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Geron Corporation (GERN)
:GERN
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Geron (GERN) AI Stock Analysis

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GERN

Geron

(NASDAQ:GERN)

Rating:54Neutral
Price Target:
$1.50
▲(4.90% Upside)
Geron's overall stock score reflects strong revenue growth and strategic leadership changes, but is tempered by ongoing profitability challenges and a negative valuation outlook. The earnings call provided positive insights into market expansion, while the new CEO appointment suggests a strategic focus on leadership.
Positive Factors
Commercial Strategy and Growth
The number of sites utilizing Rytelo has increased significantly, indicating successful commercial strategies.
Revenue and Financial Performance
Rytelo revenue in Q2 is not only a ~$2MM beat of expectations, but also an early signal of positive impact from the company's strategic efforts.
Negative Factors
Revenue Growth Variability
Revenue growth in 2Q25 compared to 4Q24 was only 3%, indicating variability in growth performance.
Sales Performance
Geron reported Q1 Rytelo net sales of $39MM, which is below the estimate of $49MM and consensus of $48MM.

Geron (GERN) vs. SPDR S&P 500 ETF (SPY)

Geron Business Overview & Revenue Model

Company DescriptionGeron Corporation (GERN) is a biopharmaceutical company focused on the development of innovative therapies for cancer treatment. The company specializes in telomere biology and is primarily engaged in the research and development of drugs that target telomerase, an enzyme that plays a crucial role in cancer cell immortality. Geron's lead product candidate, imetelstat, is an investigational telomerase inhibitor being studied for its potential to treat hematologic malignancies, particularly myelofibrosis and acute myeloid leukemia.
How the Company Makes MoneyGeron generates revenue primarily through collaborations, partnerships, and potential future product sales. The company has engaged in strategic collaborations with larger pharmaceutical companies, which can provide upfront payments, milestone payments, and royalties on product sales. As Geron advances its clinical trials and potentially gains regulatory approval for its drug candidates, it may also start to generate revenue from product sales. Additionally, the company may receive funding through grants and research contracts, especially if its therapies demonstrate significant promise in clinical trials.

Geron Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: 19.17%|
Next Earnings Date:Nov 06, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant revenue growth and strategic expansions in commercial and medical teams, with increased physician awareness and favorable payer coverage. However, challenges persist in early line usage and data limitations on patient retention.
Q2-2025 Updates
Positive Updates
RYTELO Revenue Growth
Q2 2025 RYTELO net revenues were $49 million, representing an increase of approximately 24% over the first quarter.
Expansion of Commercial and Medical Affairs Teams
Geron expanded its commercial sales force and medical affairs organization by over 20%, with new hires trained and deployed.
Increase in Physician Awareness and Prescribing Intent
HCP market research in Q2 indicated a higher willingness to prescribe RYTELO in the first 12 months of a patient's therapy.
Payer Access Improvement
Approximately 90% of U.S. covered lives are now under favorable RYTELO medical coverage policies, up from 85% in Q1.
Phase III IMpactMF Trial Progress
The trial is over 95% enrolled, with completion expected by year-end, and has shown recent enrollment momentum.
Appointment of New CEO
Harout Semerjian was announced as the new President and CEO, bringing over 30 years of experience in hematology and oncology.
Negative Updates
Challenges in Early Line Usage
RYTELO is still primarily used in later lines of therapy, with only 30% of new patient starts in first and second lines as of May 2025.
Limited Data on Patient Retention
There is no accurate data available on the number of active patients or specific line usage due to the buy-and-bill market.
Screen Failures in IMpactMF Trial
Earlier stages of the trial experienced screen failures, though these are expected to decrease as the trial nears completion.
Company Guidance
During the Geron Corporation's Q2 2025 earnings call, the company provided several key metrics and strategic updates. RYTELO net revenues for the quarter were $49 million, marking a 24% increase over the first quarter, driven by a 17% rise in demand from new patient starts, with approximately 30% of these starts occurring in first and second lines of therapy. The company's inventory at the end of Q2 remained within the target range of 2 to 4 weeks. The commercial team expanded by over 20%, and the medical affairs organization doubled in size to bolster RYTELO's market presence. Additionally, approximately 90% of U.S. covered lives now have favorable RYTELO medical coverage, an increase from 85% in the first quarter. The IMpactMF trial is over 95% enrolled, with completion expected by year-end, and Geron's cash position stood at $433 million as of June 30, 2025. The company's focus remains on increasing brand awareness, improving physician prescribing confidence, and expanding key opinion leader support to drive continued commercial success.

