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Nuvation Bio
(NYSE:NUVB)
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Rating:56Neutral
Price Target:
$7.00
▲(9.03% Upside)
Action:Reiterated
Date:07/07/26
The score is held back primarily by weak financial performance (large ongoing losses and sustained cash burn despite strong revenue growth and gross margin). Offsetting factors include constructive price trends and a positive earnings-call setup driven by commercial progress and strong liquidity, while valuation remains pressured due to negative earnings and no dividend support.
Positive Factors
Strong revenue growth & gross margin
Sustained triple‑digit top‑line growth and ~91.6% gross margin indicate attractive unit economics and successful commercial uptake of Iptrozy. Durable high gross margins support scalable revenue conversion and provide structural capacity to fund R&D and launch investments as sales scale.
Negative Factors
Sustained negative cash flow
Ongoing, large negative operating and free cash flow signals persistent cash burn to support commercialization and R&D. Without durable self‑funding from product revenue or steady external financing, losses will pressure the balance sheet and require continued capital markets access over the medium term.
Read all positive and negative factors
Positive Factors
Negative Factors
Strong revenue growth & gross margin
Sustained triple‑digit top‑line growth and ~91.6% gross margin indicate attractive unit economics and successful commercial uptake of Iptrozy. Durable high gross margins support scalable revenue conversion and provide structural capacity to fund R&D and launch investments as sales scale.
Read all positive factors
Nuvation Bio Key Performance Indicators (KPIs)
Nuvation Bio (NUVB) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$2.30B
Dividend YieldN/A
Average Volume (3M)8.03M
Price to Earnings (P/E)―
Beta (1Y)1.68
Revenue Growth1205.52%
EPS Growth81.79%
CountryUS
Employees307
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.42
Shares Outstanding348,201,970
10 Day Avg. Volume6,156,846
30 Day Avg. Volume8,034,544
Financial Highlights & Ratios
PEG Ratio0.21
Price to Book (P/B)10.01
Price to Sales (P/S)48.65
P/FCF Ratio-17.61
Enterprise Value/Market Cap<0.01
Enterprise Value/Revenue<0.01
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda>-0.01
Forecast
1Y Price Target
$15.00Price Target Upside133.64% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering7
EPS Forecast (FY)-0.35
Revenue Forecast (FY)$201.03M
Nuvation Bio Business Overview & Revenue Model
Company Description
Nuvation Bio Inc. (NUVB) is a clinical-stage biopharmaceutical company focused on developing targeted cancer therapies. The company’s pipeline consists of investigational oncology drug candidates intended to treat genetically defined or otherwise ...
How the Company Makes Money
null...
Nuvation Bio Earnings Call Summary
Earnings Call Date:May 04, 2026
(Q1-2026)
| % Change Since: |
Next Earnings Date:Aug 06, 2026
Earnings Call Sentiment Positive
The call conveyed strong commercial and clinical momentum for Iptrozy: robust physician awareness (97%), growing first‑line mix (>50% of new starts), meaningful sequential product revenue growth (18% QoQ to $18.5M), and differentiated durability and CNS efficacy (50‑month PFS/DOR in TKI‑naive; 66% intracranial RR). Financially, the quarter was bolstered by a near‑term collaboration upfront (~$60M) and a healthy cash position ($533.7M) with $50M credit available. Key challenges include a steady absolute level of new patient starts (~200/quarter), testing shortfalls in the community (<50% in some centers) that limit incidence capture, upward pressure on gross‑to‑net (targeting stabilization in the high‑20s to ~30%), and sizeable operating expenses ($73.5M). Overall, positive clinical differentiation, market access progress, partnerships, and balance sheet strength outweigh the operational and market access headwinds.Positive Updates
Consistent New Patient Starts and Growing Launch Momentum
Approximately 200 new patient starts with Iptrozy in Q1 (third consecutive quarter of ~200), totaling over 600 since launch; first-line (TKI‑naive) proportion of new starts increased from ~30% to ~40% to now >50%.
Negative Updates
Plateau in Absolute New Patient Starts
New patient starts have been steady at ~200 per quarter for three quarters, indicating that total new starts have not yet expanded despite rising first‑line share and high physician awareness.
Read all updates
Q1-2026 Updates
Positive
Negative
Consistent New Patient Starts and Growing Launch Momentum
Approximately 200 new patient starts with Iptrozy in Q1 (third consecutive quarter of ~200), totaling over 600 since launch; first-line (TKI‑naive) proportion of new starts increased from ~30% to ~40% to now >50%.
