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Krystal Biotech (KRYS)
NASDAQ:KRYS
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Krystal Biotech (KRYS) AI Stock Analysis

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KRYS

Krystal Biotech

(NASDAQ:KRYS)

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Outperform 78 (OpenAI - 4o)
Rating:78Outperform
Price Target:
$177.00
▲(5.47% Upside)
Krystal Biotech's strong financial performance and positive earnings call sentiment are the most significant factors contributing to the score. Technical analysis indicates a stable trend, while valuation concerns slightly temper the overall outlook. The company's strategic expansion plans and robust cash position support a favorable long-term growth trajectory.
Positive Factors
Regulatory Approval
The FDA's approval to expand VYJUVEK's eligible patient population enhances its market potential, reinforcing its leadership in treating DEB and potentially increasing revenue streams.
Global Expansion
Krystal Biotech's strategic global expansion into Japan and Europe positions the company for significant market growth, diversifying its revenue base and enhancing its competitive position.
Financial Health
Krystal Biotech's solid balance sheet and strong cash flow generation provide financial stability and flexibility to invest in growth opportunities and withstand market fluctuations.
Negative Factors
Revenue Decline
Anticipated revenue decline in Q3 due to seasonal factors may impact short-term financial performance, posing a challenge to maintaining consistent growth momentum.
Operational Challenges
Ongoing challenges in scaling the sales force could delay the company's ability to fully capitalize on market opportunities, potentially affecting revenue growth and market penetration.
Market Entry Delays
Potential delays in entering European and Japanese markets could hinder Krystal Biotech's global expansion efforts, affecting its ability to capture new revenue streams promptly.

Krystal Biotech (KRYS) vs. SPDR S&P 500 ETF (SPY)

Krystal Biotech Business Overview & Revenue Model

Company DescriptionKrystal Biotech, Inc., a clinical stage biotechnology company, engages in the field of redosable gene therapy to treat serious rare diseases in the United States. Its lead product candidate is beremagene geperpavec (B-VEC), which is in Phase III clinical study to treat dystrophic epidermolysis bullosa. The company is also involved in developing KB105 that is in Phase I/II clinical study for treating patients with deficient autosomal recessive congenital ichthyosis; KB301, which is in Phase I/II clinical stage for treating wrinkles and other presentations of aged or damaged skin; KB407 that is in preclinical stage for cystic fibrosis; and KB104, which is in preclinical stage for netherton syndrome. Its discovery stage product candidates include KB5xx for treating chronic skin diseases, KB3xx to treat aesthetic skin conditions, and KB3xx product. Krystal Biotech, Inc. was founded in 2015 and is headquartered in Pittsburgh, Pennsylvania.
How the Company Makes MoneyKrystal Biotech generates revenue primarily through the development and commercialization of its gene therapy products. The company's revenue model is based on potential product sales upon regulatory approval and market introduction of its therapies. Additionally, Krystal may engage in collaborative partnerships with pharmaceutical companies for research, development, and distribution, which can provide upfront payments, milestone payments, and royalties on sales. The company is also exploring avenues for funding through grants and research collaborations that support its clinical programs, enhancing its financial stability as it advances its product pipeline.

Krystal Biotech Earnings Call Summary

Earnings Call Date:Aug 04, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 10, 2025
Earnings Call Sentiment Neutral
Krystal Biotech's earnings call highlights strong financial performance and strategic global expansion, with significant revenue growth and profitability. However, challenges such as anticipated revenue decline in Q3, ongoing sales force scaling, and potential market entry delays in Europe and Japan present concerns.
Q2-2025 Updates
Positive Updates
Strong Revenue Growth for VYJUVEK
Q2 net VYJUVEK revenue was $96 million, with total net revenue since launch exceeding $525 million. The company achieved a 9% growth over the first quarter of 2025.
Global Expansion Milestones
Approval of VYJUVEK by Japan's Ministry of Health and plans for European launch in Germany and France. The company has established dedicated commercial teams in both countries.
Positive Financial Performance
Continued profitability with $1.29 per diluted share, marking two years of consistently positive EPS. Net income for the quarter was $38.3 million.
Pipeline Progress
Clinical data updates for oncology and aesthetic programs, progression of KB408 into repeat dosing for AATD, and new study starts for lung and eye diseases.
Negative Updates
Anticipated Revenue Decline in Q3
Expectation of Q3 revenues to come in below Q2 due to summer pausing trends and unpredictability in patient restart dynamics.
Operational Challenges in Scaling
Sales force hiring is still underway, with full impact of new hires only expected over the next few quarters. Compliance while on drug is expected to trend down as patient mix changes.
Potential Delays in European and Japanese Markets
European launch is subject to the continuity of the Accès Précoce program in France, and Japanese launch awaits pricing decision.
Company Guidance
During the Krystal Biotech Q2 2025 earnings call, the company provided guidance on several key metrics. Krystal reported a net product revenue of $96 million for VYJUVEK, contributing to a total net revenue of over $525 million since its launch. The company achieved an earnings per share (EPS) of $1.29 fully diluted, marking two years of consistent positive EPS. The compliance rate for patients on VYJUVEK was reported at 82%, with an expectation of a downward trend as severe patients achieve durable wound closure. The company anticipates a temporary decline in Q3 revenues due to summer pauses, with a return to growth in Q4 driven by patient restarts and sales force expansion. Krystal highlighted its global expansion plans, with upcoming launches in Europe and Japan, and maintained a strong financial position with over $820 million in cash and investments.

