Clinical Efficacy In Refractory PatientsEarly clinical data demonstrated robust and durable molecular responses in heavily pretreated chronic myeloid leukemia patients, including those who had failed multiple prior therapies.
Combination Therapy PotentialPreclinical and clinical evidence that ELVN-001 and asciminib effectively suppress resistant clones supports a combination strategy to address diverse resistance mutations.
Mechanism Of ActionELVN-001 inhibits an ATP-binding pocket distinct from competitors, enabling treatment of patients who were refractory to therapies that bind the alternate pocket.