Market PotentialAnalyst's probability of success for MZE782 has increased to 70% in PKU and 65% in CKD, resulting in a higher price target for the stock.
Regulatory PathThe validation of proteinuria and slope as surrogate endpoints would de-risk Maze’s regulatory path and potentially shorten timelines to approval.
Therapy PositioningMaze’s MZE829 is uniquely positioned as the leading APOL1 targeted therapy, directly aligned with the recent PARASOL initiative and Rosenberg et al.’s validation of proteinuria and slope as predictors of kidney failure.