ACADIA Pharmaceuticals (ACAD)
NASDAQ:ACAD
Advertisement

ACADIA Pharmaceuticals (ACAD) AI Stock Analysis

Compare
2,414 Followers

Top Page

ACAD

ACADIA Pharmaceuticals

(NASDAQ:ACAD)

Select Model
Select Model
Select Model
Outperform 73 (OpenAI - 4o)
Rating:73Outperform
Price Target:
$24.00
▼(-0.08% Downside)
ACADIA Pharmaceuticals' strong financial performance and strategic growth initiatives, particularly in DAYBUE and NUPLAZID, are key strengths. The company's valuation suggests potential upside, though technical indicators show a neutral trend. Challenges in market penetration and rising R&D expenses are notable risks.
Positive Factors
Revenue Growth
Strong revenue growth indicates effective market strategies and product demand, supporting long-term financial stability and expansion.
Pipeline Advancements
Advancing pipeline with new studies enhances future growth prospects and strengthens competitive positioning in CNS disorders.
Cash Position
A strong cash position provides financial flexibility for strategic investments and R&D, supporting sustainable growth.
Negative Factors
DAYBUE Market Penetration Challenges
Low market penetration for DAYBUE could limit revenue potential and impact long-term growth if not addressed effectively.
Disappointment in Canada
Reimbursement challenges in Canada may hinder DAYBUE's international expansion and revenue diversification efforts.
R&D Expense Increase
Rising R&D expenses could pressure margins and profitability, necessitating successful outcomes from pipeline investments.

ACADIA Pharmaceuticals (ACAD) vs. SPDR S&P 500 ETF (SPY)

ACADIA Pharmaceuticals Business Overview & Revenue Model

Company DescriptionACADIA Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of innovative medicines to address unmet medical needs in central nervous system disorders. The company is primarily engaged in the research and development of drugs for the treatment of conditions such as Parkinson's disease psychosis and schizophrenia. Its core product, NUPLAZID (pimavanserin), is approved for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis and is marketed in the United States.
How the Company Makes MoneyACADIA Pharmaceuticals generates revenue primarily through the sale of its flagship product, NUPLAZID. The company earns income from product sales to healthcare providers and pharmacies. Additionally, ACADIA may receive milestone payments and royalties from partnerships with other pharmaceutical companies involved in the development and commercialization of complementary therapies. The company also engages in research collaborations and licensing agreements that can provide additional revenue streams. Factors contributing to its earnings include the growth in demand for treatments for CNS disorders, successful marketing strategies, and potential new product approvals or expansions in indications for existing drugs.

ACADIA Pharmaceuticals Key Performance Indicators (KPIs)

Any
Any
Revenue by Product
Revenue by Product
Shows earnings from individual products, highlighting which offerings drive growth and which may need strategic adjustments. This helps assess product portfolio strength and market positioning.
Chart InsightsACADIA Pharmaceuticals is experiencing robust growth in its key products, with NUPLAZID and DAYBUE showing significant revenue increases. NUPLAZID's revenue surged by 23% due to a one-time adjustment, while DAYBUE's sales rose by 11%, despite a sequential decline attributed to seasonality and prior quarter pull-forward. The company is strategically expanding its pipeline and preparing for DAYBUE's European launch, indicating strong future prospects. However, increased R&D expenses and the discontinuation of certain programs highlight ongoing challenges in balancing growth and operational costs.
Data provided by:Main Street Data

ACADIA Pharmaceuticals Earnings Call Summary

Earnings Call Date:Nov 05, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 02, 2026
Earnings Call Sentiment Positive
The earnings call reflects a strong performance with robust revenue growth and strategic investments in DAYBUE and NUPLAZID, alongside pipeline advancements. However, challenges persist with DAYBUE's market penetration and increased R&D expenses.
Q3-2025 Updates
Positive Updates
Strong Revenue Growth
Total revenues for Q3 2025 were $278.6 million, up 11% year-over-year, with DAYBUE and NUPLAZID showing significant sales growth.
DAYBUE Sales Milestone
DAYBUE achieved net sales of $101.1 million in Q3, marking the highest revenue and total prescription volume since launch.
NUPLAZID Record Performance
NUPLAZID delivered net sales of $177.5 million in Q3, representing a 12% year-over-year growth and a 9% increase in volume.
Pipeline Advancements
Initiation of Phase II study for ACP-204 in Lewy body dementia psychosis and Phase III study of trofinetide in Japan, with additional studies planned for the coming years.
Cash Position
The company ended the quarter with $847 million in cash, up from $762 million at the end of the second quarter.
Negative Updates
DAYBUE Market Penetration Challenges
Overall market penetration for DAYBUE remains relatively low at about 40% in the U.S., with only 27% penetration in the community setting.
Disappointment in Canada
The company faced a setback with a disappointing reimbursement decision for DAYBUE in Canada.
R&D Expense Increase
R&D expenses increased to $87.8 million in Q3 2025, up from $66.6 million in the same period in 2024, driven by higher clinical trial and personnel expenses.
Company Guidance
During ACADIA Pharmaceuticals' third-quarter 2025 financial results conference call, the company provided several key metrics and guidance for the future. Total revenues reached $278.6 million, an 11% increase from the previous year. DAYBUE recorded net sales of $101.1 million, with prescriptions now exceeding 1,000 unique patients globally. Meanwhile, NUPLAZID delivered a record $177.5 million in net sales, showing a 12% year-over-year increase. The company adjusted its 2025 guidance, raising NUPLAZID's expected net sales to $685-$695 million and DAYBUE's to $385-$400 million. Operating expenses were also detailed, with R&D expenses projected at $335-$345 million and SG&A expenses at $540-$555 million for the full year. ACADIA highlighted its strategic investments in commercial and pipeline development, including a planned 30% expansion of its customer-facing team for NUPLAZID in 2026. The company remains focused on advancing its robust pipeline with multiple Phase II and III studies, aiming for over $1 billion in total revenues by year-end and sustained growth into 2026.

