Intellia Therapeutics Inc (NTLA)
NASDAQ:NTLA
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Intellia Therapeutics
(NASDAQ:NTLA)
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Rating:48Neutral
Price Target:
$13.00
▼(-13.04% Downside)
Action:Reiterated
Date:06/11/26
The score is held back primarily by weak financial performance (large losses and ongoing cash burn) and slightly bearish technical positioning (below key moving averages with negative MACD). Offsetting these are positive corporate developments (Phase 3 success and regulatory progress) and low balance-sheet leverage, while valuation remains difficult to justify given losses and no dividend support.
Positive Factors
Regulatory Progress / Phase 3 Success
A successful Phase 3 and an active rolling BLA are structural inflection points: if approved, a one-time in vivo CRISPR therapy could convert Intellia from a pre-revenue developer into a product company, materially strengthening commercial prospects and long-term competitive positioning in rare disease.
Negative Factors
Consistent Negative Cash Flow
Persistent negative operating and free cash flow indicate the company cannot self-finance growth today. Continued cash burn increases dependency on external financing or milestone receipts, raising dilution and execution risk if clinical or regulatory timelines slip or commercial timing is delayed.
Read all positive and negative factors
Positive Factors
Negative Factors
Regulatory Progress / Phase 3 Success
A successful Phase 3 and an active rolling BLA are structural inflection points: if approved, a one-time in vivo CRISPR therapy could convert Intellia from a pre-revenue developer into a product company, materially strengthening commercial prospects and long-term competitive positioning in rare disease.
Read all positive factors
Intellia Therapeutics (NTLA) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$1.73B
Dividend YieldN/A
Average Volume (3M)6.80M
Price to Earnings (P/E)―
Beta (1Y)2.10
Revenue Growth45.04%
EPS Growth32.42%
CountryUS
Employees403
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-3.54
Shares Outstanding139,722,270
10 Day Avg. Volume5,076,084
30 Day Avg. Volume6,798,778
Financial Highlights & Ratios
PEG Ratio0.09
Price to Book (P/B)1.45
Price to Sales (P/S)14.40
P/FCF Ratio-2.75
Enterprise Value/Market Cap0.88
Enterprise Value/Revenue23.07
Enterprise Value/Gross Profit-72.34
Enterprise Value/Ebitda-3.96
Forecast
1Y Price Target
$21.06Price Target Upside40.89% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering18
EPS Forecast (FY)-3.21
Revenue Forecast (FY)$59.08M
Intellia Therapeutics Business Overview & Revenue Model
Company Description
Intellia Therapeutics, Inc. is a biotechnology firm dedicated to advancing therapeutic treatments through its expertise in genome editing. The company's pipeline includes several in vivo (administered within the body) programs. NTLA-2001 is curren...
How the Company Makes Money
Intellia primarily generates revenue from collaboration and license arrangements with pharmaceutical partners rather than from product sales (as its key programs have been in clinical development and commercialization is limited or not applicable)...
Intellia Therapeutics Earnings Call Summary
Earnings Call Date:Feb 26, 2026
(Q4-2025)
| % Change Since: |
Next Earnings Date:Jul 30, 2026
Earnings Call Sentiment Neutral
The call presents a mix of important clinical and commercial progress — most notably the completed Phase 3 enrollment and upcoming pivotal readout for lonvo-z, strong patient and physician interest, durable early efficacy signals, and improved near-term financial metrics — alongside meaningful risks: a still-pending FDA hold on the large cardiomyopathy ATTR program driven by serious liver enzyme events (including one patient death), material year-over-year cash depletion, and incomplete understanding of the safety signal’s mechanism and breadth. Management has secured a partial regulatory win (MAGNITUDE-2 hold lifted with specific mitigations) and emphasizes preparedness for a potential lonvo-z launch, but the unresolved MAGNITUDE hold and safety uncertainty inject non-trivial downside risk.Positive Updates
Lonvo-z Phase 3 Enrollment and Imminent Readout
Completed enrollment of the HAELO Phase 3 trial with 80 patients in ~9 months; top-line data expected by mid-2026 and a planned BLA submission in H2 2026 — positioning Intellia for the world’s first pivotal readout for an in vivo CRISPR gene-editing therapy.
Negative Updates
Clinical Hold on MAGNITUDE (Cardiomyopathy) Remains
MAGNITUDE (ATTR-CM) remains on clinical hold after elevated liver transaminases and total bilirubin observed in a patient; while the company is actively engaged with the FDA and has proposed mitigations, the hold has not yet been lifted, creating uncertainty for a large cardimyopathy cohort that had already enrolled >650 patients (vs ~550 expected).
Read all updates
Q4-2025 Updates
Positive
Negative
Lonvo-z Phase 3 Enrollment and Imminent Readout
Completed enrollment of the HAELO Phase 3 trial with 80 patients in ~9 months; top-line data expected by mid-2026 and a planned BLA submission in H2 2026 — positioning Intellia for the world’s first pivotal readout for an in vivo CRISPR gene-editing therapy.
