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Legend Biotech Corporation (LEGN)
NASDAQ:LEGN

Legend Biotech (LEGN) AI Stock Analysis

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LEGN

Legend Biotech

(NASDAQ:LEGN)

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Neutral 46 (OpenAI - 4o)
Rating:46Neutral
Price Target:
$23.50
▲(7.21% Upside)
Legend Biotech's strong revenue growth and strategic advancements in CARVYKTI are overshadowed by significant profitability and cash flow challenges. The technical indicators suggest bearish momentum, and the valuation metrics reflect ongoing financial struggles. While the earnings call provides a positive outlook, the company's current financial health remains a concern.
Positive Factors
Revenue Growth
Strong revenue growth from CARVYKTI indicates robust market adoption and potential for sustained financial performance.
Market Position
High patient treatment numbers reinforce CARVYKTI's strong market position and competitive advantage in the CAR-T space.
Regulatory Approval
Regulatory approval for updated survival data enhances CARVYKTI's clinical credibility and marketability, supporting long-term growth.
Negative Factors
Profitability Challenges
Ongoing net losses highlight profitability challenges, potentially impacting financial sustainability and investor confidence.
Cash Flow Issues
Weak cash flow performance indicates potential liquidity constraints, affecting the company's ability to invest and grow.
Neurotoxicity Concerns
Neurotoxicity challenges could hinder CARVYKTI's clinical adoption and necessitate additional R&D investments.

Legend Biotech (LEGN) vs. SPDR S&P 500 ETF (SPY)

Legend Biotech Business Overview & Revenue Model

Company DescriptionLegend Biotech (LEGN) is a clinical-stage biotechnology company focused on the development of innovative cell therapies for the treatment of cancer and other serious diseases. The company operates primarily in the biopharmaceutical sector, leveraging its proprietary technology platform to create chimeric antigen receptor (CAR) T-cell therapies. Its core product is the investigational CAR T-cell therapy, which aims to provide treatment options for patients with hematological malignancies and solid tumors.
How the Company Makes MoneyLegend Biotech generates revenue primarily through the development and commercialization of its CAR T-cell therapies. The company engages in partnerships with larger pharmaceutical firms to facilitate research, development, and commercialization of its products. These collaborations often include upfront payments, milestone payments based on development progress, and royalties on future sales. Additionally, the company may receive funding from government grants or venture capital investments to support its research initiatives. As the company advances its therapies through clinical trials and towards potential regulatory approval, it aims to create significant revenue streams from product sales and licensing agreements.

Legend Biotech Key Performance Indicators (KPIs)

Any
Any
Carvykti Net Trade Sales
Carvykti Net Trade Sales
Reflects the sales performance of Carvykti, a key product, indicating its market acceptance and contribution to the company’s revenue growth.
Chart InsightsCarvykti's net trade sales have surged, reflecting a 136% year-over-year increase, driven by strong CAR-T launch momentum and expanded global market presence. The FDA's removal of certain regulatory barriers enhances patient access, supporting further growth. Despite a net loss due to foreign exchange impacts, operational efficiencies are improving, with a goal of breakeven by year-end 2025. Positive clinical trial results and strategic partnerships, such as with Novartis, bolster future prospects, while challenges in community oncology expansion remain a focus area for Legend Biotech.
Data provided by:The Fly

