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Protagonist Therapeutics (PTGX)
NASDAQ:PTGX
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Protagonist Therapeutics (PTGX) AI Stock Analysis

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PTGX

Protagonist Therapeutics

(NASDAQ:PTGX)

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Neutral 60 (OpenAI - 4o)
Rating:60Neutral
Price Target:
$54.00
▼(-17.10% Downside)
Protagonist Therapeutics' overall score is driven by a mix of financial performance and technical analysis. The positive trend in stock price is offset by financial instability, high valuation metrics, and the absence of consistent revenue growth.
Positive Factors
Regulatory Approval
The Breakthrough Therapy Designation for rusfertide can expedite its development and review, potentially leading to faster market entry and extended exclusivity, which could significantly enhance Protagonist Therapeutics' competitive position and revenue potential in the treatment of polycythemia vera.
Pipeline Strength
A strong and promising drug pipeline, as highlighted by recent advancements, indicates Protagonist Therapeutics' potential for future growth and market leadership in its therapeutic areas, enhancing long-term business prospects.
Management Stability
The re-election of directors and approval of executive compensation reflect shareholder confidence in the current management team, providing stability and continuity in strategic direction, which is crucial for long-term success in the biotechnology sector.
Negative Factors
Revenue Instability
The lack of consistent revenue growth and recent decline to zero highlight potential instability in Protagonist Therapeutics' business operations, which could challenge its ability to sustain long-term financial health and fund ongoing R&D activities.
Cash Flow Volatility
Volatile free cash flow growth indicates potential cash management challenges, which could impact Protagonist Therapeutics' ability to finance its operations and strategic initiatives, posing a risk to its long-term financial stability.
Financial Instability
A history of financial instability and high liabilities suggests potential risks in Protagonist Therapeutics' financial management, which could affect its ability to secure funding and invest in future growth opportunities, impacting long-term viability.

Protagonist Therapeutics (PTGX) vs. SPDR S&P 500 ETF (SPY)

Protagonist Therapeutics Business Overview & Revenue Model

Company DescriptionProtagonist Therapeutics (PTGX) is a clinical-stage biopharmaceutical company focused on developing and commercializing novel peptide-based therapeutics for the treatment of various diseases, particularly hematologic malignancies and autoimmune disorders. The company leverages its proprietary technology platform to design and optimize peptide drugs that aim to address unmet medical needs in these therapeutic areas.
How the Company Makes MoneyProtagonist Therapeutics generates revenue primarily through partnerships and collaborations with larger pharmaceutical companies, which may include upfront payments, milestone payments tied to the achievement of development or regulatory milestones, and royalties on future sales of products developed through these collaborations. Additionally, the company may receive funding from government grants and research institutions to support its clinical trials and drug development programs. As the company advances its drug candidates through clinical trials and toward commercialization, it may also seek to enter into licensing agreements that provide additional revenue streams.

Protagonist Therapeutics Financial Statement Overview

Summary
Protagonist Therapeutics shows a mixed financial picture with improved profitability and cash flow management. However, the lack of consistent revenue growth and past financial instability are concerns. The company has a strong equity position but needs to stabilize revenue streams.
Income Statement
35
Negative
Protagonist Therapeutics has experienced significant fluctuations in its revenue, with a notable decline to zero in the most recent year, indicating potential instability in its business operations. The net profit margin is currently positive due to a reversal in earnings, but the lack of consistent revenue growth is a concern. EBIT and EBITDA margins have improved significantly, suggesting better cost management.
Balance Sheet
60
Neutral
The company has a strong equity position with a positive stockholders' equity and a low debt-to-equity ratio, indicating financial stability. The equity ratio suggests a healthy proportion of assets funded by equity rather than debt. However, the industry-standard high liabilities in previous years suggest a history of financial risk.
Cash Flow
50
Neutral
Protagonist Therapeutics shows positive free cash flow and an improved operating cash flow, indicating better cash management. However, the volatility in free cash flow growth suggests potential cash flow instability. The operating cash flow to net income ratio is favorable, indicating effective conversion of earnings to cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue203.63M434.43M60.00M26.58M27.36M28.63M
Gross Profit203.03M431.47M60.00M25.55M24.58M28.63M
EBITDA25.40M252.84M-90.34M-131.37M-123.07M-63.66M
Net Income52.04M275.19M-78.95M-123.41M-122.63M-66.15M
Balance Sheet
Total Assets718.01M744.73M357.95M247.93M347.69M324.47M
Cash, Cash Equivalents and Short-Term Investments570.47M418.91M341.62M237.35M326.90M307.81M
Total Debt11.28M10.87M1.14M3.66M5.86M5.96M
Total Liabilities49.99M69.43M21.27M784.68M47.67M44.86M
Stockholders Equity668.02M675.29M336.68M-536.75M-409.36M-283.81M
Cash Flow
Free Cash Flow37.10M182.80M-70.84M-108.93M-108.97M-72.95M
Operating Cash Flow39.54M184.15M-70.24M-108.14M-107.86M-72.48M
Investing Cash Flow-257.03M-299.48M-39.26M91.47M-15.86M-90.97M
Financing Cash Flow30.45M25.85M170.48M18.84M129.92M247.63M

Protagonist Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price65.14
Price Trends
50DMA
57.65
Positive
100DMA
54.26
Positive
200DMA
48.31
Positive
Market Momentum
MACD
2.41
Negative
RSI
61.99
Neutral
STOCH
78.60
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PTGX, the sentiment is Positive. The current price of 65.14 is above the 20-day moving average (MA) of 61.06, above the 50-day MA of 57.65, and above the 200-day MA of 48.31, indicating a bullish trend. The MACD of 2.41 indicates Negative momentum. The RSI at 61.99 is Neutral, neither overbought nor oversold. The STOCH value of 78.60 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PTGX.

Protagonist Therapeutics Risk Analysis

Protagonist Therapeutics disclosed 53 risk factors in its most recent earnings report. Protagonist Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Protagonist Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
74
Outperform
$3.73B18.3852.45%43.58%491.01%
60
Neutral
$3.82B-12.56-11.39%
60
Neutral
$4.19B94.618.61%-34.45%-69.75%
58
Neutral
$3.66B-60.10-22.95%62.33%48.34%
54
Neutral
$3.57B-16.09-26.84%32.38%33.47%
43
Neutral
$3.45B-18.55-153.46%-56.78%-191.46%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PTGX
Protagonist Therapeutics
65.14
20.77
46.81%
ADMA
ADMA Biologics
14.70
-5.07
-25.64%
ZLAB
Zai Lab
32.93
8.07
32.46%
AKRO
Akero Therapeutics
47.62
18.79
65.18%
MIRM
Mirum Pharmaceuticals
72.85
32.73
81.58%
AAPG
Ascentage Pharma Group International Unsponsored ADR
38.55
21.30
123.48%

Protagonist Therapeutics Corporate Events

Executive/Board ChangesShareholder Meetings
Protagonist Therapeutics Stockholders Approve Key Proposals
Neutral
Jun 26, 2025

At the Annual Meeting, Protagonist Therapeutics‘ stockholders voted on three key proposals. The first proposal involved electing two Class III directors, Harold E. Selick, Ph.D., and Bryan Giraudo, to serve until the 2028 Annual Meeting, both of whom were elected. The second proposal, regarding the approval of executive compensation, was passed. The third proposal, ratifying Ernst & Young LLP as the company’s independent auditor for the fiscal year ending December 31, 2025, was also approved.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jun 05, 2025