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Chugai Pharmaceutical Co Ltd (JP:4519)
:4519
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Chugai Pharmaceutical Co (4519) AI Stock Analysis

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JP:4519

Chugai Pharmaceutical Co

(4519)

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Outperform 80 (OpenAI - 4o)
Rating:80Outperform
Price Target:
¥9,035.00
▲(7.89% Upside)
Chugai Pharmaceutical Co's strong financial performance and positive earnings call sentiment are the primary drivers of its solid stock score. While technical indicators suggest potential overbought conditions, the company's robust financial health and strategic initiatives provide a positive outlook. The high P/E ratio indicates potential overvaluation, which slightly tempers the overall score.
Positive Factors
Strong Cash Flow Management
The company's ability to efficiently convert net income into cash and maintain high free cash flow relative to profits ensures financial flexibility and supports future investments.
Successful R&D Milestones
Successful R&D milestones indicate a strong pipeline and potential for future revenue growth, enhancing Chugai's competitive position in the pharmaceutical industry.
Low Leverage Risk
Low leverage reduces financial risk and increases the company's ability to invest in growth opportunities without the burden of high-interest obligations.
Negative Factors
Decline in Revenue Growth
A decline in revenue growth suggests potential challenges in maintaining market share or product competitiveness, which could impact long-term financial performance.
Impact of NHI Drug Price Revisions
Price revisions and generic competition in domestic markets can pressure margins and reduce revenue, challenging Chugai's profitability in its home market.
Discontinuation of Projects
Project discontinuations may indicate resource allocation challenges and could slow innovation, potentially impacting the company's long-term growth prospects.

Chugai Pharmaceutical Co (4519) vs. iShares MSCI Japan ETF (EWJ)

Chugai Pharmaceutical Co Business Overview & Revenue Model

Company DescriptionChugai Pharmaceutical Co., Ltd., together with its subsidiaries, engages in the research, development, manufacturing, sale, importation, and exportation of pharmaceuticals in Japan and internationally. The company's products for oncology primarily include Avastin, Tecentriq, Perjeta, Alecensa, Herceptin, Kadcyla, Rituxan, Gazyva, and Xeloda; osteoporosis, including Actemra, Edirol, and Bonviva; renal diseases consist of Mircera and Oxarol; and neurology/other diseases comprise Hemlibra, CellCept, and Enspryng. It has various development product candidates in the areas of oncology, bone and joint diseases, autoimmune diseases, renal diseases, neurology, and other diseases. Chugai Pharmaceutical Co., Ltd. has strategic alliances with Roche Group; and collaboration and joint research with academia. The company was founded in 1925 and is headquartered in Tokyo, Japan. Chugai Pharmaceutical Co., Ltd. is a subsidiary of Roche Holding Ltd.
How the Company Makes MoneyChugai Pharmaceutical generates revenue primarily through the sale of its patented drugs and biologics, which are marketed in Japan and other international markets. The company benefits from a robust pipeline of new therapies that are developed through its extensive research and development efforts. Additionally, Chugai earns income through licensing agreements and collaborations, particularly with Roche, which enhances its research capabilities and expands its reach in global markets. The company's revenue model is largely driven by the success of its innovative medicines, alongside strategic partnerships that contribute to its financial performance.

Chugai Pharmaceutical Co Earnings Call Summary

Earnings Call Date:Jul 24, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Jan 29, 2026
Earnings Call Sentiment Neutral
The earnings call presented a balanced view with significant revenue growth and successful R&D milestones on one hand, and challenges such as project discontinuation and potential future tariff impacts on the other.
Q2-2025 Updates
Positive Updates
Increased Revenue and Profit
Revenue increased by 4.6% to JPY 578.5 billion. Operating profit increased by 3.5%, and net income increased by 2.1% compared to the previous year.
Successful R&D Milestones
The global Phase III trial for orforglipron showed success, and new projects such as MINT91 and AUBE00 began Phase I trials.
Strong Sales Performance
Domestic sales increased by 2.8%, and overseas sales increased by 7.3%. Actemra exports were particularly strong.
New Investments
An investment of JPY 80 billion to build a new research building at the Ukima site, focusing on environmentally friendly equipment.
Negative Updates
Impact of NHI Drug Price Revisions
Domestic sales were negatively impacted by NHI drug price revisions and the penetration of generics.
Discontinuation of Projects
Five early-stage in-house projects were discontinued to focus resources on higher priority projects.
Challenges in Export and Tariff Concerns
Delays in Hemlibra exports and potential future impact from U.S. tariffs on pharmaceuticals.
Increased Cost of Sales
Cost of sales increased by 9.4%, with a rise in the cost-to-sales ratio due to higher composition costs for Actemra.
Company Guidance
During the call, the company provided detailed guidance and updates on its financial performance and strategic initiatives for the second quarter of fiscal year 2025. Revenue increased by 4.6% compared to the previous year, reaching JPY 578.5 billion, with operating profit up by 3.5% at JPY 272 billion. Net income also saw a rise of 2.1%. The growth was primarily driven by a 5.3% increase in sales, with domestic sales up by 2.8% and overseas sales up by 7.3%. However, domestic sales were negatively impacted by NHI drug price revisions and the penetration of generics, while new products like Phesgo and Vabysmo contributed positively. The company highlighted its R&D progress, including the successful Phase III trial of orforglipron and the initiation of new trials for projects like AUBE00. Additionally, a significant investment of JPY 80 billion was announced for a new research building to enhance manufacturing capabilities. The company also addressed the discontinuation of five early-stage projects to better focus resources on high-priority areas, aiming to achieve the goals set in their TOP I 2030 strategy.

