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Scholar Rock Holding Corp (SRRK)
NASDAQ:SRRK
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Scholar Rock Holding (SRRK) AI Stock Analysis

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SRRK

Scholar Rock Holding

(NASDAQ:SRRK)

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Neutral 50 (OpenAI - 4o)
Rating:50Neutral
Price Target:
Scholar Rock's overall stock score reflects significant challenges due to financial underperformance, including a lack of revenue and ongoing losses. Despite these issues, positive strides in its SMA program and strategic leadership changes indicate potential for future growth. Mixed technical indicators and a weak valuation further moderate the outlook.
Positive Factors
SMA Program Progress
The successful BLA submission for apitegromab marks a significant milestone in Scholar Rock's SMA program, indicating strong potential for future revenue from this innovative treatment.
Leadership Changes
The appointment of a new CEO and key executives is a strategic move to enhance Scholar Rock's global commercial capabilities, potentially accelerating growth and innovation.
Commercial Preparation for Apitegromab
Preparations for the U.S. launch of apitegromab demonstrate Scholar Rock's commitment to commercializing its products, which could significantly boost future revenue streams.
Negative Factors
Financial Challenges
The lack of revenue and ongoing losses highlight financial instability, which could hinder long-term sustainability and necessitate reliance on external funding.
Negative Cash Flow
Negative cash flow indicates that Scholar Rock is not generating sufficient cash from operations, posing risks to its financial health and operational continuity.
Regulatory Uncertainty in Obesity Trials
Regulatory uncertainties in the obesity program could delay product development and impact Scholar Rock's ability to capitalize on this market opportunity.

Scholar Rock Holding (SRRK) vs. SPDR S&P 500 ETF (SPY)

Scholar Rock Holding Business Overview & Revenue Model

Company DescriptionScholar Rock Holding Corporation is a biotechnology company specializing in the discovery and development of innovative medicines for the treatment of serious diseases in which protein growth factors play a fundamental role. The company focuses on addressing unmet medical needs in areas such as neuromuscular disorders, cancer, fibrosis, and anemia, employing its proprietary platform to target latent forms of growth factors and modulate their activity.
How the Company Makes MoneyScholar Rock makes money primarily through the development and commercialization of its proprietary drug candidates. The company's revenue model includes partnerships and collaborations with larger pharmaceutical companies, which provide upfront payments, milestone payments, and royalties on future sales of successfully developed drugs. Additionally, Scholar Rock may generate income through licensing agreements, where it grants other companies the rights to develop and market its therapeutic candidates. The company's financial performance is heavily influenced by the progress of its clinical trials, regulatory approvals, and the successful commercialization of its products.

