KalVista Pharmaceuticals (KALV) AI Stock Analysis

• Market Cap: $648.90M
• Dividend Yield: N/A
• Average Volume (3M): 901.72K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.12
• Revenue Growth: N/A
• EPS Growth: -10.46%
• Country: US
• Employees: 150
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.99
• Shares Outstanding: 49,953,740
• 10 Day Avg. Volume: 651,052
• 30 Day Avg. Volume: 901,718
• PEG Ratio: N/A
• Price to Book (P/B): 0.00
• Price to Sales (P/S): 0.00
• P/FCF Ratio: 0.00
• Enterprise Value/Market Cap: 0.89
• Enterprise Value/Revenue: N/A
• Enterprise Value/Gross Profit: 2.57K
• Enterprise Value/Ebitda: -3.33
• 1Y Price Target: $31.67
• Price Target Upside: 140.65% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 9

• Rating: 45 Neutral
• Price Target: ―

KalVista Pharmaceuticals exhibits substantial financial challenges with weak revenue generation and profitability. While technical indicators show mixed momentum, the company's strategic agreement with Kaken Pharmaceutical provides a potential growth avenue. However, the negative P/E ratio and lack of dividend yield negatively impact valuation. Overall, the stock's score reflects financial struggles counterbalanced by strategic opportunities.

Positive Factors

Financial Stability

The company has a strong cash balance to support the launch of Ekterly, providing financial stability for future operations.

Market Position

KalVista grants Kaken Pharmaceutical Japanese commercial rights to sebetralstat ahead of a likely approval, which could enhance the company's market position.

Market Potential

Sebetralstat is poised to be the first on-demand HAE drug for approximately 2,500 Japanese patients, indicating a strong market potential.

Negative Factors

Formulary Limitations

One KOL was skeptical that Ekterly would ever be broadly added to formularies, suggesting it may only be available through medical exception pathways—a process that could place a substantial documentation burden on physician practices.

Reimbursement Challenges

Consensus optimism is tempered by a key caveat: as KOLs emphasized that the 50% switch rate would only be realistic if the drug is reimbursed.

KalVista Pharmaceuticals Business Overview & Revenue Model

Company Description

KalVista Pharmaceuticals (KALV) is a clinical-stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet needs. Operating primarily in the biotechnology sector, KalVista is dedicated to developing treatments for hereditary angioedema (HAE) and other plasma kallikrein-related diseases. The company's lead product candidate, sebetralstat, is being developed as a potential oral on-demand treatment for HAE attacks.

How the Company Makes Money

KalVista Pharmaceuticals generates revenue through strategic partnerships, collaborations, and licensing agreements with larger pharmaceutical companies, which provide funding and resources to support its research and development activities. As a clinical-stage company, KalVista does not yet generate revenue from product sales but aims to do so upon successful development and commercialization of its product candidates. The company's financial performance is significantly influenced by milestone payments and royalties from successful partnerships, as well as potential future sales of approved therapies.

KalVista Pharmaceuticals Financial Statement Overview

Summary

KalVista Pharmaceuticals faces significant financial challenges with low revenue generation and profitability. The company has a modest gross profit margin but struggles with negative EBIT and net income. The balance sheet shows low leverage but is affected by continuous losses. Cash flow analysis indicates high cash burn and liquidity risks, highlighting the need for improved revenue streams and expense management.

Income Statement

KalVista Pharmaceuticals has faced significant challenges in generating revenue, with total revenue at $1.2 million in the TTM. Gross profit margin is modest at 63.26%, but the company is struggling with high negative EBIT and net income, leading to negative EBIT and net profit margins. The revenue growth is inconsistent, and the overall financial health from an income perspective is weak.

Balance Sheet

The balance sheet reveals a moderate debt-to-equity ratio of 0.04, indicating low leverage. However, the company has a negative return on equity due to continuous losses. The equity ratio stands at 52.58%, showing that over half of the assets are financed by equity, which is positive, but the company's financial stability is affected by ongoing losses.