Read all positive updates
Company Guidance
Management reiterated that they expect to meet consensus 2026 net‑revenue estimates and emphasized drivers and assumptions: Q1 total revenue was $83.2M with Iptrozy net U.S. product revenue of $18.5M (up 18% QoQ) driven by ~200 new patient starts this quarter (≈600+ since launch) and a rising share of TKI‑naive first‑line starts (~30% → ~40% → >50%) with first‑line growth ~+35% q/q; clinical durability underpinning the outlook includes median DOR/PFS ≈50 months in TKI‑naive, DOR ≈20 months and pooled OS ≈30 months in pretreated patients, first‑line RR ≈90% and 2L intracranial RR ≈66%; financial guidance assumptions include gross‑to‑net normalizing to the high‑20s/≈30% (Q1 uptick from ≈25%), Q1 operating expenses $73.5M (R&D $35.0M; SG&A $38.3M), cash of $533.7M with $50M undrawn term‑loan availability, $64.7M collaboration revenue this quarter (including ≈$60M Eisai upfront) plus ~$1.7M in royalties, an expected ≈$30M Eisai EU milestone in 2027, and the statement that they do not expect to need additional external financing.Nuvation Bio Financial Statement Overview
Summary
Income Statement
34
Negative
Balance Sheet
62
Positive
Cash Flow
28
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 143.05M | 62.90M | 7.87M | 0.00 | 0.00 | 0.00 |
| Gross Profit | 131.08M | 54.46M | 795.00K | 0.00 | 0.00 | 0.00 |
| EBITDA | -129.73M | -189.21M | -566.91M | -75.58M | -104.00M | -86.66M |
| Net Income | -145.99M | -204.63M | -567.94M | -75.80M | -104.20M | -86.85M |
Balance Sheet | ||||||
| Total Assets | 610.24M | 594.82M | 540.63M | 621.48M | 672.14M | 776.15M |
| Cash, Cash Equivalents and Short-Term Investments | 533.73M | 529.21M | 502.69M | 611.21M | 661.01M | 765.39M |
| Total Debt | 9.83M | 10.15M | 8.91M | 4.01M | 4.26M | 3.06M |
| Total Liabilities | 290.68M | 289.11M | 76.84M | 16.36M | 17.07M | 30.15M |
| Stockholders Equity | 319.56M | 305.72M | 463.79M | 605.12M | 655.08M | 746.00M |
Cash Flow | ||||||
| Free Cash Flow | -126.06M | -173.78M | -130.57M | -68.07M | -96.48M | -68.47M |
| Operating Cash Flow | -125.73M | -173.43M | -130.41M | -68.00M | -96.11M | -68.19M |
| Investing Cash Flow | 1.70M | 99.52M | 122.70M | 8.92M | 63.46M | -454.67M |
| Financing Cash Flow | 202.03M | 202.53M | 331.00K | 628.00K | 1.33M | 625.53M |
Nuvation Bio Technical Analysis
Positive
6.42
Price Trends
5.52
Positive
5.06
Positive
5.69
Positive
Market Momentum
0.29
Negative
62.82
Neutral
89.23
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NUVB, the sentiment is Positive. The current price of 6.42 is above the 20-day moving average (MA) of 6.13, above the 50-day MA of 5.52, and above the 200-day MA of 5.69, indicating a bullish trend. The MACD of 0.29 indicates Negative momentum. The RSI at 62.82 is Neutral, neither overbought nor oversold. The STOCH value of 89.23 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for NUVB.
Nuvation Bio Risk Analysis
Nuvation Bio disclosed 89 risk factors in its most recent earnings report. Nuvation Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Nuvation Bio Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
60 Neutral | $8.11B | -22.09 | -43.02% | ― | -100.00% | -24.90% | |
56 Neutral | $2.30B | -15.76 | -44.10% | ― | 1205.52% | 81.79% | |
56 Neutral | $1.94B | -4.31 | -1768.51% | ― | 652.08% | -116.59% | |
56 Neutral | $3.78B | -32.78 | -21.04% | ― | ― | 13.79% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $2.39B | -8.40 | -87.00% | ― | -36.24% | 11.52% | |
48 Neutral | $1.12B | -5.56 | -50.12% | ― | -31.58% | -27.41% |
* Healthcare Sector Average
NUVB
Nuvation Bio
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Nuvation Bio Corporate Events
Business Operations and StrategyPrivate Placements and Financing
Nuvation Bio Expands Convertible Notes Offering and Financing
Positive
Jul 6, 2026
On June 30, 2026, Nuvation Bio completed a registered underwritten public offering of 0.75% Convertible Senior Notes due 2032, initially raising $250 million in aggregate principal amount. The underwriters exercised in full their 30-day greenshoe ...
Business Operations and StrategyPrivate Placements and Financing
Nuvation Bio Issues Convertible Notes, Retires Secured Debt
Positive
Jun 30, 2026
On June 30, 2026, Nuvation Bio Inc. completed a registered underwritten public offering of $250 million aggregate principal amount of 0.75% Convertible Senior Notes due 2032, following an underwriting agreement signed on June 25, 2026 with a syndi...
Executive/Board ChangesShareholder Meetings
Nuvation Bio Shareholders Approve Directors and Executive Compensation
Positive
May 27, 2026
On May 21, 2026, Nuvation Bio Inc. held its 2026 Annual Meeting of Stockholders, with 83.6% of Class A and all Class B shares represented, constituting a quorum. Shareholders elected Class A directors Robert B. Bazemore Jr. and Robert Mashal, M.D....
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.