Read all positive updates
Company Guidance
Management reiterated guidance for a big 2026 year: top‑line phase 3 lonvo‑z data by mid‑2026, a planned BLA submission in H2‑2026 and a potential launch in 2027; HAELO is fully enrolled (80 patients) and pooled data show 76% of patients ≥1 year post‑50 mg were attack‑free ≥12 months (versus ~20% attack‑free on current therapies), while market research (104 patients, 151 HCPs) showed 99% of patients would be at least somewhat likely to take lonvo‑z, 92% of HCPs could identify a patient, and physicians collectively manage ~4,000 patients (~60% of the U.S. treated population) and would prescribe to ~2,200 (54%). For ATTR, MAGNITUDE had >650 patients enrolled before the October hold, MAGNITUDE‑2 has 47 enrolled with a revised target of ~60 and is expected to complete enrollment in H2‑2026 after the FDA lifted the MAGNITUDE‑2 hold in late January; mitigation measures (extra LFT monitoring and short‑term steroid regimens) were agreed given a Grade‑4 LFT incidence of <1%. Financially, cash, cash equivalents and marketable securities were $605.1M at 12/31/25 (down from $861.7M a year earlier) with runway into H2‑2027, Q4 collaboration revenue was $23M, R&D was $88.7M (stock‑based comp $10.5M), G&A $33.1M (stock‑based comp $6.2M) and Q4 net loss was $95.8M (vs $128.9M prior year).Intellia Therapeutics Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
62
Positive
Cash Flow
24
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 66.09M | 67.67M | 57.88M | 36.27M | 52.12M | 33.05M |
| Gross Profit | -21.07M | 51.75M | 47.59M | 27.30M | 44.55M | 26.16M |
| EBITDA | -384.61M | -396.77M | -508.74M | -472.22M | -466.61M | -261.00M |
| Net Income | -394.60M | -412.69M | -519.02M | -481.19M | -474.19M | -267.89M |
Balance Sheet | ||||||
| Total Assets | 758.78M | 842.13M | 1.19B | 1.30B | 1.52B | 1.29B |
| Cash, Cash Equivalents and Short-Term Investments | 375.99M | 449.88M | 601.51M | 912.22M | 1.19B | 748.69M |
| Total Debt | 80.49M | 93.33M | 210.20M | 115.35M | 130.70M | 74.02M |
| Total Liabilities | 137.84M | 170.73M | 319.06M | 250.81M | 284.53M | 254.22M |
| Stockholders Equity | 620.94M | 671.39M | 871.96M | 1.05B | 1.24B | 1.04B |
Cash Flow | ||||||
| Free Cash Flow | -363.63M | -354.66M | -354.66M | -408.07M | -391.68M | -237.79M |
| Operating Cash Flow | -363.15M | -348.88M | -348.88M | -394.09M | -333.29M | -225.03M |
| Investing Cash Flow | 200.01M | 125.57M | 125.57M | -31.35M | 160.31M | -550.78M |
| Financing Cash Flow | 165.06M | 185.75M | 185.75M | 130.32M | 582.96M | 736.69M |
Intellia Therapeutics Technical Analysis
Negative
14.95
Price Trends
13.65
Negative
13.41
Negative
13.39
Negative
Market Momentum
-0.19
Positive
43.37
Neutral
9.63
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NTLA, the sentiment is Negative. The current price of 14.95 is above the 20-day moving average (MA) of 13.08, above the 50-day MA of 13.65, and above the 200-day MA of 13.39, indicating a bearish trend. The MACD of -0.19 indicates Positive momentum. The RSI at 43.37 is Neutral, neither overbought nor oversold. The STOCH value of 9.63 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for NTLA.
Intellia Therapeutics Risk Analysis
Intellia Therapeutics disclosed 1 risk factors in its most recent earnings report. Intellia Therapeutics reported the most risks in the "Production" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 1 New Risks
1.
Governance Q4, 2025
Intellia Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
60 Neutral | $1.40B | -8.21 | -35.89% | ― | ― | -63.41% | |
56 Neutral | $1.61B | -11.10 | -14.86% | ― | 242.66% | 15.53% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
50 Neutral | $786.54M | -2.67 | -141.95% | ― | 5.37% | -60.20% | |
48 Neutral | $1.73B | -3.71 | -57.27% | ― | 45.04% | 32.42% | |
47 Neutral | $833.05M | -7.48 | -11.85% | ― | 47.10% | -35.51% | |
46 Neutral | $361.98M | -5.50 | -39.75% | ― | -100.00% | -2.72% |
* Healthcare Sector Average
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Intellia Therapeutics Corporate Events
Executive/Board ChangesShareholder Meetings
Intellia Shareholders Back Board, Executive Pay and Auditor
Positive
Jun 10, 2026
On June 9, 2026, Intellia Therapeutics, Inc. held its Annual Meeting at which stockholders elected Muna Bhanji, R.Ph., Brian Goff and Jesse Goodman, M.D., M.P.H., as Class I directors for three-year terms ending at the 2029 annual meeting. Stockho...
Business Operations and StrategyPrivate Placements and Financing
Intellia Therapeutics Prices Public Equity Offering to Fund Pipeline
Positive
Apr 30, 2026
On April 28, 2026, Intellia Therapeutics entered into an underwriting agreement with Jefferies, Goldman Sachs, and Citigroup for a public offering of 16,744,187 common shares at $10.75 per share, plus a 30-day option for 2,511,628 additional share...
Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Intellia Reports Positive Phase 3 Results for HAE Gene Therapy
Positive
Apr 27, 2026
On April 27, 2026, Intellia Therapeutics reported positive topline Phase 3 results from its global HAELO trial of lonvoguran ziclumeran, an in vivo CRISPR-based, one-time gene-editing therapy for hereditary angioedema. The randomized, double-blind...
Business Operations and StrategyRegulatory Filings and Compliance
Intellia Therapeutics Adopts Fourth Amended and Restated Bylaws
Positive
Apr 10, 2026
On April 7, 2026, Intellia Therapeutics, Inc.’s board of directors adopted amendments to its by-laws to create a Fourth Amended and Restated By-law framework, following a recommendation from its nominating and corporate governance committee....
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.