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Moderna (MRNA)
NASDAQ:MRNA
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Moderna (MRNA) AI Stock Analysis

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MRNA

Moderna

(NASDAQ:MRNA)

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Neutral 50 (OpenAI - 4o)
Rating:50Neutral
Price Target:
$24.50
▼(-7.23% Downside)
Moderna's overall stock score reflects significant financial challenges, including declining revenues and profitability. Technical analysis indicates weak momentum, and valuation concerns persist with a negative P/E ratio. However, strategic cost reductions and partnerships provide some optimism for future growth.
Positive Factors
Strategic Partnerships
These partnerships enhance Moderna's global footprint and ensure stable revenue streams through long-term agreements, supporting sustainable growth.
Cost Reduction
Significant cost reductions improve operational efficiency and profitability, positioning Moderna to better manage financial challenges and invest in growth.
Pipeline Advancements
Advancements in the pipeline, particularly in oncology, diversify Moderna's product offerings and potential revenue sources, enhancing long-term growth prospects.
Negative Factors
Revenue Decline
A significant decline in revenue, primarily due to lower COVID vaccine demand, challenges Moderna's financial stability and growth trajectory.
Net Loss
The net loss indicates ongoing financial struggles, impacting cash flow and limiting resources for investment in new product development.
Discontinued Vaccine Program
Discontinuation of the CMV vaccine program reduces potential future revenue streams and highlights challenges in product development.

Moderna (MRNA) vs. SPDR S&P 500 ETF (SPY)

Moderna Business Overview & Revenue Model

Company DescriptionModerna, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the development of messenger RNA (mRNA) therapeutics and vaccines. Founded in 2010, Moderna focuses on creating innovative medicines for infectious diseases, immuno-oncology, and rare diseases, with its most notable product being the mRNA-1273 vaccine for COVID-19. The company operates primarily in the biotechnology sector and is known for its cutting-edge technology platform that enables rapid development and manufacturing of mRNA-based solutions.
How the Company Makes MoneyModerna generates revenue primarily through the sale of its mRNA vaccines, with significant income stemming from its COVID-19 vaccine, which has been distributed globally under various agreements with governments and organizations. The company has established substantial partnerships with entities such as the U.S. government and international health organizations, which contribute to its revenue through advanced purchase agreements and supply contracts. Additionally, Moderna is expanding its pipeline to include vaccines and therapies for other diseases, which could diversify its revenue streams in the future. The company also engages in collaborations with pharmaceutical firms and research institutions, further enhancing its financial growth through licensing agreements and shared development costs.

Moderna Key Performance Indicators (KPIs)

Any
Any
Product Sales by Geography
Product Sales by Geography
Shows where Moderna's products are selling the most, highlighting regional strengths and potential vulnerabilities due to local market conditions or regulatory environments.
Chart InsightsModerna's sales in the United States and Europe have experienced volatility, with a notable drop in 2023 and partial recovery in 2024. The recent earnings call highlights strategic cost reductions and FDA approvals, yet revenue challenges persist, particularly due to shipment delays and a significant decline in COVID vaccine sales. The company's focus on pipeline advancements and financial discipline aims to stabilize sales, but the timing shift in U.K. shipments and workforce restructuring indicate ongoing operational adjustments.
Data provided by:Main Street Data

