Competitive LandscapeA crowded obesity drug development field, including multiple programs originating from China, could make differentiation harder and pressure future market share.
Tolerability ConcernA higher frequency of vomiting reported in the Phase IIb aleniglipron program versus a comparator raises tolerability concerns that may require mitigation to preserve adoption and regulatory momentum.
Valuation And Downside SensitivitySubstantial share price appreciation increases valuation risk and makes the stock more sensitive to any unexpected clinical, regulatory, or partnership setbacks.