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Ascletis Pharma, Inc. (HK:1672)
:1672
Hong Kong Market

Ascletis Pharma, Inc. (1672) AI Stock Analysis

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HK:1672

Ascletis Pharma, Inc.

(1672)

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Neutral 54 (OpenAI - 4o)
Rating:54Neutral
Price Target:
HK$17.00
▲(37.88% Upside)
Ascletis Pharma's stock score is primarily influenced by its strong technical momentum, despite financial challenges and a difficult valuation. The company's robust balance sheet offers some stability, but ongoing losses and negative cash flow are significant concerns.
Positive Factors
Strong Balance Sheet
A strong balance sheet with substantial equity and low debt levels provides financial stability, allowing the company to weather operational challenges and invest in growth opportunities.
Cash Reserves
Robust cash reserves offer a cushion against ongoing losses, enabling continued investment in R&D and strategic initiatives without immediate liquidity concerns.
Strategic Partnerships
Strategic partnerships can enhance revenue through milestone payments and royalties, supporting long-term growth and diversification of revenue streams.
Negative Factors
Negative Cash Flow
Persistent negative cash flow indicates challenges in achieving self-sustaining operations, risking future liquidity and operational flexibility if not addressed.
Profitability Challenges
Ongoing profitability issues highlight operational inefficiencies and financial struggles, potentially limiting reinvestment capabilities and long-term viability.
Revenue Decline
Inconsistent revenue growth undermines financial stability and can hinder the company's ability to invest in R&D and expand its market presence.

Ascletis Pharma, Inc. (1672) vs. iShares MSCI Hong Kong ETF (EWH)

Ascletis Pharma, Inc. Business Overview & Revenue Model

Company DescriptionAscletis Pharma Inc., a biotechnology company, engages in the research and development, manufacture, marketing, and sale of pharmaceutical products in Mainland China and internationally. The company offers Ritonavir oral tablet, a pharmacokinetic booster of various oral antiviral drugs targeting viral proteases and a component of the approved oral antiviral drug Paxlovid; ASCLEVIR and GANOVO for the treatment of Hepatitis C virus. It is also developing ASC22 for treating chronic hepatitis B (CHB) and human immunodeficiency virus functional cure; ASC42 for chronic hepatitis B functional cure; ASC10 and ASC11 to treat COVID-19; ASC40, ASC41, ASC42, ASC43F FDC, ASC44F FDC, and ASC45F FDC for non-alcoholic steatohepatitis; and ASC42 for the treatment of primary biliary cholangitis. In addition, the company is developing ASC40 to treat recurrent glioblastoma, drug resistant breast cancer, and KRAS mutant non-small cell lung cancer; ASC61 and ASC63 for advanced solid tumors; ASC60 to treat solid tumors; and ASC40 for the treatment of acne, Ascletis Pharma Inc. was founded in 2013 and is headquartered in Hangzhou, the People's Republic of China.
How the Company Makes MoneyAscletis Pharma generates revenue through multiple streams, primarily from the commercialization of its proprietary drug products, including antiviral treatments for hepatitis and cancer therapies. The company also engages in strategic partnerships and collaborations with other pharmaceutical firms, which can provide upfront payments, milestone payments, and royalties based on sales of co-developed products. Additionally, Ascletis may receive funding through grants or investments aimed at supporting its research and development initiatives. These revenue streams are critical for funding ongoing clinical trials and expanding the company’s product pipeline.

