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Lepu Biopharma Co. Ltd. Class H (HK:2157)
:2157
Hong Kong Market
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Lepu Biopharma Co. Ltd. Class H (2157) AI Stock Analysis

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HK:2157

Lepu Biopharma Co. Ltd. Class H

(2157)

Rating:57Neutral
Price Target:
HK$8.50
▲(2.16% Upside)
The overall stock score of 57 reflects significant financial challenges faced by Lepu Biopharma Co. Ltd., including negative profitability and high leverage. However, strong technical indicators suggest positive market momentum, which partially offsets the financial risks. Valuation concerns due to negative earnings further weigh on the score, but the technical strength is a key highlight.

Lepu Biopharma Co. Ltd. Class H (2157) vs. iShares MSCI Hong Kong ETF (EWH)

Lepu Biopharma Co. Ltd. Class H Business Overview & Revenue Model

Company DescriptionLepu Biopharma Co. Ltd. Class H (2157) is a biopharmaceutical company focused on the research, development, and commercialization of innovative oncology drugs. The company operates primarily in the biotechnology and pharmaceutical sectors, aiming to deliver high-quality healthcare solutions to address unmet medical needs in cancer treatment. Its product portfolio includes a range of targeted therapies and biological medicines designed to improve patient outcomes.
How the Company Makes MoneyLepu Biopharma Co. Ltd. generates revenue through the development and sale of its oncology drugs. The company's primary revenue streams include sales of its proprietary pharmaceutical products, licensing agreements, and collaborations with other pharmaceutical companies for joint development and commercialization of treatments. Additionally, Lepu Biopharma may receive milestone payments and royalties from partners as part of its strategic partnerships. By focusing on innovative and effective cancer therapies, the company seeks to capture a significant share of the growing market for oncology treatments.

Lepu Biopharma Co. Ltd. Class H Financial Statement Overview

Summary
Lepu Biopharma Co. Ltd. faces substantial financial challenges. Despite revenue growth, the company struggles with profitability, high leverage, and negative cash flows, indicating significant operational and financial risks.
Income Statement
30
Negative
The company has shown growth in total revenue from 2022 to 2024, with a significant increase in 2024. However, profitability remains a challenge with consistently negative net income, leading to negative net profit margins. The gross profit margin is strong at 79.65% for 2024, but the EBIT and EBITDA margins are negative, pointing to operational inefficiencies.
Balance Sheet
40
Negative
The company's balance sheet reflects a high level of debt with a debt-to-equity ratio of 1.20 in 2024, indicating potential leverage risk. Stockholders' equity has decreased over the years, affecting the equity ratio negatively. The company has sufficient cash reserves, but the decline in equity raises concerns about financial stability.
Cash Flow
25
Negative
Cash flow from operations is consistently negative, and free cash flow has also remained negative, reflecting challenges in generating cash from core activities. This poses a risk to the company's liquidity position, as it may need to rely on external financing for operations.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue367.79M225.35M15.57M0.000.00
Gross Profit292.97M197.07M13.57M0.000.00
EBITDA-311.94M86.95M-596.53M-865.23M-371.01M
Net Income-411.38M-22.10M-689.05M-1.01B-581.85M
Balance Sheet
Total Assets2.28B2.38B2.53B2.08B2.42B
Cash, Cash Equivalents and Short-Term Investments464.91M498.43M669.40M205.17M753.52M
Total Debt850.16M746.82M690.30M335.26M203.08M
Total Liabilities1.60B1.50B1.63B1.23B921.89M
Stockholders Equity702.83M896.90M900.76M836.71M1.47B
Cash Flow
Free Cash Flow-258.14M-292.04M-591.38M-835.12M-724.51M
Operating Cash Flow-196.39M-250.84M-480.93M-621.74M-422.69M
Investing Cash Flow-61.75M18.26M-74.66M-3.89M-749.67M
Financing Cash Flow232.08M-11.01M1.03B380.31M1.39B

Lepu Biopharma Co. Ltd. Class H Technical Analysis

Technical Analysis Sentiment
Positive
Last Price8.32
Price Trends
50DMA
5.99
Positive
100DMA
5.00
Positive
200DMA
3.96
Positive
Market Momentum
MACD
0.81
Negative
RSI
76.56
Negative
STOCH
76.44
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For HK:2157, the sentiment is Positive. The current price of 8.32 is above the 20-day moving average (MA) of 6.98, above the 50-day MA of 5.99, and above the 200-day MA of 3.96, indicating a bullish trend. The MACD of 0.81 indicates Negative momentum. The RSI at 76.56 is Negative, neither overbought nor oversold. The STOCH value of 76.44 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for HK:2157.

