Clinical TrialsETNB's pegozafermin is showing strong progress with reaffirmed clinical data timing in NASH and severe hypertriglyceridemia, indicating a promising trajectory.
Competitive PositionETNB is well-positioned with pegozafermin as a potentially best-in-class compound due to its competitive efficacy profile and differentiation on safety, tolerability, and dosing frequency.
Mechanism ValidationCompelling 96-week results from AKRO’s Phase 2b SYMMETRY trial of efruxifermin in cirrhotic NASH patients provide positive readthrough for ETNB’s ENLIGHTEN-Cirrhosis study, validating the FGF21 mechanism.