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Vir Biotechnology, Inc. (VIR)
:VIR
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Vir Biotechnology (VIR) AI Stock Analysis

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VIR

Vir Biotechnology

(NASDAQ:VIR)

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Neutral 51 (OpenAI - 4o)
Rating:51Neutral
Price Target:
$6.50
▲(1.72% Upside)
Vir Biotechnology's overall stock score is primarily impacted by its poor financial performance, which is the most significant factor. Despite positive technical indicators suggesting short-term bullish momentum, the company's valuation remains unattractive due to negative earnings and no dividend yield. The earnings call provided some positive insights into clinical progress and a strong cash position, but these are overshadowed by ongoing financial challenges.
Positive Factors
Strong Cash Position
A strong cash position provides financial stability and flexibility, enabling continued investment in R&D and strategic initiatives without immediate funding pressures.
Progress in Clinical Programs
Timely progress in clinical trials enhances the potential for future regulatory approvals and commercialization, strengthening the company's pipeline and market position.
R&D Efficiency
Improved R&D efficiency through cost savings enhances the company's ability to allocate resources effectively, supporting long-term innovation and profitability.
Negative Factors
Negative Revenue Growth
Negative revenue growth and profitability issues can hinder sustainable business operations, limiting the company's ability to invest in future growth opportunities.
High R&D Expenses
High R&D expenses, while necessary for innovation, can strain financial resources and impact short-term profitability, requiring careful management to ensure long-term success.
Dependence on Future Data
Reliance on future clinical data introduces uncertainty, as any setbacks could delay product development and affect the company's growth trajectory and market expectations.

Vir Biotechnology (VIR) vs. SPDR S&P 500 ETF (SPY)

Vir Biotechnology Business Overview & Revenue Model

Company DescriptionVir Biotechnology, Inc., a commercial-stage immunology company, develops therapeutic products to treat and prevent serious infectious diseases. It develops Sotrovimab (VIR-7832), a SARS-CoV-2-neutralizing mAbs to treat and prevent COVID-19 infection under the Xevudy brand; VIR-2218 and VIR-3434 for the treatment of hepatitis B virus; VIR-2482 for the prevention of influenza A virus; and VIR-1111 for the prevention of human immunodeficiency virus. The company has grant agreements with Bill & Melinda Gates Foundation and National Institutes of Health; an option and license agreement with Brii Biosciences Limited and Brii Biosciences Offshore Limited; a collaboration and license agreement with Alnylam Pharmaceuticals, Inc.; license agreements with The Rockefeller University and MedImmune, Inc.; collaboration with WuXi Biologics and Glaxo Wellcome UK Ltd.; and a collaborative research agreement with GlaxoSmithKline Biologicals SA. It also has a manufacturing agreement with Samsung Biologics Co.,Ltd. for the manufacture of SARS-COV-2 antibodies; and clinical collaboration with Gilead Sciences, Inc. for chronic hepatitis B virus. Vir Biotechnology, Inc. was incorporated in 2016 and is headquartered in San Francisco, California.
How the Company Makes MoneyVir Biotechnology generates revenue primarily through the development and commercialization of its therapeutic products. Key revenue streams include sales of approved products, licensing agreements, and collaborations with pharmaceutical companies. The company has entered into significant partnerships, such as its collaboration with GlaxoSmithKline for the development of COVID-19 treatments, which can lead to milestone payments and royalties on future sales. Additionally, Vir may receive funding from government grants and contracts, especially during public health emergencies, contributing to its financial earnings.

Vir Biotechnology Key Performance Indicators (KPIs)

Any
Any
Revenue by Segment
Revenue by Segment
Provides insight into which business areas are driving sales, highlighting strengths and potential vulnerabilities in the company's revenue streams.
Chart InsightsVir Biotechnology's revenue from collaborations has shown volatility, with significant fluctuations and recent negative values, reflecting strategic challenges and dependency on partnerships, as highlighted by Alnylam's opt-out. Grant revenue has been relatively stable but modest, while contract revenue saw a notable spike in early 2024, possibly linked to new initiatives like the ECLIPSE Phase III program. Despite financial losses, Vir's strong cash position and progress in oncology and infectious disease programs provide a foundation for future growth, though strategic partnerships remain crucial for advancing key projects.
Data provided by:The Fly