Legend Biotech Earnings Call Summary

Earnings Call Date:Nov 12, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 18, 2026
Earnings Call Sentiment Positive
The earnings call reflects a largely positive outlook driven by significant sales growth of CARVYKTI, successful international expansion, and advancements in clinical trials and manufacturing capacity. However, challenges like managing neurotoxicity and achieving profitability remain.
Q3-2025 Updates
Positive Updates
Significant Increase in CARVYKTI Sales
CARVYKTI net trade sales were approximately $524 million, marking an 84% increase year-over-year, with a CAGR of 111% since launch.
Record Patient Treatment
Over 9,000 patients have been treated with CARVYKTI, showcasing robust adoption and the strongest CAR-T launch to date.
Expansion in International Markets
Strong sales growth outside the U.S. with an increase of nearly 5x compared to the same period last year, driven by launches in Germany, Spain, and Belgium.
Progress in Manufacturing Capacity
Tech Lane facility initiated commercial production, supporting increased demand in Europe, and expansion at Raritan facility in the U.S. is on track.
Advancements in Clinical Trials
Initiation of CARTITUDE-10 Phase II trial and expected completion of enrollment for CARTITUDE-5 and 6 by year-end, aiming to move CARVYKTI into the frontline setting.
Negative Updates
Challenges with Neurotoxicity
Studies suggest prophylactic dexamethasone does not reduce the risk of delayed neurotoxicity with CARVYKTI, indicating the need for effective bridging therapy to manage high tumor burden.
Profitability Not Yet Achieved
The company reported a $40 million net loss in Q3, with expectations for company-wide profitability by 2026.
Company Guidance
During the third quarter of 2025, Legend Biotech reported significant milestones, including CARVYKTI net trade sales of approximately $524 million, marking an 84% year-over-year increase. The company has treated over 9,000 patients with CARVYKTI, solidifying it as the strongest CAR-T launch to date. In the U.S., 60% of CARVYKTI's utilization is in earlier line settings, contributing to its leadership in the market. Legend Biotech highlighted the importance of treating patients in earlier lines due to improved progression-free survival (PFS) and overall survival (OS) benefits. The FDA approved an update to CARVYKTI’s label to include an OS benefit, based on Phase III CARTITUDE-4 study results. The company is focusing on expanding its manufacturing capacity to meet the growing demand, with plans to reach an annualized manufacturing capacity of 10,000 doses. Legend Biotech expects CARVYKTI to achieve profitability by the end of 2025 and aims for company-wide profitability in 2026, excluding unrealized foreign exchange gains or losses.

Legend Biotech Financial Statement Overview

Summary
Legend Biotech shows strong revenue growth but struggles with profitability and cash flow management. The balance sheet indicates moderate leverage, yet negative return on equity and cash flow issues highlight significant challenges.
Income Statement
45
Neutral
Legend Biotech shows a strong revenue growth rate of 14.06% TTM, indicating positive momentum. However, the company struggles with profitability, as evidenced by negative net profit margins and EBIT margins. The gross profit margin is relatively healthy at 61.77% TTM, but the persistent negative net income highlights ongoing challenges in achieving profitability.
Balance Sheet
50
Neutral
The company's debt-to-equity ratio of 0.37 TTM suggests moderate leverage, which is manageable. However, the return on equity is negative, indicating that the company is not generating sufficient returns on shareholders' equity. The equity ratio is not explicitly provided, but the balance sheet shows a stable equity base relative to assets.
Cash Flow
40
Negative
Legend Biotech's cash flow situation is concerning, with negative operating and free cash flows. The free cash flow growth rate is negative, and the operating cash flow to net income ratio is below 1, indicating cash flow challenges. The free cash flow to net income ratio is slightly above 1, suggesting some efficiency in converting net income to free cash flow, but overall cash flow health remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue908.96M627.24M285.14M117.00M68.83M75.00M
Gross Profit550.40M392.66M140.93M51.64M68.83M75.00M
EBITDA-183.33M-113.16M-477.87M-416.54M-392.38M-298.16M
Net Income-239.70M-177.03M-518.25M-446.35M-403.58M-266.37M
Balance Sheet
Total Assets1.71B1.67B1.85B1.33B1.12B722.09M
Cash, Cash Equivalents and Short-Term Investments992.59M1.12B1.31B1.03B882.39M506.07M
Total Debt410.24M350.60M328.67M284.53M122.97M3.70M
Total Liabilities701.69M629.61M597.24M586.65M353.52M122.27M
Stockholders Equity1.01B1.04B1.25B744.31M765.94M597.77M
Cash Flow
Free Cash Flow-188.68M-158.14M-416.00M-223.56M-243.87M-253.29M
Operating Cash Flow-170.07M-144.03M-393.28M-201.28M-198.47M-223.00M
Investing Cash Flow-16.73M-850.54M92.79M-77.09M-194.98M-24.17M
Financing Cash Flow14.00K5.70M791.49M377.98M626.66M618.88M

Legend Biotech Technical Analysis

Technical Analysis Sentiment
Negative
Last Price21.92
Price Trends
50DMA
28.87
Negative
100DMA
31.81
Negative
200DMA
33.28
Negative
Market Momentum
MACD
-2.17
Positive
RSI
32.17
Neutral
STOCH
22.27
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LEGN, the sentiment is Negative. The current price of 21.92 is below the 20-day moving average (MA) of 24.87, below the 50-day MA of 28.87, and below the 200-day MA of 33.28, indicating a bearish trend. The MACD of -2.17 indicates Positive momentum. The RSI at 32.17 is Neutral, neither overbought nor oversold. The STOCH value of 22.27 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LEGN.