ACADIA Pharmaceuticals Financial Statement Overview

Summary
ACADIA Pharmaceuticals demonstrates strong profitability and revenue growth, with significant improvements in net income and cash flow generation. The balance sheet reflects low leverage and a solid equity base, though there is room for enhancing operational efficiencies and cash flow conversion.
Income Statement
75
Positive
ACADIA Pharmaceuticals has shown a strong gross profit margin of over 91% consistently, indicating efficient cost management. The net profit margin has improved significantly, turning positive in the TTM period, reflecting enhanced profitability. Revenue growth is steady, with a notable increase in the TTM period. However, EBIT and EBITDA margins are relatively low, suggesting room for operational efficiency improvements.
Balance Sheet
70
Positive
The company maintains a low debt-to-equity ratio, indicating conservative leverage and financial stability. Return on equity has turned positive, showcasing improved profitability and shareholder returns. The equity ratio suggests a solid capital structure, though there is potential to optimize asset utilization further.
Cash Flow
68
Positive
Operating and free cash flows have improved, with positive growth rates indicating better cash generation capabilities. The operating cash flow to net income ratio is below 1, suggesting that not all net income is translating into cash flow, which could be a concern. However, the free cash flow to net income ratio is close to 1, indicating efficient cash conversion.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.05B957.80M726.44M517.24M484.14M441.75M
Gross Profit962.54M875.96M680.71M507.07M465.00M421.20M
EBITDA117.30M100.16M-67.83M-221.57M-167.09M-283.65M
Net Income261.17M226.45M-61.29M-215.97M-167.87M-281.58M
Balance Sheet
Total Assets1.33B1.19B748.96M587.81M700.12M782.62M
Cash, Cash Equivalents and Short-Term Investments847.02M755.99M438.87M416.82M520.71M631.96M
Total Debt54.81M51.99M57.20M62.00M64.43M44.46M
Total Liabilities413.50M454.96M317.20M187.40M159.23M155.61M
Stockholders Equity917.27M732.79M431.75M400.41M540.89M627.01M
Cash Flow
Free Cash Flow197.81M157.20M-23.35M-114.03M-126.78M-143.75M
Operating Cash Flow198.95M157.72M16.70M-114.03M-125.66M-136.17M
Investing Cash Flow-124.55M-30.54M32.00M73.24M-71.10M192.51M
Financing Cash Flow29.19M6.84M25.13M8.20M18.16M81.00M

ACADIA Pharmaceuticals Technical Analysis

Technical Analysis Sentiment
Positive
Last Price24.02
Price Trends
50DMA
22.42
Positive
100DMA
23.02
Positive
200DMA
20.69
Positive
Market Momentum
MACD
0.42
Negative
RSI
61.22
Neutral
STOCH
87.73
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ACAD, the sentiment is Positive. The current price of 24.02 is above the 20-day moving average (MA) of 22.47, above the 50-day MA of 22.42, and above the 200-day MA of 20.69, indicating a bullish trend. The MACD of 0.42 indicates Negative momentum. The RSI at 61.22 is Neutral, neither overbought nor oversold. The STOCH value of 87.73 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ACAD.

