Maze Therapeutics, Inc. (MAZE)
NASDAQ:MAZE
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Maze Therapeutics, Inc.
(NASDAQ:MAZE)
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Rating:47Neutral
Price Target:
$26.00
▼(-7.44% Downside)
Action:ReiteratedDate:04/23/26
The score is held back primarily by unstable financial performance (swing to zero revenue, large losses, and heavy cash burn in 2025) and weak technical trend (below major moving averages with negative MACD). Offsetting this, corporate events are constructive with meaningful new funding that extends runway and positive program/leadership updates, but valuation remains constrained by current losses.
Positive Factors
Clinical-stage pipeline progress
Durable clinical progress: Phase 2 HORIZON topline data for APOL1 inhibitor MZE829 and plans to advance to a pivotal study materially de-risk the lead program. Moving to a pivotal stage and initiating two Phase 2 trials broadens late-stage pipeline value and underpins multi-year development focus.
Negative Factors
Inconsistent revenue and earnings
Revenue and earnings volatility is a structural concern: strong 2024 results reversed to zero revenue and a large loss in 2025, reflecting an unstable commercial base and episodic milestone income. This inconsistency undermines predictable cash flows, complicates long-term planning and heightens reliance on external funding.
Read all positive and negative factors
Positive Factors
Negative Factors
Clinical-stage pipeline progress
Durable clinical progress: Phase 2 HORIZON topline data for APOL1 inhibitor MZE829 and plans to advance to a pivotal study materially de-risk the lead program. Moving to a pivotal stage and initiating two Phase 2 trials broadens late-stage pipeline value and underpins multi-year development focus.
Read all positive factors
Maze Therapeutics, Inc. (MAZE) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$1.47B
Dividend YieldN/A
Average Volume (3M)1.20M
Price to Earnings (P/E)―
Beta (1Y)0.96
Revenue GrowthN/A
EPS GrowthN/A
CountryUS
Employees125
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.65
Shares Outstanding55,248,657
10 Day Avg. Volume1,033,798
30 Day Avg. Volume1,197,096
Financial Highlights & Ratios
PEG Ratio<0.01
Price to Book (P/B)5.02
Price to Sales (P/S)0.00
P/FCF Ratio-15.79
Enterprise Value/Market Cap0.85
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit-1.09K
Enterprise Value/Ebitda-9.29
Forecast
1Y Price Target
$64.45Price Target Upside129.46% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering12
EPS Forecast (FY)-2.84
Revenue Forecast (FY)$10.00M
Maze Therapeutics, Inc. Business Overview & Revenue Model
Company Description
Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of renal, cardiovascular, related metabolic diseases, and obesity in the United States. Its lead programs includes M...
How the Company Makes Money
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Maze Therapeutics, Inc. Financial Statement Overview
Summary
Income Statement
32
Negative
Balance Sheet
63
Positive
Cash Flow
38
Negative
| Breakdown | Dec 2025 | Mar 2025 | Dec 2023 | Dec 2022 |
|---|---|---|---|---|
Income Statement | ||||
| Total Revenue | 0.00 | 167.50M | 0.00 | 0.00 |
| Gross Profit | -2.40M | 167.50M | 0.00 | 0.00 |
| EBITDA | -140.50M | 60.88M | -94.46M | -107.21M |
| Net Income | -131.12M | 52.23M | -100.42M | -114.94M |
Balance Sheet | ||||
| Total Assets | 397.13M | 240.54M | 71.50M | 149.96M |
| Cash, Cash Equivalents and Short-Term Investments | 341.92M | 196.81M | 29.16M | 99.92M |
| Total Debt | 23.31M | 26.63M | 49.62M | 32.05M |
| Total Liabilities | 42.16M | 43.64M | 61.45M | 48.51M |
| Stockholders Equity | 354.97M | 196.90M | 10.05M | 101.44M |
Cash Flow | ||||
| Free Cash Flow | -112.73M | 74.81M | -87.27M | -101.17M |
| Operating Cash Flow | -111.94M | 75.95M | -86.83M | -99.20M |
| Investing Cash Flow | -170.96M | -1.15M | -441.00K | -3.17M |
| Financing Cash Flow | 275.34M | 92.85M | 16.39M | 1.73M |
Maze Therapeutics, Inc. Risk Analysis
Maze Therapeutics, Inc. disclosed 83 risk factors in its most recent earnings report. Maze Therapeutics, Inc. reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Maze Therapeutics, Inc. Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
71 Outperform | $595.27M | 5.14 | 58.50% | ― | 617.03% | ― | |
58 Neutral | $1.91B | -67.88 | 1813.84% | ― | 157.01% | 94.31% | |
54 Neutral | $986.99M | -10.26 | -34.23% | ― | 138.82% | 52.84% | |
54 Neutral | $1.37B | -37.98 | -444.41% | ― | ― | -13.14% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
50 Neutral | $1.55B | -14.96 | -57.48% | ― | 698.96% | 73.41% | |
47 Neutral | $1.47B | -13.58 | -40.70% | ― | ― | ― |
* Healthcare Sector Average
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Maze Therapeutics, Inc. Corporate Events
Business Operations and StrategyPrivate Placements and Financing
Maze Therapeutics prices $150 million equity offering
Positive
Apr 22, 2026
On April 21, 2026, Maze Therapeutics, Inc. priced an underwritten registered offering of 5,540,000 shares of common stock at $23.50 per share and pre-funded warrants for 850,000 shares at $23.499, for expected gross proceeds of $150 million and es...
Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures
Maze Therapeutics adds Neil Kumar to board leadership
Positive
Mar 25, 2026
Maze Therapeutics reported fourth-quarter and full-year 2025 results on March 25, 2026, alongside positive Phase 2 HORIZON topline data for MZE829 showing clinically meaningful reductions in proteinuria in APOL1-mediated kidney disease, and confir...
Business Operations and StrategyPrivate Placements and Financing
Maze Therapeutics Secures New $200 Million Loan Facility
Positive
Feb 4, 2026
On February 4, 2026, Maze Therapeutics, Inc. entered into a Loan and Security Agreement with Hercules Capital, Inc. for a senior secured term loan facility of up to $200 million, with an initial $40 million tranche funded on the same date and net ...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.