Clinical Data And Procedure ConcernsQURE's mixed mHtt biomarker data and the serious nature of the administration procedure render AMT-130 a less favorable option.
Program Advancement UncertaintyDecision to advance WVE-003's HD program into Ph2/3 is putting some pressure on shares due to uncertainties around caudate imaging as an approvable surrogate biomarker and potential costs.
Therapy EffectivenessMany currently approved therapies affect central pathways with weight loss due to reduced appetite, but they are only reaching a small percentage of eligible patients and have a high discontinuation rate.