeutics

(NASDAQ:UTHR)

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Outperform 83 (OpenAI - 5.2)
Rating:83Outperform
Price Target:
$563.00
▲(18.34% Upside)
The score is driven primarily by exceptionally strong financial performance (elite margins, large free cash flow, and a debt-free balance sheet). Earnings call commentary adds support via constructive long-term guidance and pipeline progress, while the technical picture is mixed with near-term softness versus the 20-day average. Valuation appears reasonable at a ~18.6 P/E, with no dividend data available to enhance the valuation component.
Positive Factors
Revenue Growth
Consistent revenue growth indicates strong market demand for United Therapeutics' products, supporting long-term financial stability and expansion.
Pipeline Advancements
Successful clinical trials enhance the company's product portfolio, potentially leading to new revenue streams and strengthening its competitive position.
Strategic Collaborations
Strategic partnerships can expand market reach and leverage combined expertise, driving growth and innovation in product offerings.
Negative Factors
Regulatory Uncertainties
Regulatory uncertainties can delay product launches and affect market entry timing, impacting revenue projections and strategic planning.
Market Competition
Increased competition could pressure pricing and market share, challenging United Therapeutics' ability to maintain its growth trajectory.
Revenue Miss
Missing revenue expectations may indicate challenges in meeting market demand or operational inefficiencies, potentially affecting investor confidence.

United Therapeutics (UTHR) vs. SPDR S&P 500 ETF (SPY)

United Therapeutics Business Overview & Revenue Model

Company DescriptionUnited Therapeutics Corporation, a biotechnology company, engages in the development and commercialization of products to address the unmet medical needs of patients with chronic and life-threatening diseases in the United States and internationally. Its commercial therapies include Remodulin to treat patients with pulmonary arterial hypertension (PAH) to diminish symptoms associated with exercise; Tyvaso, an inhaled formulation of prostacyclin analogue treprostinil to enhance the exercise ability in PAH patients and pulmonary hypertension associated with interstitial lung disease (PH-ILD); Orenitram, a tablet dosage form of treprostinil to enhance the exercise capacity in PAH patients; Unituxin, a monoclonal antibody for treating high-risk neuroblastoma; and Adcirca, an oral PDE-5 inhibitor to enhance the exercise ability in PAH patients. The company also engages in developing Tyvaso DPI, a dry powder inhalation form of Tyvaso; Remunity Pump, a small, lightweight, durable pump and separate controller; RemoPro and Ralinepag for the treatment of PAH; Aurora-GT, a gene therapy product to rebuild the blood vessels in the lungs; and Tyvaso PERFECT and TETON studies, which are the studies of Tyvaso in patients with World Health Organization (WHO) Group 3 pulmonary hypertension associated with chronic obstructive pulmonary disease (PH-COPD). It has licensing and collaboration agreements with DEKA Research & Development Corp. to develop a semi-disposable system for the subcutaneous delivery of treprostinil; MannKind Corporation to develop and license treprostinil inhalation powder and the Dreamboat device; and Arena Pharmaceuticals, Inc. to develop Ralinepag. The company was incorporated in 1996 and is headquartered in Silver Spring, Maryland.
How the Company Makes MoneyUnited Therapeutics generates revenue primarily through the sale of its pharmaceutical products, specifically those used in the treatment of pulmonary arterial hypertension (PAH). The company's key revenue streams include sales of its flagship products like Remodulin, Tyvaso, and Orenitram, which are sold to healthcare providers and pharmacies. Additionally, United Therapeutics engages in strategic partnerships and collaborations with other companies and organizations to enhance its research capabilities and expand its product pipeline, which can lead to additional revenue opportunities. The company also benefits from government reimbursements and pricing agreements that further contribute to its earnings. Overall, the combination of product sales, partnerships, and a focus on innovative therapies forms the basis of United Therapeutics' revenue model.

United Therapeutics Key Performance Indicators (KPIs)

Any
Any
Revenue by Geography
Revenue by Geography
Breaks down revenue across different regions, revealing where the company is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Chart InsightsUnited Therapeutics' U.S. revenue continues its robust growth trajectory, with a notable surge in recent quarters, driven by the success of Tyvaso DPI. The international segment, however, remains relatively stagnant, highlighting potential growth opportunities abroad. The latest earnings call underscores strong overall financial health, with record revenue and a strategic share buyback, yet it also flags competitive pressures from Liquidia's new product. Investors should watch for upcoming TETON 2 study results, which could significantly impact future revenue streams.
Data provided by:The Fly

