Progress on ex-U.S. strategy and leadership additions
Active engagement with European medical experts, HTA work and pricing research underway with an intent to announce a commercialization approach for Europe before year-end; strengthened leadership with recruitment of a new Chief Legal Officer and two new board members.
Strong top-line growth and on-track guidance
RYTELO net revenue of $51.8 million in Q1 2026, up 31% year-over-year and 8% quarter-over-quarter; company remains on track for 2026 net revenue guidance of $220 million to $240 million.
Commercial demand and account expansion
Demand grew ~6% quarter-over-quarter and prescribing accounts expanded ~12% since launch to approximately 1,450 accounts; first- and second-line patient starts on a rolling 12-month basis are ~33%, improving sequentially from ~30%.
Clinical progress and scientific validation
IMpactMF Phase III trial is fully enrolled with an interim analysis projected in the second half of 2026 and a planned final analysis in H2 2028; publication in Blood Cancer Journal and ASH 2025 data reinforce clinical differentiation and mechanism; inclusion in the NCCN chemotherapy order template positions imetelstat as an active therapeutic in lower-risk MDS.
Financial discipline and operating expense reductions
Total operating expenses (ex-Cost of Goods Sold) were $50.4 million in Q1 2026, down from $55.1 million a year earlier (~9% reduction); SG&A was $35.4 million vs $40.0 million in Q1 2025, and R&D was flat at ~$15 million, reflecting workforce reduction and cost controls while maintaining commercial investment.
Strategic commercial investments and market engagement
Company is increasing in-person and digital presence, investing in targeted marketing channels (digital non-personal promotion, third-party education) and expanding investigator-sponsored trials and real-world evidence generation to drive adoption and education among U.S. hematologists.