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IBRN - ETF AI Analysis

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IBRN

iShares Neuroscience and Healthcare ETF (IBRN)

Rating:55Neutral
Price Target:
IBRN, the iShares Neuroscience and Healthcare ETF, reflects a mix of high-quality leaders and more speculative names, leading to a solid but not top-tier overall rating. Strong holdings like Alkermes, Neurocrine, ACADIA, Biogen, and PTC Therapeutics support the fund with solid financial performance, robust pipelines, and generally positive outlooks, while weaker holdings such as Scholar Rock, Xenon, Praxis, Arrowhead, and Dianthus face financial and profitability challenges that drag on the fund’s quality. The main risk factor is the ETF’s focus on neuroscience and biotech companies, where clinical, regulatory, and financial setbacks can create significant volatility.
Positive Factors
Strong Recent Performance
The ETF has delivered strong gains so far this year, supported by solid returns over the past few months.
Top Holdings Showing Strong Momentum
Several of the largest positions, such as Xenon, Dianthus Therapeutics, and Alkermes, have posted strong year-to-date gains, helping drive the fund’s results.
Global Exposure Within a Focused Theme
While the fund is mainly invested in U.S. companies, it also includes holdings from countries like South Korea, Sweden, and Switzerland, adding some international diversification within the neuroscience and healthcare theme.
Negative Factors
High Sector Concentration in Health Care
With the vast majority of assets in the health care sector, the ETF is heavily exposed to industry-specific risks such as regulatory changes and drug approval setbacks.
Limited Diversification Across Sectors and Countries
The fund’s strong tilt toward U.S. health care stocks means it offers little protection if this sector or region faces a downturn.
Moderately High Expense Ratio
The ETF’s expense ratio is on the higher side for a passive fund, which can modestly reduce net returns over time compared with lower-cost alternatives.

IBRN vs. SPDR S&P 500 ETF (SPY)

IBRN Summary

The iShares Neuroscience and Healthcare ETF (IBRN) tracks the NYSE FactSet Global Neuro Biopharma and MedTech Index, focusing on health care companies working on brain-related drugs, treatments, and medical technology. It mainly holds U.S. biotech and pharma firms, including well-known names like Biogen and Neurocrine, along with other specialized drug developers. Someone might invest in IBRN if they want growth potential from cutting-edge medical research and to bet on rising demand for new neurological therapies. However, this fund is heavily concentrated in health care and biotech, so its price can swing a lot and may rise or fall sharply with news about drug trials and approvals.
How much will it cost me?The iShares Neuroscience and Healthcare ETF (IBRN) has an expense ratio of 0.47%, which means you’ll pay $4.70 per year for every $1,000 invested. This is slightly higher than average because it’s a sector-focused fund that requires more active management to target specific companies in the neuroscience and healthcare fields.
What would affect this ETF?The iShares Neuroscience and Healthcare ETF (IBRN) could benefit from growing global demand for advanced neurological treatments and breakthroughs in biotechnology, as well as increased funding for health care innovation. However, it may face challenges from regulatory hurdles in drug approvals, potential economic slowdowns impacting research budgets, and competition within the pharmaceutical and biotech sectors. Its global exposure and focus on cutting-edge companies provide opportunities but also expose it to risks tied to international market conditions.

IBRN Top 10 Holdings

IBRN is essentially a bet on cutting-edge neuro-focused biotech, with a tightly packed roster of drug developers driving the story. Rising names like Dianthus Therapeutics, Xenon, Arrowhead, Neurocrine, and Argenx are doing most of the heavy lifting, helped by upbeat trial news and solid balance sheets. On the flip side, Praxis, Scholar Rock, PTC Therapeutics, and ACADIA are more mixed or lagging, as financial strains and execution risks weigh on sentiment. With almost all exposure in global health care innovators, this fund lives and dies by biotech breakthroughs.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Praxis Precision Medicines5.45%$426.31K$10.24B679.12%
58
Neutral
Dianthus Therapeutics5.12%$400.26K$6.49B459.11%
61
Neutral
ACADIA Pharmaceuticals4.82%$376.46K$4.87B11.49%
75
Outperform
Xenon4.67%$365.15K$6.04B63.09%
48
Neutral
Scholar Rock Holding4.51%$352.21K$6.40B67.21%
50
Neutral
Arrowhead Pharmaceuticals4.40%$344.16K$12.24B322.43%
57
Neutral
Alkermes4.35%$339.72K$8.23B68.88%
80
Outperform
Biogen4.06%$317.03K$31.00B51.39%
74
Outperform
PTC Therapeutics3.82%$298.32K$5.98B46.87%
72
Outperform
Denali Therapeutics3.71%$289.55K$3.90B65.99%
45
Neutral

IBRN Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
37.44
Positive
100DMA
35.88
Positive
200DMA
33.65
Positive
Market Momentum
MACD
0.47
Negative
RSI
59.13
Neutral
STOCH
73.21
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For IBRN, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 38.03, equal to the 50-day MA of 37.44, and equal to the 200-day MA of 33.65, indicating a bullish trend. The MACD of 0.47 indicates Negative momentum. The RSI at 59.13 is Neutral, neither overbought nor oversold. The STOCH value of 73.21 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for IBRN.

IBRN Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$7.83M0.47%
55
Neutral
$74.12M0.68%
66
Neutral
$64.55M0.59%
54
Neutral
$55.75M0.75%
66
Neutral
$54.36M1.00%
47
Neutral
$48.86M0.50%
58
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
IBRN
iShares Neuroscience and Healthcare ETF
39.64
15.75
65.93%
HTEC
ROBO Global Healthcare Technology and Innovation ETF
OZEM
Roundhill GLP-1 & Weight Loss ETF
HRTS
Tema Cardiovascular and Metabolic ETF
PSIL
AdvisorShares Psychedelics ETF
FMED
Fidelity Disruptive Medicine ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
DisclaimerThis AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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