United Therapeutics Earnings Call Summary

Earnings Call Date:Oct 29, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 25, 2026
Earnings Call Sentiment Positive
The earnings call reflected strong financial performance, successful clinical trials, and strategic growth initiatives, indicating a positive outlook. However, there are some uncertainties related to market competition and regulatory processes.
Q3-2025 Updates
Positive Updates
Record-Breaking Revenue
The company reported record total revenues of $800 million, representing 7% growth from the third quarter of 2024.
Successful Clinical Trials
United Therapeutics fully enrolled three Phase III trials and reported the best-ever results for pulmonary fibrosis, indicating potential to help tens of thousands of IPF patients.
Tyvaso DPI Growth
Continued double-digit revenue growth for Tyvaso DPI, with no material impact from the launch of competitor YUTREPIA. Launching new 80-microgram cartridges to provide added convenience for patients.
Strategic Collaborations and Future Growth
Potential partnerships with companies like Merck, J&J, and Novartis due to strong IPF data. Guidance for a $4 billion revenue run rate by 2027.
Innovation and Expansion
Launch of RemunityPRO pump and significant progress in ralinepag trials, with a 2040 patent life and potential for combination treatments.
Negative Updates
Uncertain Market Dynamics
Potential competition impacts are still being monitored, with some trialing of competitor products. Future market dynamics remain uncertain.
Regulatory and Timing Uncertainties
Pending results from TETON 1 in 2026 and ongoing discussions with the FDA may affect the timing of regulatory reviews and approvals.
Company Guidance
During the United Therapeutics Corporation's third-quarter 2025 corporate update, significant guidance was provided, highlighting a projected $4 billion revenue run rate by 2027, driven by substantial advancements in their pipeline and product portfolio. The company reported record total revenues of $800 million for the quarter, representing a 7% growth compared to the same period in 2024, fueled by strong sales of Tyvaso and Orenitram. They achieved full enrollment in three Phase III trials and revealed unprecedented results for pulmonary fibrosis. The company also announced plans to launch new Tyvaso DPI cartridges with higher doses, enhancing convenience for patients. The potential for partnerships with major pharmaceutical companies for international expansion was discussed, alongside the strategic positioning of ralinepag, set to leverage its long patent life and synergistic potential.

United Therapeutics Financial Statement Overview

Summary
United Therapeutics exhibits a strong financial position with impressive growth and profitability metrics. The income statement reflects robust revenue and profit margins, while the balance sheet is characterized by low leverage and high equity ratios, indicating financial stability. Cash flow generation is strong, supporting operational and strategic initiatives. The overall financial health is solid, with potential for sustained growth.
Income Statement
92
Very Positive
United Therapeutics has demonstrated strong financial performance with a consistent increase in total revenue over multiple years. The TTM revenue growth rate is approximately 4.06%, and the gross profit margin stands at a robust 89.00%. Net profit margin is currently 40.43%, indicating efficient cost management and profitability. EBIT and EBITDA margins are also strong, at 46.87% and 52.21% respectively, reflecting solid operational efficiency.
Balance Sheet
95
Very Positive
The balance sheet is marked by a strong equity position with an equity ratio of 87.89%, indicating a low reliance on debt. The debt-to-equity ratio is low at 0.03, showcasing financial stability. Return on equity is a healthy 17.79%, reflecting effective use of equity capital in generating profits. However, the relatively low total liabilities suggest limited financial leverage.
Cash Flow
90
Very Positive
The company has demonstrated positive cash flow metrics with a free cash flow growth rate of 4.45%. The operating cash flow to net income ratio is 1.17, indicating strong cash generation relative to net income. The free cash flow to net income ratio is 0.93, showing efficient translation of earnings into free cash flow. The cash flow is stable and supports the company's operational needs.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue3.13B2.88B2.33B1.94B1.69B1.48B
Gross Profit2.77B2.57B2.07B1.79B1.56B1.38B
EBITDA1.71B1.65B1.39B1.04B736.80M646.30M
Net Income1.27B1.20B984.80M727.30M475.80M514.80M
Balance Sheet
Total Assets7.35B7.36B7.17B6.04B5.17B4.62B
Cash, Cash Equivalents and Short-Term Investments2.77B3.27B2.99B2.84B1.93B1.83B
Total Debt0.00300.00M700.00M800.00M800.00M800.00M
Total Liabilities760.90M920.00M1.18B1.25B1.21B1.22B
Stockholders Equity6.59B6.44B5.98B4.80B3.96B3.40B
Cash Flow
Free Cash Flow1.12B1.08B747.60M663.70M477.40M696.40M
Operating Cash Flow1.56B1.33B978.00M802.50M598.20M755.70M
Investing Cash Flow-446.90M417.20M-719.60M-811.50M-486.90M-738.50M
Financing Cash Flow-1.32B-1.25B-11.90M75.40M44.80M-16.90M

United Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price475.73
Price Trends
50DMA
482.86
Negative
100DMA
446.54
Positive
200DMA
372.84
Positive
Market Momentum
MACD
-1.01
Positive
RSI
40.83
Neutral
STOCH
13.22
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For UTHR, the sentiment is Neutral. The current price of 475.73 is below the 20-day moving average (MA) of 498.46, below the 50-day MA of 482.86, and above the 200-day MA of 372.84, indicating a neutral trend. The MACD of -1.01 indicates Positive momentum. The RSI at 40.83 is Neutral, neither overbought nor oversold. The STOCH value of 13.22 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for UTHR.

United Therapeutics Risk Analysis

United Therapeutics disclosed 32 risk factors in its most recent earnings report. United Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

United Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
83
Outperform
$20.48B18.0320.04%13.50%17.16%
81
Outperform
$20.80B17.7730.39%18.09%3563.21%
78
Outperform
$12.13B19.0430.56%9.93%54.33%
76
Outperform
$10.77B21.019.07%12.31%60.21%
76
Outperform
$21.59B14.8928.20%24.98%127.06%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$13.28B-51.17103.32%47.55%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
UTHR
United Therapeutics
475.73
109.34
29.84%
BMRN
BioMarin Pharmaceutical
56.08
-5.17
-8.44%
EXEL
Exelixis
45.23
8.68
23.75%
INCY
Incyte
105.95
33.48
46.20%
ASND
Ascendis Pharma
217.32
85.70
65.11%
GMAB
Genmab
35.34
14.12
66.54%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 13, 2026