Record Annual Revenue Exceeding $1 Billion
Adjusted 2025 total revenues reached $1.08 billion, a 14% increase year-over-year; Q4 adjusted total revenues were $298 million, up 16% YoY — first time company annual revenues exceeded $1 billion.
NUPLAZID Strong Sales and Volume Growth
Adjusted NUPLAZID net sales were $189 million in Q4 (up 17% YoY) and $692 million for the full year (up 15% YoY); volume growth of 13% in Q4 and 9% for the full year; new prescriptions grew 18% YoY in Q4.
NUPLAZID 2026 Guidance and Long-Term Outlook
2026 NUPLAZID net sales guidance of $760–$790 million (10%–14% growth vs. 2025 adjusted); management reiterates path to approximately $1 billion annual sales by 2028.
DAYBUE Growth and New Formulation Launch
DAYBUE net product sales were $110 million in Q4 (up 13% YoY) and $391 million for 2025 (up 12% YoY); Q4 volume up 12%. FDA-approved DAYBUE STIX (powder for oral solution) approved Dec 2025, early commercial interest reported; management estimates >400 incremental patients addressable over 2–3 years.
International Expansion for DAYBUE
Named patient supply programs expanding ex-U.S.; DAYBUE liquid approved in three markets including recent approval in Israel, supporting global access outside EU approval pathway.
R&D Pipeline Momentum and Key Catalysts
Four unique molecules with combined peak sales potential of ~$11 billion; remlifanserin ~ $4 billion potential across ADP and LBDP; Phase II readout for remlifanserin expected Aug–Oct 2026; Phase III trofinetide study initiated in Japan with readout expected Q4 2026–Q1 2027; plan to initiate 5 additional Phase II/III studies by end of 2027; ACP-271 first-in-human expected before end of Q1 2026.
Solid Financial Position and One-Time Tax Benefit
Cash balance of $820 million at year-end 2025 and a one-time noncash income tax benefit of approximately $250 million related to releasing the valuation allowance on deferred tax assets.
2026 Financial Guidance
Company guides to total revenues of $1.22–$1.28 billion for fiscal 2026; DAYBUE guidance of $460–$490 million (18%–25% growth vs. 2025) driven by STIX and named patient supply; R&D expense guidance $385–$410 million; SG&A guidance $660–$700 million.
Commercial Execution and Field Expansion
NUPLAZID customer-facing team expanded ~30% (deployed by January 2026) increasing prescriber target universe from ~7,000 to ~11,000 writers; DAYBUE community expansion showed 76% of new prescriptions from community-based physicians in Q4; DAYBUE shipments reached a record 1,070 patients in Q4.