Prime Medicine, Inc. (PRME)
NASDAQ:PRME
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Prime Medicine, Inc.
(NASDAQ:PRME)
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Rating:50Neutral
Price Target:
$3.50
▼(-4.37% Downside)
Action:ReiteratedDate:03/04/26
Score is held back primarily by weak financial performance (large ongoing losses, significant cash burn, and increased debt), partially offset by improving technical momentum and constructive corporate updates on pipeline progress and runway. Valuation is constrained by negative earnings and no dividend support.
Positive Factors
Proprietary prime editing platform
Prime Medicine’s prime editing platform is a durable competitive asset: it enables precise, single-edit corrections across multiple indications, creating a high barrier to entry and licensing appeal. If clinical validation continues, the platform supports long-term partnerships, broad addressable markets and repeatable program launches.
Negative Factors
High cash burn and losses
Sustained multi‑hundred‑million dollar annual losses and negative operating cash flow force continual external financing absent disruptive clinical success. Over time this raises dilution risk, can compress investment in lower‑priority programs, and imposes pressure on management to optimize spending or seek deal terms that may be less favorable.
Read all positive and negative factors
Positive Factors
Negative Factors
Proprietary prime editing platform
Prime Medicine’s prime editing platform is a durable competitive asset: it enables precise, single-edit corrections across multiple indications, creating a high barrier to entry and licensing appeal. If clinical validation continues, the platform supports long-term partnerships, broad addressable markets and repeatable program launches.
Read all positive factors
Prime Medicine, Inc. (PRME) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$660.82M
Dividend YieldN/A
Average Volume (3M)2.39M
Price to Earnings (P/E)―
Beta (1Y)2.94
Revenue Growth647.13%
EPS Growth26.79%
CountryUS
Employees214
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-0.22
Shares Outstanding180,552,190
10 Day Avg. Volume1,822,506
30 Day Avg. Volume2,394,600
Financial Highlights & Ratios
PEG Ratio0.14
Price to Book (P/B)4.27
Price to Sales (P/S)111.44
P/FCF Ratio-3.09
Enterprise Value/Market Cap1.09
Enterprise Value/Revenue155.75
Enterprise Value/Gross Profit-268.29
Enterprise Value/Ebitda-3.69
Forecast
1Y Price Target
$5.50Price Target Upside50.27% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering5
EPS Forecast (FY)-0.93
Revenue Forecast (FY)$20.60M
Prime Medicine, Inc. Business Overview & Revenue Model
Company Description
Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address diseases by deploying gene editing technology. It offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transc...
How the Company Makes Money
Prime Medicine makes money primarily through collaboration and licensing-related revenue (e.g., upfront payments, research funding, milestone payments, and potential royalties) from partnerships that use or support its prime editing platform and/o...
Prime Medicine, Inc. Financial Statement Overview
Summary
Income Statement
14
Very Negative
Balance Sheet
38
Negative
Cash Flow
22
Negative
| Breakdown | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|
Income Statement | |||||
| Total Revenue | 4.63M | 2.98M | 0.00 | 0.00 | 0.00 |
| Gross Profit | -2.69M | 2.98M | 0.00 | 0.00 | 0.00 |
| EBITDA | -195.76M | -196.34M | -186.64M | -114.32M | -83.91M |
| Net Income | -201.14M | -195.88M | -198.13M | -121.82M | -165.37M |
Balance Sheet | |||||
| Total Assets | 342.73M | 297.51M | 193.85M | 360.31M | 301.86M |
| Cash, Cash Equivalents and Short-Term Investments | 177.68M | 190.44M | 121.67M | 293.92M | 269.62M |
| Total Debt | 116.43M | 40.79M | 13.63M | 28.75M | 10.41M |
| Total Liabilities | 221.87M | 144.36M | 60.78M | 44.04M | 62.30M |
| Stockholders Equity | 120.87M | 153.15M | 133.07M | 316.27M | 239.56M |
Cash Flow | |||||
| Free Cash Flow | -167.09M | -130.16M | -174.14M | -147.92M | -38.23M |
| Operating Cash Flow | -162.56M | -122.86M | -165.41M | -131.83M | -34.08M |
| Investing Cash Flow | -108.76M | 68.46M | 18.71M | -47.10M | -73.63M |
| Financing Cash Flow | 151.51M | 195.88M | 655.00K | 181.49M | 269.28M |
Prime Medicine, Inc. Technical Analysis
Positive
3.66
Price Trends
3.65
Positive
3.76
Negative
4.06
Negative
Market Momentum
-0.07
Negative
52.57
Neutral
70.56
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PRME, the sentiment is Positive. The current price of 3.66 is above the 20-day moving average (MA) of 3.50, above the 50-day MA of 3.65, and below the 200-day MA of 4.06, indicating a neutral trend. The MACD of -0.07 indicates Negative momentum. The RSI at 52.57 is Neutral, neither overbought nor oversold. The STOCH value of 70.56 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for PRME.
Prime Medicine, Inc. Risk Analysis
Prime Medicine, Inc. disclosed 80 risk factors in its most recent earnings report. Prime Medicine, Inc. reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Prime Medicine, Inc. Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
56 Neutral | $2.73B | -6.61 | -43.17% | ― | -16.50% | 33.02% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $1.46B | -5.79 | -39.69% | ― | -27.61% | -69.49% | |
50 Neutral | $660.82M | -2.57 | -178.61% | ― | 647.13% | 26.79% | |
50 Neutral | $556.72M | -10.19 | -36.48% | ― | ― | ― | |
49 Neutral | $1.29B | ― | -56.64% | ― | -36.36% | -945.72% | |
44 Neutral | $856.64M | -4.22 | -141.99% | ― | ― | 31.16% |
* Healthcare Sector Average
PRME
Prime Medicine, Inc.
3.70
2.38
180.30%
IMTX
Immatics
10.95
6.58
150.57%
RLAY
Relay Therapeutics
14.75
11.99
434.42%
TSHA
Taysha Gene Therapies
4.71
3.44
270.87%
SANA
Sana Biotechnology
3.48
1.78
104.71%
UPB
Upstream Bio, Inc.
10.34
2.57
33.08%
Prime Medicine, Inc. Corporate Events
Business Operations and StrategyFinancial Disclosures
Prime Medicine Reports 2025 Results, Advances Gene Editing Pipeline
Positive
Mar 3, 2026
On March 3, 2026, Prime Medicine reported full-year 2025 financial results and outlined progress across its Prime Editing pipeline, highlighting liver-focused in vivo gene editing programs for Wilson disease and Alpha-1 antitrypsin deficiency, wit...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.