Lepu Biopharma Co. Ltd. Class H Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
66
Neutral
HK$10.64B290.364.16%34.39%
57
Neutral
HK$17.75B-51.40%58.75%-1310.16%
55
Neutral
HK$19.54B-18.87%16.35%-49.63%
53
Neutral
HK$11.56B-13.97%-97.81%-117.20%
53
Neutral
HK$12.47B-55.68%-4.33%
51
Neutral
$7.38B0.42-62.86%2.37%15.61%-1.95%
45
Neutral
HK$8.69B-44.39%18989.90%18.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HK:2157
Lepu Biopharma Co. Ltd. Class H
9.55
6.48
211.07%
HK:1672
Ascletis Pharma, Inc.
11.92
11.02
1224.44%
HK:2162
Keymed Biosciences, Inc.
69.60
36.15
108.07%
HK:2171
CARsgen Therapeutics Holdings Ltd.
21.66
17.68
444.22%
HK:2315
Biocytogen Pharmaceuticals (Beijing) Co. Ltd. Class H
26.34
20.15
325.53%
HK:1541
ImmuneOnco Biopharmaceuticals (Shanghai) Inc Class H
11.16
0.22
2.01%

Lepu Biopharma Co. Ltd. Class H Corporate Events

Lepu Biopharma Reports First-Ever Profit Amid Revenue Surge
Aug 6, 2025

Lepu Biopharma Co., Ltd. announced a positive profit alert, expecting a profit of not less than RMB24 million for the first half of 2025, marking a significant turnaround from a loss of approximately RMB197.0 million in the same period of 2024. This improvement is attributed to substantial revenue growth driven by increased sales of PUYOUHENG and income from a licensing collaboration with ArriVent BioPharma, Inc. The announcement indicates a strong operational performance and potential positive implications for stakeholders, although the results are preliminary and subject to finalization.

Lepu Biopharma Announces Upcoming Board Meeting to Review Interim Results
Aug 6, 2025

Lepu Biopharma Co., Ltd. has announced that its board of directors will hold a meeting on August 20, 2025, to review and approve the interim results for the first half of the year ending June 30, 2025. The board will also consider recommending the payment of an interim dividend and address other business matters. This meeting is significant for stakeholders as it will provide insights into the company’s financial performance and potential dividend payouts, which could impact investor confidence and market positioning.

Lepu Biopharma Enters Licensing Deal with Excalipoint to Expand Global Reach
Aug 1, 2025

Lepu Biopharma Co., Ltd. announced a significant licensing transaction with Excalipoint, granting them exclusive rights to develop and commercialize two pre-clinical assets worldwide. This strategic move is part of Lepu Biopharma’s long-term strategy to globalize its pipeline and technologies, allowing the company to focus on advancing its research priorities and accelerating the commercialization of late-stage products. The deal includes an upfront payment of $10 million, potential milestone payments up to $847.5 million, and sales royalties. Additionally, Excalipoint will conduct a series A financing round, raising $41 million, which complements the licensing transaction and supports the company’s growth strategy.

Lepu Biopharma Completes H Share Full Circulation to Enhance Market Presence
Jul 21, 2025

Lepu Biopharma Co., Ltd. has successfully completed the conversion of 54,268,364 unlisted shares into H shares, marking the completion of its H share full circulation. This strategic move enhances the company’s market presence by increasing the liquidity of its shares, as the converted H shares will be listed on the Stock Exchange starting July 22, 2025. The company’s share capital structure now consists entirely of H shares, which could potentially attract more investors and improve stakeholder confidence.

Lepu Biopharma Completes HK$462.94 Million H Share Placement
Jul 11, 2025

Lepu Biopharma Co. Ltd. has successfully completed the placing of 93,825,000 new H shares, raising approximately HK$462.94 million in net proceeds. The funds will be allocated towards the commercialization and marketing of MRG003, advancing clinical trials of core products, and research and development of new product pipelines. This strategic move increases the company’s total issued shares and strengthens its financial position to enhance its market presence in the oncology sector.