Vir Biotechnology Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in key clinical programs and a strong financial position, with clear paths to future value creation. However, continuous financial losses and high R&D expenses remain challenges. The sentiment is balanced between the achievements and ongoing challenges.
Q3-2025 Updates
Positive Updates
Completion of ECLIPSE 1 Enrollment
Successfully completed enrollment in ECLIPSE 1, the first registrational Phase III study for hepatitis delta, ahead of schedule. This positions the company well for regulatory submissions with top line data expected by early 2027.
Strong Financial Position
Ended the third quarter with approximately $810.7 million in cash, cash equivalents, and investments, with a projected cash runway extending into mid-2027.
Progress in Oncology Portfolio
Substantial progress in dose escalation for VIR-5500, a PSMA-targeted T-cell engager, with promising potential for future data updates expected in Q1 2026.
Cost Savings and Reduced Expenses
Year-over-year decrease in operating expenses by $46.2 million, driven by restructuring initiatives and lower licensing expenses.
Negative Updates
Continued Financial Losses
Reported a net loss of $163.1 million for the third quarter of 2025, though it was an improvement from the previous year's loss of $213.7 million.
High R&D Expenses
R&D expenses for the third quarter of 2025 were significant at $151.5 million, driven by milestone payments and increased clinical development expenses.
Dependence on Future Data
The success of upcoming programs heavily relies on future data updates, particularly for the VIR-5500 and other T-cell engager programs.
Company Guidance
During Vir Biotechnology's third quarter 2025 earnings call, the company provided detailed guidance on its clinical programs and financial outlook. Key highlights included the completion of enrollment in the ECLIPSE 1 Phase III study for hepatitis delta, with primary completion expected by Q4 2026 and top-line data by Q1 2027. The company plans to present a comprehensive data update for the VIR-5500 T-cell engager in Q1 2026. The call also discussed the initiation of a combination study in metastatic castration-resistant prostate cancer. Financially, Vir reported a net loss of $163.1 million for the quarter, with R&D expenses totaling $151.5 million. The company ended the quarter with $810.7 million in cash and investments, projecting a cash runway into mid-2027.

Vir Biotechnology Financial Statement Overview

Summary
Vir Biotechnology is facing significant financial challenges, with negative net profit margins, declining revenue growth, and ongoing cash flow issues. The balance sheet shows low leverage but negative returns on equity, indicating financial instability.
Income Statement
35
Negative
Vir Biotechnology's income statement shows significant challenges with negative net profit margins and declining revenue growth. The TTM data reveals a gross profit margin of 95.53%, but this is overshadowed by a net loss, indicating inefficiencies in cost management. The revenue growth rate is negative, reflecting a downturn in sales performance. Overall, the company is struggling to maintain profitability.
Balance Sheet
45
Neutral
The balance sheet indicates a relatively low debt-to-equity ratio of 0.10, suggesting conservative leverage. However, the return on equity is negative, highlighting the company's inability to generate positive returns for shareholders. The equity ratio is stable, but the overall financial health is compromised by persistent losses.
Cash Flow
30
Negative
The cash flow statement shows negative operating and free cash flows, with a slight decline in free cash flow growth. The operating cash flow to net income ratio is negative, indicating cash flow challenges. The free cash flow to net income ratio is slightly above 1, suggesting some alignment between cash flow and reported earnings, but overall cash flow management remains a concern.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue16.86M74.20M86.18M1.62B1.10B67.25M
Gross Profit-438.52M-404.44M-486.65M994.83M581.54M67.25M
EBITDA-511.54M-508.91M-641.64M839.85M426.56M-291.54M
Net Income-499.65M-521.96M-615.06M515.84M528.58M-298.67M
Balance Sheet
Total Assets1.02B1.40B1.92B2.80B1.95B918.76M
Cash, Cash Equivalents and Short-Term Investments506.51M905.35M1.52B2.40B708.14M736.86M
Total Debt100.17M97.89M124.54M127.97M137.49M70.18M
Total Liabilities223.35M248.43M328.82M724.13M522.42M201.91M
Stockholders Equity796.10M1.15B1.59B2.08B1.43B716.85M
Cash Flow
Free Cash Flow-460.43M-453.65M-800.36M1.60B-69.41M-197.49M
Operating Cash Flow-453.54M-446.35M-778.78M1.66B-47.59M-190.94M
Investing Cash Flow364.46M499.37M164.73M-1.19B-140.81M-9.86M
Financing Cash Flow4.01M4.39M7.38M34.76M100.33M529.47M

Vir Biotechnology Technical Analysis

Technical Analysis Sentiment
Positive
Last Price6.39
Price Trends
50DMA
5.71
Positive
100DMA
5.38
Positive
200DMA
5.80
Positive
Market Momentum
MACD
0.11
Negative
RSI
63.61
Neutral
STOCH
83.53
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For VIR, the sentiment is Positive. The current price of 6.39 is above the 20-day moving average (MA) of 5.64, above the 50-day MA of 5.71, and above the 200-day MA of 5.80, indicating a bullish trend. The MACD of 0.11 indicates Negative momentum. The RSI at 63.61 is Neutral, neither overbought nor oversold. The STOCH value of 83.53 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for VIR.

