tiprankstipranks
Trending News
More News >
Crispr Therapeutics AG (CRSP)
NASDAQ:CRSP
Advertisement

Crispr Therapeutics AG (CRSP) AI Stock Analysis

Compare
9,775 Followers

Top Page

CR

Crispr Therapeutics AG

(NASDAQ:CRSP)

Rating:64Neutral
Price Target:
$70.00
▲(7.15%Upside)
CRISPR Therapeutics AG's overall stock score is driven by positive technical momentum and strategic corporate developments, offset by financial challenges and valuation concerns. The company's strong technical indicators suggest bullish market sentiment, while its ongoing strategic partnerships and advancements in therapy development offer long-term growth potential. However, the financial performance highlights significant risks, particularly in revenue generation and profitability, which weigh down the overall score.
Positive Factors
Collaborations and acquisitions
The recently reported acquisition of Verve by Lilly offers validation to Crispr's approach in genetic editing.
Financial performance
Crispr is uniquely positioned to achieve its goals due to its lead industry position and robust balance sheet.
Technological advancements
CRISPR Therapeutics' diverse and robust pipeline, with key technologies passing through several derisking hoops, positions it well in the gene editing landscape.
Negative Factors
Data release delays
Delaying CTX320 Lp(a) data - a catalyst to diversify the story beyond Casgevy commercial launch - is a disappointment.
Strategic considerations
Strategic rationale for delaying CTX320 data is to better contextualize the results with the upcoming Novartis and Ionis Phase 3 HORIZON readout for pelacarsen.

Crispr Therapeutics AG (CRSP) vs. SPDR S&P 500 ETF (SPY)

Crispr Therapeutics AG Business Overview & Revenue Model

Company DescriptionCRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious diseases using its proprietary Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. The company's lead product candidate is CTX001, an ex vivo CRISPR gene-edited therapy for treating patients suffering from transfusion-dependent beta-thalassemia or severe sickle cell disease in which a patient's hematopoietic stem cells are engineered to produce high levels of fetal hemoglobin in red blood cells. It also develops CTX110, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting cluster of differentiation 19 positive malignancies; CTX120, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting B-cell maturation antigen for the treatment of relapsed or refractory multiple myeloma; and CTX130, a donor-derived gene-edited allogeneic CAR-T investigational therapy targeting Cluster of Differentiation 70 to treat various solid tumors and hematologic malignancies. In addition, the company develops VCTX210, a gene-edited immune-evasive stem cell-derived product candidate for the treatment of treatment of type 1 diabetes; and pursues various in vivo gene-editing programs that target the liver, lung, muscle, and central nervous system diseases. It has strategic partnerships with Bayer Healthcare LLC, Vertex Pharmaceuticals Incorporated, ViaCyte, Inc., Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.
How the Company Makes MoneyCrispr Therapeutics AG generates revenue primarily through collaborations and strategic partnerships with other pharmaceutical and biotechnology companies. These partnerships often involve upfront payments, milestone payments, and royalties on sales resulting from successful commercialization of jointly developed therapies. Additionally, Crispr Therapeutics may receive research grants and government funding to support its development of gene-editing therapies. The company also aims to commercialize its own drug candidates, which, upon regulatory approval, would provide another revenue stream in the form of product sales.

Crispr Therapeutics AG Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Analyzes income from different business areas, highlighting which segments drive growth and profitability, and where the company might be vulnerable or have opportunities for expansion.
Chart InsightsCrispr Therapeutics AG's revenue from collaborations has been highly volatile, with significant spikes in certain quarters, notably in late 2023 and early 2024, suggesting irregular but substantial partnership deals. Meanwhile, grant revenue has remained minimal and relatively stable, indicating limited reliance on this segment. The absence of earnings call commentary leaves the reasons for these fluctuations unclear, but the pattern suggests strategic partnerships are a key driver of revenue, albeit inconsistently. Investors should watch for announcements on new collaborations to gauge future revenue potential.
Data provided by:Main Street Data

Crispr Therapeutics AG Financial Statement Overview

Summary
Crispr Therapeutics AG faces significant financial challenges, particularly in revenue generation and profitability. Despite a strong balance sheet with substantial equity and cash reserves, the company struggles with negative income and cash flow metrics. These issues highlight the need for improved operational efficiency and revenue growth strategies to ensure financial sustainability.
Income Statement
45
Neutral
Crispr Therapeutics AG has shown significant volatility in revenue and profit margins. The most recent annual report indicates a drastic revenue decline compared to previous years, with a sharp drop from 2021 to 2024. Gross and net profit margins have turned negative, highlighting operational challenges and high expenses relative to revenue. The TTM data shows a negative EBIT and EBITDA margin, indicating operational inefficiencies and ongoing financial struggles.
Balance Sheet
65
Positive
The company maintains a strong equity position with a high equity ratio, suggesting stability in its capital structure. While the debt-to-equity ratio is relatively low, indicating manageable leverage, the stockholders' equity has slightly declined over the years. The balance sheet reflects a solid cash position, which is crucial for a biotech firm investing in R&D, despite the negative net income.
Cash Flow
50
Neutral
Crispr Therapeutics AG exhibits a negative free cash flow trend, with operating cash flows consistently negative over recent years. This indicates potential liquidity challenges. The free cash flow to net income ratio is also negative, underscoring ongoing cash management issues. The cash flow from financing has been positive, which may provide temporary relief but signifies reliance on external funding.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue35.00M371.21M436.00K913.08M543.00K
Gross Profit-75.25M240.96M-109.81M895.13M-268.86M
EBITDA-447.31M-202.70M-648.99M391.48M-345.25M
Net Income-366.25M-153.61M-650.17M377.66M-348.87M
Balance Sheet
Total Assets2.24B2.23B2.24B2.75B1.83B
Cash, Cash Equivalents and Short-Term Investments1.90B1.69B1.82B2.38B1.69B
Total Debt223.69M238.63M244.02M225.03M61.43M
Total Liabilities309.95M346.77M367.58M352.42M163.73M
Stockholders Equity1.93B1.88B1.88B2.40B1.66B
Cash Flow
Free Cash Flow-144.68M-272.35M-532.93M457.27M-256.72M
Operating Cash Flow-142.77M-260.38M-495.74M538.97M-238.37M
Investing Cash Flow-280.48M374.65M-258.65M-1.04B-541.17M
Financing Cash Flow331.98M62.66M38.59M250.94M1.02B

