Taysha Gene Therapies (TSHA) AI Stock Analysis

• Market Cap: $1.17B
• Dividend Yield: N/A
• Average Volume (3M): 9.02M
• Price to Earnings (P/E): ―
• Beta (1Y): 2.47
• Revenue Growth: -36.36%
• EPS Growth: -945.72%
• Country: US
• Employees: 73
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.09
• Shares Outstanding: 273,919,370
• 10 Day Avg. Volume: 3,481,415
• 30 Day Avg. Volume: 9,019,794
• PEG Ratio: 0.08
• Price to Book (P/B): 6.05
• Price to Sales (P/S): 51.93
• P/FCF Ratio: -5.30
• Enterprise Value/Market Cap: 0.79
• Enterprise Value/Revenue: 146.92
• Enterprise Value/Gross Profit: 146.92
• Enterprise Value/Ebitda: -9.24
• 1Y Price Target: $10.27
• Price Target Upside: 161.99% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 12
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 52 Neutral
• Price Target: $4.50 ▲(14.80% Upside)

Taysha Gene Therapies' stock score is primarily influenced by financial challenges, with ongoing losses and negative cash flows. However, positive clinical and regulatory developments provide a potential upside, reflected in the earnings call sentiment. Technical indicators show mixed signals, and valuation metrics highlight the typical risks associated with early-stage biotech investments.

Positive Factors

Regulatory Advancements

The FDA's Breakthrough Therapy designation for TSHA-102 underscores its potential to transform Rett syndrome treatment, enhancing Taysha's market position and accelerating its path to commercialization.

Financial Position

A strong cash position supports Taysha's operations through 2028, providing financial stability and enabling continued investment in R&D and clinical trials.

Strategic Flexibility

Regaining full rights to TSHA-102 allows Taysha strategic flexibility in development and commercialization, potentially increasing future revenue opportunities.

Negative Factors

Negative Cash Flow

Persistent negative cash flow indicates ongoing operational challenges, which could limit Taysha's ability to fund future projects without additional financing.

Increased R&D Expenses

Rising R&D expenses, while necessary for development, increase financial strain and could impact profitability if not matched by future revenue growth.

Net Loss

Continued net losses highlight profitability challenges, which may affect investor confidence and the company's ability to sustain long-term growth.

Taysha Gene Therapies Business Overview & Revenue Model

Company Description

Taysha Gene Therapies (TSHA) is a biotechnology company focused on developing innovative gene therapies for patients with monogenic diseases, primarily targeting neurological disorders. The company leverages its expertise in adeno-associated virus (AAV) technology to create therapies that aim to address the underlying genetic causes of diseases such as spinal muscular atrophy (SMA) and other rare genetic disorders. Taysha operates in the gene therapy sector, striving to improve the quality of life for patients through advanced therapeutic solutions.

How the Company Makes Money

Taysha Gene Therapies primarily generates revenue through a combination of product sales, partnerships, and collaborations in the biotechnology sector. The company is focused on advancing its gene therapy candidates through clinical trials and subsequently commercializing these products upon regulatory approval. Key revenue streams include milestone payments from partnerships with larger pharmaceutical companies that may involve co-development or licensing of Taysha's gene therapies. Additionally, Taysha may receive royalties on sales of approved therapies, further contributing to its earnings. The company also benefits from grants and funding aimed at supporting research and development in gene therapies, which can provide crucial financial backing as it progresses through various stages of product development.

Taysha Gene Therapies Financial Statement Overview

Summary

Taysha Gene Therapies faces significant profitability and cash flow challenges typical of early-stage biotech firms. Despite improvements in leverage and revenue growth, negative net profit margins and cash flows highlight ongoing operational difficulties.

Income Statement

Taysha Gene Therapies has shown some revenue growth in the TTM period, but the company continues to operate at a significant loss with negative net profit margins. The gross profit margin is high, indicating efficient cost management relative to revenue, but the negative EBIT and EBITDA margins highlight ongoing operational challenges.

Balance Sheet

The company's debt-to-equity ratio has improved significantly in the TTM period, indicating better leverage management. However, the return on equity remains negative, reflecting ongoing profitability challenges. The equity ratio is stable, suggesting a reasonable balance between debt and equity.

Cash Flow

Cash flow metrics indicate a challenging environment with negative operating and free cash flows. The free cash flow to net income ratio is slightly above 1, suggesting that cash flow generation is aligned with net losses. However, the negative free cash flow growth rate in the TTM period is a concern.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	6.31M	8.33M	15.45M	2.50M	0.00	0.00
Gross Profit	6.31M	8.33M	15.45M	2.50M	-492.00K	-9.00K
EBITDA	-100.30M	-87.95M	-105.20M	-159.73M	-172.78M	-59.97M
Net Income	-99.93M	-89.30M	-111.57M	-166.01M	-175.46M	-43.00M
Balance Sheet
Total Assets	316.55M	160.36M	172.73M	126.28M	213.96M	258.88M
Cash, Cash Equivalents and Short-Term Investments	297.34M	139.04M	143.94M	87.88M	149.10M	251.25M
Total Debt	16.51M	63.56M	61.11M	59.93M	63.09M	0.00
Total Liabilities	97.56M	88.84M	97.79M	125.33M	118.57M	7.58M
Stockholders Equity	218.99M	71.53M	74.94M	949.00K	95.38M	251.30M
Cash Flow
Free Cash Flow	-85.16M	-81.60M	-80.39M	-113.26M	-138.60M	-39.81M
Operating Cash Flow	-84.68M	-81.22M	-73.02M	-88.39M	-117.04M	-30.73M
Investing Cash Flow	-344.00K	-363.00K	-7.35M	-24.93M	-21.55M	-9.08M
Financing Cash Flow	224.68M	76.68M	136.39M	52.10M	39.08M	291.06M

Taysha Gene Therapies Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 3.92
• 50DMA: Negative
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Positive

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSHA, the sentiment is Neutral. The current price of 3.92 is below the 20-day moving average (MA) of 4.81, below the 50-day MA of 3.97, and above the 200-day MA of 2.61, indicating a neutral trend. The MACD of 0.05 indicates Positive momentum. The RSI at 38.81 is Neutral, neither overbought nor oversold. The STOCH value of 11.98 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for TSHA.

