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Genedx Holdings Corp. (WGS)
:WGS
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GeneDx Holdings (WGS) AI Stock Analysis

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WGS

GeneDx Holdings

(NASDAQ:WGS)

Rating:66Neutral
Price Target:
$112.00
▼(-9.02% Downside)
GeneDx Holdings' overall score is driven by strong financial recovery and positive earnings call highlights. However, concerns about high valuation and an overbought technical status weigh on the score.
Positive Factors
Earnings
Test volume beat expectations, price was significantly ahead of forecasts, and EBIT margins exceeded predictions for WGS.
Guidelines and Recommendations
New guidelines from the AAP now recommend exome/genome as a first-line test for kids with developmental delay & intellectual disability, opening a big opportunity for WGS to access general pediatricians.
Market Opportunity
The '25 outlook now calls for substantial revenue growth in a market that is still largely untapped, making an attractive investment case.
Product Launch
The ultra-rapid genome was launched, offering a fast turnaround time and competitive pricing, which may help take volumes from smaller competitors.
Negative Factors
Stock Performance
While Q1 exome/genome revenue grew 62% Y/Y, the stock sold off by more than 50% due to perceived sequential slowdown.
Volume Forecast
Lowering volume estimates for Q2 and Q3 by 1% due to caution after a volume miss in Q1.

GeneDx Holdings (WGS) vs. SPDR S&P 500 ETF (SPY)

GeneDx Holdings Business Overview & Revenue Model

Company DescriptionGeneDx Holdings Corp. is a patient centered health intelligence company. It engages in transforming healthcare by applying AI and machine learning to multidimensional, longitudinal clinical and genomic data to build dynamic models of human health and defining optimal, individualized health trajectories. The firm, through its Centrellis health intelligence platform, generates a more complete understanding of disease and wellness and provides science-driven solutions to the most pressing medical needs. The company was founded by Eric Schadt in October 2015 and is headquartered in Stamford, CT.
How the Company Makes MoneyGeneDx Holdings generates revenue through a diversified model primarily centered around its genetic testing services. The company charges fees for its sequencing services, which are utilized by hospitals, clinics, and research institutions. Its revenue streams include payments from healthcare providers who order genetic tests for their patients, as well as research collaborations with pharmaceutical companies and academic institutions. Additionally, GeneDx may receive funding from partnerships aimed at developing new genomic technologies and solutions. The company benefits from the growing demand for precision medicine, which drives the need for accurate and comprehensive genetic testing, further contributing to its financial performance.

GeneDx Holdings Earnings Call Summary

Earnings Call Date:Jul 29, 2025
(Q2-2025)
|
% Change Since: 44.99%|
Next Earnings Date:Nov 17, 2025
Earnings Call Sentiment Positive
The earnings call was largely positive, with GeneDx achieving record revenue and significant growth in exome and genome testing. The company improved its reimbursement rates and expanded into new markets. Although there are challenges related to new indications and the slower adoption of testing in general pediatrics, the overall outlook remains strong with raised revenue guidance and sustained profitability.
Q2-2025 Updates
Positive Updates
Record Revenue Achievement
GeneDx delivered over $100 million in revenue for the first time in a single quarter, with total second quarter 2025 revenues reaching $102.7 million, a 49% increase year-over-year.
Exome and Genome Revenue Growth
Revenue from exome and genome tests hit a record high of $85.9 million, up 69% from the same quarter last year.
Increased Average Reimbursement Rate
Average reimbursement rate for exome and genome tests increased to over $3,700 per test, up from approximately $3,400 last quarter.
Expanded Market Opportunities
Increased engagement with pediatric neurologists and immunologists and expansion into the NICU market, which represents a $1 billion opportunity.
Improved Gross Margin
Total company adjusted gross margin expanded to a record high of 71%, driven by a favorable mix shift, improved reimbursement, and lower COGS.
Sustained Profitability
GeneDx reported $15 million in adjusted net income, marking the fourth consecutive quarter of profitability.
Raised Revenue Guidance
Full year 2025 total revenue guidance raised to between $400 million and $415 million, with exome and genome revenue expected to grow between 48% and 52%.
Negative Updates
Challenges with New Indications
The guide allows for potential denial rate increases as GeneDx submits tests for new indications, which may impact collection rates.
Slow Adoption in General Pediatrics
Minimal contribution from general pediatricians expected for this year, with broader adoption anticipated to take 18 to 24 months.
Company Guidance
During GeneDx's second quarter 2025 earnings call, the company provided updated guidance metrics and highlighted key achievements. GeneDx reported a record revenue of $102.7 million, marking a 49% year-over-year increase, with $85.9 million coming from exome and genome testing, which grew 69% from the same quarter last year. The average reimbursement rate for these tests increased to over $3,700, up from approximately $3,400 last quarter. GeneDx expects full-year revenue to be between $400 million and $415 million, raising exome and genome revenue guidance to deliver 48% to 52% growth. The company anticipates at least 30% year-over-year volume growth and has raised its full-year adjusted gross margin expectations to between 68% and 71%. GeneDx also affirmed its commitment to remain profitable each quarter on an adjusted net income basis for 2025. The call emphasized GeneDx's strategic initiatives, including expanding into new indications, leveraging their extensive genomic data set, and integrating Fabric Genomics to enhance their platform capabilities.

