tiprankstipranks
Trending News
More News >
Taysha Gene Therapies (TSHA)
NASDAQ:TSHA
US Market
Advertisement

Taysha Gene Therapies (TSHA) AI Stock Analysis

Compare
1,064 Followers

Top Page

TSHA

Taysha Gene Therapies

(NASDAQ:TSHA)

Rating:50Neutral
Price Target:
$2.50
▼(-4.94%Downside)
Taysha Gene Therapies faces significant financial challenges with ongoing losses and negative cash flows, which weigh heavily on the overall score. However, positive earnings call sentiment and strategic corporate events provide some optimism about future prospects, particularly with advancements in the TSHA-102 gene therapy program.
Positive Factors
Clinical Efficacy
TSHA's clinical data showed 100% responder rate on complex motor skills and communication milestones, indicating effective treatment outcomes.
Regulatory Progress
TSHA recently aligned with the FDA on a pivotal trial design, expected to initiate with the first patient dosed likely before year-end.
Negative Factors
Market Competition
Potential competition from other companies poses a risk to TSHA's market position.
Public Perception
Public skepticism about gene therapy presents a challenge for broader acceptance.

Taysha Gene Therapies (TSHA) vs. SPDR S&P 500 ETF (SPY)

Taysha Gene Therapies Business Overview & Revenue Model

Company DescriptionTaysha Gene Therapies, Inc., a gene therapy company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of monogenic diseases of the central nervous system. It primarily develops TSHA-120 for the treatment of giant axonal neuropathy; TSHA-102 for the treatment of Rett syndrome; TSHA-121 for the treatment of CLN1 disease; TSHA-118 for the treatment of CLN1 disease; TSHA-105 foe the treatment of for SLC13A5 Deficiency; and TSHA-101 for the treatment of GM2 gangliosidosis. Taysha Gene Therapies, Inc. has a strategic partnership with The University of Texas Southwestern Medical Center to develop and commercialize transformative gene therapy treatments. The company was incorporated in 2019 and is based in Dallas, Texas.
How the Company Makes MoneyTaysha Gene Therapies primarily generates revenue through the development and commercialization of its gene therapy products. The company seeks to commercialize its therapies either directly or through strategic partnerships and collaborations with other pharmaceutical companies. Revenue can be derived from licensing agreements, milestone payments, and royalties on sales of approved therapies. Additionally, Taysha may receive funding through research and development collaborations or grants from government and non-profit organizations focused on advancing treatments for rare diseases. The company's financial performance is significantly influenced by the success of its clinical trials, regulatory approvals, and the commercial adoption of its therapies.

Taysha Gene Therapies Earnings Call Summary

Earnings Call Date:May 15, 2025
(Q1-2025)
|
% Change Since: 10.97%|
Next Earnings Date:Aug 18, 2025
Earnings Call Sentiment Positive
The earnings call was predominantly positive, with significant regulatory progress and promising clinical data on TSHA-102 for Rett syndrome. The company is financially stable with a reduced net loss and decreased R&D expenses, although there was an increase in general and administrative costs.
Q1-2025 Updates
Positive Updates
Progress in TSHA-102 Gene Therapy Program
Significant regulatory and clinical progress with TSHA-102 for Rett syndrome, including FDA alignment on pivotal trial design without the need for an end-of-phase meeting.
Positive Clinical Data
TSHA-102 has shown early clinical improvements and functional gains in pediatric, adolescent, and adult patients with Rett syndrome, which are unlikely in the untreated population.
Strong Financial Position
Taysha has $116.6 million in cash and cash equivalents, with cash resources expected to support operations into the fourth quarter of 2026.
Decreased R&D Expenses
Research and development expenses decreased by $5.1 million compared to the prior year, driven by reduced GMP batch activities.
Negative Updates
Increased General and Administrative Expenses
General and administrative expenses increased by $1.1 million due to higher compensation expenses and increases in legal and professional fees.
Net Loss
Net loss for the three months ended March 31, 2025, was $21.5 million, although this was an improvement from the previous year's loss of $24.1 million.
Company Guidance
During the Taysha Gene Therapies First Quarter 2025 earnings call, the company provided significant updates on their TSHA-102 gene therapy program for Rett syndrome. The company announced the completion of dosing for 10 patients in Part A of their REVEAL Phase 1/2 trials, with six patients receiving a high dose of TSHA-102. Encouragingly, TSHA-102 was generally well-tolerated across both high and low dose cohorts with no treatment-related serious adverse events or dose-limiting toxicities as of April 10, 2025. Taysha highlighted their alignment with the FDA on key elements of their pivotal Part B trial design, which eliminates the need for a formal end-of-phase meeting, potentially expediting study initiation. Financially, the company reported a net loss of $21.5 million for Q1 2025, with $116.6 million in cash reserves expected to support operations into Q4 2026. Overall, Taysha expressed confidence in the therapeutic potential of TSHA-102 and its path towards regulatory approval.