Crispr Therapeutics AG Technical Analysis

Technical Analysis Sentiment
Positive
Last Price65.33
Price Trends
50DMA
44.75
Positive
100DMA
41.87
Positive
200DMA
43.74
Positive
Market Momentum
MACD
4.81
Negative
RSI
75.73
Negative
STOCH
67.14
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CRSP, the sentiment is Positive. The current price of 65.33 is above the 20-day moving average (MA) of 53.34, above the 50-day MA of 44.75, and above the 200-day MA of 43.74, indicating a bullish trend. The MACD of 4.81 indicates Negative momentum. The RSI at 75.73 is Negative, neither overbought nor oversold. The STOCH value of 67.14 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CRSP.

Crispr Therapeutics AG Risk Analysis

Crispr Therapeutics AG disclosed 85 risk factors in its most recent earnings report. Crispr Therapeutics AG reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Crispr Therapeutics AG Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$2.02B13.4424.71%20.62%14.08%
64
Neutral
$5.62B-19.71%-86.13%-67.29%
60
Neutral
$1.25B-57.92%-13.37%2.57%
56
Neutral
$2.09B-38.04%-82.38%-164.76%
54
Neutral
$1.75B-70.58%100.03%64.22%
52
Neutral
$972.55M-34.26%271.44%26.65%
52
Neutral
$7.37B-0.04-63.81%2.59%16.40%<0.01%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CRSP
Crispr Therapeutics AG
65.33
8.14
14.23%
NTLA
Intellia Therapeutics
12.63
-13.83
-52.27%
ARQT
Arcutis Biotherapeutics
14.34
4.14
40.59%
BEAM
Beam Therapeutics
21.03
-9.29
-30.64%
HRMY
Harmony Biosciences Holdings
35.25
1.75
5.22%
VERV
Verve Therapeutics
10.93
3.23
41.95%

Crispr Therapeutics AG Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
CRISPR Therapeutics Updates on Cardiovascular Programs
Positive
Jun 26, 2025

On June 26, 2025, CRISPR Therapeutics AG announced updates on its in vivo cardiovascular disease programs, including new data for CTX310™, CTX320™, and CTX340™. CTX310™, targeting ANGPTL3, continues to show promising results in reducing triglycerides and low-density lipoprotein in its Phase 1 trial, with peak reductions of up to 82% and 86% respectively, without significant liver enzyme changes. CTX320™, targeting the LPA gene, is in an ongoing Phase 1 trial, with an update expected in the first half of 2026. Meanwhile, CTX340™, targeting angiotensinogen for refractory hypertension, is progressing through preclinical studies. These developments highlight CRISPR Therapeutics AG’s strategic advancements in addressing cardiovascular diseases, potentially impacting its market position and offering new treatment avenues for patients.

The most recent analyst rating on (CRSP) stock is a Hold with a $59.00 price target. To see the full list of analyst forecasts on Crispr Therapeutics AG stock, see the CRSP Stock Forecast page.

Shareholder MeetingsBusiness Operations and Strategy
CRISPR Therapeutics AG Shareholders Approve Key Proposals
Positive
Jun 9, 2025

On June 5, 2025, CRISPR Therapeutics AG held its Annual General Meeting where shareholders approved several key proposals, including amendments to the company’s Articles of Association, financial statements for 2024, and the re-election of board members and auditors. These decisions, effective upon registration, are expected to strengthen the company’s governance and operational framework, potentially enhancing its strategic positioning in the biotechnology sector.

The most recent analyst rating on (CRSP) stock is a Hold with a $59.00 price target. To see the full list of analyst forecasts on Crispr Therapeutics AG stock, see the CRSP Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and Strategy
Crispr Therapeutics AG Partners with Sirius on siRNA Tech
Positive
May 19, 2025

On May 19, 2025, CRISPR Therapeutics AG announced a collaboration agreement with Sirius Therapeutics to co-develop and commercialize siRNA technology targeting Factor XI, with an upfront consideration of $95 million. The agreement includes the development of SRSD107, a next-generation siRNA designed to inhibit coagulation factor XI, showing promising results in Phase 1 trials with potential applications in various thrombotic conditions. The collaboration aims to leverage SRSD107’s potential to reduce thrombotic events while minimizing bleeding risks, positioning it as a differentiated therapy in the market.

The most recent analyst rating on (CRSP) stock is a Hold with a $59.00 price target. To see the full list of analyst forecasts on Crispr Therapeutics AG stock, see the CRSP Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 19, 2025