Taysha Gene Therapies Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
IMNM	55 Neutral	$1.34B	―	-81.20%	―	16.74%	59.89%
RLAY	54 Neutral	$1.18B	-3.52	-46.24%	―	-76.27%	22.77%
TSHA	52 Neutral	$1.17B	―	-64.93%	―	-36.36%	-945.72%
SPRY	52 Neutral	$894.38M	―	-23.56%	―	22367.80%	-5.15%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
PRME	43 Neutral	$784.06M	―	-154.81%	―	739.42%	24.90%
SANA	33 Underperform	$1.06B	―	-109.12%	―	―	7.58%

Taysha Gene Therapies Corporate Events

Taysha Gene Therapies’ Earnings Call Highlights Progress and Challenges

Taysha Gene Therapies’ recent earnings call conveyed a predominantly positive sentiment, driven by notable clinical and regulatory advancements with their TSHA-102 program. The company celebrated significant milestones, such as the Breakthrough Therapy designation and promising clinical data, although these achievements were balanced by increased expenses and net loss.

Taysha Gene Therapies Amends Sales Agreement, Expands Offering

On November 4, 2025, Taysha Gene Therapies announced amendments to its Sales Agreement, increasing the aggregate offering amount to $212 million, and terminating its agreement with Leerink Partners LLC. The company also reported significant progress in its TSHA-102 program for Rett syndrome, including receiving FDA Breakthrough Therapy designation and finalizing pivotal trial protocols, positioning it to expedite its Biologics License Application submission. Taysha regained full rights to the TSHA-102 program, enhancing its strategic flexibility, and appointed David McNinch as Chief Commercial Officer to strengthen its commercial leadership.

The most recent analyst rating on (TSHA) stock is a Buy with a $13.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Taysha Gene Therapies’ REVEAL Adult Study: A New Hope for Rett Syndrome?

The REVEAL Adult Study, officially titled ‘An Open-label, Randomized, Dose-escalation- and Dose-expansion Study of the Safety and Preliminary Efficacy of a Single Intrathecal Administration of TSHA-102, an AAV9-Delivered Gene Therapy, in the Treatment of Adult Females With Rett Syndrome,’ aims to assess the safety and preliminary efficacy of TSHA-102 in adult females with Rett syndrome. This study is significant as it explores a potential gene therapy treatment for a condition with limited therapeutic options.

Taysha Regains Full Rights to TSHA-102 Program

On October 16, 2025, Taysha Gene Therapies announced it has regained full rights to its lead TSHA-102 program for Rett syndrome after the expiration of a 2022 Option Agreement with Astellas. This development allows Taysha strategic flexibility to advance the program, which has shown promising safety and efficacy data, received FDA Breakthrough Therapy designation, and is poised for a pivotal trial this quarter, highlighting a significant market opportunity given the unmet medical need in Rett syndrome.

The most recent analyst rating on (TSHA) stock is a Buy with a $6.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Taysha Gene Therapies Presents Promising TSHA-102 Data

On October 9, 2025, Taysha Gene Therapies presented new supplemental data from Part A of the REVEAL Phase 1/2 trials for TSHA-102 in Rett syndrome at the 54th CNS Annual Meeting. The analysis showed 100% of patients achieved developmental milestones and additional skill gains, reinforcing TSHA-102’s potential impact on activities of daily living. This suggests a broad and consistent therapeutic effect across core domains of Rett syndrome, which could significantly influence treatment approaches and improve patient and caregiver experiences.

The most recent analyst rating on (TSHA) stock is a Buy with a $14.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Taysha Gene Therapies Gains FDA Breakthrough Designation

On October 2, 2025, Taysha Gene Therapies announced that the FDA granted Breakthrough Therapy designation to TSHA-102 for Rett syndrome, based on positive clinical evidence from their REVEAL Phase 1/2 trials. The company also finalized alignment with the FDA on the pivotal trial protocol and statistical analysis plan, aiming to expedite the Biologics License Application submission, with patient enrollment expected to begin in Q4 2025.

The most recent analyst rating on (TSHA) stock is a Buy with a $13.00 price target. To see the full list of analyst forecasts on Taysha Gene Therapies stock, see the TSHA Stock Forecast page.

Taysha Gene Therapies’ Earnings Call: Progress Amid Challenges

Taysha Gene Therapies, Inc. recently held its earnings call, revealing a mixed sentiment. While the company showcased strong progress in clinical trials and regulatory alignment, indicating a positive trajectory, it also faced financial challenges due to increased expenses and net loss.

Taysha Gene Therapies Advances Rett Syndrome Trials

Taysha Gene Therapies, Inc. is a clinical-stage biotechnology company specializing in adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system, with a focus on developing transformative medicines for conditions like Rett syndrome.