Chugai Pharmaceutical Co Financial Statement Overview

Summary
Chugai Pharmaceutical Co exhibits strong financial health with robust profitability, low leverage, and effective cash flow management. While revenue growth has slowed, the company's strong margins and financial stability position it well for future growth opportunities.
Income Statement
85
Very Positive
Chugai Pharmaceutical Co shows strong profitability with a consistent gross profit margin around 71% in TTM, indicating efficient cost management. The net profit margin is robust at 33.56%, reflecting effective control over expenses. However, the revenue growth rate has declined by 2.12% in TTM, suggesting a need for growth strategies. EBIT and EBITDA margins are healthy, indicating strong operational performance.
Balance Sheet
88
Very Positive
The company maintains a very low debt-to-equity ratio of 0.0069 in TTM, highlighting financial stability and low leverage risk. Return on equity is strong at 22.29%, showcasing effective use of equity to generate profits. The equity ratio is solid, indicating a strong capital structure with a significant portion of assets financed by equity.
Cash Flow
82
Very Positive
Chugai Pharmaceutical Co demonstrates strong cash flow management with a 12.14% growth in free cash flow in TTM. The operating cash flow to net income ratio is nearly 2, indicating efficient conversion of net income into cash. The free cash flow to net income ratio is high at 85.43%, reflecting strong cash generation relative to profits.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.20T1.17T1.11T1.26T999.76B786.95B
Gross Profit841.80B830.75B693.01B783.06B660.27B511.77B
EBITDA558.97B574.80B475.64B562.66B450.30B328.72B
Net Income395.49B387.32B325.47B374.43B303.00B214.73B
Balance Sheet
Total Assets2.28T2.21T1.93T1.87T1.54T1.24T
Cash, Cash Equivalents and Short-Term Investments1.03T996.35B738.98B503.11B471.97B378.62B
Total Debt13.20B10.90B13.46B14.11B16.04B11.28B
Total Liabilities293.22B306.87B306.97B445.37B350.68B255.50B
Stockholders Equity1.99T1.90T1.63T1.42T1.19T980.00B
Cash Flow
Free Cash Flow397.33B396.68B335.67B172.87B206.76B143.62B
Operating Cash Flow464.10B447.60B409.93B244.11B279.63B205.03B
Investing Cash Flow-190.68B-227.37B-37.29B-145.99B-118.93B-98.31B
Financing Cash Flow-169.12B-141.01B-139.33B-145.64B-107.41B-99.50B

Chugai Pharmaceutical Co Technical Analysis

Technical Analysis Sentiment
Positive
Last Price8374.00
Price Trends
50DMA
7236.72
Positive
100DMA
7006.54
Positive
200DMA
7122.32
Positive
Market Momentum
MACD
389.45
Negative
RSI
66.49
Neutral
STOCH
79.31
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4519, the sentiment is Positive. The current price of 8374 is above the 20-day moving average (MA) of 7740.75, above the 50-day MA of 7236.72, and above the 200-day MA of 7122.32, indicating a bullish trend. The MACD of 389.45 indicates Negative momentum. The RSI at 66.49 is Neutral, neither overbought nor oversold. The STOCH value of 79.31 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for JP:4519.

