Prime Medicine: Buy Rating on Prime Editing Platform Targeting High-Value Liver and Lung Genetic Diseases, Led by PM577 in Wilson’s DiseaseWe are iniang coverage on Prime Medicine (Nasdaq: PRME) under our an OUTPERFORM rang and price target of $6/share. Prime is a biotechnology company developing one-and-done gene eding therapies with a recently refocused pipeline centered around high-value indicaons with significant unmet need, including Wilson’s disease (WD), alpha-1 antrypsin deficiency (AATD), and cysc fibrosis (CF). All of these programs ulize prime eding to permanently correct the causave mutaons in each indicaon, providing a differenated approach to other CRISPR-based systems or more tradional AA V-mediated gene therapy by allowing for hotspot or mutaon-agnosc correcons to capture a larger paent pool with a theorecally improved safety profile.