Revenue and Quarterly Performance
Total 2025 revenue of $1.9B; Q4 revenue $700M (U.S. $300M; international $400M). Full-year U.S. revenue $1.2B (≈62% of total) and international $700M (≈38%). Q4 came in at the higher end of guidance.
Commercial Launch Success — MNEXT Spike
MNEXT Spike approved and launched in the U.S. in 2025 with a strong debut: 24% share of the total U.S. retail COVID market and 34% share among adults 65+. Also approved in Canada and Australia, with further international approvals targeted.
Significant Cost Reductions and Efficiency Gains
Operating expenses down $2.2B or 30% for the year; Q4 operating expenses down 31% YoY. Cost of sales decreased 41% YoY to $868M; R&D down 31% to $3.1B; SG&A down 13% to $1.0B. Company exceeded its 2025 cost reduction plan by over $1B vs. original guidance.
Improved Loss Metrics and Strong Cash Position
Full-year net loss improved to $2.8B from $3.6B in 2024; loss per share improved to $7.26 from $9.28 (≈22% improvement). Ended 2025 with $8.1B in cash and investments (includes $600M credit draw); excluding the draw would have been $7.6B—above prior guidance ranges.
Clear 2026 Financial Framework and Return-to-Growth Guidance
Guidance of up to 10% revenue growth in 2026 (driven primarily by international markets), projected cash costs of $4.2B, GAAP operating expenses ~$4.9B, and year-end 2026 cash guidance of $5.5–6.0B. Revenue expected to be weighted ~15% H1 / ~85% H2.
Pipeline Progress and Clinical Milestones
Positive five-year phase 2 data for INT (individualized cancer therapy) in adjuvant melanoma showing ~50% reduction in relapse/death. Multiple late-stage oncology studies fully enrolled (adjuvant melanoma, adjuvant RCC, muscle invasive bladder). Norovirus phase 3 and PA registrational study fully enrolled — potential readouts in 2026.
Strategic Partnerships and Geographic Expansion
New five-year strategic supply agreement with Mexico; commercialization agreement with Recordati for propionic acidemia (PA) rare disease program; full-year contributions expected from local manufacturing agreements in the U.K., Canada, and Australia in 2026.