Cash Flow

Cash flow analysis shows a negative operating cash flow of $127.6 million in the TTM, indicating cash outflows exceed inflows from operations, which is concerning. The company has a negative free cash flow and a weak cash flow to net income ratio, highlighting significant cash burn and potential liquidity risks.

Breakdown	Jun 2025	Jun 2024	Jun 2023	Jun 2022	Jun 2021
Income Statement
Total Revenue	0.00	0.00	0.00	0.00	12.69M
Gross Profit	0.00	-86.17M	-802.00K	-743.00K	12.04M
EBITDA	-173.33M	-134.28M	-92.11M	-81.60M	-45.59M
Net Income	-183.44M	-126.64M	-74.85M	-68.51M	-44.49M
Balance Sheet
Total Assets	250.77M	235.40M	183.20M	203.88M	272.01M
Cash, Cash Equivalents and Short-Term Investments	187.65M	210.40M	149.38M	166.20M	248.93M
Total Debt	6.31M	7.32M	8.23M	8.19M	5.91M
Total Liabilities	155.38M	28.82M	22.18M	18.79M	14.82M
Stockholders Equity	95.39M	206.58M	161.03M	185.09M	257.19M
Cash Flow
Free Cash Flow	-152.91M	-89.67M	-76.46M	-79.06M	-30.25M
Operating Cash Flow	-152.91M	-89.23M	-75.26M	-78.13M	-30.17M
Investing Cash Flow	91.02M	-84.72M	41.41M	57.86M	-147.65M
Financing Cash Flow	159.73M	150.71M	58.12M	1.58M	212.12M

KalVista Pharmaceuticals Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 13.16
• 50DMA: Negative
• 100DMA: Positive
• 200DMA: Positive
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For KALV, the sentiment is Positive. The current price of 13.16 is above the 20-day moving average (MA) of 12.98, below the 50-day MA of 13.44, and above the 200-day MA of 11.42, indicating a neutral trend. The MACD of -0.19 indicates Negative momentum. The RSI at 48.75 is Neutral, neither overbought nor oversold. The STOCH value of 69.87 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for KALV.

KalVista Pharmaceuticals Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
Sector *	51 Neutral	$7.83B	-0.15	-40.10%	2.29%	21.46%	-2.01%
DNTH	48 Neutral	$753.53M	―	-34.71%	―	17.87%	41.27%
LENZ	46 Neutral	$1.13B	―	-26.25%	―	―	79.90%
KALV	45 Neutral	$648.90M	―	-121.50%	―	―	-10.46%
GHRS	45 Neutral	$817.53M	―	-16.35%	―	―	-9.82%
REPL	42 Neutral	$428.53M	―	-73.44%	―	―	-1.07%
RCKT	40 Underperform	$365.79M	―	-69.65%	―	―	10.36%

KalVista Pharmaceuticals Corporate Events

KalVista Pharmaceuticals Signs Agreement with Kaken Pharmaceutical

On April 8, 2025, KalVista Pharmaceuticals entered into a License, Supply, and Distribution Agreement with Kaken Pharmaceutical for the commercialization of sebetralstat in Japan. This agreement includes an upfront payment of $11 million and potential milestone payments up to $24 million, plus royalties. Sebetralstat, if approved, would be the first oral on-demand treatment for HAE in Japan, marking a significant commercial opportunity for both companies.

Spark’s Take on KALV Stock

According to Spark, TipRanks’ AI Analyst, KALV is a Neutral.

KalVista Pharmaceuticals scores a 52.2, reflecting a blend of financial challenges and positive strategic moves. Significant weaknesses in financial performance and valuation are counterbalanced by strong technical momentum and promising corporate developments. Key risks include the company’s ongoing financial struggles, while the strategic appointment and technical indicators offer potential upside.

To see Spark’s full report on KALV stock, click here.