Maze Therapeutics: Promising Future with Strong Pipeline and Robust Financial HealthWe are updating our model to reflect Maze's (MAZE, OP) 2Q25 financial results and corporate update; data with MZE782 remain on track for this quarter, followed by initial HORIZON (MZE829) results in 1Q26. It has been another quarter of execution for Maze, which continues to advance its platform of novel, small-molecule precision medicines across renal, cardiovascular, and related metabolic diseases (see our initiation here for additional detail). For lead asset MZE829, an inhibitor of apolipoprotein L1 (APOL1), enrollment continues to progress in the Ph.2 HORIZON study (NCT06830629). This trial includes a broad population of patients with APOL1 kidney disease (AKD), including those with diabetes, non-diabetic kidney disease, and severe focal segmental glomerulosclerosis (FSGS). We continue to expect initial proof- of-concept data in the first quarter of 2026.