Nuvation Bio Inc (NUVB)
NYSE:NUVB
Want to see NUVB full AI Analyst Report?
Top Page
Nuvation Bio
(NYSE:NUVB)
Select Model
Select Model
Rating:51Neutral
Price Target:
$4.50
▼(-11.42% Downside)
Action:Reiterated
Date:05/28/26
The score is held back most by weak financial quality (large losses and continued free-cash-flow burn) and a demanding valuation (high P/E with no dividend). Offsetting these are positive earnings-call signals around commercial progress, differentiated clinical profile, and strong liquidity with management indicating no near-term financing need, while technicals are broadly neutral with longer-term trend resistance.
Positive Factors
Revenue growth & strong unit economics
Rapid TTM revenue growth paired with an ~91.6% gross margin indicates the company is converting clinical/commercial traction into attractive unit economics. Over the next 2–6 months, high gross margins support scalable revenue expansion as launch execution and market penetration continue.
Negative Factors
Persistent cash burn and negative free cash flow
Sustained negative operating and free cash flow shows the business is not yet self‑funding and is consuming cash to support launch and development. Over several months this magnifies reliance on existing cash and contingent financing events, raising execution risk if sales growth slows.
Read all positive and negative factors
Positive Factors
Negative Factors
Revenue growth & strong unit economics
Rapid TTM revenue growth paired with an ~91.6% gross margin indicates the company is converting clinical/commercial traction into attractive unit economics. Over the next 2–6 months, high gross margins support scalable revenue expansion as launch execution and market penetration continue.
Read all positive factors
Nuvation Bio (NUVB) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$1.66B
Dividend YieldN/A
Average Volume (3M)4.65M
Price to Earnings (P/E)―
Beta (1Y)1.74
Revenue Growth1205.52%
EPS Growth81.79%
CountryUS
Employees273
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.42
Shares Outstanding348,201,970
10 Day Avg. Volume4,499,616
30 Day Avg. Volume4,651,239
Financial Highlights & Ratios
PEG Ratio0.21
Price to Book (P/B)10.01
Price to Sales (P/S)48.65
P/FCF Ratio-17.61
Enterprise Value/Market Cap0.93
Enterprise Value/Revenue10.79
Enterprise Value/Gross Profit11.78
Enterprise Value/Ebitda-11.85
Forecast
1Y Price Target
$14.40Price Target Upside183.46% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering7
EPS Forecast (FY)-0.42
Revenue Forecast (FY)$202.35M
Nuvation Bio Business Overview & Revenue Model
Company Description
Nuvation Bio Inc. functions as a clinical-stage biopharmaceutical enterprise committed to discovering and advancing therapeutic solutions for oncological conditions. Its foremost experimental compound, NUV-422, is a small molecule designed to inhi...
How the Company Makes Money
Nuvation Bio is a clinical-stage biotechnology company and, as such, typically does not generate material recurring revenue from product sales because its drug candidates are still in development and not yet approved for commercialization. As a re...
Nuvation Bio Earnings Call Summary
Earnings Call Date:May 04, 2026
(Q1-2026)
| % Change Since: |
Next Earnings Date:Aug 06, 2026
Earnings Call Sentiment Positive
The call conveyed strong commercial and clinical momentum for Iptrozy: robust physician awareness (97%), growing first‑line mix (>50% of new starts), meaningful sequential product revenue growth (18% QoQ to $18.5M), and differentiated durability and CNS efficacy (50‑month PFS/DOR in TKI‑naive; 66% intracranial RR). Financially, the quarter was bolstered by a near‑term collaboration upfront (~$60M) and a healthy cash position ($533.7M) with $50M credit available. Key challenges include a steady absolute level of new patient starts (~200/quarter), testing shortfalls in the community (<50% in some centers) that limit incidence capture, upward pressure on gross‑to‑net (targeting stabilization in the high‑20s to ~30%), and sizeable operating expenses ($73.5M). Overall, positive clinical differentiation, market access progress, partnerships, and balance sheet strength outweigh the operational and market access headwinds.Positive Updates
Consistent New Patient Starts and Growing Launch Momentum
Approximately 200 new patient starts with Iptrozy in Q1 (third consecutive quarter of ~200), totaling over 600 since launch; first-line (TKI‑naive) proportion of new starts increased from ~30% to ~40% to now >50%.
Negative Updates
Plateau in Absolute New Patient Starts
New patient starts have been steady at ~200 per quarter for three quarters, indicating that total new starts have not yet expanded despite rising first‑line share and high physician awareness.
Read all updates
Q1-2026 Updates
Positive
Negative
Consistent New Patient Starts and Growing Launch Momentum
Approximately 200 new patient starts with Iptrozy in Q1 (third consecutive quarter of ~200), totaling over 600 since launch; first-line (TKI‑naive) proportion of new starts increased from ~30% to ~40% to now >50%.