Ascletis Pharma, Inc. Financial Statement Overview

Summary
Ascletis Pharma faces significant financial challenges, with sustained losses impacting its income statement and cash flow. However, the company benefits from a strong balance sheet with substantial equity and cash reserves. The biotechnology industry is characterized by high R&D costs, which can lead to initial losses, but the company needs to focus on improving its operational efficiency and revenue growth to achieve long-term sustainability.
Income Statement
Ascletis Pharma's income statement reveals significant challenges in terms of profitability. The company has a negative net profit margin and EBIT margin, indicating ongoing operational and financial struggles. Despite an increase in total revenue in 2024, the company continues to incur substantial losses, and the revenue growth has been inconsistent over the years. The biotechnology industry often requires high R&D investments, which could explain the persistent negative earnings, but it poses a risk if this trend continues.
Balance Sheet
The balance sheet of Ascletis Pharma shows a strong equity base, with a high equity ratio indicating stability. The company has maintained a low level of debt relative to equity, which is a positive sign of financial prudence. However, the persistent net losses have not yet impacted the equity base severely. The company's large cash reserves provide a buffer against operational losses, though continued losses could eventually erode this financial cushion.
Cash Flow
The cash flow statements highlight a concerning lack of positive cash flow generation. Ascletis Pharma has struggled to generate operating cash flow, and free cash flow remains negative, indicating the company's difficulty in achieving self-sustaining operations. While cash reserves remain robust, the lack of cash flow from core operations suggests potential liquidity issues if the trend continues without improvements in operational efficiency or revenue generation.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.36M1.28M56.60M54.09M76.88M35.00M
Gross Profit856.00K735.00K25.99M-24.69M39.17M-23.50M
EBITDA-408.21M-390.45M-126.09M-284.50M-169.35M-181.94M
Net Income-258.57M-300.94M-144.72M-314.84M-199.02M-209.24M
Balance Sheet
Total Assets2.00B2.12B2.49B2.66B2.83B3.07B
Cash, Cash Equivalents and Short-Term Investments1.80B1.95B2.30B2.48B2.50B2.71B
Total Debt4.27M7.63M8.42M4.24M2.75M1.59M
Total Liabilities129.00M158.41M148.94M117.16M100.89M85.42M
Stockholders Equity1.87B1.97B2.34B2.54B2.73B2.98B
Cash Flow
Free Cash Flow-313.25M-343.73M-163.32M-156.85M-154.13M-123.87M
Operating Cash Flow-311.15M-341.58M-144.16M-142.45M-146.93M-84.91M
Investing Cash Flow1.62B978.91M149.84M-1.30B-274.49M132.30M
Financing Cash Flow-72.54M-103.51M-81.50M-1.42M-31.10M-21.67M

Ascletis Pharma, Inc. Technical Analysis

Technical Analysis Sentiment
Positive
Last Price12.33
Price Trends
50DMA
12.52
Positive
100DMA
12.25
Positive
200DMA
10.34
Positive
Market Momentum
MACD
-0.28
Positive
RSI
48.93
Neutral
STOCH
71.71
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:1672, the sentiment is Positive. The current price of 12.33 is below the 20-day moving average (MA) of 13.02, below the 50-day MA of 12.52, and above the 200-day MA of 10.34, indicating a neutral trend. The MACD of -0.28 indicates Positive momentum. The RSI at 48.93 is Neutral, neither overbought nor oversold. The STOCH value of 71.71 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for HK:1672.

Ascletis Pharma, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
66
Neutral
HK$34.70B40.3927.37%2.57%18.79%
54
Neutral
HK$12.29B-43.93-12.74%-76.58%-4.90%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
HK$9.58B-16.48-42.46%1219.19%25.15%
41
Neutral
HK$1.75B-2.53-129.05%-18.99%
40
Underperform
HK$10.19B-47.78-21.42%240.05%-140.09%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:1672
Ascletis Pharma, Inc.
12.52
9.34
293.71%
HK:2157
Lepu Biopharma Co. Ltd. Class H
5.38
3.11
137.00%
HK:2171
CARsgen Therapeutics Holdings Ltd.
16.38
6.78
70.63%
HK:2179
Jiangsu Recbio Technology Co., Ltd. Class H
3.72
-4.55
-55.02%
HK:2696
Shanghai Henlius Biotech, Inc. Class H
66.15
43.65
194.00%
HK:6955
Shandong Boan Biotechnology Company., Limited. Class H
8.87
0.18
2.07%