Lepu Biopharma Announces HK$462.94 Million H Share Placement
Jul 4, 2025

Lepu Biopharma Co. Ltd. has announced a placement agreement to issue up to 93,825,000 new H shares at a price of HK$5.02 per share, aiming to raise approximately HK$462.94 million. This strategic move is expected to enhance the company’s capital base and support its growth initiatives, although the completion of the placement is contingent upon certain conditions being met.

Lepu Biopharma Enhances Governance with New Nomination Committee
Jun 27, 2025

Lepu Biopharma Co., Ltd. has established a Nomination Committee under its board of directors to enhance corporate governance by regulating the appointment of directors and senior management. This move aims to optimize the board’s composition and improve governance structures, potentially impacting the company’s operational efficiency and strategic direction.

Lepu Biopharma’s AGM Approves Key Resolutions for 2024
Jun 27, 2025

Lepu Biopharma Co., Ltd. successfully held its 2024 Annual General Meeting (AGM) on June 27, 2025, where all proposed resolutions were approved by shareholders. The resolutions included approval of financial reports, profit distribution plans, and the re-appointment of Ernst & Young as auditors, reflecting strong shareholder support and strategic alignment for the company’s future operations.

Lepu Biopharma Announces Changes to Nomination Committee
Jun 27, 2025

Lepu Biopharma Co., Ltd. announced a change in the composition of its Nomination Committee, with Dr. Pu Zhongjie stepping down and Ms. Pu Jue being appointed as a new member. This change aligns with upcoming amendments to the Listing Rules and Corporate Governance Code, effective July 1, 2025, aimed at enhancing the effectiveness, diversity, and governance practices of the company’s board.

Lepu Biopharma Secures Hong Kong Stock Exchange Listing Approval
Jun 19, 2025

Lepu Biopharma Co., Ltd. has received approval from the Hong Kong Stock Exchange for the listing of 54,268,364 H shares, marking a significant step in its conversion and listing process. This approval allows the company to convert its unlisted shares, held by four main stakeholders, into H shares, which will now represent approximately 3.17% of the company’s total issued shares. This move is expected to enhance the company’s market presence and provide greater liquidity for its shares.

Lepu Biopharma Announces 2024 AGM with Key Resolutions
Jun 6, 2025

Lepu Biopharma Co., Ltd. has announced its 2024 Annual General Meeting (AGM) scheduled for June 27, 2025, in Hong Kong. The meeting will address several key resolutions, including the approval of the 2024 annual report, financial accounts, and profit distribution plan, as well as the re-appointment of Ernst & Young as auditors. The AGM will also consider granting the Board a mandate to issue additional shares, which could impact the company’s strategic initiatives and shareholder value.

Lepu Biopharma Announces Board Changes with New Director Appointment
Jun 6, 2025

Lepu Biopharma Co., Ltd. announced the resignation of Mr. Yang Hongbing from his position as a non-executive director due to personal and professional commitments. The board expressed gratitude for his contributions and proposed the appointment of Ms. Qin Yiran as his successor, pending shareholder approval at the upcoming annual general meeting. Ms. Qin, currently an investment director at Hainan Shiyu Private Equity Management Co., Ltd., brings a strong background in biology and investment management to the role, potentially enhancing the company’s strategic direction.

Lepu Biopharma’s MRG003 Shows Promising Results in Nasopharyngeal Cancer Trial
Jun 1, 2025

Lepu Biopharma Co., Ltd. announced the presentation of pivotal clinical trial results for its drug candidate MRG003 at the 2025 ASCO Annual Meeting. MRG003, an innovative ADC targeting epidermal growth factor receptor, showed significant improvements in objective response rate and progression-free survival compared to chemotherapy in patients with recurrent or metastatic nasopharyngeal cancer. The study suggests a potential paradigm shift in treatment, demonstrating meaningful benefits while maintaining a manageable safety profile.

Lepu Biopharma Advances H Share Circulation with CSRC Filing
May 28, 2025

Lepu Biopharma Co., Ltd. has announced that it received a filing notice from the China Securities Regulatory Commission (CSRC) regarding its application for the full circulation of H shares. This development involves converting 54,268,364 unlisted domestic shares into H shares for listing on the Hong Kong Stock Exchange. While the CSRC filing has been completed, the company must still fulfill additional procedures required by relevant regulatory authorities. The announcement indicates potential changes in the company’s share structure and market presence, advising shareholders and investors to exercise caution.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 24, 2025