Read all positive updates
Company Guidance
Management reiterated that they expect to meet consensus 2026 net‑revenue estimates and emphasized drivers and assumptions: Q1 total revenue was $83.2M with Iptrozy net U.S. product revenue of $18.5M (up 18% QoQ) driven by ~200 new patient starts this quarter (≈600+ since launch) and a rising share of TKI‑naive first‑line starts (~30% → ~40% → >50%) with first‑line growth ~+35% q/q; clinical durability underpinning the outlook includes median DOR/PFS ≈50 months in TKI‑naive, DOR ≈20 months and pooled OS ≈30 months in pretreated patients, first‑line RR ≈90% and 2L intracranial RR ≈66%; financial guidance assumptions include gross‑to‑net normalizing to the high‑20s/≈30% (Q1 uptick from ≈25%), Q1 operating expenses $73.5M (R&D $35.0M; SG&A $38.3M), cash of $533.7M with $50M undrawn term‑loan availability, $64.7M collaboration revenue this quarter (including ≈$60M Eisai upfront) plus ~$1.7M in royalties, an expected ≈$30M Eisai EU milestone in 2027, and the statement that they do not expect to need additional external financing.Nuvation Bio Financial Statement Overview
Summary
Income Statement
34
Negative
Balance Sheet
62
Positive
Cash Flow
28
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 143.05M | 62.90M | 7.87M | 0.00 | 0.00 | 0.00 |
| Gross Profit | 131.08M | 54.46M | 795.00K | 0.00 | 0.00 | 0.00 |
| EBITDA | -130.26M | -190.94M | -566.91M | -75.58M | -104.00M | -86.66M |
| Net Income | -145.99M | -204.63M | -567.94M | -75.80M | -104.20M | -86.85M |
Balance Sheet | ||||||
| Total Assets | 610.24M | 594.82M | 540.63M | 621.48M | 672.14M | 776.15M |
| Cash, Cash Equivalents and Short-Term Investments | 533.73M | 529.21M | 502.69M | 611.21M | 661.01M | 765.39M |
| Total Debt | 9.83M | 10.15M | 8.91M | 4.01M | 4.26M | 3.06M |
| Total Liabilities | 290.68M | 289.11M | 76.84M | 16.36M | 17.07M | 30.15M |
| Stockholders Equity | 319.56M | 305.72M | 463.79M | 605.12M | 655.08M | 746.00M |
Cash Flow | ||||||
| Free Cash Flow | -126.06M | -173.78M | -130.57M | -68.07M | -96.48M | -68.47M |
| Operating Cash Flow | -125.73M | -173.43M | -130.41M | -68.00M | -96.11M | -68.19M |
| Investing Cash Flow | 1.70M | 99.52M | 122.70M | 8.92M | 63.46M | -454.67M |
| Financing Cash Flow | 202.03M | 202.53M | 331.00K | 628.00K | 1.33M | 625.53M |
Nuvation Bio Technical Analysis
Positive
5.08
Price Trends
4.73
Positive
4.92
Negative
5.27
Negative
Market Momentum
0.04
Negative
53.71
Neutral
23.63
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NUVB, the sentiment is Positive. The current price of 5.08 is above the 20-day moving average (MA) of 4.72, above the 50-day MA of 4.73, and below the 200-day MA of 5.27, indicating a neutral trend. The MACD of 0.04 indicates Negative momentum. The RSI at 53.71 is Neutral, neither overbought nor oversold. The STOCH value of 23.63 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for NUVB.
Nuvation Bio Risk Analysis
Nuvation Bio disclosed 89 risk factors in its most recent earnings report. Nuvation Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Nuvation Bio Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
57 Neutral | $6.91B | -21.94 | -43.02% | ― | -100.00% | -24.90% | |
55 Neutral | $1.12B | -6.33 | -56.41% | ― | -31.58% | -27.41% | |
54 Neutral | $1.61B | -6.94 | -1768.51% | ― | 652.08% | -116.59% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $1.66B | -11.32 | -44.10% | ― | 1205.52% | 81.79% | |
51 Neutral | $2.00B | -9.26 | -87.00% | ― | -36.24% | 11.52% | |
49 Neutral | $2.46B | -25.66 | -21.04% | ― | ― | 13.79% |
* Healthcare Sector Average
NUVB
Nuvation Bio
4.76
3.03
175.14%
NKTR
Nektar Therapeutics
59.21
50.62
589.29%
PGEN
Precigen
4.53
3.01
198.03%
WVE
Wave Life Sciences
5.81
-1.14
-16.40%
ELVN
Enliven Therapeutics
40.36
18.45
84.21%
PRAX
Praxis Precision Medicines
247.98
203.68
459.77%
Nuvation Bio Corporate Events
Executive/Board ChangesShareholder Meetings
Nuvation Bio Shareholders Approve Directors and Executive Compensation
Positive
May 27, 2026
On May 21, 2026, Nuvation Bio Inc. held its 2026 Annual Meeting of Stockholders, with 83.6% of Class A and all Class B shares represented, constituting a quorum. Shareholders elected Class A directors Robert B. Bazemore Jr. and Robert Mashal, M.D....
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.