Taysha Gene Therapies Financial Statement Overview

Summary
Taysha Gene Therapies is facing financial challenges with ongoing losses and declining revenues. The balance sheet shows moderate leverage, but low equity levels signal financial instability. Negative cash flows further highlight liquidity constraints, posing challenges for sustainable growth and profitability.
Income Statement
35
Negative
Taysha Gene Therapies shows persistently negative net income and declining revenues, leading to weak profitability metrics. The company exhibits low EBIT and EBITDA margins and a negative revenue growth trajectory, indicating challenges in achieving operational efficiency and revenue generation.
Balance Sheet
45
Neutral
The balance sheet reflects a moderate debt-to-equity ratio and a declining equity base, suggesting financial strain. The equity ratio indicates limited shareholder equity relative to assets. The company's leverage and low equity position present financial stability risks.
Cash Flow
40
Negative
Cash flows are negative, driven by substantial operating losses. The cash flow to net income ratios are unfavorable, pointing to cash management challenges. Limited free cash flow growth indicates potential liquidity issues, despite consistent financing inflows.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue8.33M15.45M2.50M0.000.00
Gross Profit8.33M15.45M15.00K-492.00K-9.00K
EBITDA-87.95M-105.20M-159.73M-172.78M-42.99M
Net Income-89.30M-111.57M-169.58M-175.46M-43.00M
Balance Sheet
Total Assets160.36M172.73M126.28M213.96M258.88M
Cash, Cash Equivalents and Short-Term Investments139.04M143.94M87.88M149.10M251.25M
Total Debt63.18M61.11M59.93M63.09M0.00
Total Liabilities88.84M97.79M125.33M118.57M7.58M
Stockholders Equity71.53M74.94M949.00K95.38M251.30M
Cash Flow
Free Cash Flow-81.60M-80.39M-113.26M-138.60M-39.81M
Operating Cash Flow-81.22M-73.02M-88.39M-117.04M-30.73M
Investing Cash Flow-363.00K-7.35M-24.93M-21.55M-9.08M
Financing Cash Flow76.68M136.39M52.10M39.08M291.06M

Taysha Gene Therapies Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.63
Price Trends
50DMA
2.57
Positive
100DMA
2.12
Positive
200DMA
2.02
Positive
Market Momentum
MACD
0.02
Negative
RSI
56.48
Neutral
STOCH
55.89
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSHA, the sentiment is Positive. The current price of 2.63 is above the 20-day moving average (MA) of 2.48, above the 50-day MA of 2.57, and above the 200-day MA of 2.02, indicating a bullish trend. The MACD of 0.02 indicates Negative momentum. The RSI at 56.48 is Neutral, neither overbought nor oversold. The STOCH value of 55.89 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for TSHA.

Taysha Gene Therapies Risk Analysis

Taysha Gene Therapies disclosed 83 risk factors in its most recent earnings report. Taysha Gene Therapies reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Taysha Gene Therapies Peers Comparison

Overall Rating
UnderperformOutperform
Sector (52)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
$348.15M84.232.88%61.09%
52
Neutral
$7.46B-0.04-63.82%2.49%16.43%<0.01%
50
Neutral
$687.82M-159.34%-48.97%69.32%
46
Neutral
$310.63M-41.59%0.42%
45
Neutral
$307.30M-938.38%38.82%-645.78%
41
Neutral
$266.15M-1.94%-32.07%98.22%
38
Underperform
$392.74M-48.22%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TSHA
Taysha Gene Therapies
2.63
0.39
17.41%
RNAC
Cartesian Therapeutics
12.18
-4.23
-25.78%
OLMA
Olema Pharmaceuticals
4.54
-10.28
-69.37%
GLUE
Monte Rosa Therapeutics
5.66
1.26
28.64%
TSVT
2seventy bio
5.00
0.62
14.16%
MBX
MBX Biosciences, Inc.
11.70
-9.95
-45.96%

Taysha Gene Therapies Corporate Events

Executive/Board ChangesShareholder MeetingsBusiness Operations and Strategy
Taysha Gene Therapies Approves Share Increase Amendment
Neutral
Jun 3, 2025

On June 2, 2025, Taysha Gene Therapies, Inc. held its annual meeting of stockholders where an amendment to increase the authorized number of shares of common stock from 400,000,000 to 700,000,000 was approved. Additionally, two directors were elected, and Deloitte & Touche LLP’s appointment as the independent registered public accounting firm for the fiscal year ending December 31, 2025, was ratified. These decisions reflect the company’s strategic focus on expanding its capital structure and solidifying its governance framework.

The most recent analyst rating on (TSHA) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Private Placements and Financing
Taysha Gene Therapies Announces Major Stock Offering
Neutral
May 29, 2025

On May 28, 2025, Taysha Gene Therapies announced an underwriting agreement to sell 46,868,687 shares of common stock and pre-funded warrants for 25,858,586 shares in a public offering, expecting to raise approximately $187.4 million. The offering, managed by Jefferies, BofA Securities, Piper Sandler, and Barclays, aims to fund the company’s operations and capital expenditures into 2028, with the closing expected on May 30, 2025.

The most recent analyst rating on (TSHA) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and Strategy
Taysha Gene Therapies Announces Pivotal Trial Design for TSHA-102
Positive
May 28, 2025

On May 28, 2025, Taysha Gene Therapies announced the design details for the pivotal Part B trial of TSHA-102 in Rett syndrome, following positive clinical data from Part A of the REVEAL trials. The trial, supported by the FDA, aims to assess developmental milestone gains in patients aged six and above, with the company planning to initiate the pivotal program in the third quarter of 2025. Additionally, Taysha suspended its ATM Prospectus related to $100 million of common stock but maintained the Sales Agreement in effect.

The most recent analyst rating on (TSHA) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 09, 2025