Scholar Rock Holding Earnings Call Summary

Earnings Call Date:Nov 14, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 10, 2026
Earnings Call Sentiment Neutral
The earnings call reflects a mix of optimism due to strong financial management, significant trial results for apitegromab, and strategic preparation for commercial launch. However, these positives are tempered by regulatory delays and uncertainties surrounding the approval timeline due to third-party facility compliance issues.
Q3-2025 Updates
Positive Updates
Strong Financial Position
Scholar Rock ended the third quarter with $369.6 million in cash and cash equivalents, and expects cash to be sufficient to fund operations into 2027, supported by additional expected cash from warrant exercises.
Robust Phase III Trial Results for Apitegromab
The Phase III trial for apitegromab in SMA showed statistically significant and clinically meaningful benefits in motor function for patients, as measured by the Hammersmith Motor Function Scale.
Strategic Commercial Readiness
Scholar Rock has a small, experienced U.S. customer-facing team in place and is working to broaden and deepen engagement with potential prescribing physicians and SMA treatment teams.
Pipeline Progress
Scholar Rock has initiated dosing in a Phase II OPAL trial evaluating apitegromab in infants and toddlers and plans to advance SRK-439 into a Phase I study by the end of the year.
Successful Balance Sheet Strengthening
The company raised $141.7 million during the third quarter, including $91.7 million from their ATM and $50 million from an existing debt facility.
Negative Updates
FDA Complete Response Letter for Apitegromab
Scholar Rock received a complete response letter from the FDA due to issues at the third-party fill/finish facility, delaying the approval of apitegromab for SMA.
Regulatory Delays Due to Facility Compliance
The primary issue preventing apitegromab's approval is the OAI classification of Novo Nordisk's Bloomington facility, affecting the resubmission timeline.
Uncertainty in Approval Timeline
Due to the need for a successful reinspection of the fill/finish facility, the timeline for the resubmission and approval of apitegromab remains uncertain.
Company Guidance
In the third quarter of 2025, Scholar Rock provided detailed guidance on several key metrics during their earnings call. The company emphasized their commitment to the launch of apitegromab for SMA, despite receiving a complete response letter from the FDA on September 22, 2025, due to compliance issues at a third-party manufacturing facility. Scholar Rock is confident in the eventual approval, aiming for a U.S. launch in 2026, and is expediting efforts to add a second fill/finish facility with commercial capacity secured by Q1 2026. They highlighted the substantial market opportunity, with an estimated 35,000 SMA patients globally eligible for treatment. Financially, Scholar Rock reported $369.6 million in cash and cash equivalents at the end of the quarter, with operating expenses of $103 million, including $18.3 million in noncash stock-based compensation. They bolstered their balance sheet by $141.7 million through an ATM offering and a $50 million draw from an existing debt facility, extending their cash runway into 2027. The company is strategically deferring certain investments while prioritizing key areas, including the apitegromab launch, OPAL study, and SRK-439 clinical development.

Scholar Rock Holding Financial Statement Overview

Summary
Scholar Rock Holding faces significant financial challenges with no revenue and ongoing net losses. Despite a stable balance sheet with strong liquidity and low leverage, negative cash flows indicate reliance on external financing. Critical focus is needed on revenue generation and cost management to improve future profitability.
Income Statement
25
Negative
Scholar Rock Holding has shown no revenue for 2023 and 2024, indicating an absence of sales or other income-generating activities. The company is operating at a loss, with a significantly negative net income. Gross profit is also at zero, and the company has declining EBIT and EBITDA margins due to increasing expenses relative to revenues. The lack of revenue growth is concerning for future profitability.
Balance Sheet
45
Neutral
Scholar Rock Holding maintains a moderate equity base relative to its total assets, with an equity ratio around 77.6% in 2024. The debt-to-equity ratio is low at 0.18, suggesting conservative leverage. However, the company is incurring losses, which could impact future equity levels. Positive cash and cash equivalents indicate good liquidity.
Cash Flow
40
Negative
The company experiences negative operating cash flow, which raises concerns about its ability to sustain operations without external financing. Free cash flow is also negative, indicating that the company is not generating cash from its core operations. However, financing activities have provided substantial cash inflows, helping to mitigate cash flow deficiencies.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.0033.19M18.82M15.40M
Gross Profit-1.63M-1.94M-2.84M-89.85M-89.65M-58.66M
EBITDA-351.63M-237.52M-162.94M-129.48M-127.29M-85.39M
Net Income-353.43M-246.29M-165.79M-134.50M-131.80M-86.48M
Balance Sheet
Total Assets411.72M474.92M311.04M358.17M304.44M388.31M
Cash, Cash Equivalents and Short-Term Investments369.63M437.28M279.94M315.36M252.99M341.03M
Total Debt110.08M65.13M61.82M69.40M84.47M57.14M
Total Liabilities166.72M106.29M85.82M97.93M132.37M127.53M
Stockholders Equity245.00M368.63M225.22M260.24M172.07M260.77M
Cash Flow
Free Cash Flow-274.64M-201.05M-145.30M-133.76M-132.04M-64.36M
Operating Cash Flow-274.05M-200.95M-145.23M-132.69M-126.79M-60.27M
Investing Cash Flow-15.65M-76.06M41.14M-171.70M134.31M-63.50M
Financing Cash Flow501.48M353.03M102.57M194.83M44.95M247.82M

Scholar Rock Holding Technical Analysis

Technical Analysis Sentiment
Positive
Last Price41.08
Price Trends
50DMA
34.37
Positive
100DMA
34.53
Positive
200DMA
33.73
Positive
Market Momentum
MACD
2.97
Negative
RSI
62.69
Neutral
STOCH
75.09
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SRRK, the sentiment is Positive. The current price of 41.08 is above the 20-day moving average (MA) of 36.00, above the 50-day MA of 34.37, and above the 200-day MA of 33.73, indicating a bullish trend. The MACD of 2.97 indicates Negative momentum. The RSI at 62.69 is Neutral, neither overbought nor oversold. The STOCH value of 75.09 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for SRRK.

