Bearish Market SentimentShort interest stands at 15.5% of the float, indicating a significant level of bearish sentiment in the market.
Discontinuation And Toxicity ConcernsManagement noted that most patients discontinue therapy within two years, with about 10% of scripts being discontinued every month due to CNS toxicity.
Market CompetitionPoorer-than-anticipated commercial uptake of company products, particularly taletrectinib, due to higher-than-anticipated levels of competition or other market-related factors.