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OZEM - ETF AI Analysis

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OZEM

Roundhill GLP-1 & Weight Loss ETF (OZEM)

Rating:61Neutral
Price Target:
OZEM, the Roundhill GLP-1 & Weight Loss ETF, has a solid overall rating driven mainly by large, established drug makers like Eli Lilly, Novo Nordisk, AstraZeneca, Amgen, Pfizer, and Roche, which benefit from strong financial performance, important product pipelines, and generally positive earnings outlooks. Early-stage and less profitable biotech names such as Viking Therapeutics and Ascletis Pharma add growth potential but also introduce risk due to losses, cash burn, and valuation concerns, and the fund’s focus on a single theme in the weight-loss and GLP-1 space means performance is heavily tied to this one sector of the healthcare market.
Positive Factors
Strong Recent Performance
The ETF has shown strong gains over the last three months and solid year-to-date results, indicating positive recent momentum.
Leading GLP-1 Drug Makers at the Top
Large positions in major GLP-1 and weight-loss drug companies like Novo Nordisk and Eli Lilly, which have generally performed well, help drive the fund’s returns.
Focused Yet Globally Spread Portfolio
While the fund is heavily focused on health care, it still spreads its holdings across several countries, reducing reliance on any single market.
Negative Factors
High Concentration in a Few Stocks
A significant portion of the portfolio is tied up in just a couple of large holdings, which increases the impact if those companies stumble.
Single-Sector Risk
With almost all assets in health care, the ETF is highly exposed to sector-specific risks like regulatory changes or negative drug news.
Above-Average Expense Ratio
The fund’s expense ratio is relatively high for an ETF, which means more of the returns are eaten up by fees over time.

OZEM vs. SPDR S&P 500 ETF (SPY)

OZEM Summary

The Roundhill GLP-1 & Weight Loss ETF (OZEM) is a health care fund focused on companies working on weight-loss drugs and treatments for obesity and related conditions. It doesn’t track a traditional index, but instead targets drugmakers and biotech firms leading this theme, including well-known names like Novo Nordisk and Eli Lilly. Someone might invest in OZEM if they believe new weight-loss medicines will keep growing in demand and want a simple way to spread their money across several companies in this space. A key risk is that it’s heavily concentrated in health care and can rise or fall sharply with news about drug trials, regulations, or pricing.
How much will it cost me?The Roundhill GLP-1 & Weight Loss ETF (OZEM) has an expense ratio of 0.59%, meaning you’ll pay $5.90 per year for every $1,000 invested. This is higher than average because it is actively managed, focusing on a niche sector like pharmaceuticals and biotechnology, which requires more research and specialized management.
What would affect this ETF?The Roundhill GLP-1 & Weight Loss ETF could benefit from growing global demand for innovative health solutions, particularly in obesity and metabolic disorder treatments, as well as advancements in biotechnology and pharmaceuticals led by top holdings like Novo Nordisk and Eli Lilly. However, potential risks include regulatory hurdles, competition in the weight management sector, and broader economic challenges that may impact healthcare spending or innovation funding. Global exposure also means the ETF could be affected by geopolitical events or currency fluctuations.

OZEM Top 10 Holdings

OZEM is heavily tilted toward a handful of GLP-1 powerhouses, with Eli Lilly and Novo Nordisk sitting in the driver’s seat—but both have been losing steam lately, which can weigh on the fund. Pfizer and Amgen provide steadier, more traditional pharma ballast, with recent performance leaning modestly positive. On the riskier side, Viking Therapeutics and Ascletis act like turbochargers: their momentum has been mixed but can swing the ETF sharply. Overall, this is a health care–centric, globally diversified bet on obesity and weight-loss therapies.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Eli Lilly & Co16.03%$8.08M$869.02B12.41%
72
Outperform
Novo Nordisk13.28%$6.69M$158.82B-45.98%
73
Outperform
Pfizer7.57%$3.82M$159.67B13.68%
74
Outperform
Viking Therapeutics5.68%$2.86M$3.76B26.71%
53
Neutral
Innovent Biologics4.88%$2.46MHK$147.32B78.63%
61
Neutral
Ascletis Pharma, Inc.4.67%$2.36MHK$17.66B92.82%
54
Neutral
Amgen4.04%$2.03M$189.67B15.10%
77
Outperform
Roche Holding AG4.03%$2.03M$315.49B12.61%
73
Outperform
3.59%$1.81M
AstraZeneca3.57%$1.80M$301.53B29.24%
80
Outperform

OZEM Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price
Price Trends
50DMA
33.61
Negative
100DMA
33.41
Negative
200DMA
29.75
Positive
Market Momentum
MACD
-0.91
Negative
RSI
44.34
Neutral
STOCH
49.38
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For OZEM, the sentiment is Neutral. The current price of undefined is equal to the 20-day moving average (MA) of 31.17, equal to the 50-day MA of 33.61, and equal to the 200-day MA of 29.75, indicating a neutral trend. The MACD of -0.91 indicates Negative momentum. The RSI at 44.34 is Neutral, neither overbought nor oversold. The STOCH value of 49.38 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for OZEM.

OZEM Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$50.36M0.59%
61
Neutral
$56.54M0.50%
60
Neutral
$49.96M0.75%
69
Neutral
$25.68M0.80%
62
Neutral
$20.66M0.75%
70
Neutral
$19.20M1.00%
45
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
OZEM
Roundhill GLP-1 & Weight Loss ETF
31.90
9.03
39.48%
FMED
Fidelity Disruptive Medicine ETF
HRTS
Tema Cardiovascular and Metabolic ETF
MEDI
Harbor Health Care ETF
GDOC
Goldman Sachs Future Health Care Equity ETF
PSIL
AdvisorShares Psychedelics ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
DisclaimerThis AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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