Market PerformanceAXSM shares have underperformed due to increasing investor nervousness ahead of the data, especially given the company's spotty track record of hitting its data readout timelines.
Product UptakeAntipsychotics, including Rexulti, face lackluster uptake due to class-blackbox warnings, particularly in elderly patients with dementia.
Regulatory ChallengesThe ADVANCE-2 miss makes the regulatory path less certain.