Ascletis Pharma, Inc. Corporate Events

Ascletis Pharma Upsizes Share Repurchase to HK$500 Million Amid Drug Development Success
Dec 16, 2025

Ascletis Pharma Inc. has announced an increase in its share repurchase program from HK$300 million to HK$500 million, citing the undervaluation of its stock and significant recent achievements in drug development. The company aims to enhance shareholder value and demonstrate confidence in its long-term growth prospects, with the repurchase funded by internal resources and conducted in compliance with relevant regulations.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$17.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Reports Positive Phase I Results for ASC50
Dec 15, 2025

Ascletis Pharma Inc. announced positive topline results from its U.S. Phase I study of ASC50, an oral small molecule IL-17 inhibitor. The study demonstrated that ASC50 is safe, well-tolerated, and exhibits a dose-proportional pharmacokinetic profile, supporting once-daily or potentially once-weekly dosing. The drug showed strong target engagement and is progressing to the next phase of clinical development for treating mild to moderate plaque psoriasis. These findings highlight ASC50’s potential as a best-in-class treatment option, leveraging Ascletis’s AI-assisted drug discovery technology.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$17.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma’s Acne Treatment Drug Application Accepted by China NMPA
Dec 10, 2025

Ascletis Pharma Inc. announced that the China National Medical Products Administration has accepted its New Drug Application for denifanstat (ASC40), a first-in-class fatty acid synthase inhibitor for treating moderate-to-severe acne vulgaris. This acceptance marks a significant milestone for Ascletis as it moves closer to commercializing denifanstat, which has shown promising results in Phase III trials, demonstrating significant efficacy and a favorable safety profile.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$14.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma’s ASC30 Shows Promising Results in Obesity Treatment Study
Dec 8, 2025

Ascletis Pharma Inc. announced positive results from its 13-week Phase II study of ASC30, an oral GLP-1 receptor agonist for obesity treatment. The study demonstrated significant weight loss and improved gastrointestinal tolerability compared to placebo, with no severe adverse events reported. These findings suggest a potential best-in-class profile for ASC30, positioning Ascletis favorably in the obesity treatment market as they plan to advance to Phase III trials.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$14.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Advances ASC37 for Obesity Treatment
Nov 30, 2025

Ascletis Pharma Inc. has announced the selection of its first oral GLP-1R/GIPR/GCGR triple peptide agonist, ASC37, for clinical development. This drug candidate, developed using Ascletis’ proprietary technologies, has shown significantly higher bioavailability and potency compared to existing formulations in non-human primate studies. The company plans to submit an Investigational New Drug Application to the U.S. FDA in 2026, marking a significant step in addressing unmet needs in obesity treatment and strengthening Ascletis’ position in the pharmaceutical industry.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$14.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Advances Obesity Treatment with New Co-Formulation
Nov 12, 2025

Ascletis Pharma Inc. has announced the co-formulation of ASC36, an amylin receptor agonist, and ASC35, a GLP-1R/GIPR dual agonist, both designed for once-monthly subcutaneous administration. The co-formulation demonstrated significant body weight reduction in preclinical studies and showed excellent stability, supporting its potential as a treatment for obesity. Ascletis plans to submit an Investigational New Drug Application to the FDA by the second quarter of 2026, marking a significant step in its clinical development pipeline.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$11.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Unveils Promising Obesity Treatment Results at ObesityWeek 2025
Nov 5, 2025

Ascletis Pharma Inc. announced promising results from its Phase Ib studies of ASC30, both as an oral tablet and a subcutaneous injection, along with a preclinical study of a combination therapy involving ASC31 and ASC47. The oral tablet showed up to a 6.5% placebo-adjusted mean body weight reduction, with mild-to-moderate gastrointestinal adverse events, while the injection demonstrated an extended half-life supporting monthly and quarterly dosing schedules. These findings highlight the efficacy and safety of Ascletis’ obesity treatments and reinforce the company’s competitive positioning in the obesity drug market.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$12.84 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Advances ASC36 for Obesity Treatment
Oct 30, 2025

