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HELX - ETF AI Analysis

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HELX

Franklin Genomic Advancements ETF (HELX)

Rating:61Neutral
Price Target:
HELX, the Franklin Genomic Advancements ETF, appears to be a solid but not top-tier choice, reflecting a mix of strong growth stories and meaningful risks in the genomics and biotech space. Higher-quality holdings like Krystal Biotech, United Therapeutics, Vertex Pharmaceuticals, and Natera support the fund’s rating through robust financial performance, positive earnings calls, and strategic growth initiatives, while weaker names such as Twist Bioscience and Adaptive Biotechnologies, with ongoing profitability and cash flow challenges, weigh on the overall picture. The main risk factor is the fund’s concentration in genomics and biotech companies, where high valuations, financial instability, and regulatory or competitive pressures can lead to significant volatility.
Positive Factors
Strong Recent Performance
The ETF has shown strong recent gains over the past month and quarter, indicating positive momentum in its strategy.
Leading Holdings Performing Well
Several of the largest positions, including Guardant Health, Ligand Pharma, and Twist Bioscience, have delivered strong year-to-date gains that support the fund’s returns.
Focused Exposure to Genomics and Health Care
With most assets in health care and genomic-related companies, the fund offers targeted exposure to a specialized growth area in the market.
Negative Factors
High Sector Concentration
Nearly all assets are in the health care sector, so the fund is heavily exposed to swings in one industry rather than being broadly diversified.
Top Holdings Carry Significant Weight
A small group of companies makes up a large share of the portfolio, which increases the impact if any of these stocks experience setbacks.
Moderate Expense Ratio
The fund’s expense ratio is not especially low, meaning fees could take a noticeable bite out of long-term returns compared with cheaper ETFs.

HELX vs. SPDR S&P 500 ETF (SPY)

HELX Summary

The Franklin Genomic Advancements ETF (HELX) focuses on companies working in genetic research and advanced healthcare, rather than tracking a traditional stock index. It invests mainly in U.S. health care and biotech firms involved in gene-based testing and treatments, including well-known names like Eli Lilly and Vertex Pharmaceuticals, along with smaller, fast-growing specialists. Someone might invest in HELX to seek long-term growth from the rise of personalized medicine and new genetic therapies, while also getting a mix of established and emerging companies. A key risk is that biotech and genomics stocks can be very volatile and may rise or fall sharply with news and market sentiment.
How much will it cost me?The Franklin Genomic Advancements ETF (HELX) has an expense ratio of 0.5%, meaning you’ll pay $5 per year for every $1,000 invested. This is higher than average because it is actively managed, focusing on a specialized niche in genomic advancements, which requires more research and expertise compared to passively managed funds.
What would affect this ETF?The Franklin Genomic Advancements ETF (HELX) could benefit from growing interest in personalized medicine and advancements in genetic research, as well as increased healthcare spending globally. However, it may face challenges from regulatory hurdles in biotechnology, potential setbacks in clinical trials, and broader economic pressures that could impact funding for innovation. Its heavy focus on healthcare and genomic advancements makes it sensitive to both breakthroughs and disruptions in this niche sector.

HELX Top 10 Holdings

HELX is essentially a genomic medicine play, with most of its firepower in health care names pushing the frontiers of DNA-driven diagnostics and therapies. Guardant Health and Natera have been steady to rising, acting as key engines for the fund as demand for precision oncology grows. Krystal Biotech and Ligand Pharma add more punch but have seen mixed, sometimes lagging, short-term moves as valuations look stretched. Adaptive Biotechnologies and BridgeBio are rising stars, helping performance but still wrestling with profitability. Overall, it’s a globally focused, highly concentrated bet on cutting-edge biotech rather than broad market stability.
Name
Company Name
Weight %
Market Value
Market Cap
Yearly Gain
Overall Rating
Guardant Health9.94%$2.88M$21.74B259.42%
61
Neutral
Natera7.67%$2.22M$38.35B97.96%
73
Outperform
Krystal Biotech5.50%$1.59M$10.06B131.64%
80
Outperform
Adaptive Biotechnologies4.44%$1.29M$3.61B111.82%
53
Neutral
Ligand Pharma4.41%$1.28M$5.76B115.70%
60
Neutral
BridgeBio Pharma3.88%$1.12M$15.70B67.46%
59
Neutral
United Therapeutics3.45%$1.00M$21.98B76.42%
79
Outperform
Eli Lilly & Co2.95%$854.48K$1.08T45.82%
72
Outperform
Twist Bioscience2.89%$837.59K$5.70B234.52%
43
Neutral
Vertex Pharmaceuticals2.69%$779.04K$121.09B-0.33%
78
Outperform

HELX Technical Analysis

Technical Analysis Sentiment
Positive
Last Price
Price Trends
50DMA
37.78
Positive
100DMA
35.50
Positive
200DMA
35.61
Positive
Market Momentum
MACD
0.24
Positive
RSI
53.86
Neutral
STOCH
28.24
Neutral
Evaluating momentum and price trends is crucial in ETF analysis to make informed investment decisions. For HELX, the sentiment is Positive. The current price of undefined is equal to the 20-day moving average (MA) of 39.36, equal to the 50-day MA of 37.78, and equal to the 200-day MA of 35.61, indicating a neutral trend. The MACD of 0.24 indicates Positive momentum. The RSI at 53.86 is Neutral, neither overbought nor oversold. The STOCH value of 28.24 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for HELX.

HELX Peer Comparison

Comparison Results
Name
Price
Price Target
AUM
Expense Ratio
Overall Rating
$28.97M0.50%
61
Neutral
$97.14M0.50%
71
Outperform
$96.83M0.50%
60
Neutral
$81.90M0.90%
63
Neutral
$81.31M0.75%
72
Outperform
$1.63M0.35%
60
Neutral
Performance Comparison
Ticker
Company Name
Price
Change
% Change
HELX
Franklin Genomic Advancements ETF
39.30
11.81
42.96%
FDCF
Fidelity Disruptive Communications ETF
CSNR
Cohen & Steers Natural Resources Active ETF
HECO
SPDR Galaxy Hedged Digital Asset Ecosystem ETF
FITZ
Fitz-Gerald Must Have Portfolio ETF
GNMX
Corgi Genomics & Precision Medicine ETF
Glossary
BuyAn ETF rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF is likely to deliver higher returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldAn ETF rated as a "Hold" s expected to perform in line with the overall market or a specific benchmark. This rating indicates that the ETF is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellAn ETF rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the ETF may deliver lower returns compared to other ETFs in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
DisclaimerThis AI Analyst ETF Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in ETFs carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: ―
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