Scholar Rock Holding Risk Analysis

Scholar Rock Holding disclosed 70 risk factors in its most recent earnings report. Scholar Rock Holding reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Scholar Rock Holding Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
$4.35B-18.77-39.94%
55
Neutral
$3.22B-325.76%20.63%8.09%
53
Neutral
$3.91B-29.23%-126.16%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$4.19B-218.04%-31.71%
48
Neutral
$3.31B-45.14%-38.30%
45
Neutral
$3.99B-95.93%-27.70%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SRRK
Scholar Rock Holding
41.08
1.31
3.29%
RARE
Ultragenyx Pharmaceutical
33.47
-13.64
-28.95%
VKTX
Viking Therapeutics
35.41
-15.83
-30.89%
XENE
Xenon
42.88
0.54
1.28%
IMVT
Immunovant
22.02
-6.50
-22.79%
NAMS
NewAmsterdam Pharma Company
38.33
20.06
109.80%

Scholar Rock Holding Corporate Events

Executive/Board ChangesBusiness Operations and Strategy
Scholar Rock Appoints David Hallal as New CEO
Positive
Apr 28, 2025

Scholar Rock announced a significant management transition effective April 27, 2025, with David Hallal appointed as the new Chief Executive Officer, succeeding Dr. Jay Backstrom, who will become a Senior Advisor until October 31, 2025. This transition is part of a strategic move to prepare for the global launch of apitegromab, a promising treatment for spinal muscular atrophy (SMA), and includes the addition of three key executives: Akshay Vaishnaw as President of R&D, R. Keith Woods as Chief Operating Officer, and Vikas Sinha as Chief Financial Officer. These changes are expected to bolster Scholar Rock’s evolution into a fully integrated global commercial enterprise, enhancing its positioning in the biopharmaceutical industry and potentially benefiting stakeholders by accelerating the company’s growth and innovation efforts.

Spark’s Take on SRRK Stock

According to Spark, TipRanks’ AI Analyst, SRRK is a Neutral.

Scholar Rock Holding’s stock score is hindered by the lack of revenue and ongoing losses, despite a stable balance sheet and liquidity. While technical indicators provide mixed signals, the company’s strategic progress in its SMA program and forthcoming drug launch offer a positive outlook. However, valuation concerns remain due to significant net losses and no dividend yield. The overall score reflects these challenges, balanced by the potential long-term growth from its pipeline.

To see Spark’s full report on SRRK stock, click here.

Executive/Board ChangesShareholder Meetings
Scholar Rock Holding Appoints Interim Financial Officer
Neutral
Mar 21, 2025

Scholar Rock Holding Corporation announced the appointment of Erin Moore as interim Principal Financial Officer and interim Principal Accounting Officer, effective March 21, 2025, following the departure of Edward Myles. Moore, who has been with the company since 2018 and holds extensive financial and accounting credentials, will temporarily oversee financial operations. Additionally, the company scheduled its 2025 Annual Meeting of Stockholders for May 22, 2025, with March 26, 2025, set as the record date for stockholders entitled to vote. The deadline for stockholder proposals is March 31, 2025, adhering to the Securities Exchange Act regulations.

Product-Related AnnouncementsBusiness Operations and StrategyFinancial Disclosures
Scholar Rock Advances SMA Program with Apitegromab Submission
Positive
Feb 27, 2025

Scholar Rock reported its financial results for 2024, highlighting significant progress in its SMA program with the submission of a Biologics License Application for apitegromab, anticipated to launch in the U.S. in late 2025. The company also plans to expand its research into other neuromuscular disorders and cardiometabolic indications, supported by a strong financial position and recent public offering.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 29, 2025