Moderna Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant achievements in cost reduction, strategic partnerships, and product approvals. However, these positives were tempered by notable challenges, including a significant revenue decline, a net loss for the quarter, and the discontinuation of the CMV vaccine program.
Q3-2025 Updates
Positive Updates
Cost Reduction Achievements
Moderna achieved a 34% reduction in cost of sales, R&D, and SG&A combined compared to Q3 2024 and a $2.1 billion improvement in costs over the last four quarters.
Strategic Partnerships Progress
Moderna established manufacturing facilities and multiyear offtake agreements with Canada, the U.K., and Australia, delivering the first made-in-Canada mRNA vaccines and obtaining regulatory licenses for facilities in the U.K. and Australia.
mNEXSPIKE and Spikevax Approvals
mNEXSPIKE was approved in the U.S. and Canada for the 2025-2026 season, and Spikevax received approval in 40 countries for the same period.
Cash and Investment Position
Moderna ended Q3 with $6.6 billion in cash and investments, with a projected year-end balance of $6.5 billion to $7 billion, indicating effective financial management.
Oncology and Rare Diseases Pipeline
Encouraging progress in oncology, including Phase Ib data for mRNA-4359, and target enrollment reached for the propionic acidemia registrational study.
Negative Updates
Decline in Revenue
Total revenue for Q3 was $1 billion, a 45% decline year-over-year, primarily due to lower COVID vaccine demand.
Net Loss for the Quarter
Moderna reported a net loss of $200 million for the third quarter, compared to a net income of $13 million in Q3 2024.
CMV Vaccine Program Discontinued
The CMV vaccine program did not meet its primary efficacy endpoints, resulting in discontinuation of development for congenital CMV.
Reduced U.S. Revenue Guidance
U.S. revenue guidance for 2025 was narrowed to $1 billion to $1.3 billion from previous $1 billion to $1.5 billion, reflecting lower expected COVID vaccination rates.
Company Guidance
During Moderna's third quarter 2025 conference call, key financial metrics and guidance were discussed. The company reported a revenue of $1 billion for the quarter, primarily driven by sales of its approved vaccines, Spikevax, mNEXSPIKE, and mRESVIA. Despite a net loss of $200 million, Moderna concluded the quarter with $6.6 billion in cash and investments. The company achieved a 34% reduction in combined costs of sales, R&D, and SG&A compared to the previous year, reflecting strong financial discipline. Moderna narrowed its 2025 revenue guidance to $1.6 billion to $2 billion, adjusting expectations based on COVID vaccination rates, which remain a critical variable. The company's strategic partnerships in Canada, the U.K., and Australia are expected to contribute to future growth, with local manufacturing facilities and multiyear offtake agreements established. Moderna also highlighted advancements in its pipeline, including positive Phase III flu efficacy data and ongoing regulatory submissions for several programs. Additionally, the company is focused on achieving cash breakeven by 2028, with continued cost reduction efforts projected to reduce 2025 cash costs by approximately $900 million since the beginning of the year.

Moderna Financial Statement Overview

Summary
Moderna faces significant financial challenges with declining revenues and profitability, as evidenced by negative margins and cash flows. The balance sheet shows low leverage, but negative return on equity and cash flow issues highlight operational and financial risks.
Income Statement
45
Neutral
Moderna's income statement shows significant challenges with declining revenues and negative profit margins. The TTM data indicates a substantial revenue decline of 27.4% and a negative net profit margin of -140.3%. The company is experiencing negative EBIT and EBITDA margins, reflecting operational inefficiencies. Despite past high growth rates, recent trends show a downturn, impacting overall profitability.
Balance Sheet
60
Neutral
The balance sheet remains relatively stable with a low debt-to-equity ratio of 0.07, indicating conservative leverage. However, the return on equity is negative at -31.4%, reflecting poor profitability. The equity ratio is strong, suggesting a solid capital structure, but the declining equity value due to losses is a concern.
Cash Flow
50
Neutral
Cash flow analysis reveals negative operating and free cash flows, with a free cash flow growth rate of -24.2% in the TTM period. The operating cash flow to net income ratio is negative, indicating cash flow challenges. However, the free cash flow to net income ratio is positive, suggesting some efficiency in managing cash relative to net losses.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.22B3.20B6.85B18.88B17.74B803.39M
Gross Profit265.00M1.74B2.15B13.46B15.12B764.21M
EBITDA-2.94B-3.39B-3.28B9.77B13.53B-703.38M
Net Income-3.12B-3.56B-4.71B8.36B12.20B-747.06M
Balance Sheet
Total Assets12.13B14.14B18.43B25.86B24.67B7.34B
Cash, Cash Equivalents and Short-Term Investments4.50B7.03B8.60B9.90B10.73B4.61B
Total Debt734.00M747.00M1.24B1.20B916.00M237.00M
Total Liabilities2.81B3.24B4.57B6.74B10.52B4.78B
Stockholders Equity9.33B10.90B13.85B19.12B14.14B2.56B
Cash Flow
Free Cash Flow-2.66B-4.05B-3.83B4.58B13.34B1.96B
Operating Cash Flow-1.98B-3.00B-3.12B4.98B13.62B2.03B
Investing Cash Flow1.46B1.95B4.21B-5.18B-8.52B-1.67B
Financing Cash Flow9.00M56.00M-1.38B-3.45B-873.00M2.03B