Krystal Biotech Financial Statement Overview

Summary
Krystal Biotech demonstrates strong financial health with significant revenue and profit growth, robust margins, and improved cash flow generation. The transition from losses to profitability and efficient capital management are notable. Maintaining this trajectory is crucial for sustained growth.
Income Statement
85
Very Positive
Krystal Biotech has shown impressive financial performance with a significant increase in total revenue from $50.7 million in 2023 to $290.5 million in 2024, indicating a strong revenue growth rate. The gross profit margin is robust at 93.1% for 2024, and the net profit margin stands at 30.7%, reflecting high profitability. Despite earlier losses, the company has turned profitable, with both EBIT and EBITDA margins improving significantly.
Balance Sheet
78
Positive
The balance sheet shows a solid equity position with a debt-to-equity ratio of 0.008, indicating low leverage risk. The return on equity is 9.4%, reflecting efficient use of equity to generate profits. The equity ratio is high at 89.6%, suggesting a strong capital structure with a majority of assets financed by equity.
Cash Flow
82
Very Positive
The cash flow analysis reveals a positive turnaround with a free cash flow of $119.2 million in 2024 compared to negative figures in previous years. The operating cash flow to net income ratio is 1.38, indicating effective cash generation relative to net income. The company has managed to sustain positive cash flow, enhancing its financial flexibility.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue359.20M290.51M50.70M0.000.000.00
Gross Profit333.84M270.45M47.60M-4.05M-2.77M-1.85M
EBITDA151.31M109.91M17.90M-145.20M-65.31M-30.32M
Net Income146.72M89.16M10.93M-139.97M-69.57M-32.17M
Balance Sheet
Total Assets1.14B1.06B818.36M558.45M626.29M310.84M
Cash, Cash Equivalents and Short-Term Investments681.99M597.52M532.18M379.17M438.10M271.26M
Total Debt1.62M7.26M8.09M8.93M8.02M11.55M
Total Liabilities97.75M109.46M39.71M36.22M32.72M18.76M
Stockholders Equity1.04B946.38M778.64M522.23M593.58M292.08M
Cash Flow
Free Cash Flow185.44M119.18M-100.60M-153.55M-116.27M-40.93M
Operating Cash Flow195.40M123.42M-88.80M-100.57M-47.94M-26.08M
Investing Cash Flow-183.40M-163.44M82.64M-114.08M-226.77M-11.18M
Financing Cash Flow-4.88M27.01M202.75M35.35M347.69M118.02M

Krystal Biotech Technical Analysis

Technical Analysis Sentiment
Positive
Last Price167.82
Price Trends
50DMA
149.49
Positive
100DMA
143.00
Positive
200DMA
155.47
Positive
Market Momentum
MACD
4.93
Negative
RSI
66.96
Neutral
STOCH
80.36
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For KRYS, the sentiment is Positive. The current price of 167.82 is above the 20-day moving average (MA) of 153.43, above the 50-day MA of 149.49, and above the 200-day MA of 155.47, indicating a bullish trend. The MACD of 4.93 indicates Negative momentum. The RSI at 66.96 is Neutral, neither overbought nor oversold. The STOCH value of 80.36 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for KRYS.

Krystal Biotech Risk Analysis

Krystal Biotech disclosed 75 risk factors in its most recent earnings report. Krystal Biotech reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Krystal Biotech Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
$4.69B32.7815.61%116.09%35.29%
77
Outperform
4.60B13.3925.06%-0.17%23.84%
58
Neutral
4.69B8.46-304.62%96.00%
51
Neutral
4.42B-23.36-23.60%-60.63%-216.87%
49
Neutral
5.61B-11.37-18.96%-81.18%-69.19%
41
Neutral
3.98B-22.22-208.46%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
KRYS
Krystal Biotech
167.82
-14.21
-7.81%
ALKS
Alkermes
27.89
-0.10
-0.36%
PTCT
PTC Therapeutics
58.99
21.89
59.00%
CRSP
Crispr Therapeutics AG
61.67
14.69
31.27%
MLTX
MoonLake Immunotherapeutics
61.99
11.57
22.95%
ACLX
Arcellx Inc
79.75
-3.76
-4.50%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 16, 2025