Chugai Pharmaceutical Co Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$13.76T34.6720.99%1.15%6.25%2.62%
76
Outperform
¥2.43T13.7412.22%2.54%4.48%11.08%
73
Outperform
¥3.57T28.447.97%4.61%13.24%127.88%
70
Outperform
$6.28T22.4616.66%1.64%12.56%14.58%
66
Neutral
¥7.19T210.090.54%4.63%-2.84%-88.29%
65
Neutral
$1.25T34.174.27%2.24%-3.36%-55.41%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:4519
Chugai Pharmaceutical Co
8,374.00
1,938.02
30.11%
JP:4503
Astellas Pharma
1,969.00
482.08
32.42%
JP:4568
Daiichi Sankyo Company
3,864.00
-791.98
-17.01%
JP:4151
Kyowa Kirin Co
2,630.50
204.46
8.43%
JP:4507
Shionogi & Co
2,680.50
617.46
29.93%
JP:4502
Takeda Pharmaceutical Co
4,506.00
600.66
15.38%

Chugai Pharmaceutical Co Corporate Events

Chugai Pharmaceutical Acquires Renalys Pharma to Expand IgA Nephropathy Treatment
Oct 24, 2025

Chugai Pharmaceutical Co., Ltd. has announced the acquisition of Renalys Pharma, Inc., making it a wholly-owned subsidiary to secure exclusive rights for the development and commercialization of sparsentan in Japan, South Korea, and Taiwan. This strategic move aims to strengthen Chugai’s pipeline in treating IgA nephropathy, a chronic kidney disease, by offering multiple treatment options and addressing unmet medical needs, thereby enhancing its corporate and shareholder value.

The most recent analyst rating on (JP:4519) stock is a Buy with a Yen8050.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Chugai Pharmaceutical Reports Strong Q3 Results and Announces Special Dividend
Oct 24, 2025

Chugai Pharmaceutical Co. reported a 5% increase in revenue for the nine months ending September 30, 2025, with operating profit and net income also seeing modest growth. The company announced a special dividend to mark its 100th anniversary, reflecting strong financial performance and a commitment to rewarding shareholders. The forecast for the full year 2025 remains positive, with expectations of continued revenue and profit growth.

The most recent analyst rating on (JP:4519) stock is a Buy with a Yen8050.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Chugai Pharmaceutical’s Role in Roche’s Q3 2025 Sales Announcement
Oct 23, 2025

Roche announced its third-quarter sales for 2025, which includes the performance of its subsidiary, Chugai Pharmaceutical Co., Ltd. This announcement highlights Chugai’s integral role within the Roche Group, reflecting its impact on the overall financial results and strategic positioning in the pharmaceutical market.

The most recent analyst rating on (JP:4519) stock is a Buy with a Yen8050.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Chugai Partners with Rani Therapeutics for Innovative Oral Biologics
Oct 19, 2025

Chugai Pharmaceutical Co., Ltd. has entered into a collaboration and license agreement with Rani Therapeutics to develop and commercialize an oral formulation using Rani’s RaniPill® technology and Chugai’s rare disease antibody. This partnership aims to transform biologics delivery, traditionally limited to injections, into oral therapies, enhancing patient convenience and adherence. The agreement includes a potential deal value of over $1 billion if all options are exercised, though it is not expected to impact Chugai’s financial forecast for 2025.

The most recent analyst rating on (JP:4519) stock is a Buy with a Yen7879.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Eli Lilly’s Orforglipron Shows Superior Results in Diabetes Trial
Sep 17, 2025

Chugai Pharmaceutical Co., Ltd. announced that Eli Lilly’s Phase 3 clinical trial results for orforglipron, an oral GLP-1 treatment for type 2 diabetes, showed superior efficacy in reducing HbA1c levels and promoting weight loss compared to oral semaglutide. The trial results, which demonstrated significant improvements in glycemic control and weight management, are expected to bolster Eli Lilly’s position in the diabetes treatment market, although they will not impact Chugai’s financial forecast for 2025.

The most recent analyst rating on (JP:4519) stock is a Buy with a Yen7186.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Chugai Announces Positive Phase 3 Results for Eli Lilly’s Orforglipron
Aug 26, 2025

Chugai Pharmaceutical Co., Ltd. announced that Eli Lilly’s investigational oral GLP-1 receptor agonist, orforglipron, showed positive results in the Phase 3 ATTAIN-2 trial for adults with obesity or overweight and type 2 diabetes. The trial demonstrated significant weight loss, HbA1c reduction, and improvements in cardiometabolic risk factors, with a safety profile consistent with existing GLP-1 medicines. This development is not expected to impact Chugai’s financial forecast for the fiscal year ending December 2025.

The most recent analyst rating on (JP:4519) stock is a Hold with a Yen6500.00 price target. To see the full list of analyst forecasts on Chugai Pharmaceutical Co stock, see the JP:4519 Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 13, 2025