Geron Financial Statement Overview

Summary
Geron's financials show significant challenges with profitability, marked by negative net income and EBIT margins. Despite revenue growth, the company faces persistent net losses and negative cash flows, indicating financial strain and sustainability concerns.
Income Statement
35
Negative
Geron's income statement reveals significant challenges with profitability, as highlighted by negative net income and EBIT margins over the periods analyzed. Despite a sharp increase in total revenue in the TTM period, the company still reports significant net losses, affecting its overall profitability. This indicates ongoing financial strain likely due to high operational costs or expenses exceeding revenue gains.
Balance Sheet
50
Neutral
The balance sheet indicates moderate financial health with a relatively stable debt-to-equity ratio. The company's equity ratio shows a reasonable proportion of equity financing, though total liabilities have been increasing, reflecting potential leverage concerns. However, the consistent increase in total assets suggests investment and growth potential.
Cash Flow
40
Negative
Geron's cash flow statements highlight negative free cash flow and operating cash flows, indicating cash burn likely due to ongoing investments or operational challenges. Although there are positive financing cash flows, the inability to generate positive operating cash flow is concerning for long-term sustainability.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue164.45M76.99M237.00K596.00K1.39M253.00K
Gross Profit161.21M75.74M-123.50M-272.00K610.00K-49.80M
EBITDA-63.78M-154.85M-174.78M-134.15M-111.59M-73.92M
Net Income-88.01M-174.57M-184.13M-141.03M-120.95M-75.61M
Balance Sheet
Total Assets555.20M594.46M394.08M190.57M226.03M270.73M
Cash, Cash Equivalents and Short-Term Investments387.98M406.57M333.70M173.11M183.72M196.64M
Total Debt121.84M121.72M85.90M55.75M55.00M29.72M
Total Liabilities295.67M313.46M146.13M110.58M99.62M59.78M
Stockholders Equity259.53M280.32M247.95M80.00M126.42M210.95M
Cash Flow
Free Cash Flow-178.28M-219.30M-168.57M-127.81M-95.76M-67.05M
Operating Cash Flow-178.28M-218.62M-167.74M-127.38M-95.56M-66.65M
Investing Cash Flow-31.31M-106.00M-180.32M62.07M71.95M-105.32M
Financing Cash Flow171.09M334.37M362.02M87.26M48.56M168.35M

Geron Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.43
Price Trends
50DMA
1.38
Positive
100DMA
1.40
Positive
200DMA
2.28
Negative
Market Momentum
MACD
0.01
Negative
RSI
60.23
Neutral
STOCH
86.22
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GERN, the sentiment is Positive. The current price of 1.43 is above the 20-day moving average (MA) of 1.27, above the 50-day MA of 1.38, and below the 200-day MA of 2.28, indicating a neutral trend. The MACD of 0.01 indicates Negative momentum. The RSI at 60.23 is Neutral, neither overbought nor oversold. The STOCH value of 86.22 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GERN.

Geron Risk Analysis

Geron disclosed 65 risk factors in its most recent earnings report. Geron reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Geron Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$861.32M-31.09%11877.28%63.14%
51
Neutral
$865.80M-427.47%-48.25%33.77%
51
Neutral
$7.44B-0.20-46.00%2.27%22.80%-2.27%
48
Neutral
$1.12B-113.22%2133.71%-15.38%
47
Neutral
$858.46M16.1838.35%14970.29%
40
Underperform
$563.02M-343.83%304.17%29.37%
39
Underperform
$687.64M-50.13%-79.41%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GERN
Geron
1.45
-3.01
-67.49%
CRMD
Cormedix
12.61
7.81
162.71%
QURE
uniQure
15.78
9.05
134.47%
SNDX
Syndax Pharmaceuticals
14.73
-5.23
-26.20%
ANAB
AnaptysBio
19.97
-12.48
-38.46%
AVBP
ArriVent BioPharma, Inc.
18.62
-5.24
-21.96%

Geron Corporate Events

Executive/Board ChangesBusiness Operations and Strategy
Geron Appoints Harout Semerjian as New CEO
Positive
Aug 6, 2025

On August 1, 2025, Geron Corporation’s Board of Directors appointed Harout Semerjian as the new President and CEO, effective August 7, 2025, replacing Dawn C. Bir. Mr. Semerjian brings extensive experience from his previous roles in the biotechnology and pharmaceutical sectors, including leadership positions at GlycoMimetics, Immunomedics, and Ipsen Pharma. The appointment is accompanied by an employment agreement that includes a substantial compensation package and stock options, reflecting the company’s strategic focus on strengthening its leadership team. Additionally, the company amended its severance plan and inducement award plan to align with these leadership changes, indicating a commitment to attracting and retaining top talent in the industry.

The most recent analyst rating on (GERN) stock is a Buy with a $9.00 price target. To see the full list of analyst forecasts on Geron stock, see the GERN Stock Forecast page.

Executive/Board ChangesShareholder Meetings
Geron Approves Key Proposals at Annual Meeting
Neutral
May 27, 2025

On May 21, 2025, Geron Corporation held its annual stockholders meeting where several key proposals were approved. The meeting, conducted virtually, saw stockholders approve amendments to the company’s 2018 Equity Incentive Plan and 2014 Employee Stock Purchase Plan, increasing the number of shares issuable under these plans by 20,000,000 and 6,000,000 respectively. Additionally, the stockholders elected two Class II directors and ratified the selection of Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

The most recent analyst rating on (GERN) stock is a Buy with a $9.00 price target. To see the full list of analyst forecasts on Geron stock, see the GERN Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 14, 2025