Vir Biotechnology Risk Analysis

Vir Biotechnology disclosed 61 risk factors in its most recent earnings report. Vir Biotechnology reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Vir Biotechnology Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
62
Neutral
$344.88M-43.11%-5.71%
59
Neutral
$1.32B-22.38%2147.20%-269.99%
57
Neutral
$1.02B-7.88-19.61%38.16%48.43%
53
Neutral
$913.03M-53.89%175.62%19.63%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$889.01M-49.06%-78.55%7.74%
44
Neutral
$616.04M-0.99-12.52%-82.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
VIR
Vir Biotechnology
6.39
-1.57
-19.72%
XNCR
Xencor
17.38
-8.22
-32.11%
IOVA
Iovance Biotherapeutics
2.44
-6.88
-73.82%
AVXL
Anavex Life Sciences
3.86
-5.60
-59.20%
IVA
Inventiva
4.60
1.95
73.58%
SEPN
Septerna, Inc.
29.57
4.28
16.92%

Vir Biotechnology Corporate Events

Vir Biotechnology’s Earnings Call: Achievements and Challenges
Nov 7, 2025

Vir Biotechnology, Inc.’s recent earnings call presented a balanced sentiment, reflecting both significant achievements and ongoing challenges. The company highlighted substantial progress in its key clinical programs and a robust financial position, setting a clear path for future value creation. However, continuous financial losses and high research and development (R&D) expenses remain as notable challenges.

Vir Biotechnology Reports Q3 2025 Financial Results and Clinical Progress
Nov 6, 2025

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on developing transformative therapies for serious infectious diseases and cancer, leveraging its expertise in the immune system and innovative technologies like the PRO-XTEN masking platform.

Vir Biotechnology’s Innovative HDV Study: A Potential Game-Changer in Viral Treatment
Oct 27, 2025

Study Overview: Vir Biotechnology, Inc. is conducting a Phase 2b study titled ‘A Phase 2b Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy Versus Bulevirtide in Participants With Chronic HDV Infection (ECLIPSE 3)’. The study aims to assess the efficacy and safety of a new combination therapy for chronic Hepatitis D Virus (HDV) infection, a significant health concern due to its severe liver complications.

Vir Biotechnology’s Promising Phase 3 Study for Chronic HDV Treatment
Oct 27, 2025

Vir Biotechnology, Inc. is conducting a Phase 3 clinical study titled ‘A Phase 3 Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide (ECLIPSE 2)’. The study aims to assess the effectiveness and safety of a combination therapy for patients with chronic hepatitis D virus (HDV) infection who have not responded to bulevirtide treatment.

Vir Biotechnology’s Phase 3 Study on HDV Treatment: A Potential Game-Changer?
Oct 27, 2025

Study Overview: Vir Biotechnology, Inc. is conducting a Phase 3 study titled A Phase 3 Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart + Elebsiran Combination Therapy in Participants With Chronic HDV Infection (ECLIPSE 1). The study aims to assess the effectiveness and safety of the combination therapy for treating chronic hepatitis delta, a significant health concern due to its severe liver complications.

Vir Biotechnology’s Innovative Approach in HER2-Expressing Cancer Treatment: A Study Update
Oct 27, 2025

Study Overview: Vir Biotechnology, Inc. is conducting a Phase 1 clinical study titled A Phase 1, Multicenter, Open-Label, First-in-Human Study of the Safety and Pharmacokinetics of VIR-5818 Alone and in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic HER2-Expressing Cancers. The study aims to assess the safety, pharmacokinetics, and preliminary activity of VIR-5818, both alone and combined with pembrolizumab, in treating HER2+ tumors. This research is significant as it explores new treatment avenues for challenging cancer types.

Vir Biotechnology’s Promising Prostate Cancer Study: A Potential Game-Changer?
Oct 27, 2025

Vir Biotechnology, Inc. is conducting a Phase 1 study titled A Phase 1, First-in-Human Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Participants With Prostate Cancer. The study aims to evaluate the safety and efficacy of VIR-5500 in treating hormone-refractory prostate cancer, a significant step in addressing this challenging condition.

Vir Biotechnology’s Phase 1 Study on VIR-5525: A Potential Game-Changer in Cancer Treatment?
Oct 27, 2025

Study Overview: Vir Biotechnology, Inc. is conducting a Phase 1 clinical study titled ‘A Phase 1, First-in-Human Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5525 Alone and in Combination With Pembrolizumab in Participants With Locally Advanced or Metastatic Solid Tumors.’ The study aims to evaluate the safety, pharmacokinetics, and preliminary anti-tumor activity of VIR-5525, both as a standalone treatment and in combination with pembrolizumab, for patients with EGFR-positive solid tumors.

Vir Biotechnology’s Hepatic Impairment Study: A Potential Game Changer?
Oct 27, 2025

Vir Biotechnology, Inc. is conducting a Phase 1 study titled Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434. The study aims to evaluate the pharmacokinetics, safety, and tolerability of VIR-2218 and VIR-3434, both as monotherapies and in combination, in adults with varying degrees of hepatic impairment, including cirrhosis. This research is significant as it seeks to understand how these drugs behave in patients with liver conditions, potentially informing future treatments.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 26, 2025