ACADIA Pharmaceuticals Risk Analysis

ACADIA Pharmaceuticals disclosed 55 risk factors in its most recent earnings report. ACADIA Pharmaceuticals reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

ACADIA Pharmaceuticals Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$5.89B30.1819.66%54.51%275.94%
74
Outperform
$6.05B8.8097.54%
73
Outperform
$4.06B15.4534.95%12.69%100.80%
57
Neutral
$5.23B-29.96-34.80%2816.21%73.33%
52
Neutral
$5.21B-47.18%-76.96%-425.41%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
41
Neutral
$911.44M-54.17%-157.74%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ACAD
ACADIA Pharmaceuticals
24.02
6.99
41.05%
ARWR
Arrowhead Pharmaceuticals
41.26
22.24
116.93%
PTCT
PTC Therapeutics
75.30
36.07
91.94%
KRYS
Krystal Biotech
206.16
30.52
17.38%
MLTX
MoonLake Immunotherapeutics
12.77
-35.77
-73.69%
ACLX
Arcellx Inc
89.98
1.76
2.00%

ACADIA Pharmaceuticals Corporate Events

ACADIA Pharmaceuticals Q3 2025 Earnings Call Highlights
Nov 7, 2025

ACADIA Pharmaceuticals Inc. recently conducted its third-quarter 2025 earnings call, revealing a strong performance characterized by robust revenue growth and strategic investments. The company reported significant sales increases for its key products, DAYBUE and NUPLAZID, while also advancing its pipeline. However, challenges such as DAYBUE’s market penetration and increased R&D expenses were also highlighted.

Acadia Pharmaceuticals Reports Strong Q3 2025 Growth
Nov 6, 2025

Acadia Pharmaceuticals Inc. is a biotechnology company focused on developing innovative treatments for neurological and rare diseases, with a portfolio that includes FDA-approved therapies for Parkinson’s disease psychosis and Rett syndrome.

ACADIA Pharmaceuticals Advances Alzheimer’s Disease Psychosis Study with ACP-204
Oct 29, 2025

Study Overview: ACADIA Pharmaceuticals Inc. is conducting a clinical study titled ‘A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer’s Disease Psychosis.’ The study aims to evaluate the efficacy and safety of ACP-204, a treatment for Alzheimer’s Disease Psychosis (ADP), through three independent substudies. This research is significant as it addresses a critical need for effective treatments in ADP.

ACADIA Pharmaceuticals Advances Alzheimer’s Disease Psychosis Study with ACP-204
Oct 27, 2025

Study Overview: ACADIA Pharmaceuticals Inc. is conducting a clinical study titled ‘A Master Protocol for Three Independent, Seamlessly Enrolling, Double-blind, Placebo-controlled Efficacy and Safety Studies of ACP-204 in Adults With Alzheimer’s Disease Psychosis.’ The study aims to evaluate the efficacy and safety of ACP-204, a treatment for Alzheimer’s Disease Psychosis (ADP), through three independent substudies. This research is significant as it addresses a critical need for effective treatments in ADP.

ACADIA Pharmaceuticals Advances Phase 2 Study of ACP-204 for Lewy Body Dementia Psychosis
Oct 27, 2025

Study Overview: ACADIA Pharmaceuticals Inc. is conducting a Phase 2 clinical study titled ‘A Double-Blind, Placebo-Controlled, Phase 2, Efficacy and Safety Study of ACP-204 in Adults With Lewy Body Dementia Psychosis (LBDP).’ The study aims to evaluate the efficacy and safety of ACP-204 in treating psychosis associated with Lewy Body Dementia, a significant condition affecting cognitive and motor functions in adults.

ACADIA’s ACP-204 Study: A Promising Step for Alzheimer’s Disease Psychosis Treatment
Oct 27, 2025

ACADIA Pharmaceuticals Inc. is conducting a 52-week open-label extension study titled ‘ACP-204 in Adults With Alzheimer’s Disease Psychosis.’ The study aims to assess the long-term safety and tolerability of ACP-204, a promising treatment for Alzheimer’s Disease Psychosis (ADP). This research holds significant potential for improving the quality of life for individuals affected by ADP.

ACADIA Pharmaceuticals Advances Phase 3 Study for Lewy Body Dementia Psychosis Treatment
Oct 27, 2025

ACADIA Pharmaceuticals Inc. is conducting a Phase 3, Open-Label Extension Study titled ’52-Week, Phase 3, Open-Label Extension Study of ACP-204 in Adults With Lewy Body Dementia Psychosis (LBDP)’. The study aims to evaluate the long-term safety and efficacy of ACP-204, a drug intended to treat psychosis in adults with Lewy Body Dementia. This study is significant as it addresses a critical need for effective treatments in this patient population.

ACADIA Pharmaceuticals Reports Strong Q2 2025 Earnings
Aug 8, 2025

ACADIA Pharmaceuticals Inc. recently held its earnings call, revealing a positive sentiment driven by strong revenue growth and strategic initiatives. The company showcased impressive sales figures for its key products, DAYBUE and NUPLAZID, and highlighted successful direct-to-consumer campaigns. Despite concerns regarding increased SG&A expenses and risks associated with pipeline development, the overall outlook remains optimistic.

Acadia Pharmaceuticals Reports Strong Q2 2025 Growth
Aug 7, 2025

Acadia Pharmaceuticals Inc. is a biopharmaceutical company focused on developing and commercializing innovative medicines for neurological and rare diseases. The company is known for its FDA-approved treatments for Parkinson’s disease psychosis and Rett syndrome.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025