Moderna Technical Analysis

Technical Analysis Sentiment
Positive
Last Price26.41
Price Trends
50DMA
25.86
Positive
100DMA
27.41
Negative
200DMA
28.55
Negative
Market Momentum
MACD
-0.42
Positive
RSI
52.54
Neutral
STOCH
35.66
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For MRNA, the sentiment is Positive. The current price of 26.41 is above the 20-day moving average (MA) of 25.99, above the 50-day MA of 25.86, and below the 200-day MA of 28.55, indicating a neutral trend. The MACD of -0.42 indicates Positive momentum. The RSI at 52.54 is Neutral, neither overbought nor oversold. The STOCH value of 35.66 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for MRNA.

Moderna Risk Analysis

Moderna disclosed 73 risk factors in its most recent earnings report. Moderna reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Moderna Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
81
Outperform
$20.81B17.7830.39%18.09%3563.21%
79
Outperform
$19.54B17.4020.04%13.50%17.16%
76
Outperform
$10.94B17.1830.56%9.93%54.33%
73
Outperform
$9.89B19.739.07%12.31%60.21%
73
Outperform
$17.60B12.2428.20%24.98%127.06%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$9.59B-29.32%-56.00%-38.95%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
MRNA
Moderna
26.41
-17.06
-39.25%
BMRN
BioMarin Pharmaceutical
54.93
-11.20
-16.94%
EXEL
Exelixis
42.98
7.13
19.89%
INCY
Incyte
108.16
27.58
34.23%
UTHR
United Therapeutics
459.21
58.34
14.55%
GMAB
Genmab
30.31
7.84
34.89%

Moderna Corporate Events

Moderna Reports Q3 2025 Financial Results
Nov 7, 2025

Moderna, Inc., a biotechnology company, is a leader in the development of mRNA-based medicines, focusing on vaccines and therapeutics for infectious diseases, oncology, and rare diseases.

Moderna’s Earnings Call: Balancing Achievements and Challenges
Nov 7, 2025

During Moderna’s recent earnings call, the sentiment was a mix of optimism and caution. The company celebrated significant achievements in cost reduction, strategic partnerships, and product approvals. However, these positives were overshadowed by challenges such as a notable revenue decline, a net loss for the quarter, and the discontinuation of the CMV vaccine program.

Vertex and Moderna’s VX-522 Study: A Potential Breakthrough in Cystic Fibrosis Treatment
Oct 27, 2025

Vertex Pharmaceuticals Inc., in collaboration with Moderna, is conducting a Phase 1/2 study titled ‘A Phase 1/2 Dose Escalation Study Evaluating the Safety, and Tolerability and Efficacy of VX-522 in Subjects 18 Years of Age and Older With Cystic Fibrosis and a CFTR Genotype Not Responsive to CFTR Modulator Therapy.’ The study aims to assess the safety, tolerability, and efficacy of VX-522 in adults with cystic fibrosis who do not respond to existing CFTR modulator therapies, marking a significant step in addressing unmet medical needs in this population.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025