Legend Biotech Risk Analysis

Legend Biotech disclosed 115 risk factors in its most recent earnings report. Legend Biotech reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Legend Biotech Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
62
Neutral
$10.91B-17.31-32.44%106.27%-43.90%
60
Neutral
$9.18B-45.8718.47%
59
Neutral
$7.48B-36.38-240.36%54.92%28.47%
57
Neutral
$7.67B-10.402609.26%-17.08%
57
Neutral
$7.70B-33.10-275.50%65.83%28.50%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$4.05B-17.37-22.60%74.91%31.54%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
LEGN
Legend Biotech
22.69
-11.24
-33.13%
CYTK
Cytokinetics
65.60
16.65
34.01%
AXSM
Axsome Therapeutics
154.70
67.75
77.92%
RYTM
Rhythm Pharmaceuticals
112.88
56.84
101.43%
RNA
Avidity Biosciences
72.20
40.56
128.19%
ABVX
Abivax SA Sponsored ADR
138.72
131.37
1787.35%

Legend Biotech Corporate Events

Legend Biotech Unveils Promising CARVYKTI® Data at ASH 2025
Dec 8, 2025

On December 6, 2025, Legend Biotech announced new data from the CARTITUDE studies at the ASH Annual Meeting, highlighting the long-term benefits of CARVYKTI® in treating relapsed/refractory multiple myeloma. The studies showed significant progression-free survival benefits, especially when used earlier in treatment. Additionally, first-in-human results for LUCAR-G39D in non-Hodgkin lymphoma demonstrated promising safety and efficacy. These findings reinforce Legend Biotech’s position in the cell therapy market and suggest potential improvements in patient outcomes.

Legend Biotech Reports Strong Q3 2025 Results and CARVYKTI® Progress
Nov 12, 2025

On November 12, 2025, Legend Biotech reported its unaudited financial results for the third quarter of 2025, highlighting significant growth in CARVYKTI® sales, with net trade sales reaching approximately $524 million. The company also announced regulatory updates, including FDA and European Commission label updates for CARVYKTI® to reflect its overall survival benefit. Legend Biotech has treated over 9,000 patients to date and initiated commercial production at its Tech Lane facility in Belgium. Financially, the company reported a net loss of $39.7 million for the quarter, a significant improvement from the $125.3 million loss in the same period of 2024. The company holds approximately $1.0 billion in cash and equivalents, providing a financial runway beyond 2026, with expectations of achieving company-wide profitability in 2026.

Legend Biotech to Showcase Key Research at ASH 2025
Nov 3, 2025

On November 3, 2025, Legend Biotech announced its participation in the 67th American Society of Hematology Annual Meeting, where it will present research on CARVYKTI® and a novel therapy, Lucar-G39D. These presentations highlight the company’s ongoing innovation in cell therapy and its efforts to expand treatment options for multiple myeloma and B-cell non-Hodgkin lymphoma, potentially impacting clinical practices and patient outcomes.

Legend Biotech’s CARVYKTI® Receives FDA Approval for Label Update with New Survival Data
Oct 14, 2025

On October 10, 2025, Legend Biotech announced that the U.S. FDA approved a label update for its CARVYKTI® CAR-T cell therapy to include overall survival data from the Phase 3 CARTITUDE-4 study. This update highlights a significant improvement in overall survival for patients with relapsed, refractory multiple myeloma compared to standard care. Additionally, the label now includes warnings about immune effector cell-associated enterocolitis and the reactivation of the John Cunningham virus, which can lead to serious complications, emphasizing the need for careful management by prescribing physicians.

Legend Biotech Reports Strong CARVYKTI® Sales for Q3 2025
Oct 14, 2025

On October 14, 2025, Legend Biotech announced that its product CARVYKTI® achieved approximately $524 million in net trade sales for the quarter ending September 30, 2025. This announcement highlights the product’s significant market performance, although the sales figures are preliminary and subject to further financial review. The impact on Legend Biotech’s operations and industry positioning is notable, as it underscores the company’s growing influence in the biotechnology sector.

Legend Biotech and Janssen Forge Strategic Supply Agreement
Oct 7, 2025

On October 6, 2025, Legend Biotech USA Inc., a subsidiary of Legend Biotech Corporation, entered into a Component and Product Supply Agreement with Janssen Pharmaceuticals, Inc. This agreement, which supersedes a previous interim agreement from February 2022, involves the manufacturing and supply of ciltacabtagene autoleucel (cilta-cel) for clinical and commercial use globally, excluding Greater China. The agreement outlines the shared costs and responsibilities between Legend Biotech and Janssen, including the supply of raw materials and the handling of production costs. This strategic partnership is expected to enhance Legend Biotech’s operational capabilities and strengthen its position in the global biotechnology market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 10, 2025