GeneDx Holdings Financial Statement Overview

Summary
GeneDx Holdings is in a growth phase with increasing revenues but continues to face profitability challenges. The balance sheet strength is a positive aspect, with low leverage and a solid equity base. However, negative net income and cash flow figures point to financial vulnerabilities that need addressing. The company must focus on achieving operational efficiency and cash flow management to enhance financial performance.
Income Statement
55
Neutral
GeneDx Holdings has shown a positive revenue growth trend, with a TTM revenue increase to $330.1 million compared to $305.5 million in the previous year. Despite this growth, the company remains unprofitable, as evidenced by negative EBIT and net income margins. The gross profit margin improved to 63.9% TTM, signaling better cost management. However, persistent net losses and negative EBIT margins indicate ongoing operational challenges.
Balance Sheet
60
Neutral
The balance sheet shows a stable equity position with stockholders' equity at $257.4 million. The debt-to-equity ratio improved to 0.24 TTM, reflecting a manageable leverage level. Moreover, the equity ratio of 57.7% indicates a strong capital structure. However, the company has struggled with profitability, as seen from the negative return on equity, which poses a risk to financial stability if losses continue.
Cash Flow
50
Neutral
GeneDx Holdings reports negative free cash flow and operating cash flow, reflecting cash management challenges. Despite a significant improvement in free cash flow growth from the previous year, the company still faces hurdles in generating positive cash flow. The operating cash flow to net income ratio improved slightly TTM, yet remains negative, underscoring ongoing operational inefficiencies.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue305.45M202.57M234.69M212.19M179.32M
Gross Profit194.40M60.62M-26.75M-16.60M4.03M
EBITDA-27.64M-136.46M-398.20M-219.19M-224.73M
Net Income-52.29M-175.77M-548.98M-245.39M-246.44M
Balance Sheet
Total Assets419.38M473.67M490.94M554.09M251.64M
Cash, Cash Equivalents and Short-Term Investments141.19M130.15M123.93M400.57M108.13M
Total Debt116.17M119.77M72.38M32.85M45.02M
Total Liabilities174.13M245.66M237.24M165.99M581.69M
Stockholders Equity245.25M228.02M253.71M388.10M-330.05M
Cash Flow
Free Cash Flow-33.99M-185.86M-333.48M-211.22M-125.10M
Operating Cash Flow-28.50M-180.15M-319.15M-190.43M-93.13M
Investing Cash Flow-30.13M-43.73M-141.33M-20.79M-31.97M
Financing Cash Flow44.16M186.24M197.31M493.73M129.06M

GeneDx Holdings Technical Analysis

Technical Analysis Sentiment
Positive
Last Price123.11
Price Trends
50DMA
86.01
Positive
100DMA
84.23
Positive
200DMA
82.44
Positive
Market Momentum
MACD
8.85
Negative
RSI
79.41
Negative
STOCH
97.85
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For WGS, the sentiment is Positive. The current price of 123.11 is above the 20-day moving average (MA) of 96.38, above the 50-day MA of 86.01, and above the 200-day MA of 82.44, indicating a bullish trend. The MACD of 8.85 indicates Negative momentum. The RSI at 79.41 is Negative, neither overbought nor oversold. The STOCH value of 97.85 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for WGS.

GeneDx Holdings Risk Analysis

GeneDx Holdings disclosed 74 risk factors in its most recent earnings report. GeneDx Holdings reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

GeneDx Holdings Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
$1.87B39.1510.94%9.62%-6.61%
66
Neutral
$3.34B6,583.420.60%48.70%
60
Neutral
$1.22B38.365.27%3.20%
51
Neutral
$7.43B-0.36-45.45%2.27%22.98%-2.34%
50
Neutral
$1.38B-44.40%18.59%10.96%
50
Neutral
$209.85M-74.09%7.31%-7.49%
50
Neutral
$512.22M-64.27%-5.24%23.59%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
WGS
GeneDx Holdings
123.11
90.22
274.31%
PGNY
Progyny
23.06
2.21
10.60%
SDGR
Schrodinger
19.84
-0.66
-3.22%
GDRX
GoodRx Holdings
3.56
-3.36
-48.55%
SOPH
SOPHiA GENETICS
3.11
-0.23
-6.89%
DH
Definitive Healthcare Corp
3.94
-0.07
-1.75%

GeneDx Holdings Corporate Events

Executive/Board ChangesShareholder Meetings
GeneDx Holdings Approves Key Proposals at Annual Meeting
Neutral
Jun 18, 2025

On June 18, 2025, GeneDx Holdings Corp. held its Annual Meeting of Stockholders, where key proposals were voted on and approved. The stockholders elected two Class I directors, Eli D. Casdin and Joshua Ruch, to serve three-year terms, and ratified the appointment of Ernst & Young LLP as the independent registered public accounting firm for the fiscal year ending December 31, 2025.

The most recent analyst rating on (WGS) stock is a Buy with a $43.00 price target. To see the full list of analyst forecasts on GeneDx Holdings stock, see the WGS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 31, 2025