Commercial Execution RiskThe shift toward commercial launch performance concentrates risk on pricing, distribution across targeted centers, and patient adoption, which could depress valuation if execution falls short.
Competitive LandscapePresence of approved gamma secretase inhibitors and other competing therapies creates headwinds that could limit varegacestat uptake and pressure market share expectations.
Market Sentiment And Short InterestElevated short interest exceeding 20% of the float signals pronounced market skepticism that could amplify downside pressure on the share price.