CompetitionCompetitors could prove difficult to beat out, and Astellas has the exclusive option to buy the program, which could limit upside.
Public PerceptionGeneral public skepticism about gene therapy presents a challenge to the adoption of TSHA-102.
Validation RisksThere are several risks to the Buy thesis, including long-term efficacy and safety needing validation, public skepticism about gene therapy, and potential competition from other companies.