Ascletis Pharma Inc. has announced the selection of ASC36, a once-monthly subcutaneously administered amylin receptor agonist, for clinical development targeting obesity. The preclinical studies indicate that ASC36 offers a significantly longer half-life and greater weight reduction compared to existing treatments, positioning it as a potentially best-in-class therapy. The company plans to submit an Investigational New Drug Application to the FDA by the second quarter of 2026, which could enhance its market positioning in the obesity treatment sector.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$12.84 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma to Showcase Obesity Treatment Advances at ObesityWeek 2025
Oct 27, 2025

Ascletis Pharma Inc. announced it will present study results of its obesity treatment assets, including ASC30, ASC31, and ASC47, at ObesityWeek 2025 in Atlanta. These presentations highlight the company’s commitment to developing differentiated obesity treatments, with ASC30 being a new chemical entity with patent protection until 2044, and ASC31 and ASC47 showing promising results in preclinical studies.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.50 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Completes Enrollment for Phase IIa Study of ASC30 for Obesity
Oct 20, 2025

Ascletis Pharma Inc. has completed enrollment for a U.S. Phase IIa study of its once-monthly subcutaneous depot formulation of the small molecule GLP-1 receptor agonist ASC30, aimed at treating obesity. This milestone marks significant progress in the development of ASC30, which has demonstrated a 46-day half-life, supporting its potential as a once-monthly treatment option. Topline data from this study are expected in the first quarter of 2026, potentially impacting the company’s market positioning in obesity treatment.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.50 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Advances Acne Treatment with Pre-NDA Completion
Oct 14, 2025

Ascletis Pharma Inc. has completed a pre-New Drug Application consultation with the China National Medical Products Administration for its drug denifanstat (ASC40), aimed at treating moderate-to-severe acne vulgaris. The drug has shown significant efficacy and a favorable safety profile in Phase III trials, with no severe adverse events reported. Ascletis plans to submit an NDA soon, which could enhance its market position in dermatological treatments in Greater China.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.50 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Advances ASC35 for Obesity Treatment
Oct 13, 2025

Ascletis Pharma Inc. has announced the selection of ASC35, a once-monthly subcutaneously administered GLP-1R/GIPR dual peptide agonist, for clinical development. ASC35 has shown promising results in preclinical studies, demonstrating a longer half-life and greater efficacy in weight reduction compared to tirzepatide, positioning it as a potentially best-in-class treatment for obesity. The company plans to submit an Investigational New Drug Application for ASC35 to the FDA by the second quarter of 2026, which could significantly impact its market positioning and offer scalability advantages in manufacturing.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.50 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Announces Share Repurchase Plan to Enhance Shareholder Value
Oct 2, 2025

Ascletis Pharma Inc. has announced its intention to repurchase up to 96,284,628 shares, equivalent to 10% of its issued shares, under a repurchase mandate approved by shareholders. The company plans to use up to HK$300 million of its internal financial resources for this initiative, aiming to enhance shareholder value and reflect confidence in its long-term business prospects. The repurchase will be conducted in compliance with relevant regulations and will not adversely impact the company’s financial position.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Ascletis Pharma Grants 650,000 Share Options to Employees
Sep 30, 2025

Ascletis Pharma Inc. has announced the grant of 650,000 share options to 10 employee participants under its 2025 Share Option Scheme. This move is part of the company’s strategy to incentivize its workforce, with options exercisable over a period of five years starting from 2026. The grant aims to align employee interests with company performance, although no specific performance targets are required for the options to vest. The announcement reflects Ascletis Pharma’s commitment to employee engagement and retention, potentially strengthening its position in the competitive pharmaceutical industry.

The most recent analyst rating on (HK:1672) stock is a Hold with a HK$10.00 price target. To see the full list of analyst forecasts on Ascletis Pharma, Inc